CN114432215A - Repair cream containing fullerene and preparation method thereof - Google Patents
Repair cream containing fullerene and preparation method thereof Download PDFInfo
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- CN114432215A CN114432215A CN202111289988.4A CN202111289988A CN114432215A CN 114432215 A CN114432215 A CN 114432215A CN 202111289988 A CN202111289988 A CN 202111289988A CN 114432215 A CN114432215 A CN 114432215A
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- fullerene
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- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 229910003472 fullerene Inorganic materials 0.000 title claims abstract description 50
- 230000008439 repair process Effects 0.000 title claims abstract description 38
- 239000006071 cream Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 70
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 41
- 206010000496 acne Diseases 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 26
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 20
- 239000002562 thickening agent Substances 0.000 claims abstract description 20
- 239000003906 humectant Substances 0.000 claims abstract description 16
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 15
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 15
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 15
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 claims abstract description 15
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 15
- 229940033280 alpha-arbutin Drugs 0.000 claims abstract description 15
- 229940036350 bisabolol Drugs 0.000 claims abstract description 15
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003974 emollient agent Substances 0.000 claims abstract description 14
- 239000009636 Huang Qi Substances 0.000 claims abstract description 13
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 11
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 11
- 239000002738 chelating agent Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 3
- 235000019198 oils Nutrition 0.000 claims description 37
- 238000002156 mixing Methods 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 24
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 17
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical group NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 241001671204 Stemona Species 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000003480 eluent Substances 0.000 claims description 13
- 238000004140 cleaning Methods 0.000 claims description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 9
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 8
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 8
- 229960000458 allantoin Drugs 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 8
- 229960001295 tocopherol Drugs 0.000 claims description 8
- 229930003799 tocopherol Natural products 0.000 claims description 8
- 235000010384 tocopherol Nutrition 0.000 claims description 8
- 239000011732 tocopherol Substances 0.000 claims description 8
- 108010059820 Polygalacturonase Proteins 0.000 claims description 7
- 108010093305 exopolygalacturonase Proteins 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000002255 enzymatic effect Effects 0.000 claims description 6
- 239000000469 ethanolic extract Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000000413 hydrolysate Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000011068 loading method Methods 0.000 claims description 6
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 240000001548 Camellia japonica Species 0.000 claims description 5
- 108010059892 Cellulase Proteins 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 5
- 102100022624 Glucoamylase Human genes 0.000 claims description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 5
- 229940085237 carbomer-980 Drugs 0.000 claims description 5
- 235000018597 common camellia Nutrition 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 229940119170 jojoba wax Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 235000020238 sunflower seed Nutrition 0.000 claims description 5
- 244000261559 Smilax china Species 0.000 claims description 4
- 235000000485 Smilax china Nutrition 0.000 claims description 4
- 240000009022 Smilax rotundifolia Species 0.000 claims description 4
- 235000003205 Smilax rotundifolia Nutrition 0.000 claims description 4
- 230000003020 moisturizing effect Effects 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 229940083428 artemisia argyi leaf extract Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 244000046146 Pueraria lobata Species 0.000 claims description 2
- 241001671203 Stemona japonica Species 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 125000002640 tocopherol group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 241000219781 Pueraria montana var. lobata Species 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 34
- 230000000052 comparative effect Effects 0.000 description 19
- 239000011259 mixed solution Substances 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 6
- 235000003826 Artemisia Nutrition 0.000 description 4
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 4
- 244000030166 artemisia Species 0.000 description 4
- 235000009052 artemisia Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000417534 Stemona sessilifolia Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Mycology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly discloses a repair cream containing fullerene and a preparation method thereof, wherein the repair cream containing fullerene is prepared from the following raw materials: chelating agent, water-soluble fullerene, bisabolol, antioxidant, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, kudzu root extract, soothing agent, thickening agent, astragalus membranaceus root extract, emulsifier, acne-removing composition, humectant, emollient oil and deionized water; the repair cream has good repair effect and acne removing effect, the acne removing composition can remarkably improve the acne removing effect, and the folium artemisiae argyi extract and the radix stemonae extract have remarkable synergistic effect in the aspect of acne removing.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a repair cream containing fullerene and a preparation method thereof.
