CN102225072A - Sodium humate skin external preparation for promoting wound healing - Google Patents
Sodium humate skin external preparation for promoting wound healing Download PDFInfo
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- CN102225072A CN102225072A CN2011101601134A CN201110160113A CN102225072A CN 102225072 A CN102225072 A CN 102225072A CN 2011101601134 A CN2011101601134 A CN 2011101601134A CN 201110160113 A CN201110160113 A CN 201110160113A CN 102225072 A CN102225072 A CN 102225072A
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Abstract
The invention discloses a sodium humate skin external preparation for promoting wound healing, which is a gel formulation, a film formulation, a film-forming formulation or an ointment formulation of sodium humate in addition with pharmaceutically-acceptable adjuvant materials. In terms of the mass fraction, the content of sodium humate is 0.1% to 20%. The sodium humate skin external preparation disclosed by the invention has strong effects of relieving the inflammation, reducing the exudation, promoting the regeneration of capillary vessels and increasing the generation of collagen, and can significantly reduce the time of wound healing and promote wound healing. The application range of sodium humate in the medicine field is increased, and the blank of sodium humate skin external preparations is filled in. The sodium humate skin external preparation is available in various forms for external application, such as a gel, a film, a film-forming agent and an ointment. The sodium humate skin external preparation has the characteristics of relatively-definite components, quick onset of action, stable property and accurate quality control, and is convenient to be used in the clinic and selected by patients.
Description
Technical field
The invention belongs to conglutinant technical field of pharmaceuticals, relate to the sodium humate external preparation that is used to promote wound healing.
Background technology
Wound is a kind of common surgery frequently-occurring disease, and operation, wound, infection, medicine and immunoreation and some unconventional factor such as fire, burn etc. all can make body tissue sustain damage.Be used at present promote that the method for wound healing mainly contains: genetically engineered drug (as the basic fibroblast factor), laser, biological engineering material (as chitin), medicine (new) etc. as rehabilitation.Wherein laser therapy needs Special Equipment and operator, damages normal skin easily; The active drug that is exclusively used in the promotion wound healing commonly used is less, inconvenience (biological preparation needs cryopreservation), the improper weak points such as (mostly are solution, are difficult for Dermallly affixed) of dosage form are carried in preservation, and clinical use and effect are difficult to satisfactory.
(Humic Acid is that the residual body of natural plant decomposes the formed product of extraction through decomposition or from coal HA) to humic acids, is a kind of macromole organic monoacid of complexity, has wide biological activity, and the range of application in industry and agricultural production is wider.Modern study is the result indicate, humic acid substance has multiple pharmacologically active, comprises antiinflammatory, antiviral, adjusting immunity, antibiotic, antiulcer, antitoxin, free radical resisting, treatment rheumatism or the like.
Sodium humate is the soluble sodium salt of humic acids; outward appearance is irregular, glossiness granule or black powdery solid; be alkalescence, contain hydroxyl, carboxylate isoreactivity group, have multiple functions such as ion exchange, absorption, complexation, chelating, flocculation, dispersion, bonding.Sodium humate is applied and approves in the various fields of national economy, especially adjust agent, water for industrial use stabilizing agent, cement water reducing agent, boiler detergent, ore floatation agent, waste gas waste water treating agent, water coal oar additive, coal briquette bond and negative battery plate expander etc. as ceramic additive, degumming agent, drilling mud, demonstrate great vitality, obtained the remarkable economical effect, prospect is very wide.Secondly, in agricultural,, can change Soil structure, crops be played the effect of disease resistance increasing both production and income as compound fertilizer; As feed additive, as synergist, all have effect and income preferably in the aquaculture in the livestock culture.
Sodium humate mainly is to use as the effective ingredient in single or the compound recipe is for oral administration at field of medicaments, such as the sodium humate sheet of making tablet, is mainly used in convergence, hemostasis, antidiarrheal after oral, cures mainly haematemesis, have blood in stool, have loose bowels, vomiting, epigastric pain, infantile diarrhea, insufficiency of the spleen chronic diarrhea, chronic dysentery; Also have 5% sodium humate liquid enema treatment chronic colitis, 5% sodium humate solution is oral or through the report of stomach tube treatment upper gastrointestinal hemorrhage.And compound recipe is when using, diseases such as many and other component for treating mucosa ulcer, erosion.But also there is not sodium humate to make external preparation at conglutinant report.
