CN103969459A - Full-automatic biochemical analysis method - Google Patents
Full-automatic biochemical analysis method Download PDFInfo
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- CN103969459A CN103969459A CN201410175562.XA CN201410175562A CN103969459A CN 103969459 A CN103969459 A CN 103969459A CN 201410175562 A CN201410175562 A CN 201410175562A CN 103969459 A CN103969459 A CN 103969459A
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Abstract
The invention discloses a full-automatic biochemical analysis method. The method comprises the following steps: (1) preparing; (2) sampling, sample adding and stirring: an XYZ triaxial movement system is driven by a controlling circuit module to drive a reagent-sample adding and stirring system to transfer samples from a sample cabin to a reaction cup in a reaction disc and transfer reagents from a reagent cabin to the reaction cup in the reaction disc; when the reagents and samples are transferred, liquid in the reaction cup is stirred through the reagent-sample adding and stirring system; the specific liquid volume of sampling and sample adding is controlled by a plunger pump; (3) biochemical reaction and detecting; (4) cleaning. According to the invention, procedures such as sampling, sample adding, stirring, analyzing and detecting, and cleaning are integrated, so that the degree of automation is high, the operation is convenient, the relevant equipment cost is low, the detecting efficiency is high, and the popularization and implementation are easy.
Description
Technical field
The present invention relates to a kind of full-automatic biochemical analysis method.
Background technology
At present, automatic clinical chemistry analyzer device is as one of important instrument often using in clinical examination, generally be used in each big-and-middle-sized hospital, give the diagnosis to disease clinically, treatment and prognosis and health status provide requisite information foundation, become the indispensable standard configuration instrument of big-and-middle-sized hospital, but existing automatic clinical chemistry analyzer also exists volume large, complex structure, price is high, safeguard the shortcomings such as inconvenience, an automatic clinical chemistry analyzer often needs hundreds of thousands just can purchase, small hospital, small towns health in one's power She Kang center etc. conventionally ability do not purchase, this has just limited the comprehensively universal of automatic clinical chemistry analyzer, bring the difficulty to patient diagnosis and treatment to the medical worker of vast basic unit,
Existing Biochemical Analyzer structure is very complicated, such as sample adding system and stirring system are separate configuration, for the volume-diminished of analyser is brought great obstacle; Therefore, be necessary to adopt unique design that stirring and sample adding system are integrated;
In addition, purging system complex structure, cost is high, therefore, need to design a kind of novel purging system easy to implement cheaply and complete matting;
And, existing Biochemical Analyzer, automaticity is not high, needs operating personnel to carry out manual application of sample, easily makes a fault, and affects measuring accuracy and efficiency.
In sum, be necessary to design a kind of low cost, easy to implement, and high, not high to the requirements of installation space full-automatic biochemical analysis method of automaticity in biochemical analysis process.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of full-automatic biochemical analysis method, and this full-automatic biochemical analysis method has low cost, easy to implement, and in biochemical analysis process, automaticity is high, not high to requirements of installation space.
The technical solution of invention is as follows:
A kind of new automatic biochemical analysis method, adopt new automatic Biochemical Analyzer, described new automatic Biochemical Analyzer comprises base (15), reagent-sample application and stirring system (4) and the control circuit module arranging on base, sample storing unit, reagent storage device, revolving reaction tray (13), for driving the stepper motor of reaction tray rotation, for the purging system (11) of cleaning reaction dish, for the ram pump (12) of accurate sampling and application of sample, for photodetector system (9) that liquid in reaction tray is detected and for driving the XYZ three-axis moving system of described reagent-sample application and stirring system motion,
Described reaction tray (13), stepper motor, purging system (11), ram pump (12) and photodetector system (9) are all controlled by control circuit module;
Sample storing unit comprises sample rack (8) and is arranged on the sample storehouse (7) on sample rack;
Reagent storage device comprises reagent rack (6) and is arranged on the agent bin (5) in reagent rack; Agent bin bottom is provided with cooling piece; [have another name called Peltier, semiconductor chilling plate, thermoelectric semiconductor refrigerating assembly etc., for making working temperature in the cabin of agent bin remain on 2～15 DEG C]
Reaction tray adopts cylindrical structural, and the top of reaction tray is along being circumferentially evenly provided with multiple reaction cup; Reaction tray bottom is provided with heating collar [can keep the temperature constant state of reaction tray in the time that instrument moves];
Described XYZ three-axis moving system comprises that the X being connected successively by slide rail-slide block mechanism is to slide assemblies, Y-direction slide assemblies and Z-direction slide assemblies; Described reagent-sample application and stirring system (4) are arranged on Z-direction slide assemblies;
Described reagent-sample application and stirring system comprise holder (60), stirring motor (51), driving wheel (52), eccentric wheel (54) and specimen needle (55); Stirring motor (51) is fixed on holder (60); Eccentric wheel (54) is arranged on holder (60) by clutch shaft bearing (61); Specimen needle (55) is arranged in the eccentric orfice of eccentric wheel (60) by the second bearing (56); Stirring motor (51) drives eccentric wheel (54) rotation by driving wheel (52); Driving wheel (52) is in transmission connection by belt (53) with eccentric wheel (54); Stirring motor drives eccentric wheel rotation by driving wheel; Eccentric wheel drives specimen needle to produce and stirs action, and specimen needle is stirred the liquid in container in application of sample or sampling.
