CN219156844U

CN219156844U - Movable pressing device and pathogen nucleic acid analyzer

Info

Publication number: CN219156844U
Application number: CN202223446166.5U
Authority: CN
Inventors: 林宝宝; 李保; 邹瑜亮; 杨毅
Original assignee: Beijing Zijing Biotechnology Co ltd
Current assignee: Beijing Zijing Biotechnology Co ltd
Priority date: 2022-12-22
Filing date: 2022-12-22
Publication date: 2023-06-09
Anticipated expiration: 2032-12-22

Abstract

The utility model provides a movable pressing device and a pathogen nucleic acid analyzer, wherein the movable pressing device comprises a front-back moving component and a lifting component, the front-back moving component comprises a first frame, the first frame is provided with a containing space, a first rotating shaft driven to rotate by a first driving motor is arranged in the containing space, a first sliding component is sleeved on the first rotating shaft, the lifting component is connected to the first sliding component, the lifting component is provided with a push rod capable of being driven to lift, and when the push rod is driven to descend, the push rod can press a pressing block of the pathogen nucleic acid analyzer so that a heating component of the pressing block can be contacted with a microfluidic chip. According to the utility model, the push rod is positioned at the target position corresponding to the micro-fluidic chip through the front-back moving component, so that the push rod is positioned in the horizontal direction, the lifting component is used for pressing the lower pressing plate of the temperature control device, and the heating component of the lower pressing plate can be closely contacted with the micro-fluidic chip below, and the temperature control is ensured to be stable and efficient.

Description

Movable pressing device and pathogen nucleic acid analyzer

Technical Field

The utility model belongs to the technical field of instant detection, and particularly relates to a movable pressing device and a pathogen nucleic acid analyzer.

Background

In recent years, the in-vitro diagnosis industry, particularly the molecular diagnosis industry, has become one of the fields which develop faster in the domestic medical and health industry. In vitro diagnosis, abbreviated as IVD (In Vitro Diagnostics), is a diagnostic method for detecting human body samples such as saliva, blood, urine and the like outside a human body so as to judge diseases or organism functions. Nucleic acid analysis is one of the most viable subdivision in the field of in vitro diagnosis, and is the most direct, reliable and sensitive method for realizing early, rapid and specific detection of pathogens.

Nucleic acid analysis can determine information such as the type of pathogen and the sample size in a sample to be tested in a short time by analyzing genetic material (DNA or RNA) of the pathogen. Generally comprises: sample pretreatment, nucleic acid extraction, amplification and detection. The traditional detection method needs to be completed in a laboratory with professional conditions by professional staff, a large number of complicated operations are required to be completed, and special instruments and equipment such as a temperature circulating instrument, a capillary electrophoresis instrument and the like are also required to be used, and the problems of false positive, false negative and the like caused by matched resources, limited professional staff or misoperation can be possibly caused, so that the traditional laboratory nucleic acid analysis is difficult to realize early, quick and sensitive detection on a large number of samples and give accurate results. In order to reduce the high threshold of nucleic acid detection and improve the drawbacks of the conventional detection method, a fully integrated, automatic and high-sensitivity pathogen analysis instrument is urgently needed, wherein a movable pressing device is needed to be designed, and the pressing force can be applied to corresponding components by using the displacement movement of the movable pressing device, so that the automatic pressing action is realized on the components below the movable pressing device.

Disclosure of Invention

Therefore, the technical problem to be solved by the utility model is to provide a movable pressing device and a pathogen nucleic acid analyzer, so that a pressing plate of a temperature control device in the pathogen nucleic acid analyzer can be automatically pressed down, a heating component of the pressing plate is tightly contacted with a microfluidic chip below, and the temperature control is ensured to be stable and efficient.

