CN114404329A - Seabuckthorn anti-aging composition and preparation method thereof - Google Patents
Seabuckthorn anti-aging composition and preparation method thereof Download PDFInfo
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- CN114404329A CN114404329A CN202111567348.5A CN202111567348A CN114404329A CN 114404329 A CN114404329 A CN 114404329A CN 202111567348 A CN202111567348 A CN 202111567348A CN 114404329 A CN114404329 A CN 114404329A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
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- Gerontology & Geriatric Medicine (AREA)
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Abstract
The invention discloses a seabuckthorn anti-aging composition and a preparation method thereof, wherein the seabuckthorn anti-aging composition is prepared from the following preparation raw materials: seabuckthorn total flavone extract, jojoba oil, pomegranate seed oil, tea seed oil, glycerol, cetostearyl alcohol, carbomer, guar gum, triethanolamine, cetostearyl-21, cetostearyl-2, butylated hydroxytoluene, methylparaben, propylparaben, and deionized water. The anti-aging functional components are synergistic, so that the anti-aging function of the cream is enhanced, the skin can be deeply moistened, the water is locked and the moisture is kept, the penetration is promoted, and meanwhile, the light fruity fragrance is added, so that the product is more easily accepted.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a seabuckthorn anti-aging composition and a preparation method thereof.
Background
Skin aging means progressive functional and organic degenerative changes over time, and macroscopically manifested as dry face, dandruff, dryness, sagging, wrinkles, color spots, and the like. With the improvement of the skin care consciousness of people, people pay more and more attention to finding a method for resisting aging, and anti-aging cosmetics are more and more favored. The cosmetics containing natural active ingredients have good efficacy, small side effect and higher safety, and the research and development of the natural active ingredients applied to the cosmetics become an important link for sustainable development of the cosmetic industry.
The flavonoids (flavanoids) are phenolic compounds widely existing in various natural plants, have wide pharmacological activity and remarkable anti-oxidation and anti-aging effects. The seabuckthorn fruit contains rich seabuckthorn flavone which has the functions of removing free radicals, resisting oxidation, reducing the oxidative damage of organism tissues and inhibiting apoptosis so as to resist aging. The anti-aging effect of sea buckthorn is of great concern, various related researches are in endlessly, and various related health care products and food and beverage are continuously developed to respond to the market demands. However, the seabuckthorn facial cream is not well developed, and although the existing seabuckthorn facial cream is proved to have good skin care effect through efficacy verification, the formula is old, the skin feel is poor, and the requirements of modern people on facial cream cosmetics are not met. The seabuckthorn anti-aging composition disclosed by the invention is strong in efficacy, high in safety, good in skin feel and appearance and high in stability, and more conforms to the concept of modern cosmetics.
Disclosure of Invention
The purpose of the invention is as follows: the invention provides a seabuckthorn anti-aging composition and a preparation method thereof, and the prepared seabuckthorn anti-aging composition has good anti-aging effect and good safety.
The technical scheme is as follows: in order to solve the technical problems, the technical scheme adopted by the invention is as follows: the seabuckthorn anti-aging composition comprises the following preparation raw materials in parts by weight: 1-10% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.5-3% of jojoba oil, 0.1-1% of pomegranate seed oil, 1-5% of tea seed oil, 5-10% of glycerol, 1-3% of cetearyl alcohol, 0.3-0.6% of carbomer, 0.3-0.6% of guar gum, 0.1-0.3% of triethanolamine, 0-211-3% of ceteareth-211, 20.1-0.6% of ceteareth-20.1, 0.01-0.1% of butylated hydroxytoluene, 0.05-0.2% of methylparaben, 0.05-0.2% of propylhydroxybenzoate and the balance of deionized water.
