CA3149819A1 - Hybrid amphotericin b derivatives with reduced toxicity - Google Patents

Hybrid amphotericin b derivatives with reduced toxicity Download PDF

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Publication number
CA3149819A1
CA3149819A1 CA3149819A CA3149819A CA3149819A1 CA 3149819 A1 CA3149819 A1 CA 3149819A1 CA 3149819 A CA3149819 A CA 3149819A CA 3149819 A CA3149819 A CA 3149819A CA 3149819 A1 CA3149819 A1 CA 3149819A1
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CA
Canada
Prior art keywords
unsubstituted
substituted
alkyl
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3149819A
Other languages
English (en)
French (fr)
Inventor
Martin D. Burke
Arun Maji
Jiabao Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of CA3149819A1 publication Critical patent/CA3149819A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CA3149819A 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity Pending CA3149819A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884471P 2019-08-08 2019-08-08
US62/884,471 2019-08-08
US201962927731P 2019-10-30 2019-10-30
US62/927,731 2019-10-30
PCT/US2020/045399 WO2021026450A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CA3149819A1 true CA3149819A1 (en) 2021-02-11

Family

ID=74503744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3149819A Pending CA3149819A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Country Status (9)

Country Link
US (1) US20230000891A1 (enExample)
EP (1) EP4009984A4 (enExample)
JP (1) JP2022543421A (enExample)
KR (1) KR20220058547A (enExample)
CN (1) CN114502173A (enExample)
AU (1) AU2020325054A1 (enExample)
CA (1) CA3149819A1 (enExample)
IL (1) IL290290A (enExample)
WO (1) WO2021026450A1 (enExample)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
KR102548341B1 (ko) * 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
ES3072651T3 (en) * 2014-10-17 2026-07-03 Univ Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
JP6726192B2 (ja) * 2015-01-08 2020-07-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの尿素誘導体の簡便な合成法
PT3283171T (pt) * 2015-04-15 2021-07-14 Sfunga Therapeutics Inc Derivados de anfotericina b
CN113056274A (zh) * 2018-09-07 2021-06-29 伊利诺伊大学评议会 具有降低的毒性的杂化两性霉素b衍生物

Also Published As

Publication number Publication date
EP4009984A4 (en) 2023-09-06
JP2022543421A (ja) 2022-10-12
IL290290A (en) 2022-04-01
KR20220058547A (ko) 2022-05-09
US20230000891A1 (en) 2023-01-05
WO2021026450A1 (en) 2021-02-11
CN114502173A (zh) 2022-05-13
EP4009984A1 (en) 2022-06-15
AU2020325054A1 (en) 2022-03-03

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