Background
The fullerene is composed of pure carbon atoms and has application prospects in multiple fields. The fullerene has the performance of permanently quenching free radicals, is applied to the cosmetic industry, has a good repairing effect, and can resist oxidative damage of the skin and delay skin aging.
Acne is a series of inflammatory reactions caused by the failure of skin to normally excrete oil, and is a chronic inflammatory skin symptom generated in the hair follicle sebaceous gland tissue part, and the main generation part is the area with vigorous sebum secretion, such as the face, the chest and the back. Acne can cause the patient to have the phenomena of self-confidence reduction, life quality reduction, depression and even mental disorder, the existing repair cream containing fullerene only has good repair effect, and the performance in the aspect of acne removal is insufficient.
Disclosure of Invention
The invention provides a repair cream containing fullerene and a preparation method thereof.
The invention adopts the following technical scheme for solving the technical problems:
a repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.02-0.08 part of chelating agent, 0.1-0.4 part of water-soluble fullerene, 0.1-0.5 part of bisabolol, 0.2-0.5 part of antioxidant, 0.2-0.5 part of p-hydroxyacetophenone, 0.2-0.5 part of 1, 2-hexanediol, 0.3-0.8 part of alpha-arbutin, 0.4-0.7 part of radix puerariae extract, 0.5-1 part of soothing agent, 0.5-1.2 parts of thickening agent, 0.8-1.5 parts of astragalus membranaceus root extract, 4-6 parts of emulsifier, 2.5-5 parts of acne-removing composition, 8-15 parts of humectant, 10-18 parts of emollient oil and 40-60 parts of deionized water.
As a preferable scheme, the repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.04-0.08 part of chelating agent, 0.1-0.3 part of water-soluble fullerene, 0.2-0.5 part of bisabolol, 0.3-0.5 part of antioxidant, 0.3-0.5 part of p-hydroxyacetophenone, 0.3-0.5 part of 1, 2-hexanediol, 0.4-0.8 part of alpha-arbutin, 0.5-0.7 part of radix puerariae extract, 0.6-1 part of soothing agent, 0.6-1.2 parts of thickening agent, 1-1.5 parts of moisturizing agent, 4.5-6 parts of emulsifier, 3-5 parts of acne-removing composition, 10-15 parts of emollient oil, 12-18 parts of emollient oil and 45-60 parts of deionized water.
As a preferable scheme, the repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.05 part of chelating agent, 0.2 part of water-soluble fullerene, 0.4 part of bisabolol, 0.5 part of antioxidant, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.6 part of alpha-arbutin, 0.6 part of kudzu root extract, 0.8 part of soothing agent, 1 part of thickening agent, 1.5 parts of astragalus membranaceus root extract, 5.8 parts of emulsifying agent, 4 parts of acne-removing composition, 12 parts of moisturizing agent, 15 parts of skin-moistening oil and 56.55 parts of deionized water.
As a preferred scheme, the skin moistening oil is prepared from chinaru seed oil, jojoba oil, sunflower seed oil and camellia seed oil according to the weight ratio of 3-8: 2-5: 1-4: 1 to 3.
Preferably, the acne-removing composition is prepared from stemona root extract and folium artemisiae argyi extract according to a weight ratio of 0.5-2: 1.
As a preferred scheme, the preparation method of the stemona extract comprises the following steps:
(1) cleaning and drying radix stemonae, and crushing to 50-100 meshes to obtain radix stemonae powder;
(2) adding 0.01-0.04 part by weight of endoglucanase, 0.01-0.05 part by weight of pectinase, 0.02-0.05 part by weight of glucoamylase and 1 part by weight of radix stemonae powder into 4-10 parts by weight of deionized water, and stirring at the rotating speed of 100-500 rpm at the temperature of 55-70 ℃ for 2-6 hours to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis liquid into 60-90 wt% ethanol water, uniformly mixing to obtain a mixed liquid, placing the mixed liquid in a microwave extraction device, performing microwave treatment at the temperature of 60-75 ℃ by 400-1000W for 20-40 min, filtering by a filter screen of 300-500 meshes, and drying to obtain the stemona root extract.