Summary of the invention
The problem that the present invention solves is to provide a kind of sodium humate external preparation of promoting wound healing and preparation method thereof that is used to, and this external preparation can significantly shorten wound healing time, promotes wound healing; Used medicine is natural component, and is cheap and easy to get, nontoxic nonirritant, and safety is good.
The present invention is achieved through the following technical solutions:
A kind ofly being used for conglutinant sodium humate external preparation, is to add gel, membrane, liniment or the ointment that suitable pharmaceutic adjuvant is made by sodium humate; In mass fraction, the content of sodium humate is 0.1～20%.
Describedly be used for conglutinant sodium humate external preparation and make gel, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% gel-type vehicle, 1～20% wetting agent, 0.01～5% antiseptic and 0%～5% pH regulator agent, surplus is a water;
Described gel-type vehicle is carbomer, cellulose derivative, sodium alginate, chitosan or cross linked sodium polyacrylate; Described wetting agent is glycerol, propylene glycol or sorbitol; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide; Described pH regulator agent is triethanolamine, sodium hydroxide or Borax.
Describedly be used for conglutinant sodium humate external preparation and make membrane, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% membrane substrate, 1～20% wetting agent and 0.01～5% antiseptic, surplus is a water;
Described membrane substrate is polyvinyl alcohol, ethylene copolymer, acetate ethylene copolymer, hydroxypropyl cellulose, hydroxypropyl emthylcellulose or polyvinylpyrrolidone; Described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
Describedly be used for conglutinant sodium humate external preparation and make liniment, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% liniment substrate, 1～20% wetting agent and 0.01～5% antiseptic, surplus is a water;
Described liniment substrate is polyvinyl alcohol, chitosan, sodium alginate, sodium carboxymethyl cellulose, carbomer, acrylic resin polyvinyl alcohol, polyvinyl formal-acetal/polyvinyl butyral resin or polyvinylpyrrolidone; Described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
Describedly be used for conglutinant sodium humate external preparation and make water-soluble type ointment,, comprise that 0.1～20% sodium humate, 40～99% is water-soluble type ointment base in mass fraction, 0.01～5% antiseptic, surplus is a water.
The mixture of the Polyethylene Glycol that described water-soluble type ointment base is a liquid and mixture, glycerol and the gelatin of solid Polyethylene Glycol or the mixture of soluble starch and glycerol, described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
Describedly be used for conglutinant sodium humate external preparation and make the grease type ointment,, comprise that 0.1～20% sodium humate, surplus is oil ointment base in mass fraction;
Described grease type ointment base is the mixture that vaseline and lanoline are formed.
Describedly be used for conglutinant sodium humate external preparation and make emulsion-type ointment, in mass fraction, comprise the antiseptic of 0.1～20% sodium humate, 0.1～10% emulsifying agent, 1～20% wetting agent and 0.01～5% and 20～70% oil phase substance, all the other are water;
Described oil phase substance is vaseline, lanoline, paraffin, hexadecanol, octadecanol, Cera Flava, spermaceti, stearic acid or vegetable oil; Described emulsifying agent is the polyol ester or the polyoxyethylene ether derivant of soap class, fatty acid sulfate, fatty acid sodium sulfate, higher fatty acids, and described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
Described soap class is a triethanolamine, fatty acid sodium sulfate is sodium lauryl sulphate, the polyol ester of higher fatty acids is hexadecanol, octadecanol, tristerin, stearic acid Pyrusussuriensis alcohol or polysorbate, and described polyoxyethylene ether derivant is paregal O, polyoxyethylene nonylphenol ether.
Compared with prior art, the present invention has following beneficial technical effects:
Sodium humate external preparation fixture provided by the invention has stronger antiinflammatory, and exudation promotes blood capillary regeneration, increases effects such as collagenation, can significantly shorten wound healing time, promotes wound healing, and safety, and is non-stimulated.
