CN108685721A - A kind of ozonized surfactant floral water - Google Patents
A kind of ozonized surfactant floral water Download PDFInfo
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- CN108685721A CN108685721A CN201710215590.3A CN201710215590A CN108685721A CN 108685721 A CN108685721 A CN 108685721A CN 201710215590 A CN201710215590 A CN 201710215590A CN 108685721 A CN108685721 A CN 108685721A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
Invention belongs to household chemicals technical field, more particularly to a kind of floral water containing ozonized surfactant, the floral water containing ozonized surfactant be applied to skin can effectively sterilize, anti-inflammatory, dispel itch, be antipruritic, swelling and pain relieving, prevention mosquito, hide from, fly, dim, worm etc. bite caused skin eczema, itch son, dermatitis, contact, allergic dermatitis, it is widely used in room residence, hotel, dining room, food processing factory, food market, classroom, dormitory, and aircraft and ship and field man, traveller.
Description
Technical field
The invention belongs to household chemicals technical fields, and in particular to a kind of liquid distilled from honeysuckle flowers or lotus leaves containing ozonized surfactant
Water.
Background technology
Surfactant refers to the substance that can just can significantly reduce solvent table and tension with extremely low concentration.Its molecular structure
Have the characteristics that common, i.e., molecule is made of nonpolar hydrophobic group and polar hydrophilic group two parts, and with chemical bond
It is connected, organized assembles can be formed in certain density surfactant solution, changes the surface state of system.This kind of point
Sub not only hydrophilic but also oleophylic, to generate wetting or dewetting, emulsification or demulsification, dispersion or cohesion, blistering or defoaming and solubilising
Equal a series of properties, have important application civilian and industrial etc..Currently, various new surfactant receives extensively
General concern develops novel surfactant including the aliphatic acid derived using natural animal-plant oil as raw material(See Ge Hong,
What Sun Lingxin, Wang Jun write"The progress of research work regarding surfactants derived from fatty acids", daily chemical industry, 2004,3(34):
176-180);Nontoxic and not sensitization biosurfactant(See left-handed crystal, what Wang Xuechuan write"Biosurfactant is answered
With", chemical industry and engineering technology, 2005,(26):23-27), environment-friendly green surfactant(See Lee
What Wenan was write"The application of green surfactant and progress", Agriculture of Anhui science, 2007,35(19):5691-
5692)With the new type of Gemini surfactant with high surface, low critical micelle concentration, unique viscosity characteristics(See king
It is gorgeous to write"The preparation of new type amphoteric ionic Gemini surface active and performance study"2010).
In ozonizing series of products, ozonisation olive oil, sunflower oil and soybean oil are used for cotton-padded mattress as antiseptic, deodorant
The topical drug of the treating for skin disease such as sore and ulcer has listed.Above-mentioned oil why is selected, is because of unsaturation therein
Content of fatty acid is higher.With unsaturated olefin double bond addition reaction can occur for ozone molecule, generate ozonide.Unsaturated bond
Number is more, and ozonization is more easy to happen, and more with the amount of ozone addition, and addition product can carry the number of ozone molecule
Mesh is also more.
However the above vegetable oil itself still has inherent shortcoming.Since vegetable oil is the mixture containing Multiple components,
Its constituent can be different due to the difference of the place of production, weather conditions and processing technology etc., and therefore, it is difficult to prepare with constant
The ozonisation vegetable oil of quality.Moreover, because in crude vegetal contain antioxidant substance, well imagine the antioxidant substance with
Ozone competes and then interferes the generation of ozonide.Furthermore since the shape of ozonisation vegetable oil is (for example, ozonisation olive
Oil) it is a kind of grease, the body part of outer position (for example, colony house and sink) and mammal for being spontaneously wet out by water (for example,
Hoof and skin) on when be ostracised, therefore cannot equably be coated with or be sprayed on object, become in practical application and hinder.