Further, the preparation raw materials are calculated by weight as follows: 1.5-6% of total flavonoids extract of seabuckthorn (calculated by total flavonoids extract grape seed oil solution of seabuckthorn), 0.8-2% of jojoba oil, 0.1-0.4% of pomegranate seed oil, 1.5-4% of tea seed oil, 5-7% of glycerol, 1-2% of cetearyl alcohol, 0.3-0.4% of carbomer, 0.3-0.4% of guar gum, 0.1-0.2% of triethanolamine, 211-1.5% of cetearyl polyether, 20.2-0.4% of cetearyl polyether, 0.02-0.08% of butylated hydroxytoluene, 0.1-0.15% of methylparaben, 0.05-0.1% of propylhydroxybenzoate and the balance of deionized water. A
Further, the preparation raw materials are calculated by weight as follows: 2% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.8% of jojoba oil, 0.4% of pomegranate seed oil, 3% of tea seed oil, 5% of glycerol, 1.5% of cetearyl alcohol, 0.3% of carbomer, 0.3% of guar gum, 0.2% of triethanolamine, 0-211% of ceteareth-211%, 20.3% of ceteareth-20.3%, 0.03% of butylated hydroxytoluene, 0.15% of methylparaben, 0.07% of propylparaben and the balance of deionized water.
Furthermore, the preparation method of the seabuckthorn total flavone extract comprises the following steps: weighing crushed sea buckthorn fruits, leaching with 95% ethanol for three times, combining leaching liquor, concentrating at 50-55 ℃ to dryness, extracting twice with petroleum ether, concentrating the extraction liquor at 50-55 ℃ until no solvent exists, and dissolving with grape seed oil.
Furthermore, the leaching time of leaching three times with 95% ethanol is 15min each time, and the dosage of the 95% ethanol is 3 times of the weight ratio, 3 times of the weight ratio and 2 times of the weight ratio respectively; the dosage of the petroleum ether extraction twice is respectively 4 times of the weight ratio and 3 times of the weight ratio; the dissolving amount of the grape seed oil is 10 times of the weight ratio.
Furthermore, the deionized water has the conductivity of less than 20 mu s/cm, the resistivity of more than 1M omega cm and the hardness (as CaCO)3Calculated) is less than 5 ppm.
Furthermore, the raw materials for the preparation are all chemically or analytically pure, such as glycerin, cetearyl alcohol, carbomer, guar gum, ceteareth-21%, ceteareth-2, butylated hydroxytoluene, methylparaben and propylparaben.
The invention also discloses a preparation method of the seabuckthorn anti-aging composition, which comprises the following steps: adding carbomer, guar gum and glycerol into water, fully stirring and dissolving, heating to 80-85 ℃ for swelling, adding triethanolamine to adjust the pH value of the solution to 5.5-6, then adding cetostearyl alcohol, cetostearyl polyether-21, cetostearyl polyether-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for fully emulsifying, cooling to 40-45 ℃ under a stirring state after emulsification, adding butylated hydroxytoluene, methyl hydroxybenzoate, propylhydroxybenzoate and total flavonoids of sea buckthorn, supplementing evaporated deionized water, stirring uniformly and filling to obtain the sea buckthorn anti-aging composition.
Furthermore, the stirring speed of adding carbomer, guar gum and glycerin into water for fully stirring and dissolving is 1500-30000 r/min, and the stirring time is 1-5 h.
Furthermore, the stirring time for full emulsification is 0.5-1 h.
The components of the seabuckthorn anti-aging composition and the effect profile thereof are as follows:
the hydroxyl radical is the most active and most toxic radical, can react with any molecule in living cells to trigger histiocytosis, cause various diseases and body aging, and has very high reaction speed. The flavonoid antioxidation is to interrupt the chain reaction by forming resonance stable half-roll type free radicals through the reaction of phenolic hydroxyl and free radicals; in the redox reaction in organisms, approximately 2% -5% of oxygen can generate superoxide anion free radicals which are the free radicals with the longest life in organisms, and the superoxide anion free radicals are generally used as initiators of free radical chain reaction to generate hydroxyl free radicals with stronger activity, so that the organisms are further harmed, and the research shows that the surface seabuckthorn flavone also has strong inhibition effect on the superoxide anion free radicals. By inhibiting the two free radicals, the seabuckthorn flavone shows good anti-aging effect when being applied to cosmetics.
The jojoba oil has good skin-friendly property and strong skin penetration capability, can quickly penetrate from the stratum corneum to the dermis, and can increase the elasticity of the skin by 37% after about 30 minutes. The jojoba oil has good moisture retention, can form a stable lipid layer on skin when added into skin care products, greatly reduces the evaporation loss of skin moisture, and can effectively reduce wrinkles of facial skin through the test determination of moisture retention efficiency. The jojoba oil contains abundant monounsaturated fatty acid, vitamin A, B, E, and various phenolic antioxidant substances, and can resist the generation of facial fine wrinkles and prevent skin aging.
