CN1144094A - Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy - Google Patents
Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy Download PDFInfo
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- CN1144094A CN1144094A CN94115491A CN94115491A CN1144094A CN 1144094 A CN1144094 A CN 1144094A CN 94115491 A CN94115491 A CN 94115491A CN 94115491 A CN94115491 A CN 94115491A CN 1144094 A CN1144094 A CN 1144094A
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- berberine
- membrane
- sodium fulvate
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- fulvate
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention relates to a drug for curing gynescopathy, including cervical erosion, senile vaginitis, simple vaginitis, colpitis mycotica and leukoplakia vulvae. It is characterized by containing sodium fulvate and/or herberine. Said drug can be made into the dosage form of film preparation, has no toxic side effect and its total effective rate is up to 96%.
Description
The present invention relates to mix application (compound preparation) with berberine or use separately and make the novel form membrane and control the common disease of gynecological, comprise cervical erosion and senile vaginitis, colpitis simplex, colpitis mycotica and leukoplakia vulvae with sodium fulvate.
Sodium fulvate is the water-soluble effective ingredient of a kind of energy that extracts from the Chinese medicine Anthracites.Its major function has antiinflammatory, hemostasis, astriction.Be mainly used in the various Peptic Ulcerss of treatment clinically.Learn that by retrieving and reading up the literature have only a kind of dosage form of oral liquid＜Ministry of Public Health approval at present: the accurate word of medicine 1991 No. 20114 are defended in Henan 〉, still there is not this dosage form of membrane.Berberine is a kind of active ingredient that proposes from the Chinese medicine Rhizoma Coptidis, and berberine also is " the kind that Chinese pharmacopoeia is recorded.Clinical common formulations is tablet and injection, and its major function is antiinflammatory, sterilization, is used for treating gastrointestinal tract inflammation.Retrieval is known and is not found that so far it is made membrane is used for the treatment of gynaecopathia.Especially sodium fulvate and berberine mixing application is made membrane and is used for controlling gynaecopathia, knows still do not have this kind dosage form at present by retrieving and reading up the literature.Above-mentioned two kinds of present dosage forms that have of medicine all can not be in the part after patient uses, and particularly intravaginal and cervix uteri surface forms effective concentration, brings into play curative effect better.Therefore we these two kinds of prescriptions solely or mix to use and make the membrane that is fit to local application so that make medicine performance better therapeutic.
The objective of the invention is, a kind of treatment cervical erosion, senile vaginitis, colpitis simplex, colpitis mycotica and leukoplakia vulvae medicine are provided, it contains sodium fulvate and/or berberine.
Medicine of the present invention is used in medically, can be made into various dosage forms, preferred membrane.
The manufacture method of membrane of the present invention is dissolved in the water purified polyvinyl alcohol, and its consumption must not be less than 30%.Independent then or the mixing application fetches is good sodium fulvate or berberine fine powder (more than 120 orders, mix application as two medicines, sodium fulvate and berberine optimal proportion are 2: 1) add in the polyvinyl alcohol water solution, add an amount of glycerol and tween.Heat 80-100 ℃, and fully stir, and then be poured on the flat board, paint generous uniform thin film (thickness requirement is at 1-2mm), the baking airing is cut into the film that 5cm is wide and 5cm is long, and every film content of dispersion gets final product at 0.5g.
Cervical erosion, various vaginitiss and leukoplakia vulvae are common gynecological disease and frequently-occurring disease, clinical investigation, and people's degree of adult women 80% is different suffers from one of these several diseases.The types of drugs that is used for the treatment of above-mentioned disease then is less.At present, the medicine for the treatment of above-mentioned disease both at home and abroad mostly is suppository and lotion＜as hibitane suppository, Radix Sophorae Flavescentis Suppositoria, JIEERYIN lotion etc.).The shortcoming of suppository, lotion be can not be in the part especially the surface in pathological changes paste well, and form certain effectively drug level, be difficult to bring into play preferably therapeutical effect.Go up simultaneously two kinds of dosage forms and also have to use inconvenient and the shortcoming of drug contamination underwear is arranged, what have also sends a kind of niff, and cost is higher.The present invention mixes with berberine with sodium fulvate or uses the shortcoming that the membrane of making has just overcome last two kinds of dosage forms fully separately, and making is simple, and cost is low.Above-mentioned in addition two kinds of medicines are Chinese medicine extraction and make, and use total effective rate 96% through 1,000 many cases patients clinicals, do not have what toxic and side effects.Unique shortcoming is that membrane only is applicable to the medicine that dosage is little.
For confirming that the present invention has the effect of better treatment common gynecological disease, introduces test method and result below.
