CN114502173A - 具有降低的毒性的混合两性霉素b衍生物 - Google Patents

具有降低的毒性的混合两性霉素b衍生物 Download PDF

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Publication number
CN114502173A
CN114502173A CN202080070409.4A CN202080070409A CN114502173A CN 114502173 A CN114502173 A CN 114502173A CN 202080070409 A CN202080070409 A CN 202080070409A CN 114502173 A CN114502173 A CN 114502173A
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Chinese (zh)
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M·D·伯克
A·马吉
J·张
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University of Illinois System
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University of Illinois System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CN202080070409.4A 2019-08-08 2020-08-07 具有降低的毒性的混合两性霉素b衍生物 Pending CN114502173A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884471P 2019-08-08 2019-08-08
US62/884471 2019-08-08
US201962927731P 2019-10-30 2019-10-30
US62/927731 2019-10-30
PCT/US2020/045399 WO2021026450A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CN114502173A true CN114502173A (zh) 2022-05-13

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CN202080070409.4A Pending CN114502173A (zh) 2019-08-08 2020-08-07 具有降低的毒性的混合两性霉素b衍生物

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Country Link
US (1) US20230000891A1 (enExample)
EP (1) EP4009984A4 (enExample)
JP (1) JP2022543421A (enExample)
KR (1) KR20220058547A (enExample)
CN (1) CN114502173A (enExample)
AU (1) AU2020325054A1 (enExample)
CA (1) CA3149819A1 (enExample)
IL (1) IL290290A (enExample)
WO (1) WO2021026450A1 (enExample)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
US20170088572A1 (en) * 2014-05-16 2017-03-30 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
ES3072651T3 (en) * 2014-10-17 2026-07-03 Univ Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
JP6726192B2 (ja) * 2015-01-08 2020-07-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの尿素誘導体の簡便な合成法
CN113056274A (zh) * 2018-09-07 2021-06-29 伊利诺伊大学评议会 具有降低的毒性的杂化两性霉素b衍生物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
US20170088572A1 (en) * 2014-05-16 2017-03-30 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MITCHELL P. CROATT，等: "Probing the Role of the Mycosamine C2′-OH on the Activity of Amphotericin B", 《ORG. LETT.》, vol. 13, no. 6, pages 1391 *

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Publication number Publication date
EP4009984A4 (en) 2023-09-06
JP2022543421A (ja) 2022-10-12
CA3149819A1 (en) 2021-02-11
IL290290A (en) 2022-04-01
KR20220058547A (ko) 2022-05-09
US20230000891A1 (en) 2023-01-05
WO2021026450A1 (en) 2021-02-11
EP4009984A1 (en) 2022-06-15
AU2020325054A1 (en) 2022-03-03

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