CN113368007B

CN113368007B - Multifunctional aerosol for oral cavity and preparation process thereof

Info

Publication number: CN113368007B
Application number: CN202110713600.2A
Authority: CN
Inventors: 邵庆辉; 高露阳; 赵玲霞; 俞铁彪; 杨标
Original assignee: Aino Technology Co ltd
Current assignee: Aino Technology Co ltd
Priority date: 2021-06-25
Filing date: 2021-06-25
Publication date: 2022-04-12
Anticipated expiration: 2041-06-25
Also published as: CN113368007A

Abstract

The application relates to the technical field of oral aerosol, and particularly discloses an oral multifunctional aerosol and a preparation process thereof. A multifunctional aerosol for oral cavity uses water as a solvent, and at least comprises the following components by mass concentration: 3-4 omega% of alcohol; allantoin 0.1-0.15 omega%; dipotassium glycyrrhizinate 0.1-0.15 omega%; small molecule polypeptide 0.1-0.2 omega%; vitamin E0.1-0.2 omega%; menthol 0.3-0.4 omega%; emulsifier 0.4-0.5 omega%; a preparation process of the multifunctional aerosol for the oral cavity comprises the following steps: s1, preparation of an aqueous phase W₁And an oil phase O₁(ii) a S2 preparation of W/O type milkA liquid; s3, preparing a W/O/W type emulsion; and S4, filling to obtain the oral aerosol. The oral spray has the functions of removing peculiar smell in the oral cavity, refreshing breath, preventing and relieving dental ulcer and inhibiting bacteria and bacteria.

Description

Multifunctional aerosol for oral cavity and preparation process thereof

Technical Field

The application relates to the technical field of oral aerosol, in particular to a multifunctional aerosol for oral cavity and a preparation process thereof.

Background

The aerosol is a preparation which contains medicine, emulsion or suspension and proper propellant, is packaged in a pressure-resistant container with a special valve system, and sprays the content in the form of mist under the pressure of the propellant when in use, and is used for lung inhalation or directly sprayed to mucosa, skin and space of cavity and tract for disinfection.

The oral aerosol is one of common aerosols, and is often used for cleaning oral cavity, removing oral odor or treating oral diseases, such as oral ulcer and the like. Oral aerosols are generally classified into solution type aerosols, suspension type aerosols and emulsion type aerosols according to the dispersion system.

The Chinese invention patent with the publication number of CN110897953A discloses a breath freshener of plant extracts for relieving bad breath, which is prepared from the following raw materials in percentage by mass: 3.0 to 5.0 percent of sorbitol; PEG-60 hydrogenated castor oil 2.0-3.05; 0.2 to 1.0 percent of essence; 0.5 to 1.0 percent of sodium benzoate; 0.1-0.2% of menthol; 0.05 to 0.1 percent of cetylpyridinium chloride; 0.05 to 0.1 percent of aspartame; 0.05 to 0.15 percent of citric acid; 0.05% of EDTA disodium; grapefruit (Citrus PARADISI) peel oil 0.2-0.5%; 2.0-3.0% of fructus KAKI (Diospyros KAKI) extract; the balance of water.

The preparation process of the breath freshener comprises the following steps: adding water, sorbitol, sodium benzoate, cetylpyridinium chloride, aspartame, citric acid and EDTA disodium in a preparation pot, and stirring for 30 min; dissolving essence, Mentholum, and grapefruit (Citrus PARADISI) peel oil with PEG-60 hydrogenated castor oil, adding into a preparation pot, and stirring for 30 min; adding fructus KAKI (Diospyros KAKI) extract, and stirring for 30 min; and filtering the prepared material body and filling.

In view of the above-mentioned related technologies, along with the progress and development of society, the health needs of people for oral cavity are increasing day by day, for example, the oral cavity freshener for relieving and treating gingival bleeding in oral cavity, preventing and relieving canker sore, etc. the oral cavity freshener aiming at removing the odor in oral cavity gradually fails to meet the needs of people for oral cavity health, so that a multifunctional aerosol capable of being applied to oral cavity health is needed to be sought.

Disclosure of Invention

In order to solve the problem that an oral cavity freshener for simply removing oral cavity peculiar smell cannot meet the requirement of oral cavity health, the application provides a multifunctional aerosol for the oral cavity and a preparation process thereof.