As a preferred scheme, the preparation method of the folium artemisiae argyi extract comprises the following steps:
(11) cleaning and drying folium artemisiae argyi, and crushing to 50-100 meshes to obtain folium artemisiae argyi powder
(12) Adding 1 part by weight of folium artemisiae argyi powder into 4-10 parts by weight of 50-80 wt% ethanol water solution, performing reflux extraction for 2-4 times, extracting for 2-3 hours each time, and combining extracting solutions to obtain folium artemisiae argyi ethanol extracting solution;
(13) uniformly mixing the folium artemisiae argyi ethanol extract with silica gel according to the weight ratio of 1: 0.5-2, loading the mixture into a chromatographic column, eluting the mixture at the speed of 0.2-0.8 ml/min by using acetone as an eluent, collecting the eluent, and drying to obtain the folium artemisiae argyi extract.
Preferably, the emulsifier is composed of PEG-20 methyl glucose sesquistearate and ceteareth-21 in a weight ratio of 2-5: 1-4; the humectant is prepared from glycerol, 1, 3-butanediol and sorbitol according to a weight ratio of 4-10: 2-6: 0.5 to 2.
As a preferred scheme, the chelating agent is disodium ethylene diamine tetraacetate; the thickening agent is prepared from sclerotium rolfsii gum and carbomer 980 in a weight ratio of 1: 0.2-0.8 percent; the antioxidant is tocopherol; the soothing agent is allantoin.
The invention also provides a preparation method of the repair cream containing the fullerene, which comprises the following steps:
(21) adding a chelating agent, water-soluble fullerene, a thickening agent and a soothing agent into deionized water, and uniformly dispersing to obtain a water phase;
(22) uniformly mixing an emulsifier, a humectant and emollient oil to obtain an oil phase;
(23) adding the oil phase into the water phase, uniformly stirring at the rotating speed of 200-800 rpm, homogenizing at the rotating speed of 800-2000 rpm for 5-15 min, adding bisabolol, an antioxidant, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, a radix puerariae extract, a radix astragali extract and an acne-removing composition, uniformly stirring, and cooling to obtain the repair cream containing the fullerene.
The invention has the beneficial effects that: the repair cream has good repair effect and acne removing effect, the acne removing composition can remarkably improve the acne removing effect, and the folium artemisiae argyi extract and the radix stemonae extract have remarkable synergistic effect in the aspect of acne removing.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the present invention, the parts are all parts by weight unless otherwise specified.
Example 1
A repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.05 part of disodium ethylene diamine tetraacetate, 0.2 part of water-soluble fullerene (C60), 0.4 part of bisabolol, 0.5 part of tocopherol, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.6 part of alpha-arbutin, 0.6 part of radix puerariae extract, 0.8 part of allantoin, 1 part of thickening agent, 1.5 parts of astragalus membranaceus root extract, 5.8 parts of emulsifier, 4 parts of acne-removing composition, 12 parts of humectant, 15 parts of skin-moistening oil and 56.55 parts of deionized water.
The skin moistening oil is prepared from chinaroot greenbrier seed oil, jojoba oil, sunflower seed oil and camellia seed oil according to a weight ratio of 6: 4: 3: 2.
The acne-removing composition is prepared from stemona extract and artemisia leaf extract according to a weight ratio of 1: 1.
The emulsifier is prepared from PEG-20 methyl glucose sesquistearate and ceteareth-21 according to the weight ratio of 3.8: 2.
The humectant is prepared from glycerol, 1, 3-butanediol and sorbitol according to a weight ratio of 7: 4: 1.
The thickening agent is prepared from sclerotium rolfsii gum and carbomer 980 in a weight ratio of 1: 0.5.
The preparation method of the stemona extract comprises the following steps:
(1) cleaning radix Stemonae, drying, and pulverizing to 80 mesh to obtain radix Stemonae powder;
(2) adding 0.02 weight part of endoglucanase, 0.03 weight part of pectinase, 0.05 weight part of glucoamylase and 1 weight part of radix stemonae powder into 8.9 weight parts of deionized water, and stirring at 65 ℃ and 400rpm for 5h to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis solution into 80wt% ethanol water solution (weight ratio of the enzymolysis solution to the ethanol water solution is 1: 4), mixing well to obtain mixed solution, placing the mixed solution in a microwave extraction device, performing microwave treatment at 70 deg.C under 800W for 25min, filtering with 400 mesh filter screen, and drying to obtain radix Stemonae extract.