The process that described full-automatic biochemical is analyzed is as follows:
1) preparation process:
In sample storehouse and agent bin, store respectively and carry out the required sample of reaction test and reagent;
2) sampling, application of sample and whipping step:
Control circuit module drive XYZ three-axis moving system drives reagent-sample application and stirring system that sample is transferred to the reaction cup reaction tray from sample storehouse, and reagent is transferred to the reaction cup reaction tray from agent bin; After reagent and sample have shifted, by reagent-sample application and stirring system, the liquid in reaction cup is stirred; The concrete liquid measure of sampling and application of sample is by ram pump control;
3) biochemical reaction and detecting step;
Reagent and sample carry out biochemical reaction in the reaction cup of reaction tray; In course of reaction, the heating collar of reaction tray bottom makes liquid-retentive in reaction cup at default temperature constant state; After having reacted, by photodetector system, reacted liquid is implemented to biochemistry detection and analysis, obtain and detect and analysis result;
4) cleaning step;
After having reacted, control circuit module controls purging system cleans reaction cup; In order to next round biochemistry detection and analytic process;
In above step, if relate to more than 2 reaction cup operations, rotated by step motor control reaction tray by control circuit module, make reagent-sample application and stirring system, photodetector system and purging system apply operation to different reaction cup.
Described holder is made up of with a vertical plate docking that is connected these 2 blocks of leveling boards upper and lower 2 blocks of leveling boards, the longitudinal section of holder is "] " type, between 2 blocks of leveling boards and a vertical plate, form a depressed part, described stirring motor is installed in this depressed part;
On two leveling boards of holder, be respectively provided with one for the through hole of specimen needle is installed; The dead in line of 2 through holes and be vertical direction, the through hole that is positioned at below is provided with described clutch shaft bearing and eccentric wheel; Stretch out from the through hole that is positioned at top at the top of specimen needle.
Reagent-sample application and stirring system also comprise anticollision mechanism, described anticollision mechanism comprises the upper pcb board with crashproof optocoupler (57) (59) arranging of holder (60), and the light barrier (58) arranging on the top of specimen needle (55); Between specimen needle middle part and superposed leveling board, be provided with the stage clip for resetting; Clashed into and while rising when specimen needle, driven light barrier to rise to block the light path between transmitting terminal and receiving end in crashproof optocoupler, the output signal of crashproof optocoupler is changed, trigger crashproof optocoupler and send alerting signal; The control circuit module (as microprocessor) of full automatic biochemical apparatus is received after this alerting signal, drives specimen needle rollback to avoid occurring collision again.
The axis 0.1mm of the axis runout eccentric wheel (54) of eccentric orfice.
Described purging system comprises straight-line motion mechanism and cleaning needle, and described straight-line motion mechanism comprises drive motor (21), base plate (31), driving wheel (24), engaged wheel (25), portable plate (29) and vertical plate (22);
Cleaning needle is arranged on portable plate;
Drive motor is arranged on base plate or is arranged on the lower end of vertical plate; The output shaft of drive motor connects driving wheel; Engaged wheel is arranged on the upper end of vertical plate; Driving wheel and engaged wheel axially static with respect to vertical plate; Driving wheel and engaged wheel are in transmission connection by Timing Belt (26);
2 sides of vertical plate are slide rail (23); The both sides of portable plate are provided with the pulley (30) with described slide rail adaptation; Portable plate is positioned at the front of vertical plate, and driving wheel, engaged wheel and Timing Belt are all located at the back side of vertical plate; Vertical plate middle part has the bar shaped pilot hole (41) of vertical direction; Gangbar (27) fixing on portable plate is stretched out and is fixed on Timing Belt from this bar shaped pilot hole.[drive portable plate to slide up and down along slide rail by Timing Belt.】
Be fixed with hall sensing plate (23) at the top of vertical plate; Be fixed with magnet (40) at the top of portable plate.[for the position of the relative vertical plate of sensed activity plate, avoiding specimen needle and miscellaneous part to clash into]
Portable plate is provided with an eccentric nut (39), and pulley (30) is arranged on eccentric nut (39) by screw (34).[by the U-shaped groove of eccentric nut adjustable pulley and the gap of slide rail, thereby coordinating tightness between adjustable pulley and slide rail]
Reagent rack (6) and sample rack (8) that reagent and sample are housed can be shifted onto in agent bin and sample storehouse by the guide rail on agent bin and sample storehouse, reaction tray (13) is arranged on reaction base plate (14), drive reaction tray rotation by stepper motor, reagent-sample application and stirring system (4) by X to slide assemblies (10), Y-direction slide assemblies (2), the move mode of Z-direction slide assemblies (3) three-shaft linkage carries out collection and the application of sample of reagent and sample, and the function of integrated application of sample and stirring, make its sample needle directly possess the function stirring, realize the accurate application of sample of reagent and sample by ram pump (12), complete the measuring ability of sample by photodetector system (9).
