CN112675123A - Active composition of three white ingredients, preparation method and application thereof - Google Patents
Active composition of three white ingredients, preparation method and application thereof Download PDFInfo
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- CN112675123A CN112675123A CN202110079192.XA CN202110079192A CN112675123A CN 112675123 A CN112675123 A CN 112675123A CN 202110079192 A CN202110079192 A CN 202110079192A CN 112675123 A CN112675123 A CN 112675123A
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- rhizoma typhonii
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- Cosmetics (AREA)
Abstract
The invention discloses a three-white active composition, a preparation method and application thereof, wherein the composition comprises components such as Chinese gall, green tea, turmeric, bletilla striata, bighead atractylodes rhizome, Japanese ampelopsis root, corn stigma, lactobacillus, saccharomycetes, zein, giant typhonium rhizome and the like, the bletilla striata belongs to the orchidaceae, main active ingredients of the composition comprise volatile oil, polysaccharide, bletilla striata glue with abundant mucus and the like, the composition has the effects of astringing, stopping bleeding, diminishing swelling, promoting granulation and the like, the active component can effectively inhibit tyrosinase activity and prevent and treat pigment dullness, and has excellent whitening effect, the active component can be widely applied to the field of cosmetics, including but not limited to products such as moisturizing cream, moisturizing lotion, whitening and repairing emulsion, facial mask, essence, sunscreen cream and the like, has excellent whitening and moisturizing effects, can effectively prevent the generation of melanin on the surface of skin, and all the components adopt natural raw materials, has no stimulation to skin, is safe and environment-friendly, and has higher practicability.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a three-white active composition, a preparation method and application thereof.
Background
With the progress and development of society, skin care products gradually enter our lives and become one of the indispensable articles, the moisturizing skin care emulsion can be used after face cleaning, can perform the functions of moisturizing, moisturizing and moistening on skin, reduces the stimulation of sebaceous glands, prevents the vicious circle secretion of grease, and improves the surface dryness of the skin, and the 'beauty and whitening' is the topic pursued by each girl, so that the selective research and development of a traditional Chinese medicine whitening active ingredient gradually becomes the research hotspot of traditional Chinese medicine whitening.
The existing whitening active components on the market are numerous, but most of the active components are required to be more, the preparation process is complicated, large-scale production cannot be realized, and the pollution is large because the raw materials relate to organic solvents and the like, so that the research and the development of the whitening active component which is purely natural and is prepared from traditional Chinese medicine raw materials are one of the problems which need to be solved urgently.
Disclosure of Invention
The invention aims to provide a saururus chinensis active composition, a preparation method and application thereof, so as to solve the problems in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme:
the active composition comprises the following raw materials: according to weight, 5-7 parts of Chinese gall, 4-8 parts of green tea, 5-7 parts of turmeric, 8-10 parts of bletilla striata, 8-10 parts of bighead atractylodes rhizome, 7-9 parts of ampelopsis japonica, 10-12 parts of corn stigma and 2-4 parts of zymophyte.
According to a more optimized scheme, the raw materials of each component of the three-white active composition also comprise: 3-5 parts of zein, 4-7 parts of giant typhonium rhizome and 3-5 parts of lactobacillus fermentation lysate.
According to an optimized scheme, the fermentation bacteria comprise lactic acid bacteria and yeast, and the lactic acid bacteria are lactobacillus plantarum for producing conjugated linoleic acid.
According to a more optimized scheme, the preparation method of the three-white active composition comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, reflux-extracting with ethanol, mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring, pulverizing, adding deionized water, stirring, and sterilizing at 125 deg.C under 120 deg.C to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with the traditional Chinese medicine mixed solution as a fermentation culture medium, fermenting at 30-32 ℃ and at the rotating speed of a shaking table of 140-;
(4) taking the fermented supernatant, adding corn stigma filter residue and lipase, heating and raising the temperature under a nitrogen environment, treating in a water bath at 50-55 ℃, standing, adding zein, and performing ultrasonic dispersion to obtain a material A;
pulverizing rhizoma Typhonii, sieving, adding ethanol, reflux extracting for 4-5 hr, defatting, filtering, and centrifuging to obtain rhizoma Typhonii residue and rhizoma Typhonii filtrate;
mixing and stirring rhizoma Typhonii filter residue and deionized water, heating to 80-85 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) and (3) taking the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate, mixing and stirring, and cooling to room temperature to obtain the composition.