The interior environment of body is also water environment, and with surfactant addition reaction occurs for ozone, generates ozonized surfactant, can
It is effectively increased the concentration that ozone enters blood.If ozone, unsaturated fatty acid and unsaturated surfactant three can be mixed again
It closes and addition reaction occurs, just the advantages of three can be combined together, can also carry more ozone and enter body.
The main active of floral water is mostly conventional synthesis culicifuge currently on the market, such as mosquito repellent vinegar, O-phthalic
Dimethyl phthalate, Metadelphene etc..There are studies have shown that mosquito repellent vinegar and Metadelphene that there is toxic side effect, in use, people pass through
Alimentary canal, respiratory tract absorb part mosquito repellent vinegar, can not only induce the diseases such as asthma, long-time service can also carcinogenic, teratogenesis;Metadelphene
It can cause children's encephalopathy, honor measles syndrome, allergic reaction, blood pressure are low and heartbeat reduces etc..Stop with detumescence to reach refrigerant
Itch effect, the floral water of existing market usually also adds menthol and salicylic acid, has irritation to skin, also adds simultaneously
The drying property of skin, therefore, the usage comfort of existing floral water are to be improved.
Invention content
For overcome the deficiencies in the prior art, the present invention provides a kind of floral water containing ozonized surfactant.
Floral water provided by the invention containing ozonized surfactant is removed with significant anti-inflammatory, antipruritic, sterilization, swelling and pain relieving effect
Outside fruit, also have prevention mosquito, hide from, fly, dim, worm etc. bite caused skin eczema, son of itching, dermatitis, contact, anaphylaxis skin
Inflammation is widely used in room residence, hotel, dining room, food processing factory, food market, classroom, dormitory and aircraft and ship and field work
Make personnel, traveller.The present invention contain ozonized surfactant floral water action temperature and, skin irritation is small, after use
Feel without dry skin, usage comfort is high.
Present invention relates particularly to surfactant include the amphoteric surfactant at least one olefinic double bond,
The hydrophobic group part of nonionic surfactant, cationic surfactant and anion surfactant, Shuangzi(Gemini)
Surfactant linker part, biosurfactant and green surfactant.
The surfactant of selection is the amphoteric surfactant for having at least one olefinic double bond, is selected from unsaturated hydrocarbons
The monosubstituted and polysubstituted empgen BB of base, the monosubstituted and polysubstituted Cocoamidopropyl betaine of unsaturated alkyl, no
The monosubstituted and polysubstituted dodecyl hydroxypropyl sulfobetaines of saturated hydrocarbyl, the monosubstituted and polysubstituted fatty acyl of unsaturated alkyl
The monosubstituted and polysubstituted two phosphorous base glycine betaine of glycerine of amine propyl betaine, unsaturated alkyl, unsaturated alkyl are monosubstituted and more
Replace the third hydroxyl sulfo betaine of lauramide, monosubstituted and polysubstituted the third weight ratio of the lauramide beet of unsaturated alkyl
Alkali, N, bis- (2- hydroxyls of N- dihydroxy ethyl-N- ethyl unsaturated fatty acid ester glycine betaines and N- ethyl unsaturated fatty acid esters-N, N-
Ethyl) -3-(2- hydroxypropyls)Sulfate ammonium salt, cocoyl both sexes unsaturated fatty acid salt, N- (2- fatty acid amides) ethyl imido
Unsaturated fat acid disodium and N-(2- fatty acid amides) ethyl-N, N- tri- [3,3- (2- hydroxyls) Bing Jihuangji ]In ammonia disodium salt
Any one, two kinds and two or more mixing.
The surfactant of selection is the nonionic surfactant for having at least one olefinic double bond, selected from unsaturation
Polyoxyethylene carboxylate, unsaturated fatty alcohol polyoxyethylene ether, unsaturated fat phenol polyethenoxy ether, polyoxyethylene are unsaturated
It is fatty acid amide, propylene glycol unsaturated fatty acid ester, pentaerythrite unsaturated fatty acid ester, glycerine unsaturated fatty acid ester, poly- sweet
It is oily unsaturated fatty acid ester, sorbitan unsaturated fatty acid ester, polyoxyethylene sorbitol acid anhydride unsaturated fatty acid ester, sweet
It is unsaturated to reveal sugar alcohol unsaturated fatty acid ester, sucrose unsaturated fatty acid ester, polyethylene glycol unsaturated alkyl ether and polypropylene glycol
Alkyl ether etc. have in the nonionic surfactant of at least one olefinic double bond any one, two kinds and two or more mixed
It closes.