Purging system (11) is realized moving up and down of its cleaning needle by U-shaped groove bearing fixed thereon and the cooperation of slide bar and the drive of stepper motor.
In photodetector system (9), drive the rotation of filter wheel to realize the switching of optical filter by special stepper motor.
Heating collar is arranged at reaction tray assembly bottom, in the time that moving, instrument can keep the temperature constant state of reaction tray, cuvette (being reaction cup) in reaction tray cleans by purging system (11) after test completes, reagent-sample application and stirring system (4) by X to slide assemblies (10), Y-direction slide assemblies (2), the move mode of Z-direction slide assemblies (3) three-shaft linkage carries out collection and the application of sample of reagent and sample, and the function of integrated application of sample and stirring, make its sample needle directly possess the function stirring, thereby save a set of reagent-sample stirring system, realize the accurate application of sample of reagent and sample by ram pump (12).Ram pump is a kind of device of energy liquid with precise control application of sample amount, it is to connect the plunger in ram pump by the screw rod on stepper motor, just can accurately control the upper and lower of plunger by the rotation of control step motor, thereby the turnover of liquid with precise control [ram pump is prior art] realizes the measuring ability of sample by photodetector system (9).
It in described photodetector system (9), is light splitting mode before using, by driven by motor synchronous pulley, driving filter wheel rotates, the optical filter of 8 groups of different wave lengths is housed on filter wheel, realize the demand of different reagent to different wave length, according to bright rich Beer law, use opto-electronic conversion mechanism to detect by the monochromatic light after cuvette, and be translated into electric signal.
Multiple (as 48) reaction cup is installed in reaction tray ringwise, in reagent rack (6), be placed with multiple reagent bottles (having another name called agent bin) (as 50), agent bin can slip into reagent rack by the guide rail being arranged in reagent rack, in sample rack (8), be placed with multiple sample cups or heparin tube (being sample storehouse) (as 22), sample rack can be slipped into by the guide rail being arranged on sample rack in sample storehouse, a Peltier is installed under agent bin and [has another name called
cooling piece, semiconductor chilling plate, thermoelectric semiconductor refrigerating assembly etc.] make working temperature in the cabin of agent bin remain on 2～15 DEG C, reaction tray (13) is arranged on reaction base plate (14), drive Timing Belt by stepper motor, Timing Belt drives the synchronous pulley on reaction tray assembly to rotate, freely rotating of reaction tray on realization response dish assembly, heating collar is arranged at reaction tray assembly bottom, in the time that moving, instrument can keep the temperature constant state of reaction tray, reagent-sample application and stirring system (4) have application of sample and the agitating function of reagent-sample simultaneously, can directly extend into reaction cup after the application of sample of sample completes in, stir action, thereby save a set of independent reagent-sample stirring system, reagent-sample application and stirring system (4) are arranged on the slide rail of Z-direction slide assemblies (3), can drive reagent-sample application and stirring system to do upper and lower rectilinear motion by the stepper motor of Z-direction slide assemblies, Z-direction slide assemblies is arranged on Y-direction slide assemblies, can do front and back rectilinear motion by the stepper motor drive Z-direction slide assemblies of Y-direction slide assemblies and the reagent-sample application and the stirring system that are fixed on Z-direction slide assemblies, and Y-direction slide assemblies (2) and be above-mentionedly attached to entirety on Y-direction slide assemblies and be together arranged on X on slide assemblies (10), realize its left and right rectilinear motion by X to the stepper motor on slide assemblies, reagent-sample application and stirring system (4) are connected on ram pump (12) by pipeline, can accurately control the application of sample amount of reagent-sample application and stirring system (4) by ram pump (12), photodetector system (9) is by being rotated to realize the switching of different wave length optical filter by the filter wheel of step motor control, by the Halogen lamp LED being fixed therein and the measuring ability that is fixed on the photoelectric conversion device realization response value in reaction tray (13) assembly, purging system (11) is realized moving up and down of its cleaning needle by U-shaped groove bearing fixed thereon and the cooperation of slide bar and the drive of stepper motor, by being connected to the cleaning function of cleaning needle Shang Ye road part realization response cup.
Beneficial effect:
Full-automatic biochemical analysis method of the present invention, avoid adopting conventional automatic clinical chemistry analyzer to take up room larger, complex structure, the shortcoming that cost is high, the Biochemical Analyzer adopting has been realized miniaturization, the lightness of automatic clinical chemistry analyzer, greatly reduce the requirement of installing space, convenient transport and installation, and automaticity is high.
