CN1145027C - 测定流体标本中至少一种分析物存在的分析化验装置和方法 - Google Patents
测定流体标本中至少一种分析物存在的分析化验装置和方法 Download PDFInfo
- Publication number
- CN1145027C CN1145027C CNB998110566A CN99811056A CN1145027C CN 1145027 C CN1145027 C CN 1145027C CN B998110566 A CNB998110566 A CN B998110566A CN 99811056 A CN99811056 A CN 99811056A CN 1145027 C CN1145027 C CN 1145027C
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- sample
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- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
- G01N33/54389—Immunochromatographic test strips based on lateral flow with bidirectional or multidirectional lateral flow, e.g. wherein the sample flows from a single, common sample application point into multiple strips, lanes or zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/795—Porphyrin- or corrin-ring-containing peptides
- G01N2333/805—Haemoglobins; Myoglobins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9123—Phosphotransferases in general with a nitrogenous group as acceptor (2.7.3), e.g. histidine kinases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of Radiation (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/130,164 US6171870B1 (en) | 1998-08-06 | 1998-08-06 | Analytical test device and method for use in medical diagnoses |
| US09/130,164 | 1998-08-06 | ||
| US09/353,188 US6410341B1 (en) | 1998-08-06 | 1999-07-14 | Analytical test device and method for use in medical diagnoses |
| US09/353,190 | 1999-07-14 | ||
| US09/353,188 | 1999-07-14 | ||
| US09/353,190 US6214629B1 (en) | 1998-08-06 | 1999-07-14 | Analytical test device and method for use in medical diagnoses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100039525A Division CN1250970C (zh) | 1998-08-06 | 1999-08-06 | 分析化验装置和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1318151A CN1318151A (zh) | 2001-10-17 |
| CN1145027C true CN1145027C (zh) | 2004-04-07 |
Family
ID=27383975
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100039525A Expired - Fee Related CN1250970C (zh) | 1998-08-06 | 1999-08-06 | 分析化验装置和方法 |
| CNB998110566A Expired - Fee Related CN1145027C (zh) | 1998-08-06 | 1999-08-06 | 测定流体标本中至少一种分析物存在的分析化验装置和方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100039525A Expired - Fee Related CN1250970C (zh) | 1998-08-06 | 1999-08-06 | 分析化验装置和方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6673628B2 (enExample) |
| EP (1) | EP1102989B1 (enExample) |
| JP (1) | JP2002522767A (enExample) |
| KR (1) | KR100604510B1 (enExample) |
| CN (2) | CN1250970C (enExample) |
| AT (1) | ATE237807T1 (enExample) |
| AU (2) | AU764444B2 (enExample) |
| CA (1) | CA2339599A1 (enExample) |
| DE (1) | DE69906986T2 (enExample) |
| MX (1) | MXPA01001384A (enExample) |
| WO (1) | WO2000008466A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673562B2 (en) * | 2000-08-24 | 2004-01-06 | Spectral Diagnostics, Inc. | Differential immunoassay |
| EP1947459A3 (en) * | 2000-08-24 | 2008-09-24 | Nanogen, Inc. | Differential immunoassay |
| SE0003662D0 (sv) * | 2000-10-11 | 2000-10-11 | Pharmacia Diagnostics Ab | Assay method and kit therefor |
| CA2431097A1 (en) * | 2000-12-22 | 2002-07-04 | Bio A.R.T. Bvba | Flow through assay device, diagnostic kit comprising said assay device and use of said assay device in the detection of an analyte present in a sample |
