CN114414545A - Fluorescence scanning detection system and method - Google Patents
Fluorescence scanning detection system and method Download PDFInfo
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- CN114414545A CN114414545A CN202210070008.XA CN202210070008A CN114414545A CN 114414545 A CN114414545 A CN 114414545A CN 202210070008 A CN202210070008 A CN 202210070008A CN 114414545 A CN114414545 A CN 114414545A
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- 238000004458 analytical method Methods 0.000 claims abstract description 6
- 238000009434 installation Methods 0.000 claims description 10
- 238000003825 pressing Methods 0.000 claims description 9
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- 244000005700 microbiome Species 0.000 description 6
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
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- G01N15/01—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
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- G01N2015/1022—
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- G01N2015/1024—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Abstract
The invention discloses a fluorescence scanning detection system and a method, wherein the fluorescence scanning detection system comprises: the sample mounting assembly comprises a positioning seat and a mechanical switch, and the mechanical switch is mounted at one end of the positioning seat and used for sensing whether the sample mounting assembly is mounted in place or not; the sliding assembly comprises a sliding mechanism and a plurality of optical filters, and the optical filters are arranged on the sliding mechanism; and the control component is connected with the mechanical switch and the sliding mechanism and controls the sliding mechanism to slide according to the signal of the mechanical switch. The invention can automatically clamp the sample to be detected and feed back information to the controller component, and the control component automatically controls the sample to be detected, the fluorescent filter and the light source to be matched with a camera to shoot and image for detection counting analysis, thereby improving the detection efficiency and accuracy.
Description
Technical Field
The invention relates to the field of fluorescence detection, in particular to a fluorescence scanning detection system and a fluorescence scanning detection method.
Background
The microorganisms comprise bacteria, viruses, fungi and some small protozoa, and are closely related to the life of human beings, and intensive research on the microorganisms is very necessary, for example, detection and analysis on gynecological microorganisms (such as trichomonas, hyphae, spores and the like) and CD cells can help doctors to quickly obtain specific in-vivo information and treat diseases more effectively.
At present, the detection methods of microorganisms and cells mainly comprise a traditional laboratory method and a visual detection method, the traditional laboratory method identifies the types and the quantity of microorganisms through a visual inspection method or a fluorescent marker, the visual inspection method mainly judges by monitoring the turbidity and the color change of suspended substances in a culture solution, and the two methods have the defects of low accuracy, low efficiency, high labor intensity and the like.
Disclosure of Invention
The invention provides a fluorescence scanning detection system and a fluorescence scanning detection method, which can solve the problems of low accuracy, low efficiency and high labor intensity of a traditional laboratory method and a visual detection method adopted in the detection of microorganisms and cells and realize the purpose of quickly and accurately detecting gynecological microbial cells and CD cells. In order to solve the above technical problem, the present invention provides a fluorescence scanning detection system, comprising:
the sample mounting assembly comprises a positioning seat and a mechanical switch, and the mechanical switch is mounted at one end of the positioning seat and used for sensing whether the sample mounting assembly is mounted in place or not;
the sliding assembly comprises a sliding mechanism and a plurality of optical filters, and the optical filters are arranged on the sliding mechanism;
and the control component is connected with the mechanical switch and the sliding mechanism and controls the sliding mechanism to slide according to the signal of the mechanical switch.
Preferably, the sample mounting assembly further comprises a rotating shaft seat, a rotating shaft and a pressing piece, the rotating shaft seat and the mechanical switch are mounted at one end of the positioning seat in parallel, the middle of the rotating shaft is rotatably mounted on the positioning seat through a positioning pin, one end of the rotating shaft is mounted on the rotating shaft seat, an elastic piece is arranged in the rotating shaft seat, and when the elastic piece bears pressure, one end of the rotating shaft moves upwards to enable the other end of the rotating shaft to press downwards.