Experiments show that: the pomegranate seed oil with the content of 0.5-4 mg/mL has remarkable scavenging capacity for superoxide anion free radicals, and the scavenging capacity for the free radicals is improved along with the increase of the content of the pomegranate seed oil; and it has protective effect on DNA and protein, and the damage of DNA and protein is macroscopically expressed on human body as various diseases or body aging. The addition of pomegranate seed oil can improve the vitality of facial skin and resist aging.
The tea seed oil belongs to one of natural oil, has high moisturizing degree and thick skin feel, has the greatest effect of improving skin texture except the moisturizing effect, and can effectively relieve skin aging, improve fine wrinkles and other phenomena by compounding the rose oil and some anti-aging and wrinkle-removing components. The anti-aging functional components are mutually cooperated, so that the anti-aging function of the cream is enhanced, the skin can be deeply moistened, the water is locked and the moisture is kept, the penetration is promoted, and meanwhile, the slight fruity fragrance is added, so that the product is more easily accepted.
Has the advantages that: compared with the prior art, the invention has the following advantages:
(1) the prepared seabuckthorn anti-aging composition has good anti-aging effect and high product safety.
(2) Effectively resist the generation of facial fine wrinkles, improve the vitality of facial skin and prevent skin aging.
(3) The combination of several anti-aging functional components can resist aging from different mechanisms, so that the effects are diversified. The anti-aging function of the cream is enhanced, the skin can be deeply moistened, the water is locked and the moisture is kept, the penetration is promoted, and meanwhile, the light fruity fragrance is added, so that the product is more easily accepted.
Drawings
Fig. 1 is a graph showing the results of the skin elasticity test.
Detailed Description
The present invention will be described in further detail with reference to the following examples:
the preparation method of the seabuckthorn total flavone extract used in the examples and the comparative examples is as follows:
weighing a certain mass of crushed sea buckthorn fruits, leaching the crushed sea buckthorn fruits for three times with 95% ethanol, wherein the dosage of the 95% ethanol is 3 times of the weight ratio, 3 times of the weight ratio and 2 times of the weight ratio, combining leaching solutions, concentrating the leaching solutions to be dry at 50 ℃, extracting the leaching solutions twice with petroleum ether respectively at 4 times of the weight ratio and 3 times of the weight ratio, concentrating the extraction solution at 50 ℃ until no solvent exists, and dissolving the extraction solution with 10 times of the weight ratio of grape seed oil.
Examples and comparative examples used deionized water having a conductivity of less than 20 μ s/cm, a resistivity of greater than 1M Ω & cm, and hardness (as CaCO)3Calculated) is less than 5 ppm. Other preparation raw materials are all chemical pure or analytically pure.
Example 1:
a seabuckthorn anti-aging composition comprises the following components in percentage by weight: 1% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.5% of jojoba oil, 0.1% of pomegranate seed oil, 1% of tea seed oil, 5% of glycerol, 1% of cetearyl alcohol, 0.3% of carbomer, 0.3% of guar gum, 0.1% of triethanolamine, 0.211% of ceteareth, 20.1% of ceteareth, 0.01% of butylated hydroxytoluene, 0.05% of methylparaben, 0.05% of propylhydroxybenzoate and the balance of deionized water.
The preparation method comprises the following steps: adding carbomer, guar gum and glycerol into water, stirring for 5 hours at a stirring speed of 1500r/min, fully dissolving, heating to 85 ℃, fully swelling, adding triethanolamine to adjust the pH of the solution to be between 5.5 and 6, adding cetearyl alcohol, ceteareth-21, ceteareth-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for 30 minutes to fully emulsify, cooling to 40 ℃, adding butylated hydroxytoluene, methyl hydroxybenzoate, propyl hydroxybenzoate and seabuckthorn total flavone extract (calculated on the seabuckthorn total flavone extract grape seed oil solution), supplementing evaporated deionized water, stirring uniformly and filling to obtain the seabuckthorn anti-aging composition.
