CN114467983A - Efficient and safe disinfectant for enveloped viruses - Google Patents
Efficient and safe disinfectant for enveloped viruses Download PDFInfo
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- CN114467983A CN114467983A CN202111569903.8A CN202111569903A CN114467983A CN 114467983 A CN114467983 A CN 114467983A CN 202111569903 A CN202111569903 A CN 202111569903A CN 114467983 A CN114467983 A CN 114467983A
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 60
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- 235000019737 Animal fat Nutrition 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- 241000711798 Rabies lyssavirus Species 0.000 description 2
- 239000005708 Sodium hypochlorite Substances 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
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- 239000000344 soap Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
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- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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- 239000010410 layer Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 239000002344 surface layer Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Agronomy & Crop Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a high-efficiency and safe disinfectant for enveloped viruses. Each 100 g of disinfectant comprises: 1) 40 grams of avocado oil as a disinfecting ingredient; 2) 20 g decyl glucoside, as surfactant; 3) 0.1 g potassium sorbate as an antiseptic antioxidant; 4) the balance being water. Compared with the traditional disinfectant, the disinfectant has the advantages of low cost, easy use, high safety, benefit to health and environmental protection; compared with the fatty acid disinfectant, the disinfectant has the advantages of similar cost, higher safety, greatly improved stability, approximate performance and easier manufacture.
Description
Technical Field
The invention relates to a disinfectant, in particular to a high-efficiency safe disinfectant for enveloped viruses, which is formed by dissolving oil in water for dilution.
Background
Currently, chlorine-containing disinfectants such as sodium hypochlorite (84), hypochlorous acid and chlorine dioxide are used most frequently in the new world. The principle of chlorine-containing disinfectants is generally considered to be that proteins of viruses are denatured and inactivated by oxidation, wherein hypochlorous acid has the best effect because of no electric charge and can easily penetrate through phospholipid membrane layers of cells and viruses which are usually negatively charged, and the required concentration is the lowest and the safest. In addition, 75% alcohol and the like are also widely used.
Viruses can be classified into enveloped viruses and non-enveloped viruses, and the new coronavirus belongs to the enveloped virus. Because enveloped viruses are relatively difficult to recognize by the immune system and can release replicated viruses continuously in infected cells without breaking the infected cells, so that the viruses can be released and replicated, and antibodies in body fluid can be avoided easily, the enveloped viruses are relatively fragile, but are more difficult to control and treat after infection, for example, HIV, coronavirus, influenza virus, rabies virus and the like are all enveloped viruses; non-enveloped viruses are relatively easy to recognize by the immune system, but because the outer shell is generally much stronger than enveloped viruses, the killing difficulty is higher. Because enveloped viruses are the main virus type which needs to be killed at present, the disinfection capability of the disinfectant for killing the viruses is a major concern, for example, 75% alcohol can not kill most non-enveloped viruses such as hepatitis A virus and norovirus, but can be used for killing various enveloped viruses and is widely adopted.
In addition to the common disinfectants, there is a class of disinfectants that is not widely used that uses fatty acids as a means of disinfection. For example, the fatty acid composition disclosed in CN101233852A uses caprylic/capric acid and pelargonic acid, and matches with alkyl sulfonate and acids to form a relatively stable solution, which can achieve a certain disinfection effect after diluted. The invention is mainly superior to the prior fatty acid disinfectant in that the disinfectant is more stable and is not easy to crystallize, but the invention uses hydrogen peroxide to form fatty acid peroxide to improve the sterilization and antivirus performance, and the fatty acid peroxide has great destructiveness to human health and reduces the use safety. We have noted that such products typically use medium chain fatty acids because longer chain fatty acids tend to crystallize more easily and denature for use and many products have heretofore added short chain fatty acids with significant off-flavors for stabilization. In addition to these prior art, there are now a lot of studies on the killing of enveloped viruses by polyunsaturated fatty acids, and it is generally believed that polyunsaturated fatty acids have an outstanding antiviral effect on enveloped viruses, mainly because they can destroy the surface phospholipid membrane of enveloped viruses; on the other hand, the process of fusion of virus and cell is interfered because some independent membrane lipid micro-regions formed by tight combination of cholesterol and sphingomyelin exist on the cell membrane, the membrane lipid micro-regions are called lipid rafts, the invasion and transportation of virus into cells need to be completed through the domain, and the polyunsaturated fatty acid is considered to interfere with or even eliminate the domain, thereby affecting the process of destroying the fusion of virus envelope and cell membrane.