In order to solve the problems, the utility model provides a movable pressing device which is applied to a pathogen nucleic acid analyzer and comprises a front-back moving component and a lifting component, wherein the front-back moving component comprises a first frame, the first frame is provided with a containing space, a first rotating shaft driven to rotate by a first driving motor is arranged in the containing space, a first sliding component is sleeved on the first rotating shaft, the lifting component is connected to the first sliding component, the lifting component is provided with a push rod capable of being driven to lift, and when the push rod is driven to descend, the push rod can press a pressing block of the pathogen nucleic acid analyzer so that a heating component of the pressing block can be contacted with a microfluidic chip.

In some embodiments, the first frame includes a first support and a second support that are parallel and spaced apart, and a third support and a fourth support that are parallel and spaced apart, wherein the third support and the fourth support are internally clamped between the first support and the second support, and the first rotating shaft is rotatably mounted between the third support and the fourth support.

In some embodiments, a fifth bracket is connected to one side of the third bracket and the fourth bracket away from the accommodating space, a first motor fixing plate is connected to one end of the fifth bracket beyond the accommodating space, and the first driving motor is assembled on the first motor fixing plate.

In some embodiments, the first rotary shaft of the first drive motor is coaxially drive connected to the first rotary shaft via a coupling.

In some embodiments, a first linear sliding rail assembly is connected to a side wall body of the first support and the second support corresponding to the accommodating space, the lifting assembly includes a sixth support, and a seventh support and an eighth support connected to opposite sides of the sixth support, and the seventh support and the eighth support are respectively connected to the first linear sliding assembly at sides opposite to the sixth support, which are far away from the sixth support.

In some embodiments, the lifting assembly further comprises a second rotating shaft driven to rotate by a second driving motor, a second sliding assembly is sleeved on the second rotating shaft, the second sliding assembly comprises a push rod fixing block, one end of the push rod is fixedly connected to the push rod fixing block, and the direction of the push rod following the linear motion of the push rod fixing block is parallel to the second rotating shaft.

In some embodiments, the number of the push rods is two, the two push rods are respectively located at two sides of the second rotating shaft, a guide plate is further arranged between the seventh support and the eighth support, guide holes corresponding to the push rods one by one are formed in the guide plate, and the other ends of the push rods are inserted into the guide holes.

In some embodiments, a second linear sliding component is further arranged between the push rod fixing block and the sixth bracket; and/or, one side of the sixth support, which is far away from the second rotating shaft, is connected with a second motor fixing plate, the second driving motor is assembled on the second motor fixing plate, a second rotating shaft of the second driving motor is parallel to the second rotating shaft, the corresponding end parts of the second rotating shaft and the second rotating shaft are sleeved with synchronous wheels, and the synchronous belt is tensioned on the two synchronous wheels.

In some embodiments, the second sliding assembly further comprises a second guide sleeve, the second guide sleeve is in threaded connection with the second rotating shaft, and the push rod fixing block is sleeved with the second rotating shaft through the second guide sleeve.

The utility model also provides a pathogen nucleic acid analyzer, which comprises a temperature control device and the movable pressing device, wherein the push rod can be horizontally translated to the upper part of the temperature control device and controlled to descend, so that the bottom end of the push rod can apply force on a pressing plate of the temperature control device.

According to the movable pressing device and the pathogen nucleic acid analyzer, the push rod is located at the target position corresponding to the microfluidic chip through the front-back moving component, namely, the push rod is located in the horizontal direction, the lifting component can drive the push rod to lift so as to press the pressing plate of the temperature control device, and therefore the heating component of the pressing plate can be in close contact with the microfluidic chip below, and temperature control is guaranteed to be stable and efficient.

Drawings

Fig. 1 is a schematic perspective view of a movable pressing device according to an embodiment of the present utility model (in which a push rod is in a raised state);

FIG. 2 is a schematic perspective view of a movable pushing device according to an embodiment of the present utility model (in which the push rod is in a lowered or pushed state);

FIG. 3 is a schematic perspective view of the front-back moving assembly of FIG. 1;

FIG. 4 is a schematic perspective view of the front-to-back moving assembly of FIG. 1 from another perspective;

FIG. 5 is a schematic perspective view of the lifting assembly of FIG. 1;

fig. 6 is a schematic perspective view of the lifting assembly in fig. 1 from another perspective.