The optimized scheme comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, extracting with ethanol under reflux for 2-3 times (30-40 min), mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring for 10-15min, pulverizing, adding deionized water, stirring for 10-20min, and sterilizing at 125 deg.C for 20-25min to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with traditional Chinese medicine mixed solution as fermentation medium, fermenting at 30-32 deg.C and shaking table rotation speed of 140-;
(4) adding corn stigma filter residue and lipase into the fermentation supernatant, heating and raising the temperature in a nitrogen environment, treating in a water bath at 50-55 ℃ for 30-40h, standing, adding zein, and performing ultrasonic dispersion for 20-30min to obtain a material A;
pulverizing rhizoma Typhonii, sieving with 20 mesh sieve, adding 95% ethanol, reflux extracting for 4-5 hr, defatting, filtering, and centrifuging to obtain rhizoma Typhonii residue and rhizoma Typhonii filtrate;
mixing rhizoma Typhonii residue and deionized water, stirring for 20-30min, heating to 80-85 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting for 3-4h, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) mixing and stirring the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate for 20-30min, and cooling to room temperature to obtain the composition.
According to the optimized scheme, in the step (3), the inoculation amount of the yeast and the lactobacillus is 1: 2.
according to an optimized scheme, in the step (4), the ratio of material to liquid is 1: 10.
the application of the active composition of the tribasic sodium in the moisturizing milk comprises 3-6% of glycerin, 0.1-0.3% of sodium hyaluronate, 0.1-0.3% of vitamin C ethyl ether, 3-5% of butanediol, 0.1-0.5% of pentaerythritol tetraester, 0.05-0.1% of carbomer, 0.5-0.8% of dipropylene glycol, 4-8% of the active composition of the tribasic sodium, 0.5-1% of PEG-5 glyceryl stearate, 1-2% of disodium ethylene diamine tetraacetate and the balance of purified water.
Application of a three-white active composition in skin care; application of a three-white active composition in a hydrating mask is provided.
Compared with the prior art, the invention has the following beneficial effects:
the application discloses a three-white active composition, a preparation method and an application thereof, wherein the composition comprises components such as gallnut, green tea, turmeric, bletilla striata, bighead atractylodes rhizome, Japanese ampelopsis root, corn stigma, lactic acid bacteria, saccharomycetes, zein, giant typhonium rhizome and the like, bletilla belongs to the orchid family, main active ingredients of the composition comprise volatile oil, polysaccharide, bletilla gum rich in mucus and the like, the composition has the effects of astringing to stop bleeding, relieving swelling, promoting granulation and the like, and the composition can inhibit the activity of tyrosinase and prevent the generation of melanin when being added into cosmetics; the rhizoma atractylodis macrocephalae and the radix ampelopsis have the same strong effect of inhibiting the activity of tyrosinase, and the rhizoma bletillae, the rhizoma atractylodis macrocephalae and the radix ampelopsis have the synergistic effect, so that the active components can effectively inhibit the activity of the tyrosinase, prevent and treat the dark pigment, and have excellent whitening effect.
The turmeric contains curcumin which has the effects of anti-inflammation, antioxidation, bacteriostasis and the like; the green tea can resist allergy, remove free radicals of the skin and has the effect of resisting aging; galla chinensis has antibacterial, toxic substance removing, wound astringing, and hemostatic effects; the corn stigma contains active components such as saponin, flavonoids, volatile oil, alkaloid, polysaccharide, vitamin C, organic acid, sterol substances and the like, has excellent antibacterial and antioxidant effects, can reduce the generation of free radicals, inhibit the activity of tyrosinase, and has excellent whitening and moisturizing effects; the active substances are prepared by specifically selecting Chinese medicinal components such as gallnut, green tea, turmeric, bletilla striata, bighead atractylodes rhizome, Japanese ampelopsis root, corn stigma and giant typhonium rhizome and can be widely applied to the field of cosmetics, and the excellent whitening and moisturizing effects are achieved.
When the active components are prepared, firstly, corn stigma is crushed, and then ethanol is extracted to obtain corn stigma filter residue and corn stigma filtrate, wherein the corn stigma filter residue contains a large amount of corn stigma sterol, and the corn stigma filtrate contains active components such as linoleic acid, polysaccharide and the like, the corn stigma filtrate, gallnut, green tea, turmeric, bletilla striata, bighead atractylodes rhizome and radix ampelopsis are mixed to prepare a traditional Chinese medicine mixed solution, the traditional Chinese medicine mixed solution is used as a fermentation culture medium for fermentation, and a traditional Chinese medicine compound fermentation broth containing a large amount of active components is obtained through a fermentation extraction method; the fermentation liquor contains a large amount of active substances such as polysaccharide, alkaloid and the like, can effectively reduce skin grease secretion, remove acnes, moisturize skin, whiten skin and replenish water, is safe and non-irritant to skin, and has a good whitening and acne removing effect.
