CN114437919A - Hot lid device and nucleic acid detection analyzer - Google Patents
Hot lid device and nucleic acid detection analyzer Download PDFInfo
- Publication number
- CN114437919A CN114437919A CN202011193682.4A CN202011193682A CN114437919A CN 114437919 A CN114437919 A CN 114437919A CN 202011193682 A CN202011193682 A CN 202011193682A CN 114437919 A CN114437919 A CN 114437919A
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- heat
- conducting plate
- heating
- guide
- plate
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- 238000001514 detection method Methods 0.000 title claims abstract description 22
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 17
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 15
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 81
- 238000010438 heat treatment Methods 0.000 claims abstract description 70
- 230000006978 adaptation Effects 0.000 claims abstract description 4
- 238000009833 condensation Methods 0.000 abstract description 5
- 230000005494 condensation Effects 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 description 13
- 238000003860 storage Methods 0.000 description 13
- 238000009434 installation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 230000003321 amplification Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 238000001917 fluorescence detection Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
Abstract
The invention relates to the nucleic acid detection technology, in particular to a thermal cover device and a nucleic acid detection analyzer, which comprise a cover shell and a heating structure arranged on the cover shell; heating structure includes the heat-conducting plate and with the heating element of heat-conducting plate contact, the lower surface of heat-conducting plate has the annular boss of downward salient, the shape of annular boss and the tip looks adaptation of reagent pipe, the inner wall of annular boss encloses the heating space who becomes the tip heating that is used for the reagent pipe with the lower surface of heat-conducting plate, the heat-conducting plate slides and sets up inside the cap. The invention solves the problems that the reagent box is heated unevenly and is easy to have condensation phenomenon.
Description
Technical Field
The invention relates to a nucleic acid detection technology, in particular to a hot cover device and a nucleic acid detection analyzer.
Background
The nucleic acid detection technology is a molecular biological detection method, and comprises the steps of extracting nucleic acid fragments (DNA or RNA) from a sample, then carrying out replication and amplification on the nucleic acid fragments through polymerase chain reaction, and finally detecting the nucleic acid, thereby determining the specific category or source of the nucleic acid in the sample.
The nucleic acid detection method is simple and easy to implement, has extremely wide application, and can obtain an accurate result only by a small amount of samples. During detection, a sample needs to be taken firstly, and is usually collected into a sampling tube by using a swab, then is extracted from the sampling tube to a kit, and finally is put into an instrument for reaction.
In the process of nucleic acid extraction and amplification, reagents such as a first reagent, a second reagent and the like need to be added step by step to be mixed with a sample.
After the kit is put into an instrument, the kit must be matched with a temperature control device and a fluorescence detection device to realize the reaction, amplification and detection of a sample, but the kit cannot be completely positioned in a temperature control module, and due to the temperature difference among all parts of the kit, condensation phenomenon is likely to occur in the kit, so that reagents cannot fully react, and the optical detection performance is likely to be influenced.
Disclosure of Invention
The invention provides a hot cover device, which aims to solve the problems that a reagent tube is unevenly heated and is easy to condense.
In order to achieve the purpose, the invention adopts the following technical means:
a thermal cover device comprising a cover shell, a heating structure mounted on the cover shell (as referred to herein as being mounted on the cover shell, including being directly attached to the cover shell and being indirectly mounted on the cover shell via other structures); heating structure includes the heat-conducting plate and with the heating element of heat-conducting plate contact, the lower surface of heat-conducting plate has the annular boss of downward salient, the shape of annular boss and the tip looks adaptation of reagent pipe, the inner wall of annular boss encloses the heating space who becomes the tip heating that is used for the reagent pipe with the lower surface of heat-conducting plate, the heat-conducting plate slides and sets up inside the cap. (adapted as referred to herein means that the annular boss can surround the end of the reagent vessel such that the heating space covers the end of the reagent vessel.)
In another embodiment, a fourth groove is formed in the lower surface of the heat conducting plate to form a heating space for heating the end portion of the reagent tube, and the shape of the fourth groove is matched with the end portion of the reagent tube. (where appropriate, reference is made herein to the fact that the fourth recess is able to enclose the end of the reagent vessel such that the heating space covers the end of the reagent vessel.) the same technical effect can be achieved by replacing the annular ledge with the fourth recess.
The device also comprises a guide structure; the heat-conducting plate is provided with a guide hole, and the guide structure comprises a guide shaft which is matched with the guide hole and used for limiting the movement direction of the heating plate.