The present invention has enlarged the range of application of sodium humate at field of medicaments, filled up the blank of sodium humate external preparation, and can be made into multiple different exterior-applied formulation (making gel, membrane, liniment, ointment), the gained preparation has that composition is clear and definite relatively, onset rapidly, characteristics such as stable in properties, quality control be accurate, convenient clinical and patient selects to use.
Sodium humate external preparation provided by the invention is fit to wound healing promoting, if wound has pus to use after evacuation of pus, easy to use, there is not twinge when smearing or applying, especially suitable area is big, wound is darker or in irregular shape smearing, and need not remove after the wound healing, exempted the misery of tearing that the patient often need bear.
Medicine involved in the present invention is natural component, and is cheap and easy to get, nontoxic nonirritant, and safety is good; Provide a kind of external preparation that promotes wound healing safely and effectively for clinical.
The specific embodiment
Below in conjunction with the embodiment of concrete exterior-applied formulation preparation and promote the checking of wound healing the present invention is described in further detail that the explanation of the invention is not limited.
Be used for conglutinant sodium humate external preparation, add gel, membrane, liniment or the ointment that pharmaceutic adjuvant is made by sodium humate; In mass fraction, the content of sodium humate is 0.1～20%.
Gel-type vehicle is a main adjuvant of making gel, gel-type vehicle is carbomer, cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), sodium alginate, chitosan, cross linked sodium polyacrylate, or other suitable gel substrate; Use wetting agent, antiseptic, wetting agent is selected glycerol, propylene glycol, sorbitol for use, and antiseptic is parabens (methyl ester, ethyl ester, propyl ester, butyl ester), benzoic acid/sodium benzoate or benzalkonium bromide, uses or do not use the pH regulator agent.
The preparation of embodiment 1 gel
Getting the 1g carbomer is sprinkled in the 60ml purified water, after treating its natural swelling, add the 1g sodium humate that is dissolved in the 10ml purified water, and 5ml glycerol, 0.1g ethyl hydroxybenzoate, constantly stir the triethanolamine that drips 2g down, add purified water to 100g, continue to be stirred to coagulate brownish black to black paste, packing is promptly.
The preparation of embodiment 2 gels
Get the 5g sodium carboxymethyl cellulose and be sprinkled in the 60ml purified water, treat its natural swelling after, add the 1g sodium humate be dissolved in the 10ml purified water, and 5ml glycerol, 0.1g ethyl hydroxybenzoate, add purified water to 100g, continue to be stirred to coagulate brownish black to black paste, packing is promptly.
The preparation of embodiment 3 gels
Get the 10g chitosan and be sprinkled in the 60ml purified water, treat its natural swelling after, add the 0.5g sodium humate be dissolved in the 10ml purified water, and 5ml propylene glycol, 0.1g sodium benzoate, add purified water to 100g, continue to be stirred to coagulate brownish black to black paste, packing is promptly.
The preparation of embodiment 4 gels
Get the 10g sodium alginate and be sprinkled in the 60ml purified water, treat its natural swelling after, add the 2g sodium humate be dissolved in the 10ml purified water, and 5ml sorbitol, 0.1g methyl hydroxybenzoate, add purified water to 100g, continue to be stirred to coagulate brownish black to black paste, packing is promptly.
Described membrane substrate or be coated with membrane matrix and be: polyvinyl alcohol, ethylene/vinyl acetate copolymer, hydroxypropyl cellulose/hydroxypropyl emthylcellulose or polyvinylpyrrolidone, or other suitable membrane substrate; Use wetting agent and antiseptic.
The preparation of embodiment 5 membrane
Get the 10g polyvinyl alcohol, add the 60ml purified water, stir after the swelling heating for dissolving in 90 ℃ of water-baths, filter, add the 1g sodium humate, 5g glycerol, the 0.1g ethyl hydroxybenzoate that are dissolved in the 10ml purified water, add purified water to 100g, film after stirring, drying, the cut packing is promptly.
The preparation of embodiment 6 membrane
Get the 1.5g sodium carboxymethyl cellulose, the 5g polyvinylpyrrolidone swells in respectively in the 30ml purified water, mix the back and add 0.2g sodium humate, 5g sorbitol, the 0.1g propylparaben that is dissolved in the 10ml purified water, add purified water, film after stirring to 100g, drying, the cut packing promptly.