Because each traditional Chinese medicine component contains linoleic acid, the linoleic acid can be converted into conjugated linoleic acid under the action of lactic acid bacteria in the fermentation process, corn stigma filter residue and lipase are added into the fermentation supernatant, and corn stigma sterol and the conjugated linoleic acid can generate esterification reaction under the action of the lipase to generate conjugated linoleic acid corn stigma sterol ester.
In the process, the zein and the giant typhonium rhizome polysaccharide are introduced, the giant typhonium rhizome polysaccharide is subjected to phosphorylation modification to obtain the phosphorylated giant typhonium rhizome polysaccharide, the activity is anionic polysaccharide, the phosphorylated giant typhonium rhizome polysaccharide can be electrostatically adsorbed with the zein to form composite particles, the composite particles can load components such as curcumin and alkaloid in a system, and play a slow release role, so that the using effect of the whole active component is more excellent.
The active component prepared by the application can be widely applied to the field of cosmetics, including but not limited to products such as moisturizing cream, moisturizing lotion, whitening repair emulsion, facial mask, essence, sunscreen cream and the like, has excellent whitening and moisturizing effects, can effectively prevent the generation of melanin on the surface of the skin, adopts natural raw materials for all components, has no stimulation to the skin, is safe and environment-friendly, and has high practicability.
The present application also adds a lactic acid bacteria fermentation lysate selected from ProRenew complete CLR produced by Germany CLRTM(INCI name: Lactobacillus fermentation lysate) is based on a lysate of lactococcus lactis, which is effective in promoting skin self-renewal, ProRenew complete CLRTMIs a beige suspension with opalescenceHas weak special smell, can be used for accelerating the recovery of the skin barrier function, and has excellent effect.
The invention discloses a three-white active composition, a preparation method and application thereof, the process design is reasonable, the component proportion is proper, the prepared three-white active composition has excellent oxidation resistance and excellent whitening and moisturizing effects, and meanwhile, the active composition can be widely applied to the field of cosmetics, including but not limited to products such as moisturizing cream, moisturizing water, whitening and repairing emulsion, mask, essence, sunscreen cream and the like.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
a preparation method of a three-white active composition comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, extracting with ethanol under reflux for 2 times (each for 30 min), mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring for 10min, pulverizing, adding deionized water, stirring for 10min, and sterilizing at 120 deg.C for 25min to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with the traditional Chinese medicine mixed solution as a fermentation culture medium, fermenting at 30 deg.C and shaking table rotation speed of 140r/min for 48h, sterilizing after fermentation, filtering, and centrifuging to obtain fermentation supernatant;
(4) adding corn stigma filter residue and lipase into the fermentation supernatant, heating and raising the temperature in a nitrogen environment, treating for 40 hours in a water bath at 50 ℃, standing, adding zein, and performing ultrasonic dispersion for 20min to obtain a material A;
taking rhizoma typhonii, crushing, sieving with a 20-mesh sieve, adding 95% ethanol, wherein the material-liquid ratio is 1: 10, extracting for 4 hours under reflux, degreasing, filtering and centrifuging to obtain rhizoma typhonii filter residue and rhizoma typhonii filtrate;
mixing rhizoma Typhonii residue and deionized water, stirring for 20min, heating to 80 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting for 3 hr, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) mixing and stirring the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate for 20min, and cooling to room temperature to obtain the composition.
In this embodiment, the raw materials of each component of the saururus chinensis active composition include: according to parts by weight, the Chinese herbal medicine composition comprises 5 parts of gallnut, 4 parts of green tea, 5 parts of turmeric, 8 parts of bletilla striata, 8 parts of bighead atractylodes rhizome, 7 parts of ampelopsis japonica, 10 parts of corn stigma, 2 parts of zymophyte, 3 parts of zein, 4 parts of rhizoma typhonii and 3 parts of lactobacillus fermentation lysate.
The zymocyte comprises lactobacillus and probiotics, wherein the inoculation amount of the lactobacillus and the saccharomycetes is 1: 2; the lactobacillus is lactobacillus plantarum for producing conjugated linoleic acid.