In the Biochemical Analyzer that full-automatic biochemical analysis method adopts, reagent-sample application and stirring system and purging system are of the present invention 2 large outstanding features:
(1) reagent-sample application and stirring system (being integrated sample pin application of sample and stirring system) stir reagent and sample by the shake of specimen needle self High Rotation Speed dexterously, make like this specimen needle one pin multiplex, structure is simpler and make biochemical analyzer operational efficiency higher.Specifically, be to adopt driven by motor specimen needle High Rotation Speed to make the syringe needle of specimen needle rock to stir sample and reagent, this novel rabbling mechanism makes equipment mechanism simple and stable more; Make novel rabbling mechanism and the specimen needle anticollision mechanism of specimen needle integrate simultaneously, make specimen needle can realize high-speed stirred function simultaneously; Integrated sample pin application of sample and stirring system also have collision prevention function; can protect specimen needle to exempt from shock; after specimen needle is impacted; specimen needle is raised; the change in location of optocoupler induction light barrier; provide electric signal to report to the police to the main control module of equipment (being automatic clinical chemistry analyzer device), this main control module can be according to the timely rollback of this alerting signal this integrated sample pin application of sample and stirring system, thereby plays the effect of protection specimen needle.Optocoupler is made up of two parts, and transmitting terminal and receiving end have bar gap between two parts, when light barrier rises, just in this gap, blocks the light path between transmitting terminal and receiving end being sandwiched in.Transmitting terminal continues to send light signal, and when the light path of optocoupler is not blocked, receiving end can be received the signal that transmitting terminal sends, and blocks light path once light barrier rises, and receiving end cannot be received signal, sends alerting signal.Because specimen needle can be injected sample and reagent, also can stir evenly sample and reagent, and prevent specimen needle avoid collision, therefore, this mechanism gathers multi-function in integral whole, make automatic clinical chemistry analyzer device structure more compact small and exquisite, improved the work efficiency of equipment simultaneously, use also convenient.Therefore, this integrated sample pin application of sample and stir system design are simple and ingenious, have application of sample, stirring and collision prevention function concurrently, and significantly simplified apparatus structure, easy to implement, easy to use, can effectively improve test and analysis efficiency.
(2) core of wiper mechanism is improved and is to adopt novel straight-line motion mechanism, and simple in structure, stable and smooth operation, can significantly reduce straight-line motion mechanism manufacturing cost and manufacturing accuracy requirement.This straight-line motion mechanism adopts the contact movement of 3 pulleys 30 and slide rail 3 to realize rectilinear motion, 3 pulleys 30 are pushed down respectively to slide rail (23) from the both sides of slide rail 23, make portable plate (29) on slide rail (23), to move linearly up and down and to realize guide function, the pulley (30) of one side can pass through eccentric nut (39) and regulate the dynamics and the gap that compress to realize adjusting and fixed function, this straight-line motion mechanism makes equipment mechanism simple and stable more, stable and smooth operation, can significantly reduce straight-line motion mechanism manufacturing cost and manufacturing accuracy requirement simultaneously.Between driving wheel (24) and engaged wheel (25), be connected and strain with Timing Belt (26), gangbar is fixed on Timing Belt, the relative position of driving wheel and engaged wheel is constant, portable plate (29) just can drive Timing Belt (26) to realize straight-line driving by drive motor (21) like this, this simple and compact for structure, require low to installation and manufacturing accuracy.The top of vertical plate (22) is provided with hall sensing plate (33), crashproof and positioning function is realized in position by the upper magnet (40) of installing of hall sensing plate (33) sensed activity plate (29), this structure has farthest been simplified mechanism, and by crashproof positioning function and the operability of this winding machine straight-line motion mechanism.Gland is installed in order to protect hall sensing plate (33) on hall sensing plate (33).Thereby, this novel linear motion novel structure and simple, not high to accuracy requirement, can flexible pulley and slide rail between coordinate tightness, and there is crashproof and positioning function, thereby feature richness.
In sum, full-automatic biochemical analysis method of the present invention has adopted novel integrated sample pin application of sample and stirring system, greatly dwindle the space of whole analyser, for huge contribution has been made in the miniaturization of instrument, in addition, adopt novel straight-line motion mechanism (being under the jurisdiction of purging system) to realize moving up and down of cleaning needle, simple in structure, easy to implement, cost is low, has reduced significantly the cost of analyser; Simultaneously, by the structure of reaction tray, integrated multiple reaction cup, coordinate stepper motor to drive the switching of the rotation realization response cup of reaction tray, then realize sampling and the application of sample of specimen needle by XYZ three-axis moving system, whole system structure is very compact, operation is smooth, adopts sample storehouse and the agent bin of slide rail type, easy to operate, can hold multiple sample and plurality of reagents, for analytical test brings great convenience.Therefore, the whole process robotization of the operations such as sampling, application of sample, stirring, analyzing and testing, cleaning that full-automatic biochemical analysis method of the present invention is integrated, automaticity is high, easy to operate, and the equipment cost relating to is low, and testing efficiency is high, is easy to promotion and implementation.
Brief description of the drawings
Fig. 1 is the general structure schematic diagram of new automatic Biochemical Analyzer;
Fig. 2 is the stereographic map of straight-line motion mechanism.