Example 2:
a seabuckthorn anti-aging composition comprises the following components in percentage by weight: 10% of total flavonoids extract of seabuckthorn (calculated by total flavonoids extract grape seed oil solution of seabuckthorn), 3% of jojoba oil, 1% of pomegranate seed oil, 5% of tea seed oil, 10% of glycerol, 3% of cetearyl alcohol, 0.6% of carbomer, 0.6% of guar gum, 0.3% of triethanolamine, -213% of ceteareth, 20.6% of ceteareth, 0.1% of butylated hydroxytoluene, 0.2% of methylparaben, 0.2% of propylparaben and the balance of deionized water.
The preparation method comprises the following steps: adding carbomer, guar gum and glycerol into water, stirring for 1h at a stirring speed of 30000r/min to fully dissolve the carbomer, heating to 85 ℃ to fully swell the carbomer, adding triethanolamine to adjust the pH of the solution to be between 5.5 and 6, adding cetearyl alcohol, ceteareth-21, ceteareth-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for 30min to fully emulsify the carbomer, guar gum and glycerol, cooling to 45 ℃, adding butylated hydroxytoluene, methylparaben, propylparaben and a seabuckthorn total flavone extract (calculated by a seabuckthorn total flavone extract grape seed oil solution), supplementing evaporated deionized water, stirring uniformly and filling to obtain the seabuckthorn anti-aging composition.
Example 3:
a seabuckthorn anti-aging composition comprises the following components in percentage by weight: 1.5 percent of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.8 percent of jojoba oil, 0.1 percent of pomegranate seed oil, 1.5 percent of tea seed oil, 5 percent of glycerol, 1 percent of cetearyl alcohol, 0.3 percent of carbomer, 0.3 percent of guar gum, 0.1 percent of triethanolamine, 0.211 percent of ceteareth-211 percent, 20.2 percent of ceteareth-20.2 percent, 0.02 percent of butylated hydroxytoluene, 0.1 percent of methyl hydroxybenzoate, 0.05 percent of propylhydroxybenzoate and the balance of deionized water.
The preparation method comprises the following steps: adding carbomer, guar gum and glycerol into water, stirring at a stirring speed of 6000r/min for 2 hours to fully dissolve the carbomer, heating to 85 ℃ to fully swell the carbomer, adding triethanolamine to adjust the pH value of the solution to be between 5.5 and 6, adding cetearyl alcohol, ceteareth-21, ceteareth-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for 30 minutes to fully emulsify the carbomer, guar gum and glycerol, cooling to 40 ℃, adding butylated hydroxytoluene, methylparaben, propylparaben and seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), supplementing evaporated deionized water, stirring uniformly and filling to obtain the seabuckthorn anti-aging composition.
Example 4:
a seabuckthorn anti-aging composition comprises the following components in percentage by weight: the sea buckthorn fruit oil comprises 6% of sea buckthorn total flavone extract (calculated by a sea buckthorn total flavone extract grape seed oil solution), 2% of jojoba oil, 04% of pomegranate seed oil, 4% of tea seed oil, 7% of glycerol, 2% of cetearyl alcohol, 0.4% of carbomer, 0.4% of guar gum, 0.2% of triethanolamine, 211.5% of ceteareth, 20.4% of ceteareth, 0.08% of butylated hydroxytoluene, 0.15% of methylparaben, 0.1% of propylhydroxybenzoate and the balance of deionized water.
The preparation method comprises the following steps: adding carbomer, guar gum and glycerol into water, stirring at a stirring speed of 20000r/min for 1.5 hours to fully dissolve the carbomer, heating to 85 ℃ to fully swell the carbomer, adding triethanolamine to adjust the pH of the solution to be between 5.5 and 6, adding cetostearyl alcohol, cetostearyl polyether-21, cetostearyl polyether-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for 30 minutes to fully emulsify the carbomer, guar gum and the glycerol, cooling to 45 ℃, adding butylated hydroxytoluene, methylparaben, propylparaben and a seabuckthorn total flavone extract (calculated on the seabuckthorn total flavone extract grape seed oil solution), supplementing evaporated deionized water, stirring uniformly and filling to obtain the seabuckthorn anti-aging composition.
Example 5:
a seabuckthorn anti-aging composition comprises the following components in percentage by weight: 2% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.8% of jojoba oil, 0.4% of pomegranate seed oil, 3% of tea seed oil, 5% of glycerol, 1.5% of cetearyl alcohol, 0.3% of carbomer, 0.3% of guar gum, 0.2% of triethanolamine, 0-211% of ceteareth-211%, 20.3% of ceteareth-20.3%, 0.03% of butylated hydroxytoluene, 0.15% of methylparaben, 0.07% of propylparaben and the balance of deionized water.