Preferably, the rotating shaft comprises a first rotating shaft and a second rotating shaft, the positioning pin comprises a first positioning pin and a second positioning pin, the first rotating shaft and the second rotating shaft are respectively installed on two sides of the installation plate through the first positioning pin and the second positioning pin, and the other end of the first rotating shaft and the other end of the second rotating shaft further comprise a pressing piece arranged on the other end of the first rotating shaft and used for pressing.
Preferably, the sliding assembly comprises a screw motor, a sliding seat, a guide rail, a connecting seat and a fluorescent seat; the fluorescent base is provided with installation positions of the optical filters, the fluorescent base is arranged on the sliding base through a connecting base, the sliding base is connected with a screw rod of the screw rod motor, and the sliding base is in sliding fit with the guide rail.
Preferably, the sliding assembly further comprises a travel switch and a positioning stop block, the travel switch is mounted on the sliding seat through a travel switch mounting seat, the positioning stop block is mounted at a travel position matched with the travel switch, and the travel switch and the lead screw motor are both connected with the control assembly.
Preferably, the plurality of filters include a blue light filter or an ultraviolet light filter.
Preferably, the sample mounting assembly is mounted on an XY motion platform, the XY motion platform is mounted on a lifting assembly, the lifting assembly is arranged on an upright, and a base plate is arranged below the upright.
Preferably, the control assembly comprises a motion control assembly, a screw motor driver, a voltage converter and a light source control assembly, the motion control assembly is used for controlling the XY motion platform and the lifting assembly, the screw motor driver is used for driving the screw motor, and the light source control assembly is connected with the light source assembly to control the light source.
Preferably, the fluorescence scanning analysis system further comprises an objective lens achromatic assembly, the objective lens achromatic assembly comprises an objective lens, an optical filter and a corner fixing seat, the optical filter is mounted on the optical filter seat, the objective lens is fixed on the corner fixing seat through an adjusting seat, the optical filter and the optical filter seat, the corner fixing seat is mounted on the column seat plate, and the other side of the corner fixing seat is sequentially connected with the lens cone, the tube lens and the camera.
The invention also provides a fluorescence scanning detection method, which uses the fluorescence scanning analysis system and comprises the following steps:
confirming the type of a sample to be detected;
inserting the sample slide to be detected into the mounting plate and then pushing the sample slide to the positioning seat;
the mechanical switch senses whether the sample slide to be detected is installed in place or not and feeds back an installation signal to the control assembly;
the control assembly controls the sliding mechanism to slide and switch the optical filter.
Preferably, the control module further comprises the following steps after controlling the sliding mechanism to slide and switch the optical filter:
and the control assembly controls the XY motion platform and the lifting assembly to move, so that the sample to be detected is imaged through the objective lens achromatization assembly.
The automatic clamping device can automatically clamp the sample slide to be detected after the sample slide to be detected is inserted into the mounting plate and feed back information to the control assembly, the control assembly controls the sample slide to be detected and the fluorescent filter to move to corresponding positions according to the mounting information and controls the light source to be turned on to match the camera to shoot and image, the sample to be detected does not need manual operation after being inserted, and the sample detection efficiency and accuracy are improved.
Drawings
FIG. 1 is a structural assembly diagram of a fluorescence scanning detection system;
FIG. 2 is a view of the base assembly;
FIG. 3 is a view showing the construction of the slide assembly;
FIG. 4 is a block diagram of a sample mounting assembly;
FIG. 5 is a diagram of an appliance control assembly;
FIG. 6 is a block diagram of an achromatic assembly of an objective lens;
FIG. 7 is a flowchart of the fluorescence scanning detection method in example 2.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The present embodiment provides a fluorescence scanning detection system, please refer to fig. 1-6, which includes:
the sample mounting assembly 3 comprises a positioning seat 303 and a mechanical switch 304, wherein the mechanical switch 304 is mounted at one end of the positioning seat 303 and used for sensing whether the sample mounting assembly 3 is mounted in place; the mechanical switch 304 can be a microswitch, and the microswitch is mounted on the positioning seat 303 through a microswitch mounting seat.