Example 2:
a preparation method of a three-white active composition comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, extracting with ethanol under reflux for 3 times (30 min), mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring for 13min, pulverizing, adding deionized water, stirring for 15min, sterilizing at 122 deg.C for 23min to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with the traditional Chinese medicine mixed solution as a fermentation culture medium, fermenting at 31 deg.C and 160r/min of shaking table rotation speed for 49h, sterilizing after fermentation, filtering, and centrifuging to obtain fermentation supernatant;
(4) adding corn stigma filter residue and lipase into the fermentation supernatant, heating and raising the temperature in a nitrogen environment, treating in a water bath at 53 ℃ for 35 hours, standing, adding zein, and performing ultrasonic dispersion for 25min to obtain a material A;
taking rhizoma typhonii, crushing, sieving with a 20-mesh sieve, adding 95% ethanol, wherein the material-liquid ratio is 1: 10, extracting under reflux for 4.5h, degreasing, filtering and centrifuging to obtain rhizoma typhonii filter residue and rhizoma typhonii filtrate;
mixing rhizoma Typhonii residue and deionized water, stirring for 25min, heating to 82 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting for 3.5h, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) mixing and stirring the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate for 25min, and cooling to room temperature to obtain the composition.
In this embodiment, the raw materials of each component of the saururus chinensis active composition include: according to parts by weight, 6 parts of Chinese gall, 6 parts of green tea, 6 parts of turmeric, 9 parts of bletilla striata, 9 parts of bighead atractylodes rhizome, 8 parts of Japanese ampelopsis root, 11 parts of corn stigma, 3 parts of zymophyte, 4 parts of zein, 6 parts of rhizoma typhonii and 4 parts of lactobacillus fermentation lysate.
The zymocyte comprises lactobacillus and probiotics, wherein the inoculation amount of the lactobacillus and the saccharomycetes is 1: 2; the lactobacillus is lactobacillus plantarum for producing conjugated linoleic acid.
Example 3:
a preparation method of a three-white active composition comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, extracting with ethanol under reflux for 3 times (40 min), mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring for 15min, pulverizing, adding deionized water, stirring for 20min, and sterilizing at 125 deg.C for 20min to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with the traditional Chinese medicine mixed solution as a fermentation culture medium, fermenting at 32 deg.C and shaking table rotation speed of 180r/min for 50h, sterilizing after fermentation, filtering, and centrifuging to obtain fermentation supernatant;
(4) adding corn stigma filter residue and lipase into the fermentation supernatant, heating and raising the temperature in a nitrogen environment, treating in a 55 ℃ water bath for 40h, standing, adding zein, and performing ultrasonic dispersion for 30min to obtain a material A;
taking rhizoma typhonii, crushing, sieving with a 20-mesh sieve, adding 95% ethanol, wherein the material-liquid ratio is 1: 10, extracting for 5 hours under reflux, degreasing, filtering and centrifuging to obtain rhizoma typhonii filter residue and rhizoma typhonii filtrate;
mixing rhizoma Typhonii residue and deionized water, stirring for 30min, heating to 85 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting for 4 hr, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) mixing and stirring the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate for 30min, and cooling to room temperature to obtain the composition.
In this embodiment, the raw materials of each component of the saururus chinensis active composition include: according to parts by weight, 7 parts of Chinese gall, 8 parts of green tea, 7 parts of turmeric, 10 parts of bletilla striata, 10 parts of bighead atractylodes rhizome, 9 parts of Japanese ampelopsis root, 12 parts of corn stigma, 4 parts of zymophyte, 5 parts of zein, 7 parts of rhizoma typhonii and 5 parts of lactobacillus fermentation lysate.
The zymocyte comprises lactobacillus and probiotics, wherein the inoculation amount of the lactobacillus and the saccharomycetes is 1: 2; the lactobacillus is lactobacillus plantarum for producing conjugated linoleic acid.
Example 4:
taking the active composition of the three-white prepared in the example 1, a moisturizing milk sample is prepared, and the specific components are as follows:
the moisturizing cream comprises 3% of glycerin, 0.1% of sodium hyaluronate, 0.1% of vitamin C ethyl ether, 3% of butanediol, 0.1% of pentaerythritol tetraester, 0.05% of carbomer, 0.5% of dipropylene glycol, 4% of a triglyceride active composition, 0.5% of PEG-5 glyceryl stearate, 1% of disodium ethylene diamine tetraacetate and the balance of purified water.