The reference numerals are expressed as:

1. a first bracket; 2. a third bracket; 3. a second bracket; 4. a fourth bracket; 5. a fifth bracket; 6. a first motor fixing plate; 7. moving the connecting block; 8. a first rotating shaft fixing seat; 9. the first guide sleeve; 10. a first bearing; 11. a first rotating shaft; 12. a first driving motor; 13. a coupling; 14. a first slider; 15. a first slide rail; 16. a seventh bracket; 17. a sixth bracket; 18. an eighth bracket; 19. a guide plate; 20. a second motor adjustment block; 21. a second motor fixing plate; 22. a push rod fixing block; 23. a second rotating shaft fixing seat; 24. a second bearing; 25. a second rotating shaft; 26. a push rod; 27. a second guide sleeve; 28. a synchronizing wheel; 29. a synchronous belt; 30. a second driving motor; 31. a second slider; 32. and a second slide rail.

Detailed Description

Referring to fig. 1 to 6 in combination, according to an embodiment of the present utility model, particularly referring to fig. 1 and 2, a moving and pressing device is provided, which is applied to a pathogen nucleic acid analyzer, and includes a front-back moving component (not indexed in the figure) and a lifting component (not indexed in the figure), wherein the front-back moving component includes a first frame (not indexed in the figure), the first frame has a receiving space, a first rotating shaft 11 driven to rotate by a first driving motor 12 is provided in the receiving space, a first sliding component is sleeved on the first rotating shaft 11, the lifting component is connected to the first sliding component, the first sliding component specifically includes a first guide sleeve 9 in threaded connection with the first rotating shaft 11, the first guide sleeve 9 is connected with a moving connecting block 7 as a whole, the lifting component is fixedly connected with the moving connecting block 7, thereby achieving the purpose that the rotation of the first rotating shaft 11 is converted into the linear reciprocating motion of the lifting component, the lifting component has a push rod 26 capable of being driven to lift, and when the push rod 26 is driven to descend, the push rod 26 is capable of pressing down the pathogen nucleic acid analyzer has a lower pressure block capable of contacting a micro-chip. In the technical scheme, the push rod 26 is positioned at the target position corresponding to the micro-fluidic chip through the front-back moving component, namely, the positioning of the push rod 26 in the horizontal direction is realized, and the lifting component can drive the push rod 26 to lift so as to realize the downward pressing of the lower pressing plate of the temperature control device, so that the heating component of the lower pressing plate can be in close contact with the micro-fluidic chip below, and the temperature control is ensured to be stable and efficient.

Referring to fig. 3 and 4 in combination, in a specific embodiment, the first frame includes a first bracket 1 and a second bracket 3 that are parallel and spaced apart, and a third bracket 2 and a fourth bracket 4 that are parallel and spaced apart, where the third bracket 2 and the fourth bracket 4 are clamped between the first bracket 1 and the second bracket 3, and a first rotating shaft 11 is rotatably installed between the third bracket 2 and the fourth bracket 4, and the areas where the four brackets are opposite to each other form the aforesaid accommodating space, and the first rotating shaft 11 is installed between the third bracket 2 and the fourth bracket 4 through a first rotating shaft fixing seat 8 and a first bearing 10, that is, in the accommodating space, with simple and compact structure. One side of the third support 2 and the fourth support 4 far away from the accommodating space is connected with a fifth support 5, one end of the fifth support 5 exceeding the accommodating space is connected with a first motor fixing plate 6, and the first driving motor 12 is assembled on the first motor fixing plate 6, so that reliable connection of the first driving motor 12 is realized. The first rotation shaft of the first drive motor 12 is coaxially and drivingly connected to the first rotation shaft 11 via the coupling 13, and the occurrence of a shift jam phenomenon due to the first rotation shaft 11 and the first rotation shaft being not coaxial can be prevented.