The preparation of embodiment 7 membrane
Get the 1.5g hydroxypropyl emthylcellulose and swell in the 60ml purified water, mix the back and add 2g sodium humate, 5g glycerol, the 0.1g ethyl hydroxybenzoate that is dissolved in the 10ml purified water, add purified water, film after stirring to 100g, drying, the cut packing is promptly.
The preparation of embodiment 8 liniment
Get the 10g polyvinyl alcohol, be sprinkled in the 60ml purified water, placement is spent the night, after treating its natural swelling, heating for dissolving in the water-bath is filtered, add the 1g sodium humate, 5g glycerol, the 0.1g ethyl hydroxybenzoate that are dissolved in the 10ml purified water, add purified water, stir evenly the back packing promptly to 100g.
The preparation of embodiment 9 liniment
Get 5g acrylic resin polyvinyl alcohol, be sprinkled in the 60ml purified water, placement is spent the night, after treating its natural swelling, heating for dissolving in the water-bath is filtered, add the 0.5g sodium humate, 5g propylene glycol, the 0.1g benzalkonium bromide that are dissolved in the 10ml purified water, add purified water, stir evenly the back packing promptly to 100g.
The preparation of embodiment 10 liniment
Get the 5g sodium carboxymethyl cellulose, be sprinkled in the 50ml purified water, placement is spent the night, after treating its natural swelling, heating for dissolving in the water-bath is filtered, add the 2g sodium humate, 5g propylene glycol, the 0.1g Buddhist nun that are dissolved in the 10ml purified water and moor butyl ester, add purified water, stir evenly the back packing promptly to 100g.
The preparation of embodiment 11 water-soluble type ointment
Get the 1g sodium humate and be dissolved in the 10ml purified water, add in the substrate that 88.9g is made up of PEG400 (liquid) and Macrogol 4000 weight (1: 1) such as (solids), add the 0.1g sodium benzoate again, stir packing afterwards promptly.
Solid polyethylene glycol can also be Polyethylene Glycol 3350 or Macrogol 4000.
The preparation of embodiment 12 water-soluble type ointment
Get the 2g sodium humate and be dissolved in the 10ml purified water, add in the substrate that 87.9g is made up of weight such as glycerol and gelatin (1: 1), add the 0.1g methyl hydroxybenzoate again, stir the back packing promptly.
The preparation of embodiment 13 water-soluble type ointment
Get the 0.1g sodium humate and be dissolved in the 10ml purified water, add in the substrate that 89.8g is made up of soluble starch and glycerol (1: 2), add the 0.1g methyl hydroxybenzoate again, stir the back packing promptly.
The preparation of embodiment 14 grease type ointment
Get the 1g sodium humate and be ground into impalpable powder, after adding 10g vaseline grinds well, add remaining vaseline again, stir the back packing promptly to 100g.
The preparation of embodiment 15 grease type ointment
Get the 2g sodium humate and be ground into impalpable powder, after adding 10g vaseline grinds well, add 5g lanoline and remaining vaseline, stir the back packing promptly to 100g.
Emulsion-type ointment be with oil material, emulsifying agent mixes with aqueous phase substance and get, its medium oil item material comprises vaseline, lanoline, paraffin, hexadecanol, octadecanol, Cera Flava, spermaceti, stearic acid or vegetable oil; Described emulsifying agent is soap class (as triethanolamine), fatty acid sulphuric acid (ester) sodium class (as sodium lauryl sulphate), higher fatty acids and polyhydric alcohol esters (as hexadecanol, octadecanol, tristerin, stearic acid Pyrusussuriensis alcohol, polysorbate etc.), polyoxyethylene ether derivant (as paregal O, polyoxyethylene nonylphenol ether etc.).
Embodiment 16 emulsion-type ointment
Get 12g vaseline, 7g glyceryl monostearate, 10g stearic acid, 10g liquid paraffin, heating is molten into oil phase for 60～90 ℃; Other gets 1g sodium humate, 12g glycerol, 1g sodium lauryl sulphate, 0.1g ethyl hydroxybenzoate and is dissolved in the 47ml purified water, is heated to 60～90 ℃ and is water.Water is slowly poured in the oil phase, and the limit edged stirs to coagulating, and packing promptly.