| CN1242270C (zh) * | 2001-08-09 | 2006-02-15 | 松下电器产业株式会社 | 生物传感器及测定方法 |
| US7611670B2 (en) * | 2002-04-23 | 2009-11-03 | Home Access Health Corporation | Quantitative analysis of a biological sample of unknown quantity |
| EP2287612B1 (en) * | 2002-04-23 | 2016-09-21 | Home Access Health Corporation | Quantitative analysis of a biological sample of unknown quantity |
| US7279134B2 (en) * | 2002-09-17 | 2007-10-09 | Intel Corporation | Microfluidic devices with porous membranes for molecular sieving, metering, and separations |
| US20060205086A1 (en) * | 2002-10-24 | 2006-09-14 | Spectral Diagnostics Inc. | Diagnostic device |
| US7256053B2 (en) | 2002-10-24 | 2007-08-14 | Nanogen, Inc. | Diagnostic device for analyte detection |
| JP4933258B2 (ja) * | 2003-09-22 | 2012-05-16 | クイデル コーポレーション | 試料中の複数分析物の検出装置 |
| EP1733232A1 (en) * | 2004-03-23 | 2006-12-20 | Quidel Corporation | Hybrid phase lateral flow assay |
| US20060078471A1 (en) * | 2004-10-12 | 2006-04-13 | Witty Thomas R | Apparatus and method for a precision flow assay |
| US7189522B2 (en) * | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| WO2006098804A2 (en) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US7871568B2 (en) * | 2006-01-23 | 2011-01-18 | Quidel Corporation | Rapid test apparatus |
| US7794656B2 (en) * | 2006-01-23 | 2010-09-14 | Quidel Corporation | Device for handling and analysis of a biological sample |
| US20120003727A1 (en) * | 2006-03-10 | 2012-01-05 | Javanbakhsh Esfandiari | Immunoassay Device for Detecting Antibodies and Antigens |
| US20080115798A1 (en) * | 2006-06-08 | 2008-05-22 | Donald Frank Rainey | Ultra-size cosmetic applicator having enhanced surface area |
| US8008034B2 (en) * | 2006-10-13 | 2011-08-30 | Theranos, Inc. | Reducing optical interference in a fluidic device |
| EP2178641B1 (en) * | 2007-08-09 | 2018-04-11 | Progenity, Inc. | Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material |
| CN104062454B (zh) * | 2007-10-30 | 2016-01-20 | 松下健康医疗控股株式会社 | 分析用仪器 |
| CA2725977A1 (en) * | 2008-05-27 | 2009-12-03 | Zbx Corporation | Enzymatic analytical membrane, test device and method |
| US20100022916A1 (en) | 2008-07-24 | 2010-01-28 | Javanbakhsh Esfandiari | Method and Apparatus for Collecting and Preparing Biological Samples for Testing |
| US20110243811A1 (en) * | 2008-08-26 | 2011-10-06 | Wen-Pin Hsieh | Substrate of analytical strip |
| KR20110046451A (ko) * | 2008-08-29 | 2011-05-04 | 액텀 아이엔씨. | 분석 스트립 |
| US20100285991A1 (en) * | 2008-09-16 | 2010-11-11 | Glaxosmithkline Llc | Combinatory analytical strip |
| TWI402500B (zh) * | 2008-09-19 | 2013-07-21 | Actherm Inc | 流體檢測試片 |
| JP5162031B2 (ja) | 2008-10-09 | 2013-03-13 | 紅電醫學科技股▲分▼有限公司 | 液体の検査方法 |
| EP2352026B1 (en) | 2008-10-17 | 2013-08-14 | Actherm Inc. | Liquid test strip and the method |
| EP2339019B1 (en) | 2008-10-17 | 2013-08-14 | Actherm Inc. | A fluid test strip and method thereof |
| BRPI0918101A2 (pt) | 2008-12-22 | 2015-11-24 | Koninkl Philips Electronics Nv | método para medir a troponina i em uma amostra, cartucho para ser utilizado em um dispositivo de ensaio e uso |