The surfactant of selection is the anion surfactant for having at least one olefinic double bond, to be selected from insatiable hunger
In fatty acid salt, unsaturated fatty alcohol sulfuric acid, alpha-sulfo unsaturated fatty acid ester, olefin sulphates and alkene sulfonate
Any one, two kinds and two or more mixing.
The surfactant of selection is the cationic surfactant for having at least one olefinic double bond, selected from unsaturation
The monosubstituted leptodactyline of aliphatic group, two substituted dimethyl ammonium salt of unsaturated aliphatic hydrocarbyl moiety, unsaturated aliphatic hydrocarbyl moiety are monosubstituted
The monosubstituted amine acylate of dimethyl benzyl ammonium salt, unsaturated aliphatic hydrocarbyl moiety, unsaturated aliphatic hydrocarbyl moiety two replace amine acylate
With in the cationic surfactant in N- methyl diethanolamine unsaturated fatty acid ester hydrochlorides any one, two kinds and
Two or more mixing.
The surfactant of selection is the Shuangzi for having at least one olefinic double bond(Gemini)Surfactant is selected from
Hydrophobic group part and linker part have the Shuangzi of at least one olefinic double bond(Gemini)It is arbitrary in surfactant
A kind of, two kinds and two or more mixing.
The surfactant of selection is the biosurfactant for having at least one olefinic double bond, is selected from unsaturated lipid
Her monosubstituted and polysubstituted subtilin, red moss enzyme of the monosubstituted and polysubstituted mannose of unsaturated aliphatic hydrocarbyl moiety of fat alkyl
The monosubstituted and polysubstituted Pseudomonas fluorescence metabolin of fat, unsaturated aliphatic hydrocarbyl moiety, unsaturated aliphatic hydrocarbyl moiety it is monosubstituted and
The monosubstituted and polysubstituted Lactobacillus acidophilus' metabolin of polysubstituted Bacillus acidi lactici metabolin, unsaturated aliphatic hydrocarbyl moiety, insatiable hunger
With in the monosubstituted and polysubstituted yeast Bacillus acidi lactici of aliphatic group any one, two kinds and two or more mixing.
The surfactant of selection is the green surfactant for having at least one olefinic double bond, is selected from unsaturated lipid
The monosubstituted and polysubstituted triethanolamine quaternary ammonium salt of fat alkyl, alpha-sulfo unsaturated fatty acid methyl ester, unsaturated aliphatic hydrocarbyl moiety phosphorus
The monosubstituted and polysubstituted amino acid pattern of acid esters, unsaturated aliphatic hydrocarbyl moiety, the monosubstituted and polysubstituted glycine betaine of unsaturated aliphatic hydrocarbyl moiety
The monosubstituted and polysubstituted imidazoles fundamental mode of type, unsaturated aliphatic hydrocarbyl moiety, the monosubstituted and polysubstituted more glycosides of unsaturated aliphatic hydrocarbyl moiety, insatiable hunger
With in the monosubstituted and polysubstituted glucose amide of aliphatic group and sucrose unsaturated fat acid amide any one, two kinds and two kinds
The above mixing.
The surfactant of selection is mixed with unsaturated fatty acid, is formed mixture, is ozonized by addition ozone
Surfactant.Wherein unsaturated fatty acid is selected from crotonic acid, nutmeg oleic acid, palmitoleic acid, oleic acid, antiform oleic acid, castor-oil plant
The monounsaturated fatty acids such as oleic acid, erucic acid, cetoleic acid, nervonic acid.Polyunsaturated fatty acid refers to having multiple alkene in structure
The unsaturated fatty acid of hydro carbons double bond, including linoleic acid(Unsaturated dienoic acid), leukotrienes and eleostearic acid(Unsaturated trienic acid), ten
Eight carbon tetraenoic acids and arachidonic acid(Unsaturated tetraenoic acid), eicosapentaenoic acid and clupanodonic acid(Unsaturated pentaene
Acid), docosahexaenoic acid(Unsaturated acid).Meanwhile unsaturated fatty acid includes but not limited to have 6~26 carbon originals
Son and 1~6 olefinic double bond.Surfactant according to claims 1 to 7 selects in above-mentioned surfactant
Any one, two kinds and it is two or more mixed, ozonized surfactant is obtained by addition ozone.
