CN114392313A

CN114392313A - A Chinese medicinal oral liquid for expelling parasites, and its preparation method

Info

Publication number: CN114392313A
Application number: CN202210091929.4A
Authority: CN
Inventors: 胡依凡; 余东辉; 邱天宝; 李向阳; 胡洋
Original assignee: Yinghe Jiaozuo Traditional Chinese Medicine Bioengineering Co ltd
Current assignee: Yinghe Jiaozuo Traditional Chinese