| US10203310B2 (en) | 2009-01-26 | 2019-02-12 | Detectachem Llc | Chemical detection of substances by utilizing a sample medium impregnated with solid test chemicals |
| WO2010090773A1 (en) * | 2009-02-09 | 2010-08-12 | Healthpoint Diagnostix, Inc. | Plasma sample collection device |
| AU2010221117A1 (en) * | 2009-03-06 | 2011-09-29 | President And Fellows Of Harvard College | Methods of micropatterning paper-based microfluidics |
| BRPI0925015A2 (pt) * | 2009-03-23 | 2018-02-27 | Actherm Inc | chip de teste de fluido e método para produzir o mesmo |
| CN102313802B (zh) * | 2010-07-09 | 2014-04-23 | 上海荣盛生物药业有限公司 | 检测抗原或抗体的组件及其用途 |
| US9182353B2 (en) | 2010-07-22 | 2015-11-10 | Hach Company | Lab-on-a-chip for alkalinity analysis |
| JP5650970B2 (ja) * | 2010-09-28 | 2015-01-07 | 富士フイルム株式会社 | 検査装置およびその制御方法、並びに検査用反応容器 |
| US8603835B2 (en) | 2011-02-10 | 2013-12-10 | Chembio Diagnostic Systems, Inc. | Reduced step dual path immunoassay device and method |
| JP6226872B2 (ja) * | 2011-11-22 | 2017-11-08 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | キャリブレーションおよび/またはクオリティ・コントロール溶液として再構成用の乾燥試薬を含むデバイスとその製造および使用方法 |
| KR101280054B1 (ko) * | 2012-05-31 | 2013-06-28 | 에스디 바이오센서 주식회사 | 현장진단 면역크로마토그래피용 동결건조 접합체 구조물, 이를 이용하는 면역분석용 키트 및 상기 키트를 이용하는 분석방법 |
| US9180449B2 (en) | 2012-06-12 | 2015-11-10 | Hach Company | Mobile water analysis |
| WO2014081460A1 (en) * | 2012-11-20 | 2014-05-30 | Kisner Mark | Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test |
| USD768872S1 (en) | 2012-12-12 | 2016-10-11 | Hach Company | Cuvette for a water analysis instrument |
| US9482675B1 (en) * | 2013-07-31 | 2016-11-01 | University Of Kentucky Research Foundation | Methods and systems for prognosis and diagnosis of brain damage |
| PE20170259A1 (es) | 2014-04-02 | 2017-04-14 | Chembio Diagnostic Systems Inc | Inmunoensayo que utiliza un conjugado de captura |
| RU2685660C2 (ru) * | 2014-06-16 | 2019-04-22 | Конинклейке Филипс Н.В. | Картридж для быстрого отбора пробы |
| US9885699B2 (en) * | 2014-07-31 | 2018-02-06 | Becton, Dickinson And Company | Methods for processing whole blood samples, and compositions for use in practicing the same |
| US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
| US9981264B2 (en) | 2014-11-04 | 2018-05-29 | Grace Bio-Labs, Inc. | Nitrocellulose extrusion for porous film strips |
| US10399079B2 (en) | 2015-01-30 | 2019-09-03 | Hewlett-Packard Development Company, L.P. | Diagnostic device |
| US10725031B1 (en) | 2017-04-26 | 2020-07-28 | Conquerab Inc. | Reflux device for detection of analytes in samples |
| CN107389911A (zh) * | 2017-07-12 | 2017-11-24 | 柳州康云互联科技有限公司 | 用于移动端的快速分离检测传感器 |
| EP3814011A4 (en) | 2018-06-12 | 2022-06-08 | NowDiagnostics, Inc. | Device and method for collecting plasma |
| US20230138304A1 (en) * | 2020-03-31 | 2023-05-04 | 3M Innovative Properties Company | Diagnostic Device |
| US11766369B1 (en) | 2020-09-30 | 2023-09-26 | Douglas Dillon | Single use protective cover for patient transport device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US4987065A (en) | 1983-07-05 | 1991-01-22 | Enzo Biochem, Inc. | In vivo labelling of polynucleotide sequences |