In order to achieve the above objectives, the technical solution adopted by the present invention will combine following production process and embodiment to carry out
Simple declaration.
1, ozone gas is prepared.
2, ozonized surfactant is prepared.
3, ozonized surfactant and monounsaturated fatty acids mixture are prepared.
4, ozonized surfactant and polyunsaturated fatty acid mixture are prepared.
5, the ozonized surfactant of oil-containing is prepared.
6, ozonisation polyoxyethylene sorbitan monooleate repellent antipruritic test effect observation.
Specific implementation mode
Embodiment 1 ozonizes polyoxyethylene sorbitan monooleate and prepares
1, ozone gas is prepared.The present invention prepares ozone gas using medical oxygen by ozone generator.
DRO3-A type ozone machines selected from Xi'an Derun Bio-Technology Co., Ltd.'s design production(Gong Shuai≤55W).
2, ozonisation polyoxyethylene sorbitan monooleate whole process is prepared to carry out at 20~25 DEG C, it is ensured that
Pyrolytic reaction will not occur for ozonisation polyoxyethylene sorbitan monooleate.
It 3, will be in polyoxyethylene sorbitan monooleate 3kg merging reaction kettles;Ozone is with 150m3/ h flow velocitys are added,
Total reaction time is 20 hours.After reaction, residual air inactivates.
4, it is 40 mg/L to obtain ozone concentration in ozonisation polyoxyethylene sorbitan monooleate, and 25 DEG C can stablize
It preserves ten months.
Embodiment 2 ozonizes sucrose unsaturated fatty acid ester quaternary ammonium salt and prepares
1, ozone gas is prepared.The present invention prepares ozone gas using medical oxygen by ozone generator.
DRO3-A type ozone machines selected from Xi'an Derun Bio-Technology Co., Ltd.'s design production(Gong Shuai≤55W).
2, it prepares ozonisation sucrose unsaturated fatty acid ester quaternary ammonium salt whole process to carry out at 20~25 DEG C, it is ensured that smelly
Pyrolytic reaction will not occur for oxidation sucrose unsaturated fatty acid ester quaternary ammonium salt.
It 3, will be in sucrose unsaturated fatty acid ester quaternary ammonium salt 3kg merging reaction kettles;Ozone is with 150m3/ h flow velocitys are added, always
Reaction time is 20 hours.After reaction, residual air inactivates.
4, it is 40 mg/L to obtain ozone concentration in ozonisation sucrose unsaturated fatty acid ester quaternary ammonium salt, and 25 DEG C can stablize guarantor
It deposits ten months.
Embodiment 3 ozonizes the preparation of polyoxyethylene sorbitan monooleate and oleic acid mixture
1, ozone gas is prepared.The present invention prepares ozone gas using medical oxygen by ozone generator.
DRO3-A type ozone machines selected from Xi'an Derun Bio-Technology Co., Ltd.'s design production(Gong Shuai≤55W).
2, prepare ozonisation polyoxyethylene sorbitan monooleate and oleic acid mixture whole process need 20~
25 DEG C of progress, it is ensured that pyrolytic reaction will not occur for ozonisation polyoxyethylene sorbitan monooleate and oleic acid mixture.
3, in polyoxyethylene sorbitan monooleate 1.5kg and oleic acid 1.5kg merging reaction kettles;Ozone is with 150m3/
H flow velocitys are added, and total reaction time is 20 hours.After reaction, residual air inactivates.
