CN219156870U

CN219156870U - Multichannel optical detection module driving device and pathogen nucleic acid analyzer

Info

Publication number: CN219156870U
Application number: CN202223446214.0U
Authority: CN
Inventors: 林宝宝; 李保; 邹瑜亮; 杨毅
Original assignee: Beijing Zijing Biotechnology Co ltd
Current assignee: Beijing Zijing Biotechnology Co ltd
Priority date: 2022-12-22
Filing date: 2022-12-22
Publication date: 2023-06-09
Anticipated expiration: 2032-12-22

Abstract

The utility model provides a multichannel optical detection module driving device and a pathogen nucleic acid analyzer, wherein the multichannel optical detection module driving device comprises a fixed plate, an optical detection module and a traversing driving assembly, at least two optical detection channels are arranged in the optical detection module, the traversing driving assembly is fixedly connected to the fixed plate, the traversing driving assembly comprises a rotating shaft and a guide sleeve assembly matched with the rotating shaft, the optical detection module is connected with the guide sleeve assembly, when the rotating shaft is driven to rotate, the optical detection module moves linearly along the axial direction of the rotating shaft along the guide sleeve assembly, and all the optical detection channels on the optical detection module are sequentially arranged at intervals along the axial direction of the rotating shaft. The utility model realizes that each optical detection channel on the optical detection module sequentially corresponds to the corresponding sample to be detected to realize the purpose of detecting the sample, meets the requirements of various detection projects, has simpler and more compact structure, and is beneficial to the portable design of the pathogen nucleic acid analyzer adopting the optical detection channels.

Description

Multichannel optical detection module driving device and pathogen nucleic acid analyzer

Technical Field

The utility model belongs to the technical field of instant detection, and particularly relates to a multichannel optical detection module driving device and a pathogen nucleic acid analyzer.

Background

In recent years, the in-vitro diagnosis industry, particularly the molecular diagnosis industry, has become one of the fields which develop faster in the domestic medical and health industry. In vitro diagnosis, abbreviated as IVD (In Vitro Diagnostics), is a diagnostic method for detecting human body samples such as saliva, blood, urine and the like outside a human body so as to judge diseases or organism functions. Nucleic acid analysis is one of the most viable subdivision in the field of in vitro diagnosis, and is the most direct, reliable and sensitive method for realizing early, rapid and specific detection of pathogens.

Nucleic acid analysis can determine information such as the type of pathogen and the sample size in a sample to be tested in a short time by analyzing genetic material (DNA or RNA) of the pathogen. Generally comprises: sample pretreatment, nucleic acid extraction, amplification and detection. The traditional detection method needs to be completed in a laboratory with professional conditions by professional staff, a large number of complicated operations are required to be completed, and special instruments and equipment such as a temperature circulating instrument, a capillary electrophoresis instrument and the like are also required to be used, and the problems of false positive, false negative and the like caused by matched resources, limited professional staff or misoperation can be possibly caused, so that the traditional laboratory nucleic acid analysis is difficult to realize early, quick and sensitive detection on a large number of samples and give accurate results. In order to reduce the high threshold of nucleic acid detection and improve the drawbacks of the conventional detection method, a fully integrated, automatic and high-sensitivity pathogen analysis instrument is urgently needed, wherein the multi-path design of the optical detection module can increase the detection project and further improve the detection efficiency, so that a driving device with a multi-path optical detection module is correspondingly designed, and the utility model is provided based on the design.

Disclosure of Invention

Therefore, the technical problem to be solved by the utility model is to provide a multi-channel optical detection module driving device and a pathogen nucleic acid analyzer, wherein the multi-channel optical detection module driving device can drive the multi-channel optical detection module to switch among different detection channels, so that the multi-channel optical detection module driving device meets various detection projects and has a more compact structure.

In order to solve the problems, the utility model provides a multi-channel optical detection module driving device which is applied to a pathogen nucleic acid analyzer and comprises a fixed plate, an optical detection module and a traversing driving assembly, wherein at least two optical detection channels are arranged in the optical detection module, the traversing driving assembly is fixedly connected to the fixed plate, the traversing driving assembly comprises a rotating shaft and a guide sleeve assembly matched with the rotating shaft, the optical detection module is connected with the guide sleeve assembly, when the rotating shaft is driven to rotate, the optical detection module moves along the guide sleeve assembly along the axial direction of the rotating shaft in a straight line, and each optical detection channel on the optical detection module is sequentially arranged at intervals along the axial direction of the rotating shaft.

In some embodiments, the fixing plate is provided with a first bracket and a second bracket at parallel intervals, and two ends of the rotating shaft are rotatably erected between the first bracket and the second bracket.

In some embodiments, the fixing plate is further provided with a third support, the third support is parallel to the first support, the traversing driving assembly further comprises a driving motor, the driving motor is fixedly connected to one side, facing the second support, of the third support, and a power output shaft of the driving motor is in driving connection with the first end of the rotating shaft through a synchronous belt.

In some embodiments, the power output shaft and the first end of the rotating shaft are both sleeved with synchronous wheels, and the synchronous belt is tensioned on the two synchronous wheels.

In some embodiments, the guide sleeve assembly comprises a guide sleeve and a sliding table, the guide sleeve is in threaded sleeve connection with the rotating shaft, the sliding table is provided with a mounting hole, the guide sleeve is connected to the mounting hole, the optical detection module is mounted on a fourth support, and the fourth support is connected with the sliding table.

In some embodiments, the fixing plate is further connected with a fifth bracket, the first bracket and the second bracket are respectively connected to two ends of the fifth bracket, the first bracket, the second bracket and the fifth bracket form a U-shaped bracket, and the U-shaped bracket is assembled on the fixing plate.

In some embodiments, the fifth support is provided with a guide rail, the guiding direction of the guide rail is parallel to the length direction of the rotating shaft, the bottom of the sliding table is provided with a sliding block, and the sliding block is slidably connected to the guide rail.

The utility model also provides a pathogen nucleic acid analyzer, which comprises a polishing plate and the multi-channel optical detection module driving device, wherein a light through hole is formed in the polishing plate, and the transverse moving driving assembly can drive each optical detection channel on the optical detection module to be opposite to the light through hole in sequence.

According to the multi-channel optical detection module driving device and the pathogen nucleic acid analyzer, the transverse moving driving assembly drives the optical detection module to axially move, so that the purpose of detecting samples is achieved by sequentially enabling all optical detection channels on the optical detection module to correspond to corresponding samples to be detected (detection positions of microfluidic chips), the requirements of various detection projects are met, meanwhile, the structure is simpler and more compact, and the portable design of the pathogen nucleic acid analyzer adopting the multi-channel optical detection module driving device is facilitated.

Drawings

FIG. 1 is a schematic perspective view of a driving device of a multi-channel optical detection module according to an embodiment of the present utility model;

FIG. 2 is a partial cross-sectional view of the hinge and first bracket connection area of FIG. 1;

fig. 3 is a relative positional relationship between an optical detection module and a light-polishing plate in the multi-channel optical detection module driving device in fig. 1, and shows a state in which a first optical detection channel is aligned with a light-passing hole on the light-polishing plate.

The reference numerals are expressed as:

1. a fixing plate; 2. a third bracket; 3. a first bracket; 4. a fifth bracket; 5. a second bracket; 6. a sliding table; 7. a fourth bracket; 8. a rotating shaft; 9. a bearing; 10. guide sleeve; 11. a synchronizing wheel; 12. a synchronous belt; 13. a driving motor; 14. an optical detection module; 15. polishing plate; 16. a slide block; 17. and a guide rail.

Detailed Description

Referring to fig. 1 to 3, according to an embodiment of the present utility model, a multi-channel optical detection module driving device is provided, and is applied to a pathogen nucleic acid analyzer, and includes a fixing plate 1, an optical detection module 14, and a traversing driving assembly, wherein at least two optical detection channels (four are specifically shown in fig. 1) are configured in the optical detection module 14, the traversing driving assembly is fixedly connected to the fixing plate 1, the traversing driving assembly includes a rotating shaft 8 and a guide sleeve assembly configured to match the rotating shaft 8, the optical detection module 14 is connected to the guide sleeve assembly, and when the rotating shaft 8 is driven to rotate, the optical detection module 14 moves linearly along an axial direction of the rotating shaft 8 along the guide sleeve assembly, and each optical detection channel on the optical detection module 14 is sequentially and alternately arranged along the axial direction of the rotating shaft 8. In the technical scheme, the transverse moving driving assembly drives the optical detection module 14 to axially move, so that the purpose of detecting the sample is achieved by sequentially corresponding each optical detection channel above the optical detection module 14 with the corresponding sample to be detected (the detection position of the microfluidic chip), the requirements of various detection projects are met, and meanwhile, the structure is simpler and more compact, and the portable design of the pathogen nucleic acid analyzer adopting the transverse moving driving assembly is facilitated.

In a specific embodiment, the fixing plate 1 is provided with the first bracket 3 and the second bracket 5 at parallel intervals, and two ends of the rotating shaft 8 are rotatably arranged between the first bracket 3 and the second bracket 5 through bearings 9 respectively, so that the structure is simple and reliable. The fixed plate 1 is further provided with a third support 2, the third support 2 and the first support 3 are arranged in parallel, the transverse moving driving assembly further comprises a driving motor 13, the driving motor 13 is fixedly connected to one side, facing the second support 5, of the third support 2, a power output shaft of the driving motor 13 is in driving connection with a first end of the rotating shaft 8 through a synchronous belt 12, in the technical scheme, the power output shaft of the driving motor 13 and the rotating shaft 8 are arranged in parallel and realize synchronous follow-up driving of the two through the synchronous belt 12, the length of the device is effectively reduced, and the structure is more compact. Specifically, the first ends of the power output shaft and the rotating shaft 8 are both sleeved with synchronous wheels 11 (specifically, flat key connection can be adopted), and the synchronous belt 12 is tensioned on the two synchronous wheels 11, so that the slipping phenomenon of the synchronous belt 12 can be effectively prevented.

As a specific embodiment of the guide sleeve assembly, the guide sleeve assembly comprises a guide sleeve 10 and a sliding table 6, the guide sleeve 10 is in threaded sleeve connection with the rotating shaft 8, so when the rotating shaft 8 rotates, the rotation of the rotating shaft is converted into axial linear motion of the guide sleeve 10 under the action of the threaded connection between the guide sleeve and the guide sleeve 10, the linear reciprocating motion of the guide sleeve 10 is realized through the rotation direction switching of the rotating shaft 8, at the moment, the sliding table 6 is provided with a mounting hole, the guide sleeve 10 is connected with the mounting hole, the optical detection module 14 is mounted on the fourth bracket 7, the fourth bracket 7 is connected with the sliding table 6, the position of the optical detection module 14 is switched by the rotating shaft 8, the size of the fourth bracket 7 can be reasonably selected according to the relative position of an optical detection channel on the optical detection module 14 and a light through hole on the light polishing plate 15, and the whole structure can be more reasonable.

In some embodiments, the fixing plate 1 is further connected with a fifth bracket 4, the first bracket 3 and the second bracket 5 are respectively connected to two ends of the fifth bracket 4, and the first bracket 3, the second bracket 5 and the fifth bracket 4 form a U-shaped bracket, and the U-shaped bracket is assembled on the fixing plate 1, so that components such as a traversing driving assembly can be assembled on the U-shaped bracket first, and then the whole is assembled on the fixing plate 1, thereby realizing modularized assembly and simplifying the assembly process. The first bracket 3, the second bracket 5, the third bracket 2, the fourth bracket 7 and the fifth bracket 4 can be designed into a plate structure, and the structural types of the first bracket, the second bracket, the third bracket, the fourth bracket and the fifth bracket can be optimized according to practical requirements.