The preparation method of the folium artemisiae argyi extract comprises the following steps:
(11) cleaning folium Artemisiae Argyi, drying, and pulverizing to 60 mesh to obtain folium Artemisiae Argyi powder
(12) Adding 1 weight part of folium Artemisiae Argyi powder into 6 weight parts of 70wt% ethanol water solution, reflux extracting for 3 times, each time for 3 hr, mixing extractive solutions to obtain folium Artemisiae Argyi ethanol extractive solution;
(13) mixing the folium artemisiae argyi ethanol extract and silica gel (100-200 meshes) according to the weight ratio of 1: 1, mixing uniformly, loading into a chromatographic column (the column has an outer diameter of 120mm and a length of 1000mm, and a collection bottle of 2L), eluting with acetone as eluent at a speed of 0.5ml/min for 60min, collecting the eluent, and drying to obtain folium Artemisiae Argyi extract.
The preparation method of the repair cream containing the fullerene comprises the following steps:
(21) adding disodium ethylene diamine tetraacetate, water-soluble fullerene, a thickening agent and allantoin into deionized water, and uniformly dispersing to obtain a water phase;
(22) uniformly mixing an emulsifier, a humectant and emollient oil to obtain an oil phase;
(23) adding the oil phase into the water phase, stirring uniformly at 500rpm, homogenizing at 1200rpm for 10min, adding bisabolol, tocopherol, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, radix Puerariae extract, radix astragali extract, and acne removing composition, stirring uniformly, and cooling to obtain repair cream containing fullerene.
Example 2
A repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.02 part of disodium ethylene diamine tetraacetate, 0.4 part of water-soluble fullerene, 0.1 part of bisabolol, 0.5 part of tocopherol, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.8 part of alpha-arbutin, 0.4 part of radix puerariae extract, 1 part of allantoin, 0.5 part of thickening agent, 1.5 parts of astragalus membranaceus root extract, 4 parts of emulsifier, 3 parts of acne-removing composition, 15 parts of humectant, 14 parts of skin oil and 57.78 parts of deionized water.
The skin moistening oil is prepared from chinaroot greenbrier seed oil, jojoba oil, sunflower seed oil and camellia seed oil according to a weight ratio of 6: 4: 2: 2.
The acne-removing composition is prepared from stemona extract and artemisia leaf extract according to a weight ratio of 1: 1.
The emulsifier is prepared from PEG-20 methyl glucose sesquistearate and ceteareth-21 according to the weight ratio of 2: 2.
The humectant is prepared from glycerol, 1, 3-butanediol and sorbitol according to a weight ratio of 7: 4: 1.
The thickening agent is prepared from sclerotium rolfsii gum and carbomer 980 in a weight ratio of 1: 0.5.
The preparation method of the stemona extract comprises the following steps:
(1) cleaning radix Stemonae, drying, and pulverizing to 60 mesh to obtain radix Stemonae powder;
(2) adding 0.01 weight part of endoglucanase, 0.04 weight part of pectinase, 0.03 weight part of glucoamylase and 1 weight part of radix stemonae powder into 6 weight parts of deionized water, and stirring at the rotating speed of 300rpm at 55 ℃ for 3 hours to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis solution into 70wt% ethanol water solution (weight ratio of enzymolysis solution to ethanol water solution is 1: 4), mixing well to obtain mixed solution, placing the mixed solution in a microwave extraction device, treating with 800W microwave at 70 deg.C for 30min, filtering with 400 mesh filter screen, and drying to obtain radix Stemonae extract.
The preparation method of the folium artemisiae argyi extract comprises the following steps:
(11) cleaning folium Artemisiae Argyi, drying, and pulverizing to 80 mesh to obtain folium Artemisiae Argyi powder
(12) Adding 1 weight part of folium Artemisiae Argyi powder into 9 weight parts of 70wt% ethanol water solution, reflux-extracting for 3 times, each time for 3 hr, and mixing extractive solutions to obtain folium Artemisiae Argyi ethanol extractive solution;
(13) mixing the folium artemisiae argyi ethanol extract and silica gel (100-200 meshes) according to the weight ratio of 1: 1, mixing uniformly, loading into a chromatographic column (the column has an outer diameter of 120mm and a length of 1000mm, and a collection bottle of 2L), eluting with acetone as eluent at a speed of 0.5ml/min for 60min, collecting the eluent, and drying to obtain folium Artemisiae Argyi extract.