Fats and oils are chemically defined as esters synthesized from higher fatty acids and glycerol, and the most important of them are triglycerides containing three higher fatty acids. The fatty acid used for disinfection belongs to free fatty acid, and the content of the free fatty acid is far less than that of grease in nature. Both animal fat, vegetable fat and butter in dairy products are the most of fat, and only trace free fatty acid exists, because the free fatty acid is destructive in a living body, inflammatory reaction and the like are easy to cause, and the stability of the free fatty acid is obviously inferior to that of the fat formed by combining with glycerol, the free fatty acid is usually a metabolite under specific conditions. The fatty acids in these disinfecting products are obtained by decomposing fats and oils. While we generally say that the intake of a certain fatty acid is beneficial to health, it means that the intake of a glyceride formed by the fatty acid and glycerin, i.e., a fat containing the fatty acid, is not directly intake of the associated free fatty acid.
The grease rich in medium-chain fatty acid used by the fatty acid disinfectant is mainly some specific vegetable oils such as palm oil and coconut oil, and the milk fat also has a certain content; short chain fatty acid oils are also mainly present in dairy oils and palm oil coconut oil; most vegetable and animal fatty oils are long-chain fatty acid oils. Saturated fatty acid oil is easy to coagulate, and unsaturated fatty acid oil is not easy to coagulate at normal temperature. Most of natural animal oil and fat or vegetable oil and fat contain a plurality of long-chain fatty acids, wherein the saturated fatty acids in the animal fat are high in content and are easy to coagulate at normal temperature, and the unsaturated fatty acids in the vegetable oil and fat and fish oil are high in content and are difficult to coagulate, with few exceptions.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention aims to provide a high-efficiency and safe disinfectant for enveloped viruses.
The technical scheme adopted by the invention is as follows:
a high-efficiency safe disinfectant for enveloped viruses is prepared by dissolving oil and fat in water.
The oil in the disinfectant is dissolved and diluted in water through a surfactant or an emulsifier.
The disinfectant is characterized in that the mass percentage concentration of the grease in the aqueous solution is 0.025-1% when the disinfectant is used.
The disinfectant comprises the following components in every 100 g of disinfectant:
1) 40 grams of avocado oil as a disinfecting ingredient; when in use, the mixture is diluted to 40 to 2000 times.
The disinfectant comprises the following components in every 100 g of disinfectant:
1) 40 grams of avocado oil as a disinfecting ingredient;
2) 20 g decyl glucoside, as surfactant;
the balance being water.
The disinfectant comprises the following components in every 100 g of disinfectant:
1) 40 grams of avocado oil as a disinfecting ingredient;
2) 20 g decyl glucoside, as surfactant;
3) 0.1 g potassium sorbate as an antiseptic antioxidant;
4) the balance being water.
When in use, the disinfectant is diluted to 800 times and sprayed or smeared for use.
The disinfectant is put into a humidification type aromatherapy machine to continuously disinfect air, or is sprayed by a two-fluid aromatherapy sprayer to disinfect air.
The beneficial effect of the invention is that,
on one hand, the disinfectant is prepared by directly using the grease instead of the fatty acid obtained by decomposing the grease, so that the manufacturing cost and the environmental consumption are reduced to a certain extent; on the other hand, the stability of the grease is far stronger than that of the fatty acid, so that the daily stability of the product is improved; meanwhile, because the polyunsaturated fatty acid commonly existing in various oils has long chains but low condensation temperature, compared with free polyunsaturated fatty acid, the polyunsaturated fatty acid is too unstable and does not have use conditions, and meanwhile, the free saturated fatty acid used in the fatty acid disinfectant has good stability, but the condensation temperature is higher due to the medium chain length, and the low-temperature performance problem is larger, the low-temperature performance can be obviously improved by using the oils containing the unsaturated fatty acid chains through multiple selection. The grease is used as a sterilizing component, so long as the daily edible products are selected as raw materials, the performance of ensuring health safety is obviously superior to other sterilizing products to a great extent, and the grease is also significantly superior to the disinfectant of free fatty acid and peroxyfatty acid which is relatively safe but can not be called as a health component at all.
Meanwhile, compared with other common disinfectants such as hypochlorous acid disinfection products which are considered to be the safest, although the disinfectants are nontoxic in short-time contact, the disinfectants still cannot be contacted for a long time, the safety performance of the disinfectants is obviously not disturbed by the problems of non-sustainable contact and the like, even high-quality healthy grease can have certain help effect on skin health and the like, so that the application possibility is greatly expanded, for example, air can be continuously disinfected in a aromatherapy mode under the condition of people, and the mode is an unusable mode of the disinfection products in the prior art.