The preparation method comprises the following steps: adding carbomer, guar gum and glycerol into water, stirring for 3h at a stirring speed of 15000r/min to fully dissolve the carbomer, heating to 85 ℃ to fully swell the carbomer, adding triethanolamine to adjust the pH value of the solution to be between 5.5 and 6, adding cetearyl alcohol, ceteareth-21, ceteareth-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for 30min to fully emulsify the carbomer, guar gum and glycerol, cooling to 42 ℃, adding butylated hydroxytoluene, methylparaben, propylparaben and a seabuckthorn total flavone extract (calculated by a seabuckthorn total flavone extract grape seed oil solution), supplementing evaporated deionized water, stirring uniformly and filling to obtain the seabuckthorn anti-aging composition.
Comparative example 1:
a seabuckthorn anti-aging composition has the same formula proportion and preparation method as example 5, except that the formula does not contain seabuckthorn total flavone extract.
Comparative example 2:
a seabuckthorn anti-aging composition is prepared in the same manner as in example 5 except that jojoba oil in the composition is replaced by vaseline.
Comparative example 3:
a seabuckthorn anti-aging composition has the same formula proportion and preparation method as example 5, except that the pomegranate seed oil in the formula is replaced by the same amount of vaseline.
Comparative example 4:
a seabuckthorn anti-aging composition has the same formula proportion and preparation method as example 5, except that the tea seed oil not contained in the formula is replaced by the same amount of vaseline.
The safety test and the anti-aging effect test were performed on the seabuckthorn anti-aging compositions of examples 1 to 5 and comparative examples 1 to 4, and the test procedures and results were as follows:
1) spot plaster safety test
The test sample was 30 persons, and a patch tester manufactured by Beijing Baiyida scientific and technological development Co. The test method comprises the following steps: the protective paper of the patch tester was removed, 25 micrograms of cream was placed in an aluminum patch tester, the patch tester was applied to the normal skin on both sides of the upper back spine, firmly and flatly applied and lightly pressed with the palm of the hand to remove air. The test time was 48 hours, after 48 hours the patch tester was removed and the test results were observed and collected within 30 minutes. Table 1 shows the result judgment criteria. Table 2 shows the statistics of the test results.
Table 1: criteria for determination of results ICDRG
| (Code) | Name of Chinese | Skin manifestation |
| — | No reaction | — |
| ？ | Suspicious reactions | Only faint (unclear) erythema |
| + | Weak (blister-free) positive reaction | Erythema, infiltrates, possibly Small rashes |
| ++ | Strong (blister) positive reaction | Erythema, infiltrates, papules, non-small pimples |
| +++ | Extreme positive reaction | Red and swollen with bulla |
| IR | Different types of stimulatory responses | — |
| NT | Not tested | — |
Table 2: statistics of test results
As shown in the test results of Table 2, the safety of 9 cases of the seabuckthorn anti-aging composition prepared by the invention is good, and no serious adverse reaction occurs on the skin.
2) Evaluation test of radical scavenging Effect
The creams of examples 1-5 and comparative examples 1-4 of the present invention were prepared into 4mg/mL sample solutions with PBS, and mixed well with 1mL methanol solution and 1mL DPPH radical methanol solution (2X 10-4mol/L), respectively, after standing for 30min, absorbance at 517nm was measured with a spectrophotometer, and the radical scavenging ratio was calculated with the formula. Radical clearance (%) [ (Ac-As/Ac) ] × 100%, As: the absorbance of a sample containing an object to be detected at 517 nm; ac: and substituting the measured absorbance into a free radical clearance rate formula to calculate the free radical clearance rate, wherein the higher the free radical clearance rate is, the better the anti-aging effect of the cream is represented.
The results of the radical scavenging rate (%) of the creams of examples 1 to 5 of the present invention and comparative examples 1 to 4 are shown in Table 3.