The preparation method of the repair cream containing the fullerene comprises the following steps:
(21) adding disodium ethylene diamine tetraacetate, water-soluble fullerene, a thickening agent and allantoin into deionized water, and uniformly dispersing to obtain a water phase;
(22) uniformly mixing an emulsifier, a humectant and emollient oil to obtain an oil phase;
(23) adding the oil phase into the water phase, stirring uniformly at 500rpm, homogenizing at 1200rpm for 10min, adding bisabolol, tocopherol, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, radix Puerariae extract, radix astragali extract, and acne removing composition, stirring uniformly, and cooling to obtain repair cream containing fullerene.
Example 3
A repair cream containing fullerene is prepared from the following raw materials in parts by weight: 0.08 part of disodium ethylene diamine tetraacetate, 0.1 part of water-soluble fullerene, 0.5 part of bisabolol, 0.2 part of tocopherol, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.3 part of alpha-arbutin, 0.7 part of radix puerariae extract, 0.5 part of allantoin, 1.2 parts of thickening agent, 0.8 part of astragalus membranaceus root extract, 6 parts of emulsifier, 2.5 parts of acne-removing composition, 12 parts of humectant, 18 parts of emollient oil and 56.12 parts of deionized water.
The skin moistening oil is prepared from chinaroot greenbrier seed oil, jojoba oil, sunflower seed oil and camellia seed oil according to the weight ratio of 8: 5: 3: 2.
The acne-removing composition is prepared from stemona extract and artemisia leaf extract according to a weight ratio of 1: 1.
The emulsifier is prepared from PEG-20 methyl glucose sesquistearate and ceteareth-21 according to a weight ratio of 4: 2.
The humectant is prepared from glycerol, 1, 3-butanediol and sorbitol according to a weight ratio of 7: 4: 1.
The thickening agent is prepared from sclerotium rolfsii gum and carbomer 980 in a weight ratio of 1: 0.5.
The preparation method of the stemona extract comprises the following steps:
(1) cleaning radix Stemonae, drying, and pulverizing to 60 mesh to obtain radix Stemonae powder;
(2) adding 0.04 part by weight of endoglucanase, 0.01 part by weight of pectinase, 0.05 part by weight of glucoamylase and 1 part by weight of radix stemonae powder into 4 parts by weight of deionized water, and stirring at the rotating speed of 300rpm at 55 ℃ for 3 hours to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis solution into 80wt% ethanol water solution (weight ratio of the enzymolysis solution to the ethanol water solution is 1: 4), mixing well to obtain mixed solution, placing the mixed solution in a microwave extraction device, performing microwave treatment at 70 deg.C with 600W for 35min, filtering with 400 mesh filter screen, and drying to obtain radix Stemonae extract.
The preparation method of the folium artemisiae argyi extract comprises the following steps:
(11) cleaning folium Artemisiae Argyi, drying, and pulverizing to 80 mesh to obtain folium Artemisiae Argyi powder
(12) Adding 1 weight part of folium Artemisiae Argyi powder into 9 weight parts of 60 wt% ethanol water solution, reflux-extracting for 3 times, each time for 3 hr, and mixing extractive solutions to obtain folium Artemisiae Argyi ethanol extractive solution;
(13) mixing the folium artemisiae argyi ethanol extract and silica gel (100-200 meshes) according to the weight ratio of 1: 1, mixing uniformly, loading into a chromatographic column (the column has an outer diameter of 120mm and a length of 1000mm, and a collection bottle of 2L), eluting with acetone as eluent at a speed of 0.5ml/min for 60min, collecting the eluent, and drying to obtain folium Artemisiae Argyi extract.
The preparation method of the repair cream containing the fullerene comprises the following steps:
(21) adding disodium ethylene diamine tetraacetate, water-soluble fullerene, a thickening agent and allantoin into deionized water, and uniformly dispersing to obtain a water phase;
(22) uniformly mixing an emulsifier, a humectant and emollient oil to obtain an oil phase;
(23) adding the oil phase into the water phase, stirring uniformly at 500rpm, homogenizing at 1200rpm for 10min, adding bisabolol, tocopherol, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, radix Puerariae extract, radix astragali extract, and acne removing composition, stirring uniformly, and cooling to obtain repair cream containing fullerene.