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| US4753776A (en) | 1986-10-29 | 1988-06-28 | Biotrack, Inc. | Blood separation device comprising a filter and a capillary flow pathway exiting the filter |
| US5079142A (en) | 1987-01-23 | 1992-01-07 | Synbiotics Corporation | Orthogonal flow immunoassays and devices |
| US4774192A (en) | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
| CA1303983C (en) * | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US5096809A (en) | 1988-07-25 | 1992-03-17 | Pacific Biotech, Inc. | Whole blood assays using porous membrane support devices |
| US5114890A (en) | 1988-09-02 | 1992-05-19 | Teledyne Industries, Inc. | Zirconium-containing coating composition |
| US5135716A (en) | 1989-07-12 | 1992-08-04 | Kingston Diagnostics, L.P. | Direct measurement of HDL cholesterol via dry chemistry strips |
| US5075078A (en) | 1989-10-05 | 1991-12-24 | Abbott Laboratories | Self-performing immunochromatographic device |
| US4993092A (en) | 1989-11-13 | 1991-02-19 | Weeks David B | Patient carrier cover and method |
| US5110724A (en) | 1990-04-02 | 1992-05-05 | Cholestech Corporation | Multi-analyte assay device |
| US5843691A (en) * | 1993-05-15 | 1998-12-01 | Lifescan, Inc. | Visually-readable reagent test strip |
| US6171870B1 (en) * | 1998-08-06 | 2001-01-09 | Spectral Diagnostics, Inc. | Analytical test device and method for use in medical diagnoses |
-
1999
- 1999-08-06 EP EP99940165A patent/EP1102989B1/en not_active Expired - Lifetime
- 1999-08-06 WO PCT/EP1999/005712 patent/WO2000008466A2/en not_active Ceased
- 1999-08-06 CN CNB2004100039525A patent/CN1250970C/zh not_active Expired - Fee Related
- 1999-08-06 KR KR1020017001614A patent/KR100604510B1/ko not_active Expired - Fee Related
- 1999-08-06 CN CNB998110566A patent/CN1145027C/zh not_active Expired - Fee Related
- 1999-08-06 JP JP2000564049A patent/JP2002522767A/ja active Pending
- 1999-08-06 CA CA002339599A patent/CA2339599A1/en not_active Abandoned
- 1999-08-06 AT AT99940165T patent/ATE237807T1/de not_active IP Right Cessation
- 1999-08-06 MX MXPA01001384A patent/MXPA01001384A/es active IP Right Grant
- 1999-08-06 AU AU54208/99A patent/AU764444B2/en not_active Ceased
- 1999-08-06 DE DE69906986T patent/DE69906986T2/de not_active Expired - Lifetime
-
2001
- 2001-02-06 US US09/777,549 patent/US6673628B2/en not_active Expired - Fee Related
-
2003
- 2003-11-21 AU AU2003262455A patent/AU2003262455A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU764444B2 (en) | 2003-08-21 |
| CN1519563A (zh) | 2004-08-11 |
| EP1102989B1 (en) | 2003-04-16 |
| AU5420899A (en) | 2000-02-28 |
| KR100604510B1 (ko) | 2006-07-25 |
| JP2002522767A (ja) | 2002-07-23 |
| CA2339599A1 (en) | 2000-02-17 |
| KR20010085338A (ko) | 2001-09-07 |
| AU2003262455A1 (en) | 2003-12-18 |
| CN1318151A (zh) | 2001-10-17 |
| DE69906986D1 (de) | 2003-05-22 |
| EP1102989A2 (en) | 2001-05-30 |
| DE69906986T2 (de) | 2004-02-12 |
| CN1250970C (zh) | 2006-04-12 |
| WO2000008466A3 (en) | 2000-05-18 |
| MXPA01001384A (es) | 2002-11-29 |
| US20010039059A1 (en) | 2001-11-08 |
| HK1039518A1 (en) | 2002-04-26 |
| US6673628B2 (en) | 2004-01-06 |
| WO2000008466A2 (en) | 2000-02-17 |
| ATE237807T1 (de) | 2003-05-15 |
| WO2000008466A9 (en) | 2000-06-29 |
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