Fig. 3 is the stereographic map at another visual angle of straight-line motion mechanism;
Fig. 4 is the general structure schematic diagram (stereographic map) of integral type specimen needle application of sample and stirring system;
Fig. 5 is the general structure schematic diagram (front elevation) of integral type specimen needle application of sample and stirring system;
Fig. 6 is that A-A in Fig. 5 is to sectional view.
Label declaration: 1-protective cover plate, 2-Y is to slide assemblies, and 3-Z is to slide assemblies, 4-reagent-sample application and stirring system, 5-agent bin, 6-reagent rack, 7-sample storehouse, 8-sample rack, 9-photodetector system, 10-X is to slide assemblies, 11-purging system, 12-ram pump, 13-reaction tray, 14-reacts base plate, 15-base.
21-drive motor, 22-vertical plate, 23-slide rail, 24-driving wheel, 25-engaged wheel, 26-Timing Belt, 27-gangbar, 29-portable plate, 30-pulley, 31-base plate, 33-hall sensing plate, 34-screw, 39-eccentric nut, 40-magnet, 41-bar shaped pilot hole.
51-stirring motor, 52-driving wheel, 53-belt, 54-eccentric wheel, 55-specimen needle, 56-the second bearing, the crashproof optocoupler of 57-, 58-light barrier, 59-PCB plate, 60-holder, 61-clutch shaft bearing.
Embodiment
Below with reference to the drawings and specific embodiments, the present invention is described in further details:
Embodiment 1:
As Fig. 1-6, a kind of new automatic biochemical analysis method, adopt new automatic Biochemical Analyzer, described new automatic Biochemical Analyzer comprises base (15), reagent-sample application and stirring system (4) and the control circuit module arranging on base, sample storing unit, reagent storage device, revolving reaction tray (13), for driving the stepper motor of reaction tray rotation, for the purging system (11) of cleaning reaction dish, for the ram pump (12) of accurate sampling and application of sample, for photodetector system (9) that liquid in reaction tray is detected and for driving the XYZ three-axis moving system of described reagent-sample application and stirring system motion,
Described reaction tray (13), stepper motor, purging system (11), ram pump (12) and photodetector system (9) are all controlled by control circuit module;
Sample storing unit comprises sample rack (8) and is arranged on the sample storehouse (7) on sample rack;
Reagent storage device comprises reagent rack (6) and is arranged on the agent bin (5) in reagent rack; Agent bin bottom is provided with cooling piece; [have another name called Peltier, semiconductor chilling plate, thermoelectric semiconductor refrigerating assembly etc., for making working temperature in the cabin of agent bin remain on 2～15 DEG C]
Reaction tray adopts cylindrical structural, and the top of reaction tray is along being circumferentially evenly provided with multiple reaction cup; Reaction tray bottom is provided with heating collar [can keep the temperature constant state of reaction tray in the time that instrument moves];
Described XYZ three-axis moving system comprises that the X being connected successively by slide rail-slide block mechanism is to slide assemblies, Y-direction slide assemblies and Z-direction slide assemblies; Described reagent-sample application and stirring system (4) are arranged on Z-direction slide assemblies;
Described reagent-sample application and stirring system comprise holder (60), stirring motor (51), driving wheel (52), eccentric wheel (54) and specimen needle (55); Stirring motor (51) is fixed on holder (60); Eccentric wheel (54) is arranged on holder (60) by clutch shaft bearing (61); Specimen needle (55) is arranged in the eccentric orfice of eccentric wheel (60) by the second bearing (56); Stirring motor (51) drives eccentric wheel (54) rotation by driving wheel (52); Driving wheel (52) is in transmission connection by belt (53) with eccentric wheel (54); Stirring motor drives eccentric wheel rotation by driving wheel; Eccentric wheel drives specimen needle to produce and stirs action, and specimen needle is stirred the liquid in container in application of sample or sampling.
The process that described full-automatic biochemical is analyzed is as follows:
1) preparation process:
In sample storehouse and agent bin, store respectively and carry out the required sample of reaction test and reagent;
2) sampling, application of sample and whipping step:
Control circuit module drive XYZ three-axis moving system drives reagent-sample application and stirring system that sample is transferred to the reaction cup reaction tray from sample storehouse, and reagent is transferred to the reaction cup reaction tray from agent bin; After reagent and sample have shifted, by reagent-sample application and stirring system, the liquid in reaction cup is stirred; The concrete liquid measure of sampling and application of sample is by ram pump control;
3) biochemical reaction and detecting step;
Reagent and sample carry out biochemical reaction in the reaction cup of reaction tray; In course of reaction, the heating collar of reaction tray bottom makes liquid-retentive in reaction cup at default temperature constant state; After having reacted, by photodetector system, reacted liquid is implemented to biochemistry detection and analysis, obtain and detect and analysis result;
4) cleaning step;
After having reacted, control circuit module controls purging system cleans reaction cup; In order to next round biochemistry detection and analytic process;
In above step, if relate to more than 2 reaction cup operations, rotated by step motor control reaction tray by control circuit module, make reagent-sample application and stirring system, photodetector system and purging system apply operation to different reaction cup.