Therefore, compared with the traditional disinfectant, the disinfectant has the advantages of low cost, easy use, high safety, health benefit and environmental friendliness; compared with the fatty acid disinfectant, the disinfectant has the advantages of similar cost, higher safety, greatly improved stability, approximate performance and easier manufacture.
Detailed Description
The principles and embodiments of the present invention are further described below.
Principle of the invention
We have noted that the use of soap, a sodium aliphatate solution, for cleaning, is the standard recommended procedure for rapid rabies virus treatment, but there are many tests that demonstrate that soap is only effective in killing enveloped viruses and is not ideal. It is assumed that the killing effect of hypochlorous acid is obviously better than that of sodium hypochlorite, and the surface layer of the phospholipid membrane is usually in a negative charge state, while most of fatty acid in the solution of sodium fatty acid exists in a negative ion state, so that the fatty acid cannot be smoothly close to the phospholipid membrane with the same general negative charge state on the surface, and the killing effect is reduced. Free fatty acids, without electrical charge, are normally accessible to and react with phospholipid membranes.
From more studies, we can see that the disinfection properties are very likely to be related to chain length, and long chain fatty acids have more excellent disinfection properties, but are more difficult to keep stable.
We reasoned further that it is likely that the structure of fatty acid chains is present only, is uncharged, and is uniformly distributed in aqueous solution at an appropriate concentration to produce a strong killing effect, and further that it is likely that the longer the fatty acid chains, the better the killing effect. It should also be possible to achieve a definite killing effect as long as the oil is dissolved in water with a surfactant and an appropriate concentration is found to ensure that the fatty acid chains are properly and uniformly dispersed in the solution. Although the efficacy may be slightly lower than that of free fatty acids due to the fact that the tridentate structure of the majority of triglyceride molecules in fat is less dispersed than that of free fatty acids, there is ultimately no great difference in terms of the enhancing effect of the added long chains. In particular, it is expected that the effect on enveloped viruses should be very definite. The technology for stably dissolving the grease, but not the fatty acid, in the water is very mature in the fine chemical industry and has abundant technical schemes for selection. Meanwhile, the fatty acid in a large amount of optional oil contains polyunsaturated fatty acid, the unsaturated fatty acid cannot be coagulated at a daily temperature range even at a low temperature, the fatty acid extracted from coconut oil commonly used by a contrast fatty acid type disinfectant can be coagulated at about 25 ℃, and a large amount of vegetable oil can be coagulated at about zero temperature or even about several degrees below zero without using auxiliary components. Therefore, the stability and low-temperature performance of the product can be ensured more easily.
In order to verify that the guess that excellent antiviral effect can be obtained by directly using an aqueous solution fully diluted by grease is verified, a simple test is firstly carried out, an emulsified component which is lecithin and is considered to have no obvious antiviral capacity is prepared, 20% alcohol is matched and is divided into two groups AB with the same quantity, the group A is directly mixed with an HIV virus culture solution, the group B is added with avocado oil with the mass concentration of 0.5% and is fully dissolved and then is mixed with the HIV virus culture solution, the group C is a control group, distilled water with the mass equal to that of the group AB solution is added into the HIV virus culture solution, the three groups are added into a cell culture solution after being mixed for 10 minutes and are cultured, and the test shows that virus infection is reduced by about 40% in the group A culture solution without the avocado oil compared with the distilled water group C, and almost no infection phenomenon is found in the group B culture solution with the avocado oil. The avocado oil which is fully dispersed and dissolved can be judged to have extremely strong anti-HIV effect obviously, and the expectation is met.
Subsequently, a solution in which 0.05% of avocado oil is dissolved by using trace sodium dodecyl sulfate is prepared, and a professional testing organization is entrusted to test according to European Union EN14476 standard, so that the killing rate of the vaccinia virus is more than 99.99% in 5 minutes and the killing rate of the human coronavirus is more than 99.99% in 10 minutes. It is thus seen that excellent antiviral properties can be obtained using a fully diluted aqueous oil solution.
Examples
A concentrated oil disinfectant. Each 100 g of disinfectant comprises:
1) 40 grams of avocado oil as the main disinfecting ingredient;
2) 20 g decyl glucoside, as surfactant;
3) 0.1 g potassium sorbate as an antiseptic antioxidant; in addition, it is clear that in the case of short-term storage or ready-to-use, no preservative antioxidants have to be added.