Comparative example 1
Comparative example 1 is different from example 1 in that comparative example 1 uses the same amount of stemona root extract instead of artemisia argyi leaf extract, and the others are the same.
Comparative example 2
Comparative example 2 is different from example 1 in that comparative example 2 uses the same amount of artemisia leaf extract instead of the stemona root extract, and the others are the same.
Comparative example 3
Comparative example 3 is different from example 1 in that the method for preparing the stemona sessilifolia extract described in comparative example 3 is different from example 1, and the rest is the same.
In this comparative example, a single pectinase was used to treat the stemona powder.
The preparation method of the stemona extract comprises the following steps:
(1) cleaning radix Stemonae, drying, and pulverizing to 80 mesh to obtain radix Stemonae powder;
(2) adding 01 parts by weight of pectinase and 1 part by weight of radix stemonae powder into 8.9 parts by weight of deionized water, and stirring at the rotating speed of 400rpm for 5 hours at 65 ℃ to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis solution into 80wt% ethanol water solution (weight ratio of the enzymolysis solution to the ethanol water solution is 1: 4), mixing well to obtain mixed solution, placing the mixed solution in a microwave extraction device, performing microwave treatment at 70 deg.C under 800W for 25min, filtering with 400 mesh filter screen, and drying to obtain radix Stemonae extract.
Comparative example 4
Comparative example 4 is different from example 1 in that the preparation method of the artemisia argyi leaf extract described in comparative example 4 is different from example 1, and the rest is the same.
In this comparative example, 70wt% aqueous ethanol was used as the eluent.
The preparation method of the folium artemisiae argyi extract comprises the following steps:
(11) cleaning folium Artemisiae Argyi, drying, and pulverizing to 60 mesh to obtain folium Artemisiae Argyi powder
(12) Adding 1 weight part of folium Artemisiae Argyi powder into 6 weight parts of 70wt% ethanol water solution, reflux extracting for 3 times, each time for 3 hr, mixing extractive solutions to obtain folium Artemisiae Argyi ethanol extractive solution;
(13) mixing the folium artemisiae argyi ethanol extract and silica gel (100-200 meshes) according to the weight ratio of 1: 1, mixing, loading into a chromatographic column (column external diameter of 120mm, length of 1000mm, collection bottle 2L), eluting with 70wt% ethanol water solution as eluent at 0.5ml/min for 60min, collecting eluate, and drying to obtain folium Artemisiae Argyi extract.
To further demonstrate the effect of the present invention, the following test methods were provided:
1. acne removal performance test (conventional method): the anti-acne cream described in the embodiments 1-3 and the comparative examples 1-4 of the invention is subjected to antibacterial performance determination by referring to appendix C4 of GB 15979-2002 hygienic Standard for Disposable sanitary articles, namely the test method for antibacterial performance of dissolution-type antibacterial (bacteriostatic) products: the 24h (Propionibacterium acnes and Paeonia furfur, respectively) culture of the test bacteria was washed with 0.03mol/L phosphate buffer solution to make 106cfu/mL bacterial suspension; 2. 1g of a test sample (the acne cream described in examples 1-3 and comparative examples 1-4) is respectively taken, 0.1mL of the bacterial suspension is added for uniform coating and mixing, 9mL of 0.03mol/L phosphate buffer solution is added for sufficient mixing after timing is started for 20min, 3 dilutions are taken, and 1mL is respectively placed in two parallel plates. Adding corresponding culture medium, and performing mixed culture for bacterial colony counting. The above experiment was repeated 3 times, and the average was taken while a blank control was set. Calculating the formula: x (%) - (a-B)/ax100, wherein X is the bacteriostatic rate and a is the average number of recovered colonies of the control sample; b is the average number of recovered colonies of the test samples, and the test results are shown in Table 1.
TABLE 1 Performance test results
As can be seen from Table 1, the repair cream containing fullerene has a good acne removing effect.
As can be seen from examples 1 to 3, different raw material ratios and preparation parameters of the extract can affect the acne removing effect within a certain range, wherein example 1 is the optimal ratio.
As can be seen from the comparison of the example 1 and the comparative examples 1-2, the radix stemonae extract and the folium artemisiae argyi extract have a remarkable synergistic effect in the aspect of acne removal.