The cover shell comprises an upper cover shell and a lower cover shell which is matched and connected with the upper cover shell, the upper cover shell and the lower cover shell are both of a hollow structure, the upper end of the upper cover shell is sealed, and a first mounting step and a second mounting step are arranged on the inner wall of the lower cover shell; the guide plate of the guide structure is arranged on the first step, and the heat conduction plate of the heating structure is arranged on the second step.
The heat conducting plate is provided with at least two guide holes; the number of the guide shafts of the guide structure is equal to that of the guide holes.
The heat conducting plate is provided with a sensor mounting groove, and a temperature sensor is mounted in the sensor mounting groove.
The heating element is a PI heating film and is adhered to the upper surface of the heat conducting plate.
The guide structure further comprises a guide plate and an elastic part, the elastic part is located between the heat conducting plate and the guide plate, and the guide shaft is installed on the lower surface of the guide plate.
The guide plate is provided with a waist-shaped hole for passing a wire.
Still include the ejector pin structure, the ejector pin structure includes the ejector pin mounting bracket on the lid shell (what mention here installs on the lid shell, including the lug connection on the lid shell and through other structure indirect mounting on the lid shell), install the actuating element on the ejector pin mounting bracket, slide the ejector pin that sets up on the ejector pin mounting bracket and be connected with the actuating element cooperation, the tip of ejector pin is arranged in heating space.
The driving element is a linear motor, and the ejector rod is connected with a sliding block of the linear motor in a matching mode.
And a third groove is formed in the middle of the ejector rod and is connected with a sliding block of the linear motor in a matching manner.
The end part of the ejector rod is provided with an ejector rod boss. (the ejector rod boss is used for puncturing a sealing film at a position corresponding to the reagent storage tube and is in fit connection with the top of the reagent storage tube so as to ensure that the reagent storage tube is vertically stressed downwards and further push the reagent storage tube to move downwards.)
The ejector rod mounting frame is provided with a linear bearing, and the ejector rod is mounted on the linear bearing.
A first ejector rod through hole for the ejector rod to pass through is formed in the heat conducting plate of the heating structure, and a second ejector rod through hole for the ejector rod to pass through is formed in the guide plate.
The beneficial effects of the hot cover device of the invention are as follows:
(1) the heat-conducting plate is used for covering the end part of the reagent tube, so that the reagent tube is prevented from condensing due to uneven heating;
(2) the heat conducting plate can slide and tightly press the reagent tube under the action of the elastic force of the elastic part, so that the reagent tube can be tightly pressed, the other end of the reagent tube is positioned in the temperature control device and tightly abutted against the fluorescence detection device, and subsequent reaction and detection are guaranteed;
(3) the heat conducting plate can slide, so that the reagent tube pressing device can adapt to reagent tubes with different heights, and the reagent tubes with different heights can be tightly pressed, so that the processing precision requirements of the reagent tubes and the heating plate are greatly reduced;
(4) the hot cover device is provided with the ejector rod, and the ejector rod can reciprocate to pierce the sealing membrane, so that the movement of the reagent storage tube and the addition of a second reagent are realized, the process is completely finished by an instrument without manual operation, and the hot cover does not need to be opened, so that the problem that a sample is polluted in the reaction process is thoroughly solved, the whole reaction process is carried out in a stable environment, and the stability of the reaction and the accuracy of a detection result are facilitated;
(5) according to the invention, the pressing device, the heating device and the automatic adding device of the second reagent of the reagent tube are integrated on the cover which is originally required by the nucleic acid detection analyzer, so that the space is greatly saved, the structure of the instrument is simplified, and the operation steps are simplified, thereby improving the use experience of a user.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the structure of another embodiment of the present invention;
FIG. 3 is a cross-sectional view of a housing cover of the present invention;
FIG. 4 is a schematic view of the internal structure of the present invention;
fig. 5 is a schematic structural view of the heat-conducting plate of the present invention.
The reference numbers in the figures denote:
4-hot cover device, 41-cover shell, 411-upper cover shell, 412-lower cover shell, 413-first installation step, 414-second installation step, 42-heat conduction plate, 421-annular boss, 422-sensor installation groove, 43-guide plate, 431-elastic piece, 432-waist-shaped hole, 441-ejector rod installation frame, 442-linear motor, 443-ejector rod and 444-linear bearing;
5-reagent tube.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The invention provides a hot cover device, which aims to solve the problems that a reagent box is heated unevenly and is easy to condense.
As shown in fig. 1, 2, 3 and 4, a hot lid device 4 includes a lid housing 41, a heating structure mounted on the lid housing 41, a guide structure, and a push rod structure.