The sliding assembly 2 comprises a sliding mechanism and a plurality of optical filters, and the optical filters are arranged on the sliding mechanism; the fluorescent filter sheet is placed on the fluorescent connecting seat 205, the fluorescent connecting seat 205 is installed on the guide rail 203 through the sliding block 202, and the fluorescent connecting seat 205 drives the screw rod to make linear motion through the screw rod motor 208, so that the filter sheet is moved to a proper position to be matched with a light source, and the light source is filtered.
The control component 7 is connected with the mechanical switch 304 and the sliding mechanism, the sliding mechanism is controlled to slide according to the signal of the mechanical switch 304, the mechanical switch 304 senses that the sample slide to be detected is installed in place and then feeds back the signal to the control component 7, and the control component 7 controls the sliding mechanism to move the filter plate to the lower part of the light source for matching.
In this embodiment, sample installation component 3 still includes pivot seat 301, pivot and compresses tightly the piece, pivot seat 301 with mechanical switch 304 is installed side by side positioning seat 303 one end, the pivot middle part is passed through the locating pin and is rotated and install on the positioning seat 303, pivot one end is installed on pivot seat 301, set up the spring in the pivot seat 301 make during the spring pressure-bearing pivot one end upward movement makes the pivot other end pushes down, compresses tightly and waits to examine the sample slide, the slide adopts standard glass piece, also can adopt the other household utensils that accord with the mounting panel size to replace.
In this embodiment, the rotating shafts include a first rotating shaft 305 and a second rotating shaft 309, the positioning pins include a first positioning pin 306 and a second positioning pin 308, the first rotating shaft 305 and the second rotating shaft 309 are respectively installed on two sides of the installation plate 302 through the first positioning pin 306 and the second positioning pin 308, and the other ends of the first rotating shaft 305 and the second rotating shaft 309 further include pressing members 307 and 310 arranged thereon for pressing.
In this embodiment, the sliding assembly 2 includes a lead screw motor 208, a sliding base 204, a guide rail 203, a connecting base 201 and a fluorescent base 205; the fluorescent seat 205 is provided with two installation positions of the optical filter, the fluorescent seat 205 is arranged on the sliding seat 204 through a connecting seat 201, the sliding seat 204 is connected with a screw rod of the screw rod motor 208, and the sliding seat 204 is in sliding fit with the guide rail 203.
In this embodiment, the sliding assembly 2 further includes a travel switch 206 and a positioning stopper 209, the travel switch 206 is installed on the sliding base 204 through a travel switch installation seat 207, the positioning stopper 209 is installed at a travel position matched with the travel switch 206, the travel switch 206 and the lead screw motor 208 are both connected to the control assembly 7, and the sliding assembly 2 is integrally installed on the Z sliding table 103.
In this embodiment, the plurality of optical filters include an ultraviolet light filter 210 and a blue light filter 211, and the optical filters are made of plastic or glass sheets and further added with a coating layer, and are used for filtering light within a certain wavelength range to play a role of a monochromator. The ultraviolet light filter can only allow ultraviolet light to pass through, and the blue light filter can only allow blue light to pass through.
In this embodiment, the sample mounting assembly 3 is installed on an XY motion platform 104, the XY motion platform 104 is installed on a lifting assembly, the lifting assembly is installed on a column 102, a column seat plate 101 is installed below the column 102, four support legs 105 are installed below the column seat plate and used for keeping stable and a certain height, the column is installed on the column seat plate 101, a Z sliding table 103 is installed on the column 101, and all the components are connected through hexagon socket head bolts.