Compared with the comparative example 3, the stemona japonica extract obtained by treating the stemona sessilifolia with different enzymes has different acne removing effects, and the stemona sessilifolia extract prepared by the method can obviously improve the acne removing effect.
Compared with the comparative example 4, the folium artemisiae argyi extract disclosed by the invention can obviously improve the acne removing effect, the folium artemisiae argyi extracts obtained by eluting with different eluents have different acne removing effects, and the folium artemisiae argyi extract prepared by the preparation method of the folium artemisiae argyi extract disclosed by the invention can obviously improve the acne removing effect.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The repair cream containing fullerene is characterized by being prepared from the following raw materials in parts by weight: 0.02-0.08 part of chelating agent, 0.1-0.4 part of water-soluble fullerene, 0.1-0.5 part of bisabolol, 0.2-0.5 part of antioxidant, 0.2-0.5 part of p-hydroxyacetophenone, 0.2-0.5 part of 1, 2-hexanediol, 0.3-0.8 part of alpha-arbutin, 0.4-0.7 part of radix puerariae extract, 0.5-1 part of soothing agent, 0.5-1.2 parts of thickening agent, 0.8-1.5 parts of astragalus membranaceus root extract, 4-6 parts of emulsifier, 2.5-5 parts of acne-removing composition, 8-15 parts of humectant, 10-18 parts of emollient oil and 40-60 parts of deionized water.
2. The repair cream containing fullerene as claimed in claim 1, characterized by being prepared from the following raw materials in parts by weight: 0.04-0.08 part of chelating agent, 0.1-0.3 part of water-soluble fullerene, 0.2-0.5 part of bisabolol, 0.3-0.5 part of antioxidant, 0.3-0.5 part of p-hydroxyacetophenone, 0.3-0.5 part of 1, 2-hexanediol, 0.4-0.8 part of alpha-arbutin, 0.5-0.7 part of radix puerariae extract, 0.6-1 part of soothing agent, 0.6-1.2 parts of thickening agent, 1-1.5 parts of moisturizing agent, 4.5-6 parts of emulsifier, 3-5 parts of acne-removing composition, 10-15 parts of emollient oil, 12-18 parts of emollient oil and 45-60 parts of deionized water.
3. The repair cream containing fullerene as claimed in claim 1, characterized by being prepared from the following raw materials in parts by weight: 0.05 part of chelating agent, 0.2 part of water-soluble fullerene, 0.4 part of bisabolol, 0.5 part of antioxidant, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.6 part of alpha-arbutin, 0.6 part of kudzu root extract, 0.8 part of soothing agent, 1 part of thickening agent, 1.5 parts of astragalus membranaceus root extract, 5.8 parts of emulsifying agent, 4 parts of acne-removing composition, 12 parts of moisturizing agent, 15 parts of skin-moistening oil and 56.55 parts of deionized water.
4. The repair cream containing fullerene as claimed in claim 1, wherein the emollient oil is prepared from chinaroot greenbrier seed oil, jojoba oil, sunflower seed oil and camellia seed oil in a weight ratio of 3-8: 2-5: 1-4: 1 to 3.
5. The repair cream containing fullerene as claimed in claim 1, wherein the acne-removing composition is prepared from stemona root extract and artemisia argyi leaf extract according to a weight ratio of 0.5-2: 1.
6. The repair cream containing fullerene as claimed in claim 5, wherein the stemona japonica extract is prepared by a method comprising:
(1) cleaning and drying radix stemonae, and crushing to 50-100 meshes to obtain radix stemonae powder;
(2) adding 0.01-0.04 part by weight of endoglucanase, 0.01-0.05 part by weight of pectinase, 0.02-0.05 part by weight of glucoamylase and 1 part by weight of radix stemonae powder into 4-10 parts by weight of deionized water, and stirring at the rotating speed of 100-500 rpm at the temperature of 55-70 ℃ for 2-6 hours to obtain an enzymatic hydrolysate;
(3) adding the enzymolysis liquid into 60-90 wt% ethanol water, uniformly mixing to obtain a mixed liquid, placing the mixed liquid in a microwave extraction device, performing microwave treatment at the temperature of 60-75 ℃ by 400-1000W for 20-40 min, filtering by a filter screen of 300-500 meshes, and drying to obtain the stemona root extract.
