CN114404333B - 一种具有祛痘功效的洁面慕斯及其制备方法和应用 - Google Patents
一种具有祛痘功效的洁面慕斯及其制备方法和应用 Download PDFInfo
- Publication number
- CN114404333B CN114404333B CN202210083324.0A CN202210083324A CN114404333B CN 114404333 B CN114404333 B CN 114404333B CN 202210083324 A CN202210083324 A CN 202210083324A CN 114404333 B CN114404333 B CN 114404333B
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- face
- acne
- azelaic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 24
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 23
- 241000195940 Bryophyta Species 0.000 title claims abstract description 22
- 235000011929 mousse Nutrition 0.000 title claims abstract description 22
- 230000000694 effects Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000004140 cleaning Methods 0.000 title abstract description 13
- BDJRBEYXGGNYIS-UHFFFAOYSA-N azelaic acid group Chemical group C(CCCCCCCC(=O)O)(=O)O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims abstract description 60
- 150000002148 esters Chemical class 0.000 claims abstract description 19
- 229940119170 jojoba wax Drugs 0.000 claims abstract description 10
- 239000004006 olive oil Substances 0.000 claims abstract description 10
- 235000008390 olive oil Nutrition 0.000 claims abstract description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 239000000284 extract Substances 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 14
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 14
- 230000001815 facial effect Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 claims description 7
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 7
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 claims description 7
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 7
- 241001278898 Glycyrrhiza inflata Species 0.000 claims description 7
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 7
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 7
- 241000246044 Sophora flavescens Species 0.000 claims description 7
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 7
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 7
- 229940101267 panthenol Drugs 0.000 claims description 7
- 235000020957 pantothenol Nutrition 0.000 claims description 7