In order to further improve the smoothness of adjusting the horizontal position of the lifting assembly, a first linear sliding rail assembly is connected to a side wall body of the corresponding accommodating space between the first bracket 1 and the second bracket 3, the lifting assembly comprises a sixth bracket 17, a seventh bracket 16 and an eighth bracket 18 connected to opposite sides of the sixth bracket 17, the seventh bracket 16 and the eighth bracket 18 are respectively connected with a first linear sliding assembly far away from opposite sides of the sixth bracket 17, the first linear sliding rail assembly comprises a first sliding rail 15 connected to the brackets and a first sliding block 14 connected to the first sliding rail 15 in a sliding manner, and the seventh bracket 16 and the eighth bracket 18 are respectively connected with the two first sliding blocks 14.

Referring to fig. 5 and 6, the lifting assembly further includes a second rotating shaft 25 driven to rotate by a second driving motor 30, a second sliding assembly is sleeved on the second rotating shaft 25, the second sliding assembly includes a push rod fixing block 22, one end of a push rod 26 is fixedly connected to the push rod fixing block 22, the direction of the push rod 26 following the linear motion of the push rod fixing block 22 is parallel to the second rotating shaft 25, the lifting of the lifting assembly is reliably guided by the second sliding assembly, and the lifting of the push rod 26 is more stable. It can be appreciated that the second shaft is rotatably connected to the sixth bracket 17 by a second shaft fixing seat 23 and a corresponding second bearing 24.

The two push rods 26 are respectively positioned at two sides of the second rotating shaft 25, a guide plate 19 is further arranged between the seventh bracket 16 and the eighth bracket 18, guide holes corresponding to the push rods 26 one by one are formed in the guide plate 19, the other ends of the push rods 26 are inserted into the guide holes, the push rods 26 slide up and down in the guide holes, and reliable limiting is formed on the positions of the push rods 26.

In some embodiments, a second linear sliding component is further disposed between the push rod fixing block 22 and the sixth bracket 17 to ensure stable lifting of the push rod fixing block 22, where the second linear sliding component specifically includes, for example, a second sliding rail 32 connected to the sixth bracket 17 and a second sliding block 31 slidingly connected to the second sliding rail 32. In a preferred embodiment, a second motor fixing plate 21 is connected to a side of the sixth support 17 away from the second rotating shaft 25, the second driving motor 30 is assembled on the second motor fixing plate 21, a second rotating shaft of the second driving motor 30 is parallel to the second rotating shaft 25, corresponding ends of the second rotating shaft and the second rotating shaft 25 are sleeved with synchronous wheels 28, and the synchronous belt 29 is tensioned on the two synchronous wheels 28, so that space occupation of the second driving motor 30 can be more compact, the second motor fixing plate 21 is further provided with a second motor adjusting block 20, and tension of the synchronous belt 29 can be adjusted by adjusting the axial distance between the second motor adjusting block and the second rotating shaft 25, reliable power transmission of the synchronous belt 29 is ensured, and slipping is prevented.

The second sliding assembly further comprises a second guide sleeve 27, the second guide sleeve 27 is in threaded connection with the second rotating shaft 25, the push rod fixing block 22 is sleeved with the second rotating shaft 25 through the second guide sleeve 27, and therefore rotation of the second rotating shaft 25 is converted into reciprocating linear motion of the second guide sleeve 27 along the axial direction of the second rotating shaft 25, and the push rod fixing block 22 and the push rod 26 are driven to move up and down.

The utility model also provides a pathogen nucleic acid analyzer, which comprises a temperature control device and the movable pressing device, wherein the push rod 26 can be horizontally translated to the upper part of the temperature control device and controlled to descend, so that the bottom end of the push rod 26 applies force on a pressing plate of the temperature control device.

It will be readily appreciated by those skilled in the art that the above advantageous ways can be freely combined and superimposed without conflict.

The foregoing description of the preferred embodiments of the utility model is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the utility model. The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that it will be apparent to those skilled in the art that modifications and variations can be made without departing from the technical principles of the present utility model, and these modifications and variations should also be regarded as the scope of the utility model.

