CN114450278A - 一个烟醇醚衍生物的马来酸盐及其晶型和应用 - Google Patents

一个烟醇醚衍生物的马来酸盐及其晶型和应用 Download PDF

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CN114450278A
CN114450278A CN202080063645.3A CN202080063645A CN114450278A CN 114450278 A CN114450278 A CN 114450278A CN 202080063645 A CN202080063645 A CN 202080063645A CN 114450278 A CN114450278 A CN 114450278A
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chlorobenzyl
pyridine
bromo
phenylbenzyloxy
methoxy
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CN114450278B (zh
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冯志强
陈晓光
马辰
杨阳
来芳芳
王雨辰
季鸣
郭凯静
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Institute of Materia Medica of CAMS
Tianjin Chase Sun Pharmaceutical Co Ltd
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Abstract

本发明涉及医药技术领域，公开了一个烟醇醚衍生物的马来酸盐及其晶型和应用，即(S)‑N‑(2‑(吡啶‑3‑甲氧基)‑4‑(2‑溴‑3‑苯基苄氧基)‑5‑氯苄基)丝氨酸异丙酯马来酸盐及其立体异构体、晶型及其制法和药物组合物与用途。具体而言，涉及式I所示的S)‑N‑(2‑(吡啶‑3‑甲氧基)‑4‑(2‑溴‑3‑苯基苄氧基)‑5‑氯苄基)丝氨酸异丙酯马来酸盐以及其晶型，其立体异构体及其制备方法，含有该化合物或其晶型的组合物，和该化合物或其晶型在制备治疗与PD‑1/PD‑L1信号通路有关的疾病如癌症、感染性疾病、自身免疫性疾病的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080063645.3A 2019-09-09 2020-09-09 一个烟醇醚衍生物的马来酸盐及其晶型和应用 Active CN114450278B (zh)

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EP4029863A4 (en) * 2019-09-09 2023-10-25 Institute Of Materia Medica, Chinese Academy Of Medical Sciences MALEATE OF NICOTINYL ALCOHOL ETHER DERIVATIVES, CRYSTAL FORM THEREOF AND APPLICATION THEREOF
WO2023050104A1 (zh) * 2021-09-28 2023-04-06 中国医学科学院药物研究所 二氢吲哚衍生物、及其制法和药物组合物与用途

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CN109153670A (zh) * 2016-05-23 2019-01-04 中国医学科学院药物研究所 烟醇醚类衍生物、及其制法和药物组合物与用途
CN111925318B (zh) * 2019-09-09 2023-02-28 天津红日药业股份有限公司 一个烟醇醚衍生物的马来酸盐及其晶型和应用

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EP2817317A1 (en) * 2012-02-21 2014-12-31 Allergan, Inc. Phenoxy derivatives as sphingosine 1-phosphate (s1p) receptor modulators
CN103787902B (zh) * 2014-02-17 2016-08-17 华东理工大学 苄基取代的苯胺类化合物及其应用
US9850225B2 (en) * 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators

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CN109153670A (zh) * 2016-05-23 2019-01-04 中国医学科学院药物研究所 烟醇醚类衍生物、及其制法和药物组合物与用途
CN111925318B (zh) * 2019-09-09 2023-02-28 天津红日药业股份有限公司 一个烟醇醚衍生物的马来酸盐及其晶型和应用

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EP4029863A4 (en) 2023-10-25
CN111925318B (zh) 2023-02-28
WO2021047528A1 (zh) 2021-03-18
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