4, it is 50mg/L to obtain ozone concentration in ozonisation polyoxyethylene sorbitan monooleate and oleic acid, and 25 DEG C can
Stablize and preserves ten months.
Embodiment 4 ozonizes the preparation of polyoxyethylene sorbitan monooleate and linoleic acid mixture
1, ozone gas is prepared.The present invention prepares ozone gas using medical oxygen by ozone generator.
DRO3-A type ozone machines selected from Xi'an Derun Bio-Technology Co., Ltd.'s design production(Gong Shuai≤55W).
2, it prepares ozonisation polyoxyethylene sorbitan monooleate and linoleic acid mixture whole process need be 20
~25 DEG C of progress, it is ensured that pyrolysis will not occur for ozonisation polyoxyethylene sorbitan monooleate and linoleic acid mixture instead
It answers.
3, polyoxyethylene sorbitan monooleate 1.5kg and linoleic acid 1.5kg are respectively implanted in reaction kettle, mixing,
Ozone is with 150m3/ h flow velocitys are added, and total reaction time is 20 hours.After reaction, residual air inactivates.
4, obtain ozonisation polyoxyethylene sorbitan monooleate and linoleic acid in ozone concentration be 60 mg/L, 25
It DEG C can stablize preservation ten months.
Embodiment 5 ozonizes the preparation of polyoxyethylene sorbitan monooleate and olive oil mixture
1, ozone gas is prepared.The present invention prepares ozone gas using medical oxygen by ozone generator.
DRO3-A type ozone machines selected from Xi'an Derun Bio-Technology Co., Ltd.'s design production(Gong Shuai≤55W).
2, it prepares ozonisation polyoxyethylene sorbitan monooleate and olive oil mixture whole process need be 20
~25 DEG C of progress, it is ensured that pyrolysis will not occur for ozonisation polyoxyethylene sorbitan monooleate and olive oil mixture instead
It answers.
3, polyoxyethylene sorbitan monooleate 2.5kg and olive oil 0.5kg are respectively implanted in reaction kettle, mixing,
Ozone is with 150m3/ h flow velocitys are added, and total reaction time is 20 hours.After reaction, residual air inactivates.
4, obtain ozonisation polyoxyethylene sorbitan monooleate and olive oil in ozone concentration be 60 mg/L, 25
It DEG C can stablize preservation ten months.
Embodiment 6 ozonizes the observation of polyoxyethylene sorbitan monooleate repellent antipruritic test effect
1. test method:Selection is by the volunteer 500 of bite by mosquitos, wherein man 250, female 250, the age at 20-50 Sui,
5 groups are randomly divided by the principle of parallel control, ozonisation polyoxyethylene sorbitol prepared by every group of 100 people, respectively embodiment 1
Alcohol acid anhydride monoleate low, middle and high dose groups, comparative example group and positive controls (compound menthol Ointment, Chinese medicines quasi-word
H20013294a, The Mentholatum Company).After bite by mosquitos skin, ozonisation prepared by Example 1 is poly-
Ethylene oxide sorbitan monooleate presses 125PPM with deionized water, the dosage formulation of 250PPM, 500PPM at floral water,
Uniformly be applied at red swelling of the skin, smear dosage and adjusted according to Tumor size, and the effect of record floral water repellent antipruritic and
Volunteer's number of cases that antipruritic effect works in 3min.
2. therapeutic evaluation:
It is effective:Red swelling of the skin, heat, pain, symptom of itching rapid regression;
Generally:Red swelling of the skin, heat, pain, symptom of itching mitigate;
In vain:Repellent antipruritic effect unobvious or exacerbation.
3. test result:It is shown in Table 1.
Antipruritic effect action volunteer's number of cases in 1 3min of table
By above-mentioned test result it is found that the present invention contain ozonisation polyoxyethylene sorbitan monooleate floral water for
Red swelling of the skin caused by bite by mosquitos, heat, pain, symptom of itching have significant repellent antipruritic effect, effect higher than positive controls.