In this embodiment, the control component 7 includes a motion control component 701, a lead screw motor driver 703, a voltage converter 704 and a light source control component 705, the motion control component 701 is used for controlling the XY motion platform 104 and the lifting component, the lead screw motor driver 703 is used for driving the lead screw motor 208, the light source control component 705 is connected to the light source component 4 to control the light source, the motion control component 701, the lead screw motor driver 703 and the voltage converter 704 are installed on one side of the electrical board 702, and the light source control component 705 is installed on the other side of the electrical board 702.
In this embodiment, the fluorescence scanning detection system further includes an objective lens achromatic assembly 6, the objective lens achromatic assembly 6 includes an objective lens 601, an optical filter 603 and a corner fixing seat 606, the optical filter 603 is installed on the optical filter seat 604, the objective lens 601 is fixed on the corner fixing seat 605 through an adjusting seat 602, the optical filter 603 and the optical filter seat 604, the corner fixing seat 605 is installed on the column seat 101, the other side of the corner fixing seat 605 is sequentially connected with a lens barrel 606, a barrel lens 607 and a camera 5, and the camera 5 shoots a clearer slide image through the effect of the objective lens achromatic assembly 6.
Example 2
This embodiment provides a fluorescence scanning detection method, using the fluorescence scanning detection system described in embodiment 1, as shown in fig. 7, including the following steps:
s101, confirming the type of a sample to be detected;
s201, inserting a sample slide to be detected into the mounting plate 302 and then pushing the sample slide to the positioning seat 303;
s301, sensing whether the sample slide to be detected is mounted in place by the mechanical switch 304, and feeding back a mounting signal to the control component 7;
s401, the control component 7 controls the sliding mechanism to slide and switch the optical filter.
In this embodiment, the step of controlling the sliding mechanism to slide and switch the optical filter by the control component 7 further includes:
the control component 7 controls the XY moving platform 104 and the lifting component to move, so that the sample to be detected is imaged through the objective lens achromatization component 6.
In the embodiment, gynecological microbial cells or CD cells are manufactured into a sample slide to be detected by adopting a smear method, a sheet spreading method, a sheet pressing method or other methods, the sample slide to be detected is inserted into a mounting plate 302 and then pushed to a positioning seat 303, a spring arranged in a rotating shaft seat 301 is triggered to bear pressure, rotating shafts 305 and 309 rotate around positioning pins 306 and 308 to press the sample slide to be detected downwards under the action of the spring arranged in the rotating shaft seat 301, a mechanical switch 304 senses whether the sample slide to be detected is arranged in place or not and feeds back an installation signal to a control component 7, the control component 7 controls a travel switch 206 and a lead screw motor 208 to be started to drive a sliding seat 204 to slide on a sliding rail 203, so that an optical filter is conveyed below a light source to be used together with the light source, the control component 7 also controls an XY motion platform 104 and a lifting component to move the sample to be detected to be moved below the light source, a camera 5 shoots an image of the sample slide to be detected through an objective lens achromatic component 6, and the image is transmitted to a computer for analysis and processing, so that the counting and biological detection of the gynecological microbial cells or CD cells are realized.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (11)
1. A fluorescence scanning detection system, comprising:
the sample mounting assembly comprises a positioning seat and a mechanical switch, and the mechanical switch is mounted at one end of the positioning seat and used for sensing whether the sample mounting assembly is mounted in place or not;
the sliding assembly comprises a sliding mechanism and a plurality of optical filters, and the optical filters are arranged on the sliding mechanism;
and the control component is connected with the mechanical switch and the sliding mechanism and controls the sliding mechanism to slide according to the signal of the mechanical switch.
2. The fluorescence scanning detection system of claim 1, wherein said sample mounting assembly further comprises a shaft seat, a shaft and a pressing member, said shaft seat and said mechanical switch are mounted in parallel at one end of said positioning seat, said shaft middle portion is rotatably mounted on said positioning seat by a positioning pin, one end of said shaft is mounted on said shaft seat, an elastic member is disposed in said shaft seat, and when said elastic member is pressed, said one end of said shaft moves upward to press down the other end of said shaft.