Claims

1. The utility model provides a remove pushing device, is applied to pathogen nucleic acid analyzer, a serial communication port, including back-and-forth movement subassembly and lifting unit, wherein, back-and-forth movement subassembly includes first frame, first frame has the accommodation space, be equipped with in the accommodation space and receive first driving motor (12) drive rotatory first pivot (11), the cover is equipped with first subassembly that slides on first pivot (11), lifting unit connect in on the first subassembly that slides, lifting unit has push rod (26) that can be driven to go up and down, when push rod (26) are driven to descend, push rod (26) can push down the briquetting that pathogen nucleic acid analyzer had so that the heating element that the briquetting had down can contact with the micro-fluidic chip.

2. The movable pressing device according to claim 1, wherein the first frame comprises a first bracket (1) and a second bracket (3) which are arranged in parallel and at intervals, and a third bracket (2) and a fourth bracket (4) which are arranged in parallel and at intervals, wherein the third bracket (2) and the fourth bracket (4) are internally clamped between the first bracket (1) and the second bracket (3), and the first rotating shaft (11) is rotatably arranged between the third bracket (2) and the fourth bracket (4).

3. The movable pressing device according to claim 2, wherein a fifth bracket (5) is connected to one side, away from the accommodating space, of the third bracket (2) and the fourth bracket (4), a first motor fixing plate (6) is connected to one end, exceeding the accommodating space, of the fifth bracket (5), and the first driving motor (12) is assembled on the first motor fixing plate (6).

4. A mobile pressing device according to claim 3, characterized in that the first rotation shaft of the first drive motor (12) is in coaxial driving connection with the first rotation shaft (11) via a coupling (13).

5. The movable pressing device according to claim 2, wherein a first linear sliding component is connected to a side wall body of the first bracket (1) and the second bracket (3) corresponding to the accommodating space, the lifting component comprises a sixth bracket (17), and a seventh bracket (16) and an eighth bracket (18) connected to opposite sides of the sixth bracket (17), and the seventh bracket (16) and the eighth bracket (18) are respectively connected with the first linear sliding component at a side away from the sixth bracket (17).

6. The movable pressing device according to claim 5, wherein the lifting assembly further comprises a second rotating shaft (25) driven to rotate by a second driving motor (30), a second sliding assembly is sleeved on the second rotating shaft (25), the second sliding assembly comprises a push rod fixing block (22), one end of the push rod (26) is fixedly connected to the push rod fixing block (22), and the direction of the push rod (26) following the linear motion of the push rod fixing block (22) is parallel to the second rotating shaft (25).

7. The movable pressing device according to claim 6, wherein the number of the push rods (26) is two, the two push rods (26) are respectively located at two sides of the second rotating shaft (25), a guide plate (19) is further arranged between the seventh support (16) and the eighth support (18), guide holes corresponding to the push rods (26) one by one are formed in the guide plate (19), and the other ends of the push rods (26) are inserted into the guide holes.

8. The mobile pressing device according to claim 6, characterized in that a second linear sliding assembly is also provided between the push rod fixing block (22) and the sixth bracket (17); and/or, one side of the sixth support (17) far away from the second rotating shaft (25) is connected with a second motor fixing plate (21), a second driving motor (30) is assembled on the second motor fixing plate (21), a second rotating shaft of the second driving motor (30) is parallel to the second rotating shaft (25), and a synchronous wheel (28) is sleeved at the corresponding end part of the second rotating shaft and the corresponding end part of the second rotating shaft (25), and a synchronous belt (29) is tensioned on the two synchronous wheels (28).

9. The movable pressing device according to claim 6, wherein the second sliding assembly further comprises a second guide sleeve (27), the second guide sleeve (27) is in threaded connection with the second rotating shaft (25), and the push rod fixing block (22) is sleeved with the second rotating shaft (25) through the second guide sleeve (27).

10. A pathogen nucleic acid analyzer, characterized by comprising a temperature control device and a movable pressing device according to any one of claims 1 to 9, the push rod (26) being translatable in a horizontal direction above the temperature control device and being controlled to descend so that a bottom end of the push rod (26) is forced against a pressing plate provided in the temperature control device.