4) The balance being water, this example containing 39.9 grams of water.
When in use, the disinfectant can be sprayed or smeared for use in the mode of the traditional disinfectant by only diluting to 40 to 2000 times, preferably to 800 times. Meanwhile, the air can be continuously disinfected in a humidifying type aromatherapy machine, and the air can also be disinfected by using a two-fluid aromatherapy sprayer for spraying.
The avocado oil in the formula is highly healthy; decyl glucoside, as an APG surfactant, is also considered highly mild and healthy for a long-term widespread use in household products; the potassium sorbate is used according to the standard of edible preservatives, the whole formula is obviously, highly, safely and mildly, the daily storage is emulsion-shaped, the adaptive temperature is wide, and the condensation phenomenon is extremely difficult to occur above zero.
The embodiments in the above description can be further combined or replaced, and the embodiments are only described as preferred examples of the present invention, and do not limit the concept and scope of the present invention, and various changes and modifications made to the technical solution of the present invention by those skilled in the art without departing from the design concept of the present invention belong to the protection scope of the present invention. The scope of the invention is given by the appended claims and any equivalents thereof.
Claims (8)
1. A high-efficiency safe disinfectant for enveloped viruses is characterized in that: is prepared by dissolving oil and fat in water.
2. The disinfectant as set forth in claim 1, wherein: the oil in the disinfectant is dissolved and diluted in water by a surfactant or an emulsifier.
3. The disinfectant as set forth in claim 1, wherein: when the disinfectant is used, the mass percentage concentration of the grease in the water solution is 0.025 percent to 1 percent.
4. The disinfectant as set forth in claim 1, wherein: each 100 g of disinfectant comprises:
1) 40 grams of avocado oil as a disinfecting ingredient; when in use, the mixture is diluted to 40 to 2000 times.
5. The disinfectant as set forth in claim 4, wherein: each 100 g of disinfectant comprises:
1) 40 grams of avocado oil as a disinfecting ingredient;
2) 20 g decyl glucoside, as surfactant;
the balance being water.
6. The disinfectant as set forth in claim 5, wherein: each 100 g of disinfectant comprises:
1) 40 grams of avocado oil as a disinfecting ingredient;
2) 20 g decyl glucoside, as surfactant;
3) 0.1 g potassium sorbate as an antiseptic antioxidant;
4) the balance being water.
7. A disinfectant according to any one of claims 4 to 6, wherein:
when in use, the medicine is diluted to 800 times and sprayed or smeared for use.
8. A disinfectant according to any one of claims 4 to 6, wherein:
putting into a humidifying type aromatherapy machine for continuously disinfecting air, or spraying through a two-fluid aromatherapy sprayer for use to disinfect air.
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| US20070036831A1 (en) * | 2005-08-09 | 2007-02-15 | Nanobio Corporation | Nanoemulsion compositions having anti-inflammatory activity |
| CN103327960A (en) * | 2010-08-09 | 2013-09-25 | 蒙特雷尖端科技研究所 | Antimicrobial, antibacterial and spore germination inhibiting activity from an avocado extract enriched in bioactive compounds |
| CN106038695A (en) * | 2015-04-09 | 2016-10-26 | 高雄医学大学 | Use of avocado extract, avocadol B and (2R,4R) -1,2, 4-trihydroxyheptadeca-16-alkyne, and health food containing avocado extract |
| CN108669094A (en) * | 2018-06-25 | 2018-10-19 | 合肥华盖生物科技有限公司 | A kind of high-efficiency multi-function type air sterillization preparation |
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2021
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070036831A1 (en) * | 2005-08-09 | 2007-02-15 | Nanobio Corporation | Nanoemulsion compositions having anti-inflammatory activity |
| CN103327960A (en) * | 2010-08-09 | 2013-09-25 | 蒙特雷尖端科技研究所 | Antimicrobial, antibacterial and spore germination inhibiting activity from an avocado extract enriched in bioactive compounds |
| CN106038695A (en) * | 2015-04-09 | 2016-10-26 | 高雄医学大学 | Use of avocado extract, avocadol B and (2R,4R) -1,2, 4-trihydroxyheptadeca-16-alkyne, and health food containing avocado extract |
| CN108669094A (en) * | 2018-06-25 | 2018-10-19 | 合肥华盖生物科技有限公司 | A kind of high-efficiency multi-function type air sterillization preparation |
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