The floral water antipruritic effect of 1 group of preparation of the embodiment of the present invention is rapid-action, and repellent antipruritic curative effect total effective rate is high, and significant effect is better than
Positive controls illustrate that floral water of the present invention containing ozonisation polyoxyethylene sorbitan monooleate has and significantly disappear
Swollen antipruritic effect.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, according to the technical essence of the invention to above example into
Row modification or equivalent replacement of some of the technical features.All within the spirits and principles of the present invention, appoint made by
What modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of ozonized surfactant floral water, which is characterized in that by amphoteric surfactant, non-ionic surface work
The hydrophobic group part of property agent, cationic surfactant and anion surfactant, Shuangzi(Gemini)Surfactant connects
The surfactant at least one olefinic double bond in base portion point, biosurfactant, green surfactant is connect to add
Ozonized surfactant is obtained at ozone, obtained ozonized surfactant is diluted with water, filling, and this product is applied to
Skin can sterilize effectively, anti-inflammatory, dispel itch, be antipruritic, swelling and pain relieving, prevention mosquito, hide from, fly, skin is wet caused by dim, worm etc. bites
Rash, itch son, dermatitis, contact, allergic dermatitis, are widely used in room residence, hotel, dining room, food processing factory, food market, religion
Room, dormitory and aircraft and ship and field man, traveller.
2. a kind of ozonized surfactant floral water, which is characterized in that by amphoteric surfactant, non-ionic surface work
The hydrophobic group part of property agent, cationic surfactant and anion surfactant, Shuangzi(Gemini)Surfactant connects
The surfactant at least one olefinic double bond in base portion point, biosurfactant, green surfactant is connect to add
Ozonized surfactant is obtained at ozone, obtained ozonized surfactant is diluted with water, filling, and this product is applied to
Skin can sterilize effectively, anti-inflammatory, dispel itch, be antipruritic, analgesic, prevention mosquito, hide from, fly, dim, worm etc. bite caused skin eczema,
Itch son, dermatitis, contact, allergic dermatitis, be widely used in room residence, hotel, dining room, food processing factory, food market, classroom,
Dormitory and aircraft and ship and field man, traveller.
3. ozonized surfactant according to claims 1 to 2, which is characterized in that the hydrophobic group part has extremely
The surfactant of a few olefinic double bond is the amphoteric surface for having at least one olefinic double bond selected from hydrophobic group part
Nonionic surfactant at least one olefinic double bond of activating agent, hydrophobic group part, hydrophobic group part are at least
The cation form of anion surfactant and hydrophobic group part at least one olefinic double bond of one olefinic double bond
In the activating agent of face any one, two kinds and two or more mixing.
4. ozonized surfactant according to claims 1 to 2, which is characterized in that the hydrophobic group part has extremely
The amphoteric surfactant of a few olefinic double bond, selected from the monosubstituted and polysubstituted empgen BB of unsaturated alkyl,
The monosubstituted and polysubstituted dodecyl hydroxyl of the monosubstituted and polysubstituted Cocoamidopropyl betaine of unsaturated alkyl, unsaturated alkyl
The monosubstituted and polysubstituted fattyamidopropyl betaine of propylsultaine glycine betaine, unsaturated alkyl, unsaturated alkyl it is monosubstituted and
Monosubstituted and polysubstituted the third hydroxyl sulfo betaine of lauramide of two phosphorous base glycine betaine of polysubstituted glycerine, unsaturated alkyl, no
Monosubstituted and polysubstituted the third hydroxyl sulfo betaine of lauramide of saturated hydrocarbyl, N, N- dihydroxy ethyl-N- ethyl unsaturated fats
Acid esters glycine betaine, N- ethyl unsaturated fatty acid esters-N, N- bis- (2- ethoxys) -3-(2- hydroxypropyls)Sulfate ammonium salt, cocounut oil
Base both sexes unsaturated fatty acid salt, N- (2- fatty acid amides) ethyl imido unsaturated fat acid disodiums and N-(2- fatty acid amides) second
Base-N, N- tri- [3,3- (2- hydroxyls) Bing Jihuangji ]In ammonia disodium salt any one, two kinds and two or more mixing.