Described holder is made up of with a vertical plate docking that is connected these 2 blocks of leveling boards upper and lower 2 blocks of leveling boards, the longitudinal section of holder is "] " type, between 2 blocks of leveling boards and a vertical plate, form a depressed part, described stirring motor is installed in this depressed part;
On two leveling boards of holder, be respectively provided with one for the through hole of specimen needle is installed; The dead in line of 2 through holes and be vertical direction, the through hole that is positioned at below is provided with described clutch shaft bearing and eccentric wheel; Stretch out from the through hole that is positioned at top at the top of specimen needle.
Reagent-sample application and stirring system also comprise anticollision mechanism, described anticollision mechanism comprises the upper pcb board with crashproof optocoupler (57) (59) arranging of holder (60), and the light barrier (58) arranging on the top of specimen needle (55); Between specimen needle middle part and superposed leveling board, be provided with the stage clip for resetting; Clashed into and while rising when specimen needle, driven light barrier to rise to block the light path between transmitting terminal and receiving end in crashproof optocoupler, the output signal of crashproof optocoupler is changed, trigger crashproof optocoupler and send alerting signal; The control circuit module (as microprocessor) of full automatic biochemical apparatus is received after this alerting signal, drives specimen needle rollback to avoid occurring collision again.
The axis 0.1mm of the axis runout eccentric wheel (54) of eccentric orfice.
Described purging system comprises straight-line motion mechanism and cleaning needle, and described straight-line motion mechanism comprises drive motor (21), base plate (31), driving wheel (24), engaged wheel (25), portable plate (29) and vertical plate (22);
Cleaning needle is arranged on portable plate;
Drive motor is arranged on base plate or is arranged on the lower end of vertical plate; The output shaft of drive motor connects driving wheel; Engaged wheel is arranged on the upper end of vertical plate; Driving wheel and engaged wheel axially static with respect to vertical plate; Driving wheel and engaged wheel are in transmission connection by Timing Belt (26);
2 sides of vertical plate are slide rail (23); The both sides of portable plate are provided with the pulley (30) with described slide rail adaptation; Portable plate is positioned at the front of vertical plate, and driving wheel, engaged wheel and Timing Belt are all located at the back side of vertical plate; Vertical plate middle part has the bar shaped pilot hole (41) of vertical direction; Gangbar (27) fixing on portable plate is stretched out and is fixed on Timing Belt from this bar shaped pilot hole.[drive portable plate to slide up and down along slide rail by Timing Belt.】
Be fixed with hall sensing plate (23) at the top of vertical plate; Be fixed with magnet (40) at the top of portable plate.[for the position of the relative vertical plate of sensed activity plate, avoiding specimen needle and miscellaneous part to clash into]
Portable plate is provided with an eccentric nut (39), and pulley (30) is arranged on eccentric nut (39) by screw (34).[by the U-shaped groove of eccentric nut adjustable pulley and the gap of slide rail, thereby coordinating tightness between adjustable pulley and slide rail]
Reagent rack (6) and sample rack (8) that reagent and sample are housed can be shifted onto in agent bin and sample storehouse by the guide rail on agent bin and sample storehouse, reaction tray (13) is arranged on reaction base plate (14), drive reaction tray rotation by stepper motor, reagent-sample application and stirring system (4) by X to slide assemblies (10), Y-direction slide assemblies (2), the move mode of Z-direction slide assemblies (3) three-shaft linkage carries out collection and the application of sample of reagent and sample, and the function of integrated application of sample and stirring, make its sample needle directly possess the function stirring, realize the accurate application of sample of reagent and sample by ram pump (12), complete the measuring ability of sample by photodetector system (9).
Purging system (11) is realized moving up and down of its cleaning needle by U-shaped groove bearing fixed thereon and the cooperation of slide bar and the drive of stepper motor.
In photodetector system (9), drive the rotation of filter wheel to realize the switching of optical filter by special stepper motor.
Heating collar is arranged at reaction tray assembly bottom, in the time that moving, instrument can keep the temperature constant state of reaction tray, cuvette (being reaction cup) in reaction tray cleans by purging system (11) after test completes, reagent-sample application and stirring system (4) by X to slide assemblies (10), Y-direction slide assemblies (2), the move mode of Z-direction slide assemblies (3) three-shaft linkage carries out collection and the application of sample of reagent and sample, and the function of integrated application of sample and stirring, make its sample needle directly possess the function stirring, thereby save a set of reagent-sample stirring system, realize the accurate application of sample of reagent and sample by ram pump (12).Ram pump is a kind of device of energy liquid with precise control application of sample amount, it is to connect the plunger in ram pump by the screw rod on stepper motor, just can accurately control the upper and lower of plunger by the rotation of control step motor, thereby the turnover of liquid with precise control [ram pump is prior art] realizes the measuring ability of sample by photodetector system (9).