The cover case 41 includes an upper cover case 411 and a lower cover case 412 cooperatively connected with the upper cover case 411, both the upper cover case 411 and the lower cover case 412 are hollow structures, the upper end of the upper cover case 411 is sealed, and the inner wall of the lower cover case 412 is provided with a first mounting step 413 and a second mounting step 414.
The heating structure comprises a heat conduction plate 42 and a heating element in contact with the heat conduction plate 42, a first ejector rod through hole is formed in the heat conduction plate, an annular boss 421 protruding downwards is arranged on the lower surface of the heat conduction plate 42, the shape of the annular boss 421 is matched with the end portion of the reagent tube, and a heating space for heating the end portion of the reagent tube is defined by the inner wall of the annular boss 421 and the lower surface of the heat conduction plate 42 (the mentioned matching means that the annular boss 421 can surround the end portion of the reagent tube, so that the heating space covers the end portion of the reagent tube).
In another embodiment, the heating structure comprises a heat conducting plate 42 and a heating element contacting with the heat conducting plate 42, the heat conducting plate is provided with a first pin through hole, the lower surface of the heat conducting plate 42 is provided with a fourth groove to form a heating space for heating the end portion of the reagent tube, and the shape of the fourth groove is matched with the end portion of the reagent tube (where the fourth groove is matched, it means that the fourth groove can surround the end portion of the reagent tube, so that the heating space covers the end portion of the reagent tube). The fourth groove is used for replacing the annular boss, and the same technical effect can be achieved.
As shown in fig. 4 and 5, the heat conducting plate 42 is provided with three guiding holes; the heat conducting plate 42 is provided with a sensor mounting groove 422, and a temperature sensor is mounted in the sensor mounting groove; the heating element is a PI heating film, which is adhered to the upper surface of the heat conductive plate 42.
Guide structure includes deflector 43, installs three guiding axles on deflector 43 lower surface, overlaps and establish the elastic component 431 on the guiding axle, and elastic component 431 is the spring in this embodiment, and second ejector pin via hole and waist type hole 432 have been seted up to deflector 43, and waist type hole 432 is used for crossing the line, and heating film and temperature sensor all need the line connection.
The roughness on the surface of the guide shaft is low, so that the smooth movement is guaranteed, and the tail end of the guide shaft is provided with a groove, so that the clamp spring is convenient to fix and limit.
The ejector rod structure comprises an ejector rod mounting frame 441 arranged on the guide plate 43, a linear motor 442 arranged on the ejector rod mounting frame 441, and an ejector rod 443 which is arranged on the ejector rod mounting frame 441 in a sliding manner and is in fit connection with a sliding block of the linear motor 442;
the ejector rod mounting frame 441 is provided with a linear bearing 444, and the ejector rod 443 is arranged on the linear bearing 444; and a third groove is formed in the middle of the ejector rod and is connected with a sliding block of the linear motor in a matching manner.
The end part of the ejector rod is provided with an ejector rod boss. The reagent storage tube for storing the reagent is only required to be pre-packaged in the reagent tube, and the ejector rod boss is used for puncturing a sealing film at a position corresponding to the position of the reagent storage tube and is matched with the structure at the top of the reagent storage tube to ensure that the reagent storage tube is vertically stressed downwards, so that the reagent storage tube is pushed to move downwards.
The guide plate 43 of the guide structure is installed on the first step 413, the heat conductive plate 42 of the heating structure is located on the second step 414, the guide hole on the heat conductive plate 42 is in fit connection with the guide shaft, and the elastic member 431 is located between the heat conductive plate 42 and the guide plate 43, and the end of the ejector 443 passes through the first ejector pin through hole and the second ejector pin through hole and is located in the heating space.
The principle of the hot lid device of the present invention is:
the reagent tube is mounted on the sample addition table and a thermal cap is placed over the reagent tube so that the reagent tube is housed within the instrument and has one end located in the heated space. The specific process is as follows: when the lower surface of the heat conductive plate 42 comes into contact with the end of the reagent tube 32, the heat conductive plate 42 receives a reaction force, so that the heat conductive plate 42 moves toward the guide plate 43 along the guide shaft and the elastic member 431 is compressed until the heat cover reaches a designated position. Since the elastic member is in a compressed state, the elastic force pushes the heat conducting plate 42 to press the reagent tube tightly, ensuring that the reagent tube 5 is positioned at a designated position for heating, reacting and detecting the reagent tube 5. The mode that can open and close that adopts commonly used between hot lid and the application of sample platform for example adopt modes such as buckle or magnetism to guarantee that hot lid covers on the application of sample platform.
After the cover reaches the designated position, the heating elements heat the plate 42 to maintain the heating space at the desired temperature. On one hand, the sample can react at the temperature to expose the nucleic acid in the sample, and on the other hand, the whole reagent tube is in a higher temperature environment, so that the condensation phenomenon can be effectively avoided. The temperature of the heating space is fed back through the first temperature sensor, the temperature of the general heating space is kept at 90-110 ℃, and the effect of preventing condensation is good.
When a second reagent needs to be added, the linear motor 442 moves to drive the ejector rod 443 to slide in the linear bearing 444, the boss of the ejector rod can pierce the sealing film at the position corresponding to the position of the reagent storage tube and push the reagent storage tube to move downwards, so that the second reagent moves downwards into the reaction solution; the ejector pin 443 then returns to the home position.
And after the detection is finished, the thermal cover is opened, and the reagent tube is taken out, so that the whole detection process is finished.
The beneficial effects of the hot cover device of the invention are as follows:
because the heat conducting plate 42 is used for covering the end part of the reagent tube and the heat conducting plate 42 can be heated, the reagent tube 5 can be ensured to carry out amplification reaction and optical detection, and meanwhile, the phenomenon of condensation caused by uneven heating can not occur.
Because heat-conducting plate 42 can slide to compress tightly the reagent pipe under the elasticity effect of elastic component, can compress tightly the reagent pipe, guarantee that the other end of reagent pipe is located temperature control device, and tightly support with fluorescence detection device, thereby provide the guarantee for follow-up reaction and detection. Meanwhile, the heat conducting plate 42 can slide to adapt to reagent tubes with different heights, so that the reagent tubes with different heights can be tightly pressed, and the requirement on the processing precision of the reagent tubes and the heating plate is greatly reduced.
Because the hot cover device is internally provided with the ejector rod, and the ejector rod 443 can reciprocate to pierce the sealing membrane, the movement of the reagent storage tube and the addition of a second reagent are realized, the process is completely finished by an instrument without manual operation, and the hot cover does not need to be opened, so that the problem that a sample is polluted in the reaction process is thoroughly solved, the whole reaction process is carried out in a stable environment, and the stability of the reaction and the accuracy of the detection result are facilitated.
The nucleic acid detection analyzer is provided with a cover for adding the reagent tube or the sample into the instrument, and the compressing device, the heating device and the automatic adding device of the second reagent of the reagent tube are integrated on the cover, so that the space is greatly saved, the structure of the instrument is simplified, the operation steps are simplified, and the use experience of a user is improved.
Since the structure inside the thermal cover device is large, dividing the cover case 41 into two parts facilitates the installation of the internal structure of the thermal cover device.
The first and second mounting steps 413 and 414 are less difficult to machine, and the remaining structures are less difficult to mount on the first and second mounting steps 413 and 414.
The heating space is created by means of the annular projection 421 or the fourth recess, which are both simple to manufacture and do not require additional parts to be mounted, and which facilitate the conduction of heat from the heating element to the heating space.
The PI heating film is adopted for heating, so that a structure special for mounting a heating element can be avoided being processed on the heat conducting plate.
The guide plate 43 is used to mount the ram structure and guide the heating structure.
Because the heat-conducting plate 42 is guided by the guiding shaft, the heat-conducting plate 42 is limited by the second step in the axial direction of the guiding shaft, and the processing precision requirement and the installation difficulty are greatly reduced. The specific reasons are as follows: if the limit structure of the heat conducting plate 42 in the axial direction of the guide shaft is arranged on the guide shaft, the matching precision of the guide shaft and the guide hole and the position precision and the installation precision of the limit structure need to be ensured at the same time, the processing precision requirement is very high, and the installation difficulty is high because the inner space of the heat cover device is small; similarly, if the structure for guiding is arranged on the cover shell, the processing precision requirement of the cover shell is very high, and the processing difficulty is higher considering that the structure of the cover shell is relatively thin; in this scheme, only need consider the guiding axle with the cooperation precision of guiding hole can, only need on the lid shell guarantee limit structure's position precision can, the processing degree of difficulty is very little.
The linear motor 442 is used for driving the ejector rod to move, and a sliding block of the linear motor is connected with the third groove of the ejector rod 443 in a matched mode. Other common transmission structures can be adopted to replace the transmission mechanism, for example, a rotating motor is adopted to be matched with a gear rack or a worm wheel and worm or a lead screw sliding rail to carry out transmission; or an air pump or a hydraulic pump is used for driving the mandril to move.
Claims (10)
1. A hot lid apparatus comprising a lid shell, characterized in that: the heating structure is arranged on the cover shell; heating structure includes the heat-conducting plate and with the heating element of heat-conducting plate contact, the lower surface of heat-conducting plate has the annular boss of downward salient, the shape of annular boss and the tip looks adaptation of reagent pipe, the inner wall of annular boss encloses the heating space who becomes the tip heating that is used for the reagent pipe with the lower surface of heat-conducting plate, the heat-conducting plate slides and sets up inside the cap.
2. A hot lid apparatus comprising a lid shell, characterized in that: the heating structure is arranged on the cover shell; the heating structure includes the heat-conducting plate and the heating element who contacts with the heat-conducting plate, set up the fourth recess on the lower surface of heat-conducting plate, form the heating space that is used for the tip heating of reagent pipe, the shape of fourth recess and the tip looks adaptation of reagent pipe, the heat-conducting plate slides and sets up inside the cap.
3. A hot cover device according to claim 1 or 2, wherein: the device also comprises a guide structure; the heat-conducting plate is provided with a guide hole, and the guide structure comprises a guide shaft which is matched with the guide hole and used for limiting the movement direction of the heating plate.
4. The thermal cover device of claim 3, wherein: the guide structure further comprises a guide plate and an elastic part, the elastic part is located between the heat conducting plate and the guide plate, and the guide shaft is installed on the lower surface of the guide plate. Furthermore, the guide plate is provided with a waist-shaped hole for threading.
5. The thermal cover device of claim 4, wherein: a first ejector rod through hole is formed in the heat conducting plate of the heating structure, and a second ejector rod through hole is formed in the guide plate.
6. The hot lid apparatus as claimed in claim 4 or 5, wherein: the cover shell comprises an upper cover shell and a lower cover shell which is matched and connected with the upper cover shell, the upper cover shell and the lower cover shell are both of a hollow structure, the upper end of the upper cover shell is sealed, and a first mounting step and a second mounting step are arranged on the inner wall of the lower cover shell; the guide plate of the guide structure is arranged on the first step, and the heat conduction plate of the heating structure is arranged on the second step.
7. The thermal cover device of claim 3, wherein: the heat conducting plate is provided with at least two guide holes; the number of the guide shafts of the guide structure is equal to that of the guide holes.
8. The hot lid apparatus as claimed in claim 1 or 2 or 4 or 5 or 6 or 7, wherein: a sensor mounting groove is formed in the heat conducting plate, and a temperature sensor is mounted in the sensor mounting groove;
and/or the first and/or second light sources,
the heating element is a PI heating film and is adhered to the upper surface of the heat conducting plate.
9. The hot lid apparatus as claimed in claim 1 or 2 or 4 or 5 or 6, wherein: still include the ejector pin structure, the ejector pin structure is including installing ejector pin mounting bracket on the lid shell, installing drive element on the ejector pin mounting bracket, sliding the ejector pin that sets up on the ejector pin mounting bracket and be connected with the drive element cooperation, the tip of ejector pin is arranged in heating space. Further, the driving element is a linear motor, and the ejector rod is connected with a sliding block of the linear motor in a matching manner; a third groove is formed in the middle of the ejector rod and is in fit connection with a sliding block of the linear motor; the end part of the ejector rod is provided with an ejector rod boss; the ejector rod mounting frame is provided with a linear bearing, and the ejector rod is mounted on the linear bearing.
10. A nucleic acid detection analyzer comprises a frame, and is characterized in that: a reagent tube and a thermal cover device according to any one of claims 1 to 9 are mounted on the frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011193682.4A CN114437919A (en) | 2020-10-30 | 2020-10-30 | Hot lid device and nucleic acid detection analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011193682.4A CN114437919A (en) | 2020-10-30 | 2020-10-30 | Hot lid device and nucleic acid detection analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114437919A true CN114437919A (en) | 2022-05-06 |
Family
ID=81357369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011193682.4A Pending CN114437919A (en) | 2020-10-30 | 2020-10-30 | Hot lid device and nucleic acid detection analyzer |
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| Country | Link |
|---|---|
| CN (1) | CN114437919A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114958580A (en) * | 2022-05-31 | 2022-08-30 | 山东省高精生物诊断分析产业技术研究院有限公司 | A hot lid structure for full-automatic nucleic acid analytic system |
-
2020
- 2020-10-30 CN CN202011193682.4A patent/CN114437919A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114958580A (en) * | 2022-05-31 | 2022-08-30 | 山东省高精生物诊断分析产业技术研究院有限公司 | A hot lid structure for full-automatic nucleic acid analytic system |
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