The fifth bracket 4 is provided with a guide rail 17, the guiding direction of the guide rail 17 is parallel to the length direction of the rotating shaft 8, the bottom of the sliding table 6 is provided with a sliding block 16, and the sliding block 16 is slidably connected to the guide rail 17, so that the purpose of stable guiding and alignment for position switching of the optical detection module 14 is realized.

The utility model also provides a pathogen nucleic acid analyzer, which comprises a polishing plate 15 and the multi-channel optical detection module driving device, wherein a light through hole is formed in the polishing plate 15, and the transverse movement driving assembly can drive each optical detection channel on the optical detection module 14 to be opposite to the light through hole in sequence.

It will be readily appreciated by those skilled in the art that the above advantageous ways can be freely combined and superimposed without conflict.

The foregoing description of the preferred embodiments of the utility model is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the utility model. The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that it will be apparent to those skilled in the art that modifications and variations can be made without departing from the technical principles of the present utility model, and these modifications and variations should also be regarded as the scope of the utility model.

Claims

1. The utility model provides a multichannel optical detection module drive arrangement, is applied to pathogen nucleic acid analyzer, its characterized in that includes fixed plate (1), optical detection module (14) and sideslip drive assembly, be configured with two at least optical detection channels in optical detection module (14), sideslip drive assembly fixed connection in on fixed plate (1), sideslip drive assembly include pivot (8) and with pivot (8) supporting set up guide pin bushing subassembly, optical detection module (14) with guide pin bushing subassembly is connected, when pivot (8) are driven rotatory, optical detection module (14) follow guide pin bushing subassembly is followed the axial rectilinear movement of pivot (8), each optical detection channel on optical detection module (14) is followed the axial of pivot (8) is interval set up in proper order.

2. The multi-channel optical detection module driving device according to claim 1, wherein a first bracket (3) and a second bracket (5) are arranged on the fixed plate (1) at parallel intervals, and two ends of the rotating shaft (8) are rotatably arranged between the first bracket (3) and the second bracket (5).

3. The multi-channel optical detection module driving device according to claim 2, wherein a third bracket (2) is further arranged on the fixing plate (1), the third bracket (2) is arranged in parallel with the first bracket (3), the traversing driving assembly further comprises a driving motor (13), the driving motor (13) is fixedly connected to one side, facing the second bracket (5), of the third bracket (2), and a power output shaft of the driving motor (13) is in driving connection with the first end of the rotating shaft (8) through a synchronous belt (12).

4. A multi-channel optical detection module driving device according to claim 3, wherein the power output shaft and the first end of the rotating shaft (8) are both sleeved with synchronous wheels (11), and the synchronous belt (12) is tensioned on the two synchronous wheels (11).

5. The multi-channel optical detection module driving device according to claim 2, wherein the guide sleeve assembly comprises a guide sleeve (10) and a sliding table (6), the guide sleeve (10) is sleeved on the rotating shaft (8) in a threaded manner, a mounting hole is formed in the sliding table (6), the guide sleeve (10) is connected to the mounting hole, the optical detection module (14) is mounted on a fourth support (7), and the fourth support (7) is connected with the sliding table (6).

6. The driving device for the multi-channel optical detection module according to claim 5, wherein a fifth bracket (4) is further connected to the fixing plate (1), the first bracket (3) and the second bracket (5) are respectively connected to two ends of the fifth bracket (4), and the first bracket (3), the second bracket (5) and the fifth bracket (4) form a U-shaped bracket, and the U-shaped bracket is assembled on the fixing plate (1).

7. The multi-channel optical detection module driving device according to claim 6, wherein a guide rail (17) is arranged on the fifth bracket (4), the guiding direction of the guide rail (17) is parallel to the length direction of the rotating shaft (8), a sliding block (16) is arranged at the bottom of the sliding table (6), and the sliding block (16) is slidably connected to the guide rail (17).

8. A pathogen nucleic acid analyzer, characterized by comprising a polishing plate (15) and the multi-channel optical detection module driving device according to any one of claims 1 to 7, wherein a light-passing hole is formed on the polishing plate (15), and the traversing driving assembly can drive each optical detection channel on the optical detection module (14) to be opposite to the light-passing hole in sequence.