7. The repair cream containing fullerene as claimed in claim 5, wherein the preparation method of the folium artemisiae argyi extract comprises:
(11) cleaning folium Artemisiae Argyi, drying, and pulverizing to 50-100 mesh to obtain folium Artemisiae Argyi powder
(12) Adding 1 part by weight of folium artemisiae argyi powder into 4-10 parts by weight of 50-80 wt% ethanol water solution, performing reflux extraction for 2-4 times, extracting for 2-3 hours each time, and combining extracting solutions to obtain folium artemisiae argyi ethanol extracting solution;
(13) uniformly mixing the folium artemisiae argyi ethanol extract with silica gel according to the weight ratio of 1: 0.5-2, loading the mixture into a chromatographic column, eluting the mixture at the speed of 0.2-0.8 ml/min by using acetone as an eluent, collecting the eluent, and drying to obtain the folium artemisiae argyi extract.
8. The repair cream containing fullerene as claimed in claim 1, wherein the emulsifier is composed of PEG-20 methyl glucose sesquistearate and ceteareth-21 in a weight ratio of 2-5: 1-4; the humectant is prepared from glycerol, 1, 3-butanediol and sorbitol according to a weight ratio of 4-10: 2-6: 0.5 to 2.
9. The repair cream containing fullerene according to claim 1, wherein the chelating agent is disodium ethylenediaminetetraacetate; the thickening agent is prepared from sclerotium rolfsii gum and carbomer 980 in a weight ratio of 1: 0.2-0.8 percent; the antioxidant is tocopherol; the soothing agent is allantoin.
10. A method for producing a repair cream containing fullerene according to any one of claims 1 to 9, characterized by comprising the steps of:
(21) adding a chelating agent, water-soluble fullerene, a thickening agent and a soothing agent into deionized water, and uniformly dispersing to obtain a water phase;
(22) uniformly mixing an emulsifier, a humectant and emollient oil to obtain an oil phase;
(23) adding the oil phase into the water phase, uniformly stirring at the rotating speed of 200-800 rpm, homogenizing at the rotating speed of 800-2000 rpm for 5-15 min, adding bisabolol, an antioxidant, p-hydroxyacetophenone, 1, 2-hexanediol, alpha-arbutin, a radix puerariae extract, a radix astragali extract and an acne-removing composition, uniformly stirring, and cooling to obtain the repair cream containing the fullerene.
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|---|---|---|---|---|
| CN106727151A (en) * | 2017-01-06 | 2017-05-31 | 湖北大学 | A kind of mildy wash and preparation method thereof |
| CN107308030A (en) * | 2017-06-09 | 2017-11-03 | 佛山市汇汾化妆品科技有限公司 | A kind of anti-aging reinforcing gel cream |
| KR20180079673A (en) * | 2017-01-02 | 2018-07-11 | 퀴아오셩 리 | Skin whitening and sunscreen composition comprising nano materials and chinese medicine extract |
| CN109106911A (en) * | 2018-08-27 | 2019-01-01 | 湖南博隽生物医药有限公司 | A kind of Anti inflammation pain relieving plaster and preparation method thereof based on fullerene |
| CN109481322A (en) * | 2018-10-10 | 2019-03-19 | 广州雷诺生物科技有限公司 | A kind of fullerene essence cream |
-
2021
- 2021-11-02 CN CN202111289988.4A patent/CN114432215A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180079673A (en) * | 2017-01-02 | 2018-07-11 | 퀴아오셩 리 | Skin whitening and sunscreen composition comprising nano materials and chinese medicine extract |
| CN106727151A (en) * | 2017-01-06 | 2017-05-31 | 湖北大学 | A kind of mildy wash and preparation method thereof |
| CN107308030A (en) * | 2017-06-09 | 2017-11-03 | 佛山市汇汾化妆品科技有限公司 | A kind of anti-aging reinforcing gel cream |
| CN109106911A (en) * | 2018-08-27 | 2019-01-01 | 湖南博隽生物医药有限公司 | A kind of Anti inflammation pain relieving plaster and preparation method thereof based on fullerene |
| CN109481322A (en) * | 2018-10-10 | 2019-03-19 | 广州雷诺生物科技有限公司 | A kind of fullerene essence cream |
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