Table 3: radical scavenging ratio (%)
| Test article | Free radical scavenging rate |
| Example 1 | 86.7％ |
| Example 2 | 88.6％ |
| Example 3 | 93.5％ |
| Example 4 | 90.4％ |
| Example 5 | 97.6％ |
| Comparative example 1 | 68.2％ |
| Comparative example 2 | 75.3％ |
| Comparative example 3 | 62.8％ |
| Comparative example 4 | 59.1％ |
As can be seen from table 3, the addition of one or more of the total flavonoids of hippophae rhamnoides, jojoba oil, pomegranate seed oil and tea seed oil to the cream can produce the effect of scavenging free radicals and resisting aging, but the effect of scavenging free radicals and resisting aging is not strong while the addition of the total flavonoids of hippophae rhamnoides, jojoba oil, pomegranate seed oil and tea seed oil to the cream has the same effect, and the effect of scavenging free radicals and resisting aging is significantly improved. The component proportion of the compound in the invention is the best case, wherein the efficiency of scavenging free radicals and resisting aging of the compound in the embodiment 5 is the highest.
3) Anti-aging test on actual human skin
The detection sample is 300 persons, the face is cleaned by using clean water at fixed time in the morning and at fixed time in the evening, a proper amount (1-3mg) of the facial cream prepared in the embodiment 5 of the invention is uniformly smeared on the skin of the face, the facial cream is gently massaged until the facial cream is completely absorbed, and the test time is 12 weeks. Detecting the elasticity parameters of the skin at the 4 th week, the 8 th week and the 12 th week respectively after the skin is used, averaging the elasticity parameters, wherein the instrument for detecting the elasticity parameters of the skin is an MPA580 type skin elasticity tester produced by CK company of Germany, R2 is selected as an index of the skin elasticity, R2 is the ratio of the rebound quantity of the skin when the skin is not stressed to the maximum stretching quantity when the skin is stressed, and the closer to 1R 2, the better the elasticity of the skin is; the instrument used for detecting the skin roughness parameter is a Visoline VL650 skin wrinkle tester produced by CK company in Germany, R3 is selected as an index of the skin roughness, R3 is the average value of the difference value of the highest point and the lowest point in N sections of tested skin, and the smaller R3, the smaller the skin roughness, the less wrinkles on the face and the younger and smoother the skin.
The results of the tests are shown in fig. 1, R2 and R3 have a tendency to decrease and increase respectively after 4 weeks of use, indicating a slight decrease in the elasticity of the skin and a small increase in roughness after 4 weeks of use compared to the skin before use, but after continued use R2 and R3 continuously increase and decrease at 8 and 12 weeks, and the values of R2 and R3 are respectively significantly greater and less than the initial values, indicating a significant increase in the elasticity of the skin after 12 weeks of use and a degree of smoothness significantly greater than before 12 weeks.
4) Quality evaluation of sea-buckthorn anti-aging composition
The cream prepared in the embodiment 5 of the invention is comprehensively evaluated according to glossiness, fineness, spreadability, centrifugal stability, cold resistance stability and heat resistance stability, and twenty individuals are respectively found for scoring. (score 10, score 6 or more, score 7 or more, and excellent score 8 or more) the results are shown in Table 4.
Table 4: example 5 average score of Each index and evaluation results of Hippophae rhamnoides anti-aging composition
As can be seen from Table 4, the average scores and evaluation results of various indexes of the seabuckthorn anti-aging composition prepared by the invention are as follows: the sea-buckthorn anti-aging composition prepared by the invention has excellent glossiness, fineness, spreadability, standing stability, cold resistance stability and heat resistance stability.
It should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will be able to modify the invention in its various equivalent forms after reading the present disclosure without departing from the scope of the invention as defined by the appended claims.
Claims (10)
1. The seabuckthorn anti-aging composition is characterized by comprising the following preparation raw materials in parts by weight: 1-10% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.5-3% of jojoba oil, 0.1-1% of pomegranate seed oil, 1-5% of tea seed oil, 5-10% of glycerol, 1-3% of cetearyl alcohol, 0.3-0.6% of carbomer, 0.3-0.6% of guar gum, 0.1-0.3% of triethanolamine, 0-211-3% of ceteareth-211, 20.1-0.6% of ceteareth-20.1, 0.01-0.1% of butylated hydroxytoluene, 0.05-0.2% of methylparaben, 0.05-0.2% of propylhydroxybenzoate and the balance of deionized water.
