CN114432380A - 一种治疗湿疹乳膏的中药与益生菌组合物及其制作工艺 - Google Patents
一种治疗湿疹乳膏的中药与益生菌组合物及其制作工艺 Download PDFInfo
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Abstract
本发明公开了一种治疗湿疹乳膏的中药与益生菌组合物,属于中药制剂技术领域,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。其制备工艺,包括如下步骤:(1)将马齿苋鲜榨搅汁,加热回流提取,超声提取;(2)将黄柏、黄芩、车前子粉碎过筛,加热回流提取,超声提取;(3)将地榆、丹参混合粉碎后提取纯化;(4)与水隔水加热;(5)将丙二醇与冰片溶解与甘油混合加热;(6)将鳄梨油、氢化小麦胚芽油与乳化剂天然有机橄榄油乳化蜡,鲸蜡基葡萄糖苷混合加热;(7)混合后加入玫瑰花油打均质乳化;(8)乳化后加入乳酸杆菌搅拌至均匀。本申请将益生菌与中药结合用于治疗湿疹,乳酸杆菌加入起到皮肤调理剂功能,增强皮肤菌群平衡。
Description
技术领域
本发明属于中药制剂加工技术领域,具体涉及一种治疗湿疹乳膏的中药与益生菌组合物及其制作工艺。
背景技术
湿疹是由多种内外因素引起的一种具有明显渗出倾向的炎症性皮肤病,临床上急性期皮损以丘疱疹为主,有渗出倾向,慢性期以苔藓样变为主,皮疹呈多形性。慢性期则局限,而且有浸润、肥厚、瘙痒剧烈等现象,容易复发,病因复杂。口服中药并结合中药湿敷、拔罐、火针疗法、中药熏蒸疗法,是现今比较好得治疗湿疹得方法,效果较好。对于湿疹后期出现的皲裂性慢性苔藓样湿疹,可以使用中药封包联合蜡疗,疗效较好。但是现今的中药制剂多是多种中药成分进行配伍制备,对皮肤屏障修复、微生态调理效果一般。
正常菌群具有较强的自身稳定性,能阻止外籍菌的定植。在正常情况下,微生物与生物之间、微生物与宿主之间保持动态的微生态平衡。起到参与皮肤组织代谢、营养作用、免疫作用、自净以及屏蔽作用,然而现今的治疗湿疹的乳膏虽然对湿疹有一定的治疗效果,但是不具有改善皮肤菌群的作用,甚至对皮肤表面的正常菌群有破坏作用。
如申请号为:CN201410501172.7公开了一种治疗湿疹的乳膏及其制备方法。本发明提供一种治疗湿疹的乳膏及其制备方法,由下列质量份的组分组成:丹皮5~15份、黄柏5~15份、紫草5~15份、桔梗3~12份、赤芍3~12份、甘油30~50份、水包油型乳膏基质500~1000份。本发明提供的治疗湿疹的乳膏具有清热解毒,燥湿止痒的功效,通过外涂患处能有效治疗急慢性湿疹、神经性皮炎、接触性皮炎、过敏性皮炎、毛囊炎。且本发明能适用于婴幼儿及敏感性肤质人群,无任何副作用,疗效显著,无后遗症,使用方便,安全。该申请的乳膏虽然疗效显著,但是不具有平衡菌群的作用,因此,在应用的过程中不一定适合所有群众。
发明内容
本发明的目的是针对现有的问题,提供了一种治疗湿疹乳膏的中药与益生菌组合物及其制作工艺。
本发明是通过以下技术方案实现的:
一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。
进一步地,所述中药的重量组成为:马齿苋30~50g;黄柏30g;黄芩10~15g;车前子30g;地榆10~15g;丹参10~20g;冰片2g。
进一步地,所述油脂的重量组成为:鳄梨油8份;氢化小麦胚芽油10份;玫瑰花油0.1份。
进一步地,所述益生菌的重量组成为乳酸杆菌0.9份。