3. The fluorescence scanning detection system of claim 2, wherein the rotation shaft comprises a first rotation shaft and a second rotation shaft, the positioning pins comprise a first positioning pin and a second positioning pin, the first rotation shaft and the second rotation shaft are respectively mounted on two sides of the mounting plate through the first positioning pin and the second positioning pin, and the other end of the first rotation shaft and the other end of the second rotation shaft further comprise a pressing member arranged thereon for pressing.
4. The fluorescence scanning detection system of claim 1, wherein the slide assembly comprises a lead screw motor, a slide carriage, a guide rail, a connecting seat, and a fluorescence seat; the fluorescent base is provided with installation positions of the optical filters, the fluorescent base is arranged on the sliding base through a connecting base, the sliding base is connected with a screw rod of the screw rod motor, and the sliding base is in sliding fit with the guide rail.
5. The fluorescence scanning detection system of claim 4, wherein said slide assembly further comprises a travel switch and a positioning stop, said travel switch is mounted on said slide base by a travel switch mounting seat, said positioning stop is mounted at a travel position matched with said travel switch, and said travel switch and said lead screw motor are both connected to said control assembly.
6. The fluorescence scanning detection system of claim 4, wherein said plurality of filters comprise blue filters or ultraviolet filters.
7. The fluorescence scanning detection system of claim 1, wherein said sample mounting assembly is mounted on an XY motion stage, said XY motion stage being mounted on a lift assembly, said lift assembly being disposed on a column, said column having a base plate disposed thereunder.
8. The fluorescence scan detection system of claim 7, wherein the control assembly comprises a motion control assembly for controlling the XY motion stage and the lift assembly, a lead screw motor driver for driving the lead screw motor, a voltage converter, and a light source control assembly connected to the light source assembly for controlling the light source.
9. The fluorescence scanning detection system of any of claims 1-8, wherein said fluorescence scanning analysis system further comprises an objective lens achromatic assembly, said objective lens achromatic assembly comprises an objective lens, a filter and a corner fixing seat, said filter is mounted on the filter seat, said objective lens is fixed on said corner fixing seat through an adjusting seat and said filter, said corner fixing seat is mounted on the column seat, and the other side of said corner fixing seat is connected with the lens barrel, the tube lens and the camera in sequence.
10. A fluorescence scanning assay method, using a fluorescence scanning assay system according to any one of claims 1 to 9, comprising the steps of:
confirming the type of a sample to be detected;
inserting the sample slide to be detected into the mounting plate and then pushing the sample slide to the positioning seat;
the mechanical switch senses whether the sample slide to be detected is installed in place or not and feeds back an installation signal to the control assembly;
the control assembly controls the sliding mechanism to slide and switch the optical filter.
11. The fluorescence scanning detection method of claim 10, wherein the step of controlling the sliding mechanism to slide and switch the optical filter by the control module further comprises:
and the control assembly controls the XY motion platform and the lifting assembly to move, so that the sample to be detected is imaged through the objective lens achromatization assembly.
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| CN202210070008.XA CN114414545B (en) | 2022-01-21 | 2022-01-21 | Fluorescent scanning detection system and method |
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| CN202210070008.XA CN114414545B (en) | 2022-01-21 | 2022-01-21 | Fluorescent scanning detection system and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116735461A (en) * | 2023-08-10 | 2023-09-12 | 成都云芯医联科技有限公司 | Three categorised optical detection systems of leucocyte |
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| CN116735461A (en) * | 2023-08-10 | 2023-09-12 | 成都云芯医联科技有限公司 | Three categorised optical detection systems of leucocyte |
| CN116735461B (en) * | 2023-08-10 | 2023-11-10 | 成都云芯医联科技有限公司 | Three categorised optical detection systems of leucocyte |
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