2. The seabuckthorn anti-aging composition according to claim 1, comprising the following preparation raw materials by weight: 1.5-6% of total flavonoids extract of seabuckthorn (calculated by total flavonoids extract grape seed oil solution of seabuckthorn), 0.8-2% of jojoba oil, 0.1-0.4% of pomegranate seed oil, 1.5-4% of tea seed oil, 5-7% of glycerol, 1-2% of cetearyl alcohol, 0.3-0.4% of carbomer, 0.3-0.4% of guar gum, 0.1-0.2% of triethanolamine, 211-1.5% of cetearyl polyether, 20.2-0.4% of cetearyl polyether, 0.02-0.08% of butylated hydroxytoluene, 0.1-0.15% of methylparaben, 0.05-0.1% of propylhydroxybenzoate and the balance of deionized water.
3. The seabuckthorn anti-aging composition according to claim 1, comprising the following preparation raw materials by weight: 2% of seabuckthorn total flavone extract (calculated by seabuckthorn total flavone extract grape seed oil solution), 0.8% of jojoba oil, 0.4% of pomegranate seed oil, 3% of tea seed oil, 5% of glycerol, 1.5% of cetearyl alcohol, 0.3% of carbomer, 0.3% of guar gum, 0.2% of triethanolamine, 0-211% of ceteareth-211%, 20.3% of ceteareth-20.3%, 0.03% of butylated hydroxytoluene, 0.15% of methylparaben, 0.07% of propylparaben and the balance of deionized water.
4. The seabuckthorn anti-aging composition according to any one of claims 1 to 3, wherein: the preparation method of the seabuckthorn total flavone extract comprises the following steps: weighing crushed sea buckthorn fruits, leaching with 95% ethanol for three times, combining leaching liquor, concentrating at 50-55 ℃ to dryness, extracting twice with petroleum ether, concentrating the extraction liquor at 50-55 ℃ until no solvent exists, and dissolving with grape seed oil.
5. The seabuckthorn anti-aging composition according to claim 4, wherein: the leaching time of leaching three times with 95% ethanol is 15min each time, and the dosage of 95% ethanol is 3 times of the weight ratio, 3 times of the weight ratio and 2 times of the weight ratio respectively; the dosage of the petroleum ether extraction twice is respectively 4 times of the weight ratio and 3 times of the weight ratio; the dissolving amount of the grape seed oil is 10 times of the weight ratio.
6. The seabuckthorn anti-aging composition according to any one of claims 1 to 3, wherein: the deionized water has conductivity less than 20 μ s/cm, resistivity greater than 1M omega cm, and hardness (as CaCO)3Calculated) is less than 5 ppm.
7. The anti-aging composition of hippophae rhamnoides according to any one of claims 1 to 3, wherein the raw materials used in the preparation are all chemically or analytically pure glycerol, cetearyl alcohol, carbomer, guar gum, ceteareth-21%, ceteareth-2, butylated hydroxytoluene, methylparaben, propylparaben.
8. A method of preparing the anti-aging composition of hippophae rhamnoides of claim 1, comprising the steps of: adding carbomer, guar gum and glycerol into water, fully stirring and dissolving, heating to 80-85 ℃ for swelling, adding triethanolamine to adjust the pH value of the solution to 5.5-6, then adding cetostearyl alcohol, cetostearyl polyether-21, cetostearyl polyether-2, jojoba oil, pomegranate seed oil and tea seed oil, stirring for fully emulsifying, cooling to 40-45 ℃ under a stirring state after emulsification, adding butylated hydroxytoluene, methyl hydroxybenzoate, propylhydroxybenzoate and total flavonoids of sea buckthorn, supplementing evaporated deionized water, stirring uniformly and filling to obtain the sea buckthorn anti-aging composition.
9. The method of preparing a seabuckthorn anti-aging composition according to claim 8, wherein: adding carbomer, guar gum and glycerol into water, fully stirring and dissolving at a stirring speed of 1500-30000 r/min for 1-5 h.
10. The method of preparing a seabuckthorn anti-aging composition according to claim 8, wherein: the stirring time for full emulsification is 0.5-1 h.
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| US20130095196A1 (en) * | 2011-10-17 | 2013-04-18 | Sherry May Raymond - Coblantz | Blended oil skin moisturizer and skin repairer |
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| CN108066168A (en) * | 2017-12-19 | 2018-05-25 | 浙江万里学院 | A kind of Isorhamnetin moisturizing whitening cream and preparation method thereof |
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