Embodiment 17 emulsion-type ointment
Get 15g hexadecanol, 10g Cera Flava, the heating of 20g stearic acid is molten into oil phase for 60～90 ℃; Other gets 0.5g sodium humate, 12g propylene glycol, 1g triethanolamine, 0.1g ethyl hydroxybenzoate and is dissolved in the 47ml purified water, is heated to 60～90 ℃ and is water.Water is slowly poured in the oil item, and the limit edged stirs to coagulating, and packing promptly.
Embodiment 18 emulsion-type ointment
Get 5g lanoline, 15g spermaceti, the heating of 20g stearic acid is molten into oil phase for 60～90 ℃; Other gets 2g sodium humate, 12g sorbitol, 1g stearic acid Pyrusussuriensis alcohol, 1g paregal O, 0.1g ethyl hydroxybenzoate and is dissolved in the 60ml purified water, is heated to 60～90 ℃ and is water.Water is slowly poured in the oil item, and the limit edged stirs to coagulating, and packing promptly.
Describe the promotion wound healing effect of sodium humate below in detail:
Get 36 of SD rats, 6 of the wound surface of the about 1.5cm of diameter are manufactured in anesthesia back with special card punch in the back same area, the circular holostrome excision of skin, hemostasis, form the mechanical damage animal model, be divided into blank group, negative control group, positive controls, three dosed administration groups of sodium humate (0.5%, 1%, 2%) preparation at random, 6 every group.Blank is organized not administration, and positive controls (bEGF spraying) is sprayed at every turn, three the each partial smearing administration of dosage group 500ul of negative control group (normal saline) and sodium humate, and each is organized and sooner or later respectively is administered once every day, continues 14 days.
The result is specifically as shown in table 1, and blank group of postoperative 24 hours and negative group wound be moistening, transudate is arranged; The sodium humate group and the positive are formed face and a little blush occurred, show that granulation tissue is in growth.
Table 1 sodium humate is to rat skin healing rate and time relation
Compare * P＜0.05 with the blank group, #P＜0.05 is compared with negative group in * * P＜0.01
Postoperative 3 days, each is organized all the newborn epidermis tongue and the infiltration of inflammatory cell under the blood crusts, a small amount of FB cell occurs.Blank group and feminine gender are formed some red and swollen and a little transudate of face; Each group of sodium humate and the positive are organized the granulation tissue growth obviously, and the part has grown thin layer or some columnar epithelium, and the edge of wound contraction of skin is obvious.The healing rate of each dosage group of sodium humate is apparently higher than blank and negative group (P＜0.05), the wherein healing rate of 2% sodium humate group the highest (P＜0.01).HE dyeing shows respectively to organize all the newborn epidermis tongue and the infiltration of inflammatory cell under the blood crusts, a small amount of FB cell occurs; Sodium humate group and positive group inflammatory cell are less.
Postoperative 6 days: blank group and negative group wound are moistening, and exudate is arranged, and shrink not obviously, and rarely seen thin layer granulation is not seen significantly epithelize newly; Sodium humate group and positive group wound drying, nothing infect, and wound surface is filled by granulation tissue substantially.The healing rate of each dosage group of sodium humate is apparently higher than blank and negative group (P＜0.01), and middle and high dosage group is apparently higher than low dose group and positive group (P＜0.05).HE dyeing shows that blank group and negative group present stronger inflammatory reaction, and epidermal area is thin, and the FB cell is dispersed in; Sodium humate group and the newborn epidermis of positive group obviously thicken, and the obvious hypertrophy of granulation tissue, intradermal see that little blood vessel grows into and find a large amount of FB cells.
9 days blank groups of postoperative are slowly grown with negative group granulation tissue, and wound surface skin begins to shrink; Each group of sodium humate and the positive are formed face knot kermesinus crust.The healing rate of each dosage group of sodium humate is apparently higher than blank and negative group (P＜0.01), and middle and high dosage group is apparently higher than low dose group and positive group (P＜0.05).HE dyeing shows that the FB cell is bred in a large number in each group tissue, and new capillary vessel is more, and each organizes the collagen arrangement disorder; Blank group and negative group still have the inflammatory infiltration phenomenon, and flap coverage and hierarchy are not obvious fully as yet for epidermal area; Sodium humate group and positive group inflammatory infiltration are not obvious, and epidermal area heals substantially and has tangible hierarchy.