进一步地,所述乳化剂的重量组成为:天然有机橄榄油乳化蜡5~10份、鲸蜡基葡萄糖苷2~5份。
一种治疗湿疹乳膏的中药与益生菌组合物的制备工艺,包括如下步骤:
(1)将马齿苋30~50g鲜榨搅汁,加热回流提取,超声提取,得到超声提取物1;
(2)将黄柏30g、黄芩10~15g、车前子30g粉碎过筛,加热回流提取,超声提取,得到超声提取物提取2;
(3)将地榆10~15g、丹参10~20g混合粉碎后进行乙醇提取纯化,得到提取物3;
(4)将步骤(1)、(2)、(3)中所得的提取物与40~60份水隔水加热,得到中药液;
(5)将丙二醇4份与冰片2份溶解与甘油10份混合加热后得混合物备用;
(6)将鳄梨油8份、氢化小麦胚芽油10份与乳化剂天然有机橄榄油乳化蜡5~10份,鲸蜡基葡萄糖苷2~5份混合加热,得到油脂混合液;
(7)将步骤(4)所得的中药液、步骤(5)所得的混合物、步骤(6)所得的油脂混合液混合后加入玫瑰花油0.1份打均质乳化;
(8)乳化后冷却至30℃后加入乳酸杆菌搅拌至均匀。
本发明相比现有技术具有以下优点:
本申请将益生菌加入到中药乳膏中,乳酸杆菌加入起到皮肤调理剂功能,增强皮肤菌群平衡并且冷却后加入乳酸杆菌避免失活。成品安全,对于治疗湿疹的效果很好。
具体实施方式
实施例1:
一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。
中药的重量组成为:马齿苋30g;黄柏30g;黄芩10g;车前子30g;地榆10g;丹参10g;冰片2g。
油脂的重量组成为:鳄梨油8份;氢化小麦胚芽油10份;玫瑰花油0.1份。
益生菌的重量组成为乳酸杆菌0.9份。
乳化剂的重量组成为:天然有机橄榄油乳化蜡5份、鲸蜡基葡萄糖苷2份。
一种治疗湿疹乳膏的中药与益生菌组合物的制备工艺,包括如下步骤:
(1)将马齿苋30g鲜榨搅汁,加热回流提取,超声提取,得到超声提取物1;
(2)将黄柏30g、黄芩10g、车前子30g粉碎过筛,加热回流提取,超声提取,得到超声提取物提取2;
(3)将地榆10g、丹参10g混合粉碎后进行乙醇提取纯化,得到提取物3;
(4)将步骤(1)、(2)、(3)中所得的提取物与40份水隔水加热,得到中药液;
(5)将丙二醇4份与冰片2份溶解与甘油10份混合加热后得混合物备用;
(6)将鳄梨油8份、氢化小麦胚芽油10份与乳化剂天然有机橄榄油乳化蜡5份,鲸蜡基葡萄糖苷2份混合加热,得到油脂混合液;
(7)将步骤(4)所得的中药液、步骤(5)所得的混合物、步骤(6)所得的油脂混合液混合后加入玫瑰花油0.1份打均质乳化;
(8)乳化后冷却至30℃后加入乳酸杆菌搅拌至均匀。
实施例2:
一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。
中药的重量组成为:马齿苋40g;黄柏30g;黄芩12.5g;车前子30g;地榆12.5g;丹参15g;冰片2g。
油脂的重量组成为:鳄梨油8份;氢化小麦胚芽油10份;玫瑰花油0.1份。
益生菌的重量组成为乳酸杆菌0.9份。
乳化剂的重量组成为:天然有机橄榄油乳化蜡7.5份、鲸蜡基葡萄糖苷3.5份。
一种治疗湿疹乳膏的中药与益生菌组合物的制备工艺,包括如下步骤:
(1)将马齿苋40g鲜榨搅汁,加热回流提取,超声提取,得到超声提取物1;
(2)将黄柏30g、黄芩12.5g、车前子30g粉碎过筛,加热回流提取,超声提取,得到超声提取物提取2;
(3)将地榆12.5g、丹参15g混合粉碎后进行乙醇提取纯化,得到提取物3;
(4)将步骤(1)、(2)、(3)中所得的提取物与50份水隔水加热,得到中药液;
(5)将丙二醇4份与冰片2份溶解与甘油10份混合加热后得混合物备用;
(6)将鳄梨油8份、氢化小麦胚芽油10份与乳化剂天然有机橄榄油乳化蜡7.5份,鲸蜡基葡萄糖苷3.5份混合加热,得到油脂混合液;
(7)将步骤(4)所得的中药液、步骤(5)所得的混合物、步骤(6)所得的油脂混合液混合后加入玫瑰花油0.1份打均质乳化;
(8)乳化后冷却至30℃后加入乳酸杆菌搅拌至均匀。
实施例3:
一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。
中药的重量组成为:马齿苋50g;黄柏30g;黄芩15g;车前子30g;地榆15g;丹参20g;冰片2g。
油脂的重量组成为:鳄梨油8份;氢化小麦胚芽油10份;玫瑰花油0.1份。
益生菌的重量组成为乳酸杆菌0.9份。
乳化剂的重量组成为:天然有机橄榄油乳化蜡10份、鲸蜡基葡萄糖苷5份。
一种治疗湿疹乳膏的中药与益生菌组合物的制备工艺,包括如下步骤:
(1)将马齿苋50g鲜榨搅汁,加热回流提取,超声提取,得到超声提取物1;
(2)将黄柏30g、黄芩15g、车前子30g粉碎过筛,加热回流提取,超声提取,得到超声提取物提取2;
(3)将地榆15g、丹参20g混合粉碎后进行乙醇提取纯化,得到提取物3;
(4)将步骤(1)、(2)、(3)中所得的提取物与60份水隔水加热,得到中药液;
(5)将丙二醇4份与冰片2份溶解与甘油10份混合加热后得混合物备用;
(6)将鳄梨油8份、氢化小麦胚芽油10份与乳化剂天然有机橄榄油乳化蜡10份,鲸蜡基葡萄糖苷5份混合加热,得到油脂混合液;
(7)将步骤(4)所得的中药液、步骤(5)所得的混合物、步骤(6)所得的油脂混合液混合后加入玫瑰花油0.1份打均质乳化;
(8)乳化后冷却至30℃后加入乳酸杆菌搅拌至均匀。
对照组:
申请号为:CN201410501172.7公开了一种治疗湿疹的乳膏及其制备方法。
为了对比本申请技术效果,分别用对照组的方法和本申请的方法制备乳膏,然后进行关于炎症症状抑制作用和皮肤刺激性的动物试验。具体为:
试验材料:昆明小鼠18~22g,雌雄各半;SD大鼠200~230g,雌雄各半。
(1)对二甲苯所致小鼠耳廓肿胀的影响
昆明小鼠18~22g 30只,雌雄各半,随机分为两组,每组15只,分别为对照组、实施例2组涂实施例2方法制备的乳膏,对照组涂对照组方法制备的乳膏,0.5g/只,每日2次,连续3天,第4天涂药后1小时各组以蒸馏水洗去药物,用干棉球擦净。然后各组小鼠右耳涂以二甲苯0.05mL/只,左耳作对照,30分钟后处死动物,用8mm打孔器将小鼠左右耳同等部位等面积切下,用电子天平称重,以左右耳片重量之差为肿胀度,计算各组肿胀度,求出肿胀抑制率,结果如下表:
由上表1可以得出,本申请方法制备的乳膏能明显减轻二甲苯所致小鼠耳肿胀度,对小鼠耳肿胀炎症具有明显抑制作用,并且效果优于对照组。
(2)对SD大鼠完整皮肤的局部刺激试验
取SD大鼠10只,在背部脊柱两侧用弯剪剪出3cmx3cm的脱毛区2块,注意勿损伤皮肤,24小时后进行试验。试验时每块脱毛区分别涂以0.5g乳膏和0.5g(凡士林),用一层油纸及双层纱布覆盖后胶布固定。24小时后用水擦洗,除去残余药膏及凡士林,观察除去残留药物后1小时、24小时、48小时和72小时的皮肤刺激反应(涂药部位有无红斑、水肿),进行积分评价结果,各去毛区皮肤未见红斑、水肿等刺激反应,积分值为0。
(3)对SD大鼠破损皮肤的局部刺激试验