It in described photodetector system (9), is light splitting mode before using, by driven by motor synchronous pulley, driving filter wheel rotates, the optical filter of 8 groups of different wave lengths is housed on filter wheel, realize the demand of different reagent to different wave length, according to bright rich Beer law, use opto-electronic conversion mechanism to detect by the monochromatic light after cuvette, and be translated into electric signal.
Multiple (as 48) reaction cup is installed in reaction tray ringwise, in reagent rack (6), be placed with multiple reagent bottles (having another name called agent bin) (as 50), agent bin can slip into reagent rack by the guide rail being arranged in reagent rack, in sample rack (8), be placed with multiple sample cups or heparin tube (being sample storehouse) (as 22), sample rack can be slipped into by the guide rail being arranged on sample rack in sample storehouse, a Peltier is installed under agent bin and [has another name called
cooling piece, semiconductor chilling plate, thermoelectric semiconductor refrigerating assembly etc.] make working temperature in the cabin of agent bin remain on 2～15 DEG C, reaction tray (13) is arranged on reaction base plate (14), drive Timing Belt by stepper motor, Timing Belt drives the synchronous pulley on reaction tray assembly to rotate, freely rotating of reaction tray on realization response dish assembly, heating collar is arranged at reaction tray assembly bottom, in the time that moving, instrument can keep the temperature constant state of reaction tray, reagent-sample application and stirring system (4) have application of sample and the agitating function of reagent-sample simultaneously, can directly extend into reaction cup after the application of sample of sample completes in, stir action, thereby save a set of independent reagent-sample stirring system, reagent-sample application and stirring system (4) are arranged on the slide rail of Z-direction slide assemblies (3), can drive reagent-sample application and stirring system to do upper and lower rectilinear motion by the stepper motor of Z-direction slide assemblies, Z-direction slide assemblies is arranged on Y-direction slide assemblies, can do front and back rectilinear motion by the stepper motor drive Z-direction slide assemblies of Y-direction slide assemblies and the reagent-sample application and the stirring system that are fixed on Z-direction slide assemblies, and Y-direction slide assemblies (2) and be above-mentionedly attached to entirety on Y-direction slide assemblies and be together arranged on X on slide assemblies (10), realize its left and right rectilinear motion by X to the stepper motor on slide assemblies, reagent-sample application and stirring system (4) are connected on ram pump (12) by pipeline, can accurately control the application of sample amount of reagent-sample application and stirring system (4) by ram pump (12), photodetector system (9) is by being rotated to realize the switching of different wave length optical filter by the filter wheel of step motor control, by the Halogen lamp LED being fixed therein and the measuring ability that is fixed on the photoelectric conversion device realization response value in reaction tray (13) assembly, purging system (11) is realized moving up and down of its cleaning needle by U-shaped groove bearing fixed thereon and the cooperation of slide bar and the drive of stepper motor, by being connected to the cleaning function of cleaning needle Shang Ye road part realization response cup.
Be understandable that; for the person of ordinary skill of the art; can make other various corresponding changes and distortion according to technical scheme of the present invention and technical conceive, and all these changes and distortion all should belong to the protection domain of the accompanying claim of the present invention.
Claims (7)
1. a new automatic biochemical analysis method, it is characterized in that, adopt new automatic Biochemical Analyzer, described new automatic Biochemical Analyzer comprises base (15), reagent-sample application and stirring system (4) and the control circuit module arranging on base, sample storing unit, reagent storage device, revolving reaction tray (13), for driving the stepper motor of reaction tray rotation, for the purging system (11) of cleaning reaction dish, for the ram pump (12) of accurate sampling and application of sample, for photodetector system (9) that liquid in reaction tray is detected and for driving the XYZ three-axis moving system of described reagent-sample application and stirring system motion,
Described reaction tray (13), stepper motor, purging system (11), ram pump (12) and photodetector system (9) are all controlled by control circuit module;
Sample storing unit comprises sample rack (8) and is arranged on the sample storehouse (7) on sample rack;
Reagent storage device comprises reagent rack (6) and is arranged on the agent bin (5) in reagent rack; Agent bin bottom is provided with cooling piece;
Reaction tray adopts cylindrical structural, and the top of reaction tray is along being circumferentially evenly provided with multiple reaction cup; Reaction tray bottom is provided with heating collar;
Described XYZ three-axis moving system comprises that the X being connected successively by slide rail-slide block mechanism is to slide assemblies, Y-direction slide assemblies and Z-direction slide assemblies; Described reagent-sample application and stirring system (4) are arranged on Z-direction slide assemblies;
Described reagent-sample application and stirring system comprise holder (60), stirring motor (51), driving wheel (52), eccentric wheel (54) and specimen needle (55); Stirring motor (51) is fixed on holder (60); Eccentric wheel (54) is arranged on holder (60) by clutch shaft bearing (61); Specimen needle (55) is arranged in the eccentric orfice of eccentric wheel (60) by the second bearing (56); Stirring motor (51) drives eccentric wheel (54) rotation by driving wheel (52); Driving wheel (52) is in transmission connection by belt (53) with eccentric wheel (54); Stirring motor drives eccentric wheel rotation by driving wheel; Eccentric wheel drives specimen needle to produce and stirs action, and specimen needle is stirred the liquid in container in application of sample or sampling.