In a first aspect, the present application provides a multifunctional aerosol for oral cavity, which adopts the following technical scheme:

a multifunctional aerosol for oral cavity uses water as a solvent, and at least comprises the following components by mass concentration: 3-4 omega% of alcohol; allantoin 0.1-0.15 omega%; dipotassium glycyrrhizinate 0.1-0.15 omega%; small molecule polypeptide 0.1-0.2 omega%; vitamin E0.1-0.2 omega%; menthol 0.3-0.4 omega%; 0.4-0.5 omega% of emulsifier.

By adopting the technical scheme, water is used as a main solvent to dissolve the components in the aerosol, and the components which are difficult to dissolve in water form an oil-in-water type emulsion system in water through the arrangement of the emulsifier, so that the aerosol exists in an evenly dispersed and stable emulsion form in the storage and use processes, and the action effect of the oral aerosol can be improved to a certain extent.

Allantoin has effects of promoting cell growth and accelerating wound healing, can be used for relieving and treating oral ulcer and stomatitis, and is stable under weakly acidic and alkaline conditions, and is not easy to generate decomposition reaction.

The dipotassium glycyrrhizinate has good water solubility and special sweet taste, and can play a certain seasoning role on the aerosol; meanwhile, the dipotassium glycyrrhizinate has good anti-inflammatory and deodorizing effects, can be used for treating and relieving dental ulcer, stomatitis and the like, and can relieve the problem of halitosis caused by bacterial breeding in the oral cavity. The small molecular polypeptide can repair adhesion and accelerate recovery of oral ulcer to a certain extent.

Vitamin E is a fat-soluble vitamin and still has good stability under acidic and heating conditions. The low dose of vitamin E has antioxidant effect, and the vitamin E can receive electrons of peroxy radicals generated on cell membranes, reduce the damage of free radicals to unsaturated fatty acid in human body, and the unsaturated fatty acid has the function of protecting internal organs, thereby reducing the harm of the free radicals to the human body. Meanwhile, the vitamin E can play a role in preventing dental ulcer.

The menthol is extremely slightly dissolved in water and is very easy to dissolve in ethanol, the dissolution degree of the menthol in the oral aerosol is further improved by adding the ethanol, meanwhile, the menthol has the special fragrance of mint and cool mouthfeel after being taken in the mouth, and the menthol plays a role in removing the peculiar smell in the oral cavity while further improving the flavor of the oral aerosol.

The oral aerosol in the application has the functions of removing peculiar smell in the oral cavity and refreshing breath, and can further prevent and relieve oral diseases such as oral ulcer and the like, thereby realizing the function of one dose for multiple purposes.

Preferably, the aerosol is also added with polyethylene glycol-32 with the mass concentration of 0.6-0.7 omega%; 0.2-0.25 omega% of PEG-40 hydrogenated castor oil.

By adopting the technical scheme, the polyethylene glycol-32 plays a role of a humectant, and the PEG-40 hydrogenated castor oil can uniformly disperse lipophilic substances in the oral aerosol into water to form a stable and transparent solution to play a role of solubilization, so that the oral aerosol is uniformly dispersed liquid drops when being sprayed out of the spray bottle. Meanwhile, the PEG-40 hydrogenated castor oil has the effect of easy degradation, so that the PEG-40 hydrogenated castor oil can be automatically degraded and cannot remain in the oral cavity of a human body after the oral aerosol acts on the oral cavity of the human body.

Preferably, the aerosol is also added with polyethylene glycol-32 with the mass concentration of 0.67 omega%; 0.2-0.25 omega% of PEG-40 hydrogenated castor oil.

Preferably, the aerosol is also added with a atomization improving agent with the mass concentration of 0.1-0.2 omega%, the atomization improving agent consists of PEG-400 and ceteareth-6, and the mass ratio of the PEG-400 to the ceteareth-6 is (2-3): (1-2).

By adopting the technical scheme, the PEG-400 is easily soluble in water and ethanol, the PEG-400 has lower relative molecular weight, can play the roles of a cosolvent and a stabilizer, is beneficial to dissolving and dispersing all components in the aerosol, and simultaneously maintains the stability of an emulsification system to a certain extent; ceteareth-6 has a certain emulsifying capacity and further promotes the formation of an emulsifying system.

Preferably, the emulsifier is composed of the following raw materials in parts by weight: 6-7.5 parts of 1-capric acid monoglyceride; 4-5 parts of lauric acid monoglyceride; 5-8 parts of hydroxypropyl cellulose; tween-2010-12.5 parts, wherein the mass ratio of the 1-capric acid monoglyceride to the lauric acid monoglyceride is 3: 2.

by adopting the technical scheme, the 1-capric acid monoglyceride plays a role of an oil phase solvent, the lauric acid monoglyceride is uniformly mixed with the 1-capric acid monoglyceride as a lipophilic surfactant, after the vitamin E is dissolved in the 1-capric acid monoglyceride, the addition of the lauric acid monoglyceride enables the water phase dissolved with the polypeptide and the oil phase dissolved with the vitamin E to be uniformly mixed, and a relatively stable W/O emulsification system is formed. And then adding the W/O emulsification system into the uniformly mixed water phase system, so that the W/O/W emulsification system is formed in the aerosol finally, the slow release effect on the polypeptide and the vitamin E is achieved, and after the aerosol enters the oral cavity, the polypeptide and the vitamin E can be slowly released and act on the oral cavity, so that the repair of the oral mucosa is realized, and the oral ulcer is treated.

The hydroxypropyl cellulose is dissolved in water at normal temperature, is used as an emulsifier to increase the emulsification degree of each component in the emulsion, and can form a film on oral mucosa after being sprayed into the oral cavity, so that vitamin E, polypeptide and the like in the film act on the oral ulcer, the contact action time of the vitamin E and the polypeptide with the oral ulcer is increased, and the effect of accelerating the recovery of the oral ulcer is enhanced to a certain extent.

Preferably, the aerosol is also added with a sweetening agent with the mass concentration of 0.9-1.2 omega%, the sweetening agent consists of sorbitol and erythritol, and the mass ratio of the sorbitol to the erythritol is (4-6): (5-6).

By adopting the technical scheme, the sorbitol is easily dissolved in water, has cool sweet taste and can enhance the taste and flavor of the oral aerosol; and meanwhile, the sorbitol can not be converted into glucose after being taken into a human body and is not influenced by insulin, so that a diabetic does not need to worry about taking the glucose when using the oral aerosol. Erythritol is easily dissolved in water, has refreshing sweet taste, is a filling sweetener, still has better stability under the conditions of acidity, alkalinity and heating, and is easy to be absorbed by human body but does not participate in sugar metabolism; erythritol can inhibit the growth of bacteria in oral cavity, so as to protect teeth and prevent dental caries.

Preferably, the aerosol is further added with a preservative with the mass concentration of 0.2-0.4 omega%, the preservative is composed of potassium sorbate and citric acid, and the mass ratio of the potassium sorbate to the citric acid is 1: (1-2).

By adopting the technical scheme, the potassium sorbate is easily dissolved in water, and the potassium sorbate is combined with sulfydryl of a microbial enzyme system to destroy the microbial enzyme system, so that the effects of inhibiting microbial breeding and preventing corrosion are achieved. The potassium sorbate can fully exert the preservative effect under the acidic condition, but the preservative effect of the potassium sorbate under the neutral condition is weaker, and the potassium sorbate is easy to generate oxidative decomposition reaction and turns brown when exposed to the air.

The citric acid is easily dissolved in water, has strong acidity, has strong sour taste when being taken, can stimulate taste bud cells, increases salivary secretion, and plays a role in further improving the flavor of the oral aerosol. The citric acid can chelate calcium and magnesium ions on bacterial cell membranes, so that a lipopolysaccharide layer is separated from cell walls, the performance of the antioxidant in the oral aerosol is enhanced, the effect of the synergist of the antioxidant is achieved, the antioxidant effect of the antioxidant is further improved, and the influence of free radicals on a human body is reduced. The citric acid and the potassium sorbate are compounded for use, so that the preservative effect on the oral spray is realized, and meanwhile, the pH value of the oral spray is adjusted to be acidic by the citric acid, so that the potassium sorbate can fully volatilize the preservative effect.

Meanwhile, citric acid and lauric acid monoglyceride can generate a synergistic effect, and the growth of bacteria can be further inhibited, so that the antibacterial and bacteriostatic effects of the oral aerosol are further enhanced.

Preferably, lysine with the mass concentration of 0.1-0.2 omega% is also added into the aerosol.

By adopting the technical scheme, lysine can be ionized and generate positive charges after being dissolved in water, so that the polypeptide and the vitamin E are positioned in the membrane to carry partial positive charges. The mucus layer on the surface of the oral mucosa is a mucin which is composed of flexible cross-linked glycoprotein chains and has strong internal cohesion. Under physiological pH, mucus is negatively charged due to the presence of acidic species such as sialic acid at the end of the glycoprotein chain, which can result in high charge density. After the membrane containing the polypeptide and the vitamin E is released, the membrane containing the polypeptide and the vitamin E is further adsorbed on the oral mucosa under the action of electrostatic attraction force and further acts on the oral ulcer, so that the effect of accelerating the recovery of the oral ulcer is enhanced to a certain extent.

In a second aspect, the application provides a preparation process of an oral multifunctional aerosol, which adopts the following technical scheme:

the preparation process of the multifunctional aerosol for the oral cavity comprises the following process steps:

s1, dissolving the small molecular polypeptide, lysine and hydroxypropyl cellulose in water to form a water phase W₁Dissolving vitamin E in 1-capric acid monoglyceride and mixing with lauric acid monoglyceride to form oil phase O₁；

S2, mixing the water phase W₁Adding into oil phase O₁Performing high-speed dispersion to obtain W/O type emulsion;

s3, dissolving the rest components of the aerosol in water to form a water phase W₂Adding the W/O type emulsion into the water phase W₂Performing high-speed dispersion to obtain W/O/W type emulsion;

and S4, filling the W/O/W type emulsion to obtain the oral aerosol.

Preferably, the aqueous phase W₁And the aqueous phase W₂0.05 omega% NaCl is also added.

Preferably, the speed of high-speed dispersion in the step S2 is 9000r/min, and the dispersion time is 6 min; in the step S3, the high-speed dispersion speed is 3000r/min, and the dispersion time is 3 min.

By adopting the technical scheme, polypeptide, lysine and vitamin E are respectively dissolved to obtain a water phase W₁And an oil phase W₁And the W/O/W type emulsion is prepared by a high-speed dispersion mode, so that the polypeptide and the vitamin E can keep better activity and are uniformly distributed in the W/O/W type emulsion in the storage process of the oral aerosol. Meanwhile, the W/O/W type emulsion is arranged, so that after the oral aerosol enters the oral cavity of a human body, the polypeptide and the vitamin E have a slow release function, the positive charge generated by hydrolysis of lysine enables the partial solution to be positively charged, and due to the action of electrostatic attraction, the membrane where the polypeptide and the vitamin E are located is further adsorbed on the oral mucosa, so that the retention time of the polypeptide and the vitamin E in the oral cavity of the human body is prolonged, and oral ulcer is further prevented and treated.

The addition of NaCl further reduces W₁The tension of the/O interface reduces the particle size of the W/O emulsion, increases the viscosity of the W/O emulsion, and increases the O/W₂The tension of the interface makes the W/O/W type emulsion in a more uniform and stable state。

In summary, the present application has the following beneficial effects:

1. the allantoin, the dipotassium glycyrrhizinate and the vitamin E are added, so that the oral aerosol has the functions of preventing and further treating the oral ulcer; due to the addition of alcohol, citric acid, potassium sorbate and allantoin, the oral aerosol has bacteriostatic, antibacterial and antiseptic functions; due to the addition of the sweetening agent and the menthol, the oral aerosol has better flavor and mouthfeel, and the use experience of a user is enhanced.

2. In the application, 1-capric acid monoglyceride and lauric acid monoglyceride are preferably adopted as oil phases, so that vitamin E can be well dispersed in the oil phases, and meanwhile, Tween-20 is preferably adopted as a water phase emulsifier, so that stable and uniformly dispersed W/O type emulsion is formed in the oral aerosol, the activity of polypeptide and vitamin E is further preserved, the polypeptide and vitamin E have a slow release function, the action time of the polypeptide and vitamin E in the oral cavity is prolonged, and the oral ulcer is further prevented and treated.