- 239000011619 pantothenol Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229940079779 disodium cocoyl glutamate Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 241000202807 Glycyrrhiza Species 0.000 claims description 4
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 4
- 229940010454 licorice Drugs 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims description 4
- NSIZXNCOZHAEQN-UHFFFAOYSA-L C(C)(=O)[O-].C(C)(=O)O.C(C)(=O)O.C(C)(=O)[O-].C(C(=O)O)(=O)O.[Na+].[Na+] Chemical compound C(C)(=O)[O-].C(C)(=O)O.C(C)(=O)O.C(C)(=O)[O-].C(C(=O)O)(=O)O.[Na+].[Na+] NSIZXNCOZHAEQN-UHFFFAOYSA-L 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000686 essence Substances 0.000 claims 2
- 230000003255 anti-acne Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 206010040880 Skin irritation Diseases 0.000 abstract description 7
- 230000036556 skin irritation Effects 0.000 abstract description 7
- 231100000475 skin irritation Toxicity 0.000 abstract description 7
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 5
- 239000000654 additive Substances 0.000 abstract description 3
- 230000008021 deposition Effects 0.000 abstract description 3
- 125000004185 ester group Chemical group 0.000 abstract description 3
- 230000003020 moisturizing effect Effects 0.000 abstract description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 206010046865 Vaccinia virus infection Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000007089 vaccinia Diseases 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- -1 hydroxypropyl Chemical group 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003837 chick embryo Anatomy 0.000 description 1
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种具有祛痘功效的洁面慕斯及其制备方法和应用，本发明用羟丙基‑β‑环糊精包裹壬二酸，在提高壬二酸溶解度的同时显著降低了壬二酸的皮肤刺激性，并使得溶液澄清透明，羟丙基‑β‑环糊精含有羟丙基，使得壬二酸能够残留于皮肤表面，在清洗面部后残留于面部皮肤的壬二酸能够继续发挥抗炎功效。霍霍巴蜡PEG‑120酯类和橄榄油PEG‑7酯类含有酯基，具有润肤功效的同时降低了产品的皮肤刺激性，并利于壬二酸和活性添加物的沉积，添加的活性物组分具有辅助抗炎活性，与壬二酸共同发挥祛痘功效。
Description
技术领域
本发明属于洁面产品技术领域，具体涉及一种具有祛痘功效的洁面慕斯及其制备方法和应用。
背景技术
洁面产品在化妆品中属于一大品类，占护肤品市场的20 %以上，目前国内市场洁面产品种类繁多，洁面产品日益受到消费者和生产厂家的重视，人们对洁面产品的要求也越来越高，洁面产品配方开发也显得越来越重要。洁面慕斯让丰富的泡沫能直接从泵口挤出，配方简单，免增稠，表活浓度较低，温和，清爽无残留，适合各种皮肤类型和各种季节使用。