The process that described full-automatic biochemical is analyzed is as follows:
1) preparation process:
In sample storehouse and agent bin, store respectively and carry out the required sample of reaction test and reagent;
2) sampling, application of sample and whipping step:
Control circuit module drive XYZ three-axis moving system drives reagent-sample application and stirring system that sample is transferred to the reaction cup reaction tray from sample storehouse, and reagent is transferred to the reaction cup reaction tray from agent bin; After reagent and sample have shifted, by reagent-sample application and stirring system, the liquid in reaction cup is stirred; The concrete liquid measure of sampling and application of sample is by ram pump control;
3) biochemical reaction and detecting step;
Reagent and sample carry out biochemical reaction in the reaction cup of reaction tray; In course of reaction, the heating collar of reaction tray bottom makes liquid-retentive in reaction cup at default temperature constant state; After having reacted, by photodetector system, reacted liquid is implemented to biochemistry detection and analysis, obtain and detect and analysis result;
4) cleaning step;
After having reacted, control circuit module controls purging system cleans reaction cup; In order to next round biochemistry detection and analytic process;
In above step, if relate to more than 2 reaction cup operations, rotated by step motor control reaction tray by control circuit module, make reagent-sample application and stirring system, photodetector system and purging system apply operation to different reaction cup.
2. new automatic biochemical analysis method according to claim 1, it is characterized in that, described holder is made up of with a vertical plate docking that is connected these 2 blocks of leveling boards upper and lower 2 blocks of leveling boards, the longitudinal section of holder is "] " type, between 2 blocks of leveling boards and a vertical plate, form a depressed part, described stirring motor is installed in this depressed part;
On two leveling boards of holder, be respectively provided with one for the through hole of specimen needle is installed; The dead in line of 2 through holes and be vertical direction, the through hole that is positioned at below is provided with described clutch shaft bearing and eccentric wheel; Stretch out from the through hole that is positioned at top at the top of specimen needle.
3. new automatic biochemical analysis method according to claim 2, it is characterized in that, reagent-sample application and stirring system also comprise anticollision mechanism, described anticollision mechanism comprises the upper pcb board with crashproof optocoupler (57) (59) arranging of holder (60), and the light barrier (58) arranging on the top of specimen needle (55); Between specimen needle middle part and superposed leveling board, be provided with the stage clip for resetting; Clashed into and while rising when specimen needle, driven light barrier to rise to block the light path between transmitting terminal and receiving end in crashproof optocoupler, the output signal of crashproof optocoupler is changed, trigger crashproof optocoupler and send alerting signal; The control circuit module (as microprocessor) of full automatic biochemical apparatus is received after this alerting signal, drives specimen needle rollback to avoid occurring collision again.
4. new automatic biochemical analysis method according to claim 3, is characterized in that, the axis 0.1mm of the axis runout eccentric wheel (54) of eccentric orfice.
5. according to the new automatic biochemical analysis method described in claim 1-4 any one, it is characterized in that, described purging system comprises straight-line motion mechanism and cleaning needle, and described straight-line motion mechanism comprises drive motor (21), base plate (31), driving wheel (24), engaged wheel (25), portable plate (29) and vertical plate (22);
Cleaning needle is arranged on portable plate;
Drive motor is arranged on base plate or is arranged on the lower end of vertical plate; The output shaft of drive motor connects driving wheel; Engaged wheel is arranged on the upper end of vertical plate; Driving wheel and engaged wheel axially static with respect to vertical plate; Driving wheel and engaged wheel are in transmission connection by Timing Belt (26);
2 sides of vertical plate are slide rail (23); The both sides of portable plate are provided with the pulley (30) with described slide rail adaptation; Portable plate is positioned at the front of vertical plate, and driving wheel, engaged wheel and Timing Belt are all located at the back side of vertical plate; Vertical plate middle part has the bar shaped pilot hole (41) of vertical direction; Gangbar (27) fixing on portable plate is stretched out and is fixed on Timing Belt from this bar shaped pilot hole.
6. new automatic biochemical analysis method according to claim 5, is characterized in that, is fixed with hall sensing plate (23) at the top of vertical plate; Be fixed with magnet (40) at the top of portable plate.
7. new automatic biochemical analysis method according to claim 6, it is characterized in that, portable plate is provided with an eccentric nut (39), and pulley (30) is arranged on eccentric nut (39) by screw (34).
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Address after: No. 7 Road 518106 Guangdong Guangming New District of Shenzhen City High-tech Park West Germany Overseas Science Park A building 11 floor Patentee after: SHENZHEN ICUBIO BIOTECHNOLOGY CO.,LTD. Address before: No. 7 Road 518106 Guangdong Guangming New District of Shenzhen City High-tech Park West Germany Overseas Science Park A building 11 floor Patentee before: SHENZHEN ICUBIO BIOMEDICAL TECHNOLOGY CO.,LTD. |
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