3. Through the addition of lysine, after the polypeptide and the vitamin E are released, the membrane in which the polypeptide and the vitamin E are located carries part of positive charges, is further adsorbed on the oral mucosa and further acts on the oral ulcer part due to the action of electrostatic attraction force, and the effect of accelerating the recovery of the oral ulcer is enhanced to a certain extent.

Detailed Description

The present application will be described in further detail with reference to examples and comparative examples.

Examples

Example 1

A multifunctional aerosol for oral cavity takes water as a solvent, and each 1L of the aerosol comprises the following components in parts by mass:

30g of alcohol; 1g of allantoin; 1g dipotassium glycyrrhizinate; 1g of a small molecule polypeptide; 1g of vitamin E; 4g of an emulsifier; 3g of menthol; the balance of water.

Wherein the emulsifier is span 80 produced by Baishi chemical industry Co., Ltd, Tianjin.

The preparation process of the multifunctional aerosol for the oral cavity specifically comprises the following process steps: mixing the components in proportion and stirring to obtain O/W type emulsion, and filling the O/W type emulsion to obtain the oral aerosol.

Example 2

30g of alcohol; 1g of allantoin; 1g dipotassium glycyrrhizinate; 1g of a small molecule polypeptide; 1g of vitamin E; 9g of a sweetener; 4g of an emulsifier; 2g of preservative; 3g of menthol; 1g of lysine; 6g of polyethylene glycol-32; 2g PEG hydrogenated castor oil; the balance of water.

Wherein the sweetener is aspartame produced by Shanghai Jinjinle industry Co Ltd; the emulsifier is span 80 produced by Baishi chemical industry Co., Ltd, Tianjin; the antiseptic is potassium sorbate, and the menthol is PH44870(Coolshot shock).

Example 3

30g of alcohol; 1g of allantoin; 1g dipotassium glycyrrhizinate; 1g of a small molecule polypeptide; 1g of vitamin E; 9g of a sweetener; 4g of an emulsifier; 2g of preservative; 3g of menthol; 1g of lysine; 6g of polyethylene glycol-32; 2g PEG hydrogenated castor oil; 1g of an atomization improver; the balance of water.

Wherein the sweetener is aspartame produced by Shanghai Jinjinle industry Co Ltd; the emulsifier is span 80 produced by Baishi chemical industry Co., Ltd, Tianjin; the preservative is potassium sorbate; the atomization improving agent comprises 0.5g PEG-400 and 0.5g ceteareth-6, wherein ceteareth-6 is from Hangzhou Huafei chemical Co., Ltd, and menthol is selected from PH44870(coolshot Cool shock)

In the case of the example 4, the following examples are given,

example 4 differs from example 3 in that: the sweetener comprises 3.6g sorbitol and 5.4g erythritol.

Example 5

Example 5 differs from example 3 in that: the emulsifier comprises 0.96g of 1-capric acid monoglyceride; 0.64g of lauric acid monoglyceride; 0.8g of hydroxypropyl cellulose and 2g of tween-20; the 1-capric acid monoglyceride is from Xia chemical technology (Shandong) Co.Ltd; the lauric acid monoglyceride is from western Asia chemical technology (Shandong) Co., Ltd., namely lauric acid monoglyceride; hydroxypropyl cellulose is from Shanghai Haohua chemical Co., Ltd; tween-20 is from Baishi chemical Co., Ltd, Tianjin.

Example 6

Example 6 differs from example 3 in that: the preservative included 1g potassium sorbate and 1g citric acid.

Example 7 differs from example 3 in that: the sweetener comprises 3.6g sorbitol and 5.4g erythritol; the emulsifier comprises 0.96g of 1-capric acid monoglyceride; 0.64g of lauric acid monoglyceride; 0.8g of hydroxypropyl cellulose and 2g of tween-20; the 1-capric acid monoglyceride is from Xia chemical technology (Shandong) Co.Ltd; the lauric acid monoglyceride is from western Asia chemical technology (Shandong) Co., Ltd., namely lauric acid monoglyceride; hydroxypropyl cellulose is from Shanghai Haohua chemical Co., Ltd; tween-20 is from Baishi chemical Co., Ltd, Tianjin; the preservative included 1g potassium sorbate and 1g citric acid.