5. ozonized surfactant according to claims 1 to 2, which is characterized in that the hydrophobic group part has extremely
The nonionic surfactant of a few olefinic double bond, it is poly- selected from unsaturated fatty acid polyoxyethylene ester, unsaturated fatty alcohol
Ethylene oxide ether, unsaturated fat phenol polyethenoxy ether, polyoxyethylene unsaturated fat amide, propylene glycol unsaturated fatty acid ester,
Pentaerythrite unsaturated fatty acid ester, glycerine unsaturated fatty acid ester, polyglycereol unsaturated fatty acid ester, sorbitan insatiable hunger
It is unsaturated with aliphatic ester, polyoxyethylene sorbitol acid anhydride unsaturated fatty acid ester, mannitol unsaturated fatty acid ester, sucrose
In aliphatic ester, polyethylene glycol unsaturated alkyl ether and polypropylene glycol unsaturated alkyl ether any one, two kinds and two kinds with
Upper mixing.
6. ozonized surfactant according to claims 1 to 2, which is characterized in that the hydrophobic group part has extremely
The anion surfactant of a few olefinic double bond, selected from unsaturated fatty acid salt, unsaturated fatty alcohol sulfuric acid, α-
In sulfo group unsaturated fatty acid ester, olefin sulphates and alkene sulfonate any one, two kinds and two or more mixing.
7. ozonized surfactant according to claims 1 to 2, which is characterized in that the hydrophobic group part has extremely
The cationic surfactant of a few olefinic double bond, to be selected from the monosubstituted leptodactyline of unsaturated aliphatic hydrocarbyl moiety, insatiable hunger
With two substituted dimethyl ammonium salt of aliphatic group, the monosubstituted dimethyl benzyl ammonium salt of unsaturated aliphatic hydrocarbyl moiety, unsaturated aliphatic hydrocarbyl moiety
Monosubstituted amine acylate, unsaturated aliphatic hydrocarbyl moiety two replace amine acylate and N- methyl diethanolamine unsaturated fatty acids
In ester hydrochloride any one, two kinds and two or more mixing.
8. any type ozonized surfactant according to claims 1 to 7, which is characterized in that with selected from crotonic acid,
Nutmeg oleic acid, palmitoleic acid, oleic acid, antiform oleic acid, ricinoleic acid, erucic acid, cetoleic acid, nervonic acid, linoleic acid(It is unsaturated
Dienoic acid), leukotrienes and eleostearic acid(Unsaturated trienic acid), parinaric acid and arachidonic acid(Unsaturated tetraenoic acid), two
Ten carbon 5 alkene acids and clupanodonic acid(Unsaturated five olefin(e) acid), docosahexaenoic acid(Unsaturated acid)It is this kind of to have
In the unsaturated fatty acid of one and multiple olefinic double bonds any one, two kinds and two or more mixing, by electrophilic plus
At ozone, the ozonized surfactant containing ozonisation unsaturated fatty acid is obtained.
9. any type ozonized surfactant according to claims 1 to 8, which is characterized in that with selected from olive oil,
Soya-bean oil, sunflower oil, linseed oil, rapeseed oil, Semen setariae oil, corn oil, maize germ oil, sesame oil, cottonseed oil, castor oil,
Peanut oil, tea-seed oil, perilla herb oil, safflower seed oil, apricot kernel oil, hazelnut oil, walnut oil, pine-seed oil, shinyleaf yellowhorn oil, edible reconciliation
The mixing of one or more of oil, cod-liver oil and fish oil, by electrophilic addition ozone, obtains the ozonisation containing various oil
Surfactant.
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| CN112544573A (en) * | 2021-01-07 | 2021-03-26 | 遵义医科大学 | Laboratory culture system and method for blood sucking midges |
| CN116033824A (en) * | 2021-03-01 | 2023-04-28 | 艾哈迈德·于米特·萨班哲 | Liposome ozone nano solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112544573A (en) * | 2021-01-07 | 2021-03-26 | 遵义医科大学 | Laboratory culture system and method for blood sucking midges |
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