14 days blank groups of postoperative begin incrustation with negative group; The positive organizes and administration group crust partly comes off and cicatrix is obvious.The healing rate of each group of sodium humate and positive group is apparently higher than blank and negative group (P＜0.05), and middle and high dosage group is apparently higher than low dose group and positive group (P＜0.05).HE dyes, and the FB cell is respectively organized in demonstration and blood capillary is less, and blank group and feminine gender are organized inflammatory cell and reduced, and FB is more, forms the skin lamination structure, but newborn collagen arrangement disorder; Sodium humate group and positive group FB cell obviously reduce and newborn collagen marshalling, and cell differentiation is obvious, wound healing.
Postoperative was respectively formed face in 21 days and is healed substantially, and blank group and negative group cicatrix are obviously and take on a red color; The cicatrix zone of sodium humate group and positive group reduces and is yellowish pink.HE dyeing shows that respectively forming face heals substantially, and inflammatory cell disappears substantially, and FB cell and blood capillary are less.Blank group and feminine gender are formed face and are covered by newborn epidermis fully, but the cell of epidermal area also is relatively immature, and the collagen fiber of skin corium are tiny, arrangement disorder; Sodium humate group and positive group epidermal area are near normal cell, and each layer differentiation is obvious, and cell is asked a large amount of collagen, and it is thicker that collagen fiber become at this moment, arranges in order.
Untoward reaction: compare with matched group, the sodium humate administration group of various dose there is no the generation of untoward reaction such as redness, stimulation, allergy significantly.
Above result shows:
1, sodium humate can obviously alleviate the wound surface inflammatory reaction, reduce and ooze out, and shortens wound healing time.Wherein 1%, 2% sodium humate promotes the wound healing effect significantly better than 0.5% sodium humate.
2, sodium humate can obviously alleviate inflammatory reaction, reduces inflammatory exudation, increases wound blood capillary quantity, promotes growth of fibroblasts and collagen deposition.
3, sodium humate topical application safety does not have tangible untoward reaction.
Claims (8)
1. one kind is used for conglutinant sodium humate external preparation, it is characterized in that, is to add gel, membrane, liniment or the ointment that pharmaceutic adjuvant is made by sodium humate; In mass fraction, the content of sodium humate is 0.1～20%.
2. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make gel, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% gel-type vehicle, 1～20% wetting agent, 0.01～5% antiseptic and 0%～5% pH regulator agent, surplus is a water;
Described gel-type vehicle is carbomer, cellulose derivative, sodium alginate, chitosan or cross linked sodium polyacrylate; Described wetting agent is glycerol, propylene glycol or sorbitol; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide; Described pH regulator agent is triethanolamine, sodium hydroxide or Borax.
3. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make membrane, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% membrane substrate, 1～20% wetting agent and 0.01～5% antiseptic, surplus is a water;
Described membrane substrate is polyvinyl alcohol, ethylene copolymer, acetate ethylene copolymer, hydroxypropyl cellulose, hydroxypropyl emthylcellulose or polyvinylpyrrolidone; Described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
4. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make liniment, in mass fraction, comprise 0.1～20% sodium humate, 0.5～20% liniment substrate, 1～20% wetting agent and 0.01～5% antiseptic, surplus is a water;
Described liniment substrate is polyvinyl alcohol, chitosan, sodium alginate, sodium carboxymethyl cellulose, carbomer, acrylic resin polyvinyl alcohol, polyvinyl formal-acetal/polyvinyl butyral resin or polyvinylpyrrolidone; Described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
5. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make water-soluble type ointment, in mass fraction, comprise that 0.1～20% sodium humate, 40～99% is water-soluble type ointment base, 0.01～5% antiseptic, surplus are water.
The mixture of the Polyethylene Glycol that described water-soluble type ointment base is a liquid and mixture, glycerol and the gelatin of solid Polyethylene Glycol or the mixture of soluble starch and glycerol, described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
6. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make the grease type ointment,, comprise that 0.1～20% sodium humate, surplus is oil ointment base in mass fraction;
Described grease type ointment base is the mixture that vaseline and lanoline are formed.