Example 5:
taking the active composition of the Sanbai prepared in the example 2, a moisturizing milk sample is prepared, and the specific components are as follows:
the moisturizing cream comprises 4% of glycerin, 0.2% of sodium hyaluronate, 0.2% of vitamin C ethyl ether, 4% of butanediol, 0.3% of pentaerythritol tetraester, 0.08% of carbomer, 0.6% of dipropylene glycol, 5% of a triglyceride active composition, 0.8% of PEG-5 glyceryl stearate, 1.2% of disodium ethylene diamine tetraacetate and the balance of purified water.
Example 6:
taking the active composition of the Sanbai prepared in the example 2, a moisturizing milk sample is prepared, and the specific components are as follows:
the moisturizing cream comprises 6% of glycerin, 0.3% of sodium hyaluronate, 0.3% of vitamin C ethyl ether, 5% of butanediol, 0.5% of pentaerythritol tetraester, 0.1% of carbomer, 0.8% of dipropylene glycol, 8% of a triglyceride active composition, 1% of PEG-5 glyceryl stearate, 2% of disodium ethylene diamine tetraacetate, and the balance of purified water.
And (3) testing:
the following experiments were conducted using the moisturizing creams prepared in examples 4 to 6, respectively, with the moisturizing cream without the tribasic active ingredient added as a control, and all the testers signed an informed consent.
1. And (3) safety test: the safety test is carried out according to the technical specification for cosmetic safety 2015 edition, the test method is a human body skin patch test, and the test result is observed and recorded.
| Item | Example 4(40 persons) | Example 5(40 persons) | Example 6(40 persons) |
| Extent of reaction | All have no adverse reaction | All have no adverse reaction | All have no adverse reaction |
| Grade of rating | 0 | 0 | 0 |
2. Whitening effect: 8 male and female volunteers with dark skin color are respectively taken, the active composition is coated on the left face after the face is cleaned in the morning and evening, the control emulsion is coated on the right face, the active composition is coated on the right face at intervals of 12 hours in the morning and evening, after the active composition is coated on the right face for 3 weeks, a trial evaluation table is filled according to whitening effect and sensory evaluation, and the score is scored according to the minimum score of 1 (the effect is not significant) and the maximum score of 5 (the effect is significant).
3. The moisturizing effect is as follows: 12 healthy female volunteers without allergic history of 20-30 years old were selected and divided into 4 groups of 3 persons each, and moisturizing milks prepared in examples 4-6 were tested, respectively.
In the test, the inner sides of the forearms of both hands of the subject were used as test areas, and the initial moisture content (ug/cm) of the left forearm and the right forearm was measured by using a skin moisture content tester2) Then, a 0.08g moisturizing emulsion sample is smeared, the right front arm is smeared with the emulsion of the control group, the final moisture content is tested after 3 hours, and the data of each group are averaged, and the specific data are shown in the following table:
and (4) conclusion: the invention discloses a three-white active composition, a preparation method and application thereof, the process design is reasonable, the component proportion is proper, the prepared three-white active composition has excellent oxidation resistance and excellent whitening and moisturizing effects, and meanwhile, the active composition can be widely applied to the field of cosmetics, including but not limited to products such as moisturizing cream, moisturizing water, whitening and repairing emulsion, mask, essence, sunscreen cream and the like.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A three-white active composition, characterized by: the raw materials of each component of the three-white active composition comprise: according to weight, 5-7 parts of Chinese gall, 4-8 parts of green tea, 5-7 parts of turmeric, 8-10 parts of bletilla striata, 8-10 parts of bighead atractylodes rhizome, 7-9 parts of ampelopsis japonica, 10-12 parts of corn stigma and 2-4 parts of zymophyte.
2. The saururus chinensis active composition according to claim 1, wherein: the raw materials of each component of the three-white active composition also comprise: 3-5 parts of zein, 4-7 parts of giant typhonium rhizome and 3-5 parts of lactobacillus fermentation lysate.
3. The saururus chinensis active composition according to claim 1, wherein: the zymocyte comprises lactobacillus and yeast, and the lactobacillus is lactobacillus plantarum for producing conjugated linoleic acid.