Example 8 differs from example 7 in that: a preparation process of an oral multifunctional aerosol comprises the following process steps:

s1, dissolving the small molecular polypeptide in water to form a water phase W₁Water phase W₁The content of small and medium molecular polypeptide is 10 omega%, and the vitamin E is dissolved in 1-decanoic acid according to a proportionMixing monoglyceride with lauric monoglyceride to form oil phase O₁；

S2, mixing the water phase W₁Adding into oil phase O₁Mixing, and dispersing at high speed by a high-speed dispersing instrument, wherein the high-speed dispersing speed is controlled to be 6000r/min, the dispersing time is controlled to be 6min, and the W/O type emulsion is obtained after high-speed dispersion;

s3, dissolving alcohol, allantoin, dipotassium glycyrrhizinate, menthol, polyethylene glycol-32, PEG-40 hydrogenated castor oil, PEG-400, ceteareth-6, potassium sorbate, citric acid and Tween-20 in water to form water phase W₂Adding the W/O emulsion obtained in S2 into the water phase W₂Performing high-speed dispersion by high-speed dispersion, controlling the high-speed dispersion speed to be 3000r/min and the dispersion time to be 3min, and obtaining a W/O/W type emulsion after high-speed dispersion;

s4, filling the W/O/W type emulsion to obtain the oral aerosol.

Example 9

Example 9 differs from example 8 in that: water phase W₁And the aqueous phase W₂0.05 omega% NaCl is also added.

Examples 10 to 13

The differences between the material ratios of the oral aerosols of examples 10 to 13 and example 9 are shown in Table 1, and the rest is the same as example 9.

TABLE 1 raw material ratios of oral aerosols of examples 10-13

Examples 14 to 17

The differences in the raw material ratios of the sweetener, emulsifier, preservative and atomization improver in examples 14 to 17 from example 9 are shown in Table 2, and the rest is the same as in example 9.

TABLE 2 raw material ratios of sweetener, emulsifier, preservative and atomization improver in examples 14 to 17

Comparative example

Comparative example 4

Comparative example 4 differs from example 9 in that citric acid is not added to the preservative.

Comparative example 5

Comparative example 5 used a conventional oral aerosol commercially available.

Performance test

Oral aerosols were tested for performance in examples 1-17 and comparative examples 4-5 of the present application.

Oral aerosol flavor testing

The method comprises the following steps: 10-15 adults were randomly selected, oral sprays were made using the oral aerosols of examples 1-17 and comparative examples 4-5, respectively, and the evaluation of the flavor of each component was recorded, with flavor being evaluated on a 1-10 scale, 1 being poor and 10 being better, with statistics being made between 1-10 on an order of 0.1.

Test of bacteriostatic Property

The method comprises the following steps: the oral aerosols of examples 1 to 17 and comparative examples 4 to 5 were used, agar was selected and added to a sterile petri dish, then a culture medium was inoculated on the sterile petri dish, a test bacterial solution was prepared according to the method of GB/T20944.1-2007 and inoculated on the culture medium, the oral aerosols of each component were sprayed on the culture medium, cultured for 18 to 24 hours, and the area of the strain on the culture medium was observed.

Emulsion stability test

The method comprises the following steps: using the oral aerosols of examples 1 to 17 and comparative examples 4 to 5, the components were centrifuged and shaken, and the separation of the emulsions after centrifugation at 3000r/min for 20min was recorded.

Oral ulcer relief efficacy test

The method comprises the following steps: 3-4 patients with oral ulcer are selected, the oral aerosol in examples 1-17 and comparative examples 4-5 are respectively adopted, visual observation statistics is carried out every 8 hours, and the ulcer condition and pain feedback in the oral cavity of the patients with oral ulcer are respectively recorded.

The test results are shown in table 3.

Table 3 table of performance test results

By combining examples 1-9 and comparative examples 4-5 and table 3, it can be seen that the components of allantoin, dipotassium glycyrrhizinate and alcohol in the oral aerosol can improve the antibacterial performance of the oral aerosol and relieve the problem of halitosis caused by bacterial growth in the oral cavity to a certain extent; meanwhile, the sodium citrate in the preservative can further improve the antibacterial and antibacterial properties of the oral aerosol; the oral aerosol adopts a W/O/W emulsion system, so that the antibacterial component in the aerosol can be further promoted to be uniformly and stably dispersed in the emulsion system, and the action degree of the antibacterial component and the bacteria in the oral cavity is further improved, thereby improving the antibacterial and antibacterial effects of the oral aerosol.

As can be seen by combining examples 1 to 3 and comparative examples 4 to 5 with Table 3, the menthol with PH44870(coolshot cooling and bursting) can improve the taste and flavor of the oral aerosol to some extent and has the function of breath freshening.

It can be seen by combining examples 1, 4 and 7 and comparative examples 4 to 5 and combining table 3 that the taste and flavor of the oral aerosol can be remarkably improved by selecting the sweetener in the application, and the taste and flavor of the oral aerosol can be improved to a certain extent by adding citric acid, so that the taste and flavor of a user can be improved.

As can be seen by combining examples 1-8 and comparative examples 4-5 with Table 3, the emulsifier in the present application and the oral aerosol adopting O/W emulsion system can make the components in the oral aerosol disperse in the oral aerosol more uniformly and stably; the oral aerosol adopts a W/O/W emulsion system, can further improve the dispersion degree of each component of the oral aerosol in the emulsion system, and has better stability.

As can be seen by combining examples 1 to 9 and comparative examples 4 to 5 with Table 3, the oral aerosol of the present application can accelerate the restoration and relieve of canker sores; the oral aerosol adopts a W/O/W emulsion system, so that the effects of repairing and treating the oral ulcer can be obviously improved, and the treatment time of the oral ulcer is shortened.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. The multifunctional aerosol for the oral cavity is characterized by taking water as a solvent and at least comprising the following components in mass concentration: 30-40g/L of alcohol; 1-1.5g/L of allantoin; 1-1.5g/L dipotassium glycyrrhizinate; 1-2g/L of small molecule polypeptide; 1-2g/L of vitamin E; 3-4g/L of menthol; 4-5g/L of emulsifier;

the emulsifier comprises the following raw materials in parts by weight: 6-7.5 parts of 1-capric acid monoglyceride; 4-5 parts of lauric acid monoglyceride; 5-8 parts of hydroxypropyl cellulose; tween-2010-12.5 parts, wherein the mass ratio of the 1-capric acid monoglyceride to the lauric acid monoglyceride is 3: 2;

the aerosol is also added with a sweetening agent with the mass concentration of 9-12g/L, wherein the sweetening agent is composed of sorbitol and erythritol, and the mass ratio of the sorbitol to the erythritol is (4-6): (5-6);

the aerosol is also added with a preservative with the mass concentration of 2-4g/L, the preservative is composed of potassium sorbate and citric acid, and the mass ratio of the potassium sorbate to the citric acid is 1: (1-2);

lysine with the mass concentration of 1-2g/L is also added into the aerosol;

the preparation process comprises the following process steps:

and S4, filling the W/O/W type emulsion to obtain the oral aerosol.

2. The multi-functional aerosol for oral use according to claim 1, wherein: polyethylene glycol-32 with the mass concentration of 6-7g/L is also added into the aerosol; 2-2.5g/L PEG-40 hydrogenated castor oil.

3. The multifunctional aerosol for the oral cavity as claimed in claim 1 or 2, wherein the aerosol is further added with a atomization improving agent with a mass concentration of 1-2g/L, the atomization improving agent is composed of PEG-400 and ceteareth-6, and the mass ratio of PEG-400 to ceteareth-6 is (2-3): (1-2).

4. The multi-functional aerosol for oral use according to claim 1, wherein: water phase W₁And the aqueous phase W₂0.05g/L NaCl was also added.

5. The multi-functional aerosol for oral use according to claim 1, wherein: in the step S2, the high-speed dispersion speed is 9000r/min, and the dispersion time is 6 min; in the step S3, the high-speed dispersion speed is 3000r/min, and the dispersion time is 3 min.