7. as claimed in claim 1ly be used for conglutinant sodium humate external preparation, it is characterized in that, describedly be used for conglutinant sodium humate external preparation and make emulsion-type ointment, in mass fraction, comprise the antiseptic of 0.1～20% sodium humate, 0.1～10% emulsifying agent, 1～20% wetting agent and 0.01～5% and 20～70% oil phase substance, all the other are water;
Described oil phase substance is vaseline, lanoline, paraffin, hexadecanol, octadecanol, Cera Flava, spermaceti, stearic acid or vegetable oil; Described emulsifying agent is the polyol ester or the polyoxyethylene ether derivant of soap class, fatty acid sulfate, fatty acid sodium sulfate, higher fatty acids, and described wetting agent is glycerol, propylene glycol, sorbitol or diethyl phthalate; Described antiseptic is Nipagin ester, sodium benzoate or benzalkonium bromide.
8. as claimed in claim 7ly be used for conglutinant sodium humate external preparation, it is characterized in that, described soap class is a triethanolamine, fatty acid sodium sulfate is sodium lauryl sulphate, the polyol ester of higher fatty acids is hexadecanol, octadecanol, tristerin, stearic acid Pyrusussuriensis alcohol or polysorbate, and described polyoxyethylene ether derivant is paregal O, polyoxyethylene nonylphenol ether.
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| CN109804849A (en) * | 2019-02-01 | 2019-05-28 | 浙江省林业科学研究院 | A kind of ornamental Chinese tallow tree method for cultivating seedlings of polychrome leaf |
| CN110615958A (en) * | 2019-08-16 | 2019-12-27 | 山东森工新材料科技有限公司 | Humic acid composite gel material and preparation method thereof |
| CN112641708A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Formula and preparation method of humic acid essence for promoting wound healing |
| CN114230810A (en) * | 2021-10-22 | 2022-03-25 | 汉中聚智达远环能科技有限公司 | Antibacterial biodegradable intelligent response hydrogel and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918059A (en) * | 1987-03-12 | 1990-04-17 | Rutgerswerke Ag | Low molecular weight alkali metal huminates, method for their preparation and applications thereof |
| CN1144094A (en) * | 1994-08-31 | 1997-03-05 | 陶燃 | Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy |
-
2011
- 2011-06-15 CN CN2011101601134A patent/CN102225072A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918059A (en) * | 1987-03-12 | 1990-04-17 | Rutgerswerke Ag | Low molecular weight alkali metal huminates, method for their preparation and applications thereof |
| CN1144094A (en) * | 1994-08-31 | 1997-03-05 | 陶燃 | Membrane agent drug made of sodium fulvate and/or berberine for curing gynecopathy |
Non-Patent Citations (2)
| Title |
|---|
| 《江西腐植酸》 19821231 何深义 等 腐植酸钠治疗烧烫伤116例临床观察与体会 60-62 1-8 , 第1期 * |
| 《白求恩医科大学学报》 19971231 陈霞 等 黄腐酸钠抗炎作用的初步研究 361-362 1-8 第23卷, 第4期 * |
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| CN102406959A (en) * | 2011-11-29 | 2012-04-11 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN106139240A (en) * | 2016-07-29 | 2016-11-23 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of the Wound-protection liquid for treating skin ulcer |
| CN107041893A (en) * | 2016-11-21 | 2017-08-15 | 深圳市用必法生物科技有限公司 | A kind of phytic acid mixture and burn-treating liquid |
| CN109804849A (en) * | 2019-02-01 | 2019-05-28 | 浙江省林业科学研究院 | A kind of ornamental Chinese tallow tree method for cultivating seedlings of polychrome leaf |
| CN110615958A (en) * | 2019-08-16 | 2019-12-27 | 山东森工新材料科技有限公司 | Humic acid composite gel material and preparation method thereof |
| CN112641708A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Formula and preparation method of humic acid essence for promoting wound healing |
| CN114230810A (en) * | 2021-10-22 | 2022-03-25 | 汉中聚智达远环能科技有限公司 | Antibacterial biodegradable intelligent response hydrogel and preparation method thereof |
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