4. A preparation method of a three-white active composition is characterized by comprising the following steps: the method comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, reflux-extracting with ethanol, mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring, pulverizing, adding deionized water, stirring, and sterilizing at 125 deg.C under 120 deg.C to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with the traditional Chinese medicine mixed solution as a fermentation culture medium, fermenting at 30-32 ℃ and at the rotating speed of a shaking table of 140-;
(4) taking the fermented supernatant, adding corn stigma filter residue and lipase, heating and raising the temperature under a nitrogen environment, treating in a water bath at 50-55 ℃, standing, adding zein, and performing ultrasonic dispersion to obtain a material A;
pulverizing rhizoma Typhonii, sieving, adding ethanol, reflux extracting for 4-5 hr, defatting, filtering, and centrifuging to obtain rhizoma Typhonii residue and rhizoma Typhonii filtrate;
mixing and stirring rhizoma Typhonii filter residue and deionized water, heating to 80-85 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) and (3) taking the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate, mixing and stirring, and cooling to room temperature to obtain the composition.
5. The method for preparing a Saururi active composition according to claim 4, wherein: the method comprises the following steps:
(1) preparing materials;
(2) pulverizing stigma Maydis, extracting with ethanol under reflux for 2-3 times (30-40 min), mixing extractive solutions, concentrating, standing, precipitating, filtering, and centrifuging to obtain stigma Maydis residue and stigma Maydis filtrate;
(3) mixing Galla chinensis, green tea, Curcuma rhizome, rhizoma Bletillae, Atractylodis rhizoma, radix Ampelopsis and stigma Maydis filtrate, stirring for 10-15min, pulverizing, adding deionized water, stirring for 10-20min, and sterilizing at 125 deg.C for 20-25min to obtain Chinese medicinal mixed solution;
respectively activating lactobacillus and yeast to obtain lactobacillus seed solution and yeast seed solution; inoculating lactobacillus seed solution and yeast seed solution with traditional Chinese medicine mixed solution as fermentation medium, fermenting at 30-32 deg.C and shaking table rotation speed of 140-;
(4) adding corn stigma filter residue and lipase into the fermentation supernatant, heating and raising the temperature in a nitrogen environment, treating in a water bath at 50-55 ℃ for 30-40h, standing, adding zein, and performing ultrasonic dispersion for 20-30min to obtain a material A;
pulverizing rhizoma Typhonii, sieving with 20 mesh sieve, adding 95% ethanol, reflux extracting for 4-5 hr, defatting, filtering, and centrifuging to obtain rhizoma Typhonii residue and rhizoma Typhonii filtrate;
mixing rhizoma Typhonii residue and deionized water, stirring for 20-30min, heating to 80-85 deg.C, adding sodium sulfate and sodium polyphosphate, adjusting pH to 5, reacting for 3-4h, precipitating with ethanol, dialyzing, centrifuging, and collecting precipitate to obtain phosphated rhizoma Typhonii polysaccharide;
(5) mixing and stirring the material A, the phosphated rhizoma typhonii polysaccharide, the rhizoma typhonii filtrate and the lactobacillus fermentation lysate for 20-30min, and cooling to room temperature to obtain the composition.
6. The method for preparing a Saururi active composition according to claim 5, wherein: in the step (3), the inoculation amount of the yeast and the lactobacillus is 1: 2.
7. the method for preparing a Saururi active composition according to claim 5, wherein: in the step (4), the ratio of material to liquid is 1: 10.
8. use of a tri-white active composition prepared according to any one of claims 1 to 7 in a moisturizing milk, characterized in that: the moisturizing milk comprises 3-6% of glycerin, 0.1-0.3% of sodium hyaluronate, 0.1-0.3% of vitamin C ethyl ether, 3-5% of butanediol, 0.1-0.5% of pentaerythritol tetraester, 0.05-0.1% of carbomer, 0.5-0.8% of dipropylene glycol, 4-8% of a triglyceride active composition, 0.5-1% of PEG-5 glyceryl stearate, 1-2% of ethylene diamine tetraacetic acid disodium and the balance of purified water.
9. Use of a tri-white active composition prepared according to any one of claims 1 to 7 in skin care applications.
10. Use of the tri-white active composition prepared according to any one of claims 1 to 7 in a hydrating mask.
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| CN117243885A (en) * | 2023-11-15 | 2023-12-19 | 北京青藤谷禧干细胞科技研究院有限公司 | Stem cell exosome composition for improving skin and preparation method thereof |
| CN117243885B (en) * | 2023-11-15 | 2024-01-26 | 北京青藤谷禧干细胞科技研究院有限公司 | Stem cell exosome composition for improving skin and preparation method thereof |
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