取SD大鼠10只,在背部脊柱两侧用弯剪剪出3cmx3cm的脱毛区2块,24小时后进行试验。试验时用消毒针头在脱毛区皮上画出“#”形擦痕,以轻度渗血为度,皮损区分别涂以0.5g乳膏和0.5g(凡士林),用一层油纸及双层纱布覆盖后胶布固定。24小时后用水擦洗,除去残余药膏及凡士林,观察除去残留药物后1小时、24小时、48小时和72小时的皮肤刺激反应(涂药部位有无红斑、水肿),进行积分评价。
刺激性反应积分的计算公式为:
刺激性反应级数机评价标准如下表2和表3所示:
表2皮肤刺激性反应级数
反应级数 | 红斑及焦痂 | 水肿 |
0 | 无红斑 | 无水肿 |
1 | 轻微红斑 | 轻微可见水肿 |
2 | 中度红斑 | 轻微隆起水肿 |
3 | 重度红斑 | 中度水肿 |
4 | 中度红斑至轻度焦痂形成 | 重度水肿 |
表3皮肤刺激性评价标准
反应级数(J) | 评价标准 |
0.0<J≤0.5 | 无刺激性 |
0.5<J≤2.0 | 轻度刺激性 |
2.0<J≤6.0 | 中度刺激性 |
J>6.0 | 重度刺激性 |
表4破损皮肤刺激反应实验结果
由上表4可以看出,本申请对完整及破损皮肤刺激反应实验均未见皮肤红斑、水肿等刺激反应,积分值为0,表明乳膏对SD大鼠完整及破损皮肤均无刺激性。
Claims (6)
1.一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,包括:中药、油脂、益生菌、乳化剂、水、甘油、丙二醇。
2.根据权利要求1所述一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,所述中药的重量组成为:马齿苋30~50g;黄柏30g;黄芩10~15g;车前子30g;地榆10~15g;丹参10~20g;冰片2g。
3.根据权利要求2所述一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,所述油脂的重量组成为:鳄梨油8份;氢化小麦胚芽油10份;玫瑰花油0.1份。
4.根据权利要求3所述一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,所述益生菌的重量组成为乳酸杆菌0.9份。
5.根据权利要求4所述一种治疗湿疹乳膏的中药与益生菌组合物,其特征在于,所述乳化剂的重量组成为:天然有机橄榄油乳化蜡5~10份、鲸蜡基葡萄糖苷2~5份。
6.一种如权利要求5中所述的治疗湿疹乳膏的中药与益生菌组合物的制备工艺,其特征在于,包括如下步骤:
(1)将马齿苋30~50g鲜榨搅汁,加热回流提取,超声提取,得到超声提取物1;
(2)将黄柏30g、黄芩10~15g、车前子30g粉碎过筛,加热回流提取,超声提取,得到超声提取物提取2;
(3)将地榆10~15g、丹参10~20g混合粉碎后进行乙醇提取纯化,得到提取物3;
(4)将步骤(1)、(2)、(3)中所得的提取物与40~60份水隔水加热,得到中药液;
(5)将丙二醇4份与冰片2份溶解与甘油10份混合加热后得混合物备用;
(6)将鳄梨油8份、氢化小麦胚芽油10份与乳化剂天然有机橄榄油乳化蜡5~10份,鲸蜡基葡萄糖苷2~5份混合加热,得到油脂混合液;
(7)将步骤(4)所得的中药液、步骤(5)所得的混合物、步骤(6)所得的油脂混合液混合后加入玫瑰花油0.1份打均质乳化;
(8)乳化后冷却至30℃后加入乳酸杆菌搅拌至均匀。
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