Sodium fulvate and berberine are separately or mixes application and make the influence of membrane to the rat vagina chemical injury.
At random 70 rats are divided into 7 groups, 10 every group, the first group model group; Second group of blank group; The 3rd group of sodium fulvate film group (10mg/mg); The 4th group is berberine film group (10mg/kg); The 5th group is sodium fulvate and berberine hybrid films group (10mg/kg); The 6th group is excipient group (21.5mg/kg); The 7th group of positive controls (the rotten clever film 10mg/kg in palace).The medicine cotton balls (the about 1cm of diameter) that will contain 2,4 one dinitro-chloro-benzene (1%) 0.15ml solution is inserted in the rat vagina gently, takes out after 48 hours, changes second piece, takes out after 96 hours.Each medication group and excipient group vagina administration every day then, continuous 5 days, put to death every group 1/2 animal in the 6th day, all the other animals continue administrations, all put to death in the 9th day and dissect, and take out vagina tissue and make pathological section, and microscopically is observed.
The result shows: each medication group has treatment, repair different and degree to the rat vagina inflammatory damage due to 2,4 one dinitro-chloro-benzenes.But hybrid films group trend is obvious.Each medication group and model group more all have P＜0.05, but do not have significant difference between each medication group.Behind the vagina medicinal 8 days, the most of new epithelium of the vagina tissue that is damaged forms, the edematous fluid basic absorption, and the connective tissue trend is normal, and inflammatory cell reduces.And pathological model group untreated, degree of injury recovers naturally not as the medication group.
Embodiment (1)
The preparation of sodium fulvate film
Under aseptic condition, receive to heat 80 ℃ after 13g, polyvinyl alcohol 7g, glycerol 2ml, tween 0.2ml, distilled water 100ml mix with fulvic acid and stir, paint the thin film of thick 1-2mm then, oven dry gets final product.
Embodiment (2)
The preparation of berberine film
Under aseptic condition, to stir with heating 80 ℃ after berberine 13g, polyvinyl alcohol 7g, glycerol 2ml, tween 0.2ml, the distilled water 100ml mixing, the thin film oven dry of painting thick 1-2mm then gets final product.
Sodium fulvate mixes the preparation of back compound recipe film with berberine.
Under aseptic condition, stir with heating 80 ℃ after sodium fulvate 9g, berberine 4g, polyvinyl alcohol 7g, glycerol 2ml, tween 0.2ml, the distilled water 100ml mixing, paint the thin film of thick 1-2mm then, oven dry gets final product.
Claims (5)
1, a kind of gynaecopathia medicine of (comprising cervical erosion, senile vaginitis, colpitis simplex, colpitis mycotica and leukoplakia vulvae) that is used for the treatment of, its feature contains sodium fulvate and/or berberine.
2, according to the described medicine of claim 1, it is characterized by membrane.
3, membrane according to claim 2, wherein surfactant is tween 80 or sodium lauryl sulphate.
4, membrane according to claim 2, plasticizer wherein are glycerol or sorbitol.
5, membrane according to claim 2, wherein membrane thickness is grown 1 centimetre to 20 centimetres at 0.5 millimeter to 5 millimeters, and is wide 1 centimetre to 20 centimetres.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94115491A CN1144094A (en) | 1994-08-31 | 1994-08-31 | Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94115491A CN1144094A (en) | 1994-08-31 | 1994-08-31 | Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1144094A true CN1144094A (en) | 1997-03-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94115491A Pending CN1144094A (en) | 1994-08-31 | 1994-08-31 | Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1144094A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225072A (en) * | 2011-06-15 | 2011-10-26 | 西安交通大学 | Sodium humate skin external preparation for promoting wound healing |
| CN106819775A (en) * | 2017-01-21 | 2017-06-13 | 潍坊中创药业有限公司 | A kind of additive of de- mycotoxin and its application |
| CN108653396A (en) * | 2018-08-08 | 2018-10-16 | 河北向日葵生物科技有限公司 | The special irrigation of gynaecology containing fulvic acid |
-
1994
- 1994-08-31 CN CN94115491A patent/CN1144094A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225072A (en) * | 2011-06-15 | 2011-10-26 | 西安交通大学 | Sodium humate skin external preparation for promoting wound healing |
| CN106819775A (en) * | 2017-01-21 | 2017-06-13 | 潍坊中创药业有限公司 | A kind of additive of de- mycotoxin and its application |
| CN108653396A (en) * | 2018-08-08 | 2018-10-16 | 河北向日葵生物科技有限公司 | The special irrigation of gynaecology containing fulvic acid |
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