壬二酸是一种有机化合物，分子式为C9H16O4，外观为白色至微黄色单斜棱晶、针状结晶或粉末，是一种针对易生粉刺、痘痘的油性肌肤，快速去除粉刺、暗疮、痘痘，解决青春痘反复发作问题，并收紧毛孔，消除痘印，是最新一代的祛痘产品组分，但是壬二酸对皮肤有一定的刺激作用，并且溶解度较低，因此其应用受到限制。
发明内容
本部分的目的在于概述本发明的实施例的一些方面以及简要介绍一些较佳实施例。在本部分以及本申请的说明书摘要和发明名称中可能会做些简化或省略以避免使本部分、说明书摘要和发明名称的目的模糊，而这种简化或省略不能用于限制本发明的范围。
本发明提供一种具有祛痘功效的洁面慕斯，其特征在于：由以下组分组成：乙二酸四乙酸二钠0.01~0.1份、甲基葡糖醇聚醚-20 0.2~4份、甘油 0.2~5份、霍霍巴蜡 PEG-120酯类0.05~0.5份、丁二醇0.2~5份、椰油酰谷氨酸二钠1~5份、月桂基羟基磺基甜菜碱1~4份、月桂酰两性基乙酸钠1~3份、1,2-己二醇0.1~1份、对羟基苯乙酮0.1~1份、苦参（SOPHORAANGUSTIFOLIA）根提取物 0.002~0.05份、胀果甘草（GLYCYRRHIZA INFLATA）根提取物0.002~0.05份、黄芩（SCUTELLARIA BAICALENSIS）根提取物 0.002~0.05份、泛醇 0.1~1份、羟丙基-β-环糊精 2~12份、壬二酸0.9~1.5份、橄榄油 PEG-7 酯类 0.3~0.8份、水 余量至100份。
作为本发明所述的具有祛痘功效的洁面慕斯的一种优选方案：还包括，柠檬酸0.3~0.6份。
作为本发明所述的具有祛痘功效的洁面慕斯的一种优选方案：还包括，香精 0.01~0.1份。
作为本发明所述的具有祛痘功效的洁面慕斯的一种优选方案：由以下组分组成：乙二酸四乙酸二钠0.03~0.06份、甲基葡糖醇聚醚-20 0.8~1.2份、甘油0.8~1.2份、霍霍巴蜡 PEG-120 酯类0.2~0.3份、丁二醇0.6~1.2份、椰油酰谷氨酸二钠2~4份、月桂基羟基磺基甜菜碱2~3份、月桂酰两性基乙酸钠2.97份、1,2-己二醇0.4~0.6份、对羟基苯乙酮0.4~0.6份、苦参（SOPHORA ANGUSTIFOLIA）根提取物 0.01~0.02份、胀果甘草（GLYCYRRHIZAINFLATA）根提取物 0.01~0.02份、黄芩（SCUTELLARIA BAICALENSIS）根提取物 0.01~0.03份、泛醇0.4~0.6份、羟丙基-β-环糊精7~10份、壬二酸1~1.2份、橄榄油 PEG-7 酯类 0.4~0.6份、香精 0.04~0.06份、柠檬酸 0.3~0.5份、水 余量至100份。
作为本发明所述的具有祛痘功效的洁面慕斯的一种优选方案：由以下组分组成：乙二酸四乙酸二钠0.05份、甲基葡糖醇聚醚-20 1份、甘油1份、霍霍巴蜡 PEG-120 酯类0.25份、丁二醇1份、椰油酰谷氨酸二钠 3份、月桂基羟基磺基甜菜碱2.4份、月桂酰两性基乙酸钠2.97份、1,2-己二醇0.5份、对羟基苯乙酮0.5份、苦参（SOPHORA ANGUSTIFOLIA）根提取物 0.015份、胀果甘草（GLYCYRRHIZA INFLATA）根提取物 0.015份、黄芩（SCUTELLARIABAICALENSIS）根提取物 0.02份、泛醇0.5份、羟丙基-β-环糊精8份、壬二酸1份、橄榄油PEG-7 酯类 0.5份、香精 0.05份、柠檬酸 0.4份、水 余量至100份。
作为本发明的另一个方面，本发明还提供制备所述的具有祛痘功效的洁面慕斯的方法：将羟丙基-β-环糊精和壬二酸混合，加入到10~25份水中，加热到60~65℃搅拌混合均匀，备用。室温下依次加入水、乙二酸四乙酸二钠、甲基葡糖醇聚醚-20、甘油、霍霍巴蜡PEG-120 酯类、丁二醇、椰油酰谷氨酸二钠、月桂基羟基磺基甜菜碱、月桂酰两性基乙酸钠、1,2-己二醇、对羟基苯乙酮、苦参（SOPHORA ANGUSTIFOLIA）根提取物、胀果甘草（GLYCYRRHIZA INFLATA）根提取物、黄芩（SCUTELLARIA BAICALENSIS）根提取物、泛醇、橄榄油 PEG-7 酯类、羟丙基-β-环糊精和壬二酸的混合物，混合均匀。
优选的，还包括，加入柠檬酸、香精。
作为本发明的另一个方面，本发明还提供所述的具有祛痘功效的洁面慕斯在制备洁面产品中的应用。
本发明的有益效果：本发明用羟丙基-β-环糊精包裹壬二酸，在提高壬二酸溶解度的同时显著降低了壬二酸的皮肤刺激性，并使得溶液澄清透明，羟丙基-β-环糊精含有羟丙基，使得壬二酸能够残留于皮肤表面，在清洗面部后残留于面部皮肤的壬二酸能够继续发挥抗炎功效。霍霍巴蜡 PEG-120 酯类和橄榄油 PEG-7 酯类含有酯基，具有润肤功效的同时降低了产品的皮肤刺激性，并利于壬二酸和活性添加物的沉积，添加的活性物组分具有辅助抗炎活性，与壬二酸共同发挥祛痘功效。
具体实施方式
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合具体实施例对本发明的具体实施方式做详细的说明。
实施例1：
洁面慕斯配方如下：
制备方法：将羟丙基-β-环糊精和壬二酸混合，加入到20份水中，加热到60℃搅拌混合均匀，备用。室温下依次加入水、乙二酸四乙酸二钠、甲基葡糖醇聚醚-20、甘油、霍霍巴蜡 PEG-120 酯类、丁二醇、椰油酰谷氨酸二钠、月桂基羟基磺基甜菜碱、月桂酰两性基乙酸钠、1,2-己二醇、对羟基苯乙酮、苦参（SOPHORA ANGUSTIFOLIA）根提取物、胀果甘草（GLYCYRRHIZA INFLATA）根提取物、黄芩（SCUTELLARIA BAICALENSIS）根提取物、泛醇、橄榄油 PEG-7 酯类、（日用）香精、羟丙基-β-环糊精和壬二酸的混合物、柠檬酸，混合均匀。
实施例2：
洁面慕斯配方如下：
制备方法同实施例1。
实施例3：
洁面慕斯配方如下：
制备方法同实施例1。
对比例1：
洁面慕斯配方如下：
制备方法同实施例1。
对比例1由于直接添加的壬二酸难以溶解，因此溶液不澄清，并且壬二酸具有皮肤刺激性。
本发明测试结果：
使用部位：面部；
使用方法：取适量洁面慕斯清洗面部；
使用频率和周期：每天早晚各一次，连续使用10天；
受试者性别：女性；
受试者年龄：20-35岁；
受试者肤质要求：受试者为面部皮肤有粉刺者；
受试者人数：60名。
图像法测试：皮肤快速光学成像系统PRIMOS CR检测痘痘体积。
测得受试者脸部粉刺均值为14.2mm3，将受试者分为三组，每组受试者分别使用实施例1-3洁面慕斯清洗面部10天，测试使用前后的粉刺平均体积。
鸡胚绒毛尿囊膜实验测试洁面慕斯产品皮肤刺激性：
本发明用羟丙基-β-环糊精包裹壬二酸，在提高壬二酸溶解度的同时显著降低了壬二酸的皮肤刺激性，并使得溶液澄清透明，羟丙基-β-环糊精含有羟丙基，使得壬二酸能够残留于皮肤表面，在清洗面部后残留于面部皮肤的壬二酸能够继续发挥抗炎功效。霍霍巴蜡 PEG-120 酯类和橄榄油 PEG-7 酯类含有酯基，具有润肤功效的同时降低了产品的皮肤刺激性，并利于壬二酸和活性添加物的沉积，添加的活性物组分具有辅助抗炎活性，与壬二酸共同发挥祛痘功效。
应说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的精神和范围，其均应涵盖在本发明的权利要求范围当中。
Claims (3)
1.一种具有祛痘功效的洁面慕斯，其特征在于：以重量份数计，由以下组分组成：乙二酸四乙酸二钠0.05份、甲基葡糖醇聚醚-20 1份、甘油1份、霍霍巴蜡 PEG-120 酯类0.25份、丁二醇1份、椰油酰谷氨酸二钠 3份、月桂基羟基磺基甜菜碱2.4份、月桂酰两性基乙酸钠2.97份、1,2-己二醇0.5份、对羟基苯乙酮0.5份、苦参（SOPHORA ANGUSTIFOLIA）根提取物0.015份、胀果甘草（GLYCYRRHIZA INFLATA）根提取物 0.015份、黄芩（SCUTELLARIABAICALENSIS）根提取物 0.02份、泛醇0.5份、羟丙基-β-环糊精 8份、壬二酸1份、橄榄油PEG-7 酯类 0.5份、香精 0.05份、柠檬酸 0.4份、水 余量至100份。
2.制备权利要求1所述的具有祛痘功效的洁面慕斯的方法，其特征在于：将羟丙基-β-环糊精和壬二酸混合，加入到10~25份水中，加热到60~65℃搅拌混合均匀，备用，室温下依次加入水、乙二酸四乙酸二钠、甲基葡糖醇聚醚-20、甘油、霍霍巴蜡 PEG-120 酯类、丁二醇、椰油酰谷氨酸二钠、月桂基羟基磺基甜菜碱、月桂酰两性基乙酸钠、1,2-己二醇、对羟基苯乙酮、苦参（SOPHORA ANGUSTIFOLIA）根提取物、胀果甘草（GLYCYRRHIZA INFLATA）根提取物、黄芩（SCUTELLARIA BAICALENSIS）根提取物、泛醇、橄榄油 PEG-7 酯类、羟丙基-β-环糊精和壬二酸的混合物、香精、柠檬酸，混合均匀。
3.权利要求1所述的具有祛痘功效的洁面慕斯在制备洁面产品中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210083324.0A CN114404333B (zh) | 2022-01-25 | 2022-01-25 | 一种具有祛痘功效的洁面慕斯及其制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210083324.0A CN114404333B (zh) | 2022-01-25 | 2022-01-25 | 一种具有祛痘功效的洁面慕斯及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114404333A CN114404333A (zh) | 2022-04-29 |
| CN114404333B true CN114404333B (zh) | 2024-03-29 |
Family
ID=81278222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210083324.0A Active CN114404333B (zh) | 2022-01-25 | 2022-01-25 | 一种具有祛痘功效的洁面慕斯及其制备方法和应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114404333B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117567764A (zh) * | 2023-11-20 | 2024-02-20 | 无锡知妍生物科技有限公司 | 一种壬二酸/甜菜碱/泛醇自识别des体系及制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080086229A (ko) * | 2007-03-22 | 2008-09-25 | 한국콜마 주식회사 | 아젤라산을 이용한 여드름 치료용 화장료 조성물 및 그 제조방법 |
| CN108785122A (zh) * | 2018-06-28 | 2018-11-13 | 武汉百思凯瑞生物科技有限公司 | 一种祛痘共输送纳米组合物及其制备方法和应用 |
| CN108852948A (zh) * | 2018-09-19 | 2018-11-23 | 李燕 | 一种中药祛痘精华液及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150119427A1 (en) * | 2008-06-17 | 2015-04-30 | Epikinetics Pharma, LLC | Waterborne topical compositions for the delivery of azelaic acid for treatment of skin conditions such as acne vulgaris, rosacea, seborrheic dermatitis |
-
2022
- 2022-01-25 CN CN202210083324.0A patent/CN114404333B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080086229A (ko) * | 2007-03-22 | 2008-09-25 | 한국콜마 주식회사 | 아젤라산을 이용한 여드름 치료용 화장료 조성물 및 그 제조방법 |
| CN108785122A (zh) * | 2018-06-28 | 2018-11-13 | 武汉百思凯瑞生物科技有限公司 | 一种祛痘共输送纳米组合物及其制备方法和应用 |
| CN108852948A (zh) * | 2018-09-19 | 2018-11-23 | 李燕 | 一种中药祛痘精华液及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114404333A (zh) | 2022-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105796424B (zh) | 一种祛痘组合物及其在化妆品中的应用 | |
| CN110123659B (zh) | 一种防脱发组合物及其在制备防脱发洗护产品中的应用 | |
| CN114404333B (zh) | 一种具有祛痘功效的洁面慕斯及其制备方法和应用 | |
| WO2006064974A1 (ja) | 美白用皮膚外用剤、美白剤、美白方法および美白用皮膚外用剤の製造方法 | |
| CN110772435A (zh) | 一种去屑洗发水及其制备方法 | |
| CN110236967B (zh) | 一种祛痘凝胶 | |
| CN106236676B (zh) | 一种具有抗衰老功效的植物组合物及其应用 | |
| CN112022783A (zh) | 一种防脱生发精华液及其制作方法 | |
| CN114588060A (zh) | 一种具有祛痘功效的美白保湿面膜及其制备方法 | |
| KR102029078B1 (ko) | 새로운 올리고당 화합물 및 이의 미용학적 용도 | |
| JP4027949B2 (ja) | 養毛剤 | |
| CN112494376A (zh) | 一种汉方洗发水及其制备方法 | |
| CN110882172B (zh) | 一种含丹皮酚多效护发洗发液及其制备方法 | |
| JP3435181B2 (ja) | メラニン生成抑制外用剤 | |
| CN114569531A (zh) | 一种清凉型面膜用修复基液及其制备方法 | |
| CN109125205A (zh) | 一种抗衰老精华液及其制备方法 | |
| CN115040441A (zh) | 一种含铁皮石斛发酵物的组合物及精华液的制备方法 | |
| CN114306189A (zh) | 一种护发洗发配方及其制备方法 | |
| JP3908245B2 (ja) | 養毛剤 | |
| CN114533643A (zh) | 一种保湿精华彩珠隔离产品 | |
| CN112156152A (zh) | 一种中药祛痘乳膏的制备方法 | |
| CN113413345A (zh) | 一种牡丹润颜滋养精华液及其制备方法 | |
| CN109833237A (zh) | 一种含有黑果枸杞提取物的化妆品组合物及精华乳 | |
| CN113520930A (zh) | 一种控油滋养洗发水及其制备方法 | |
| CN113069377A (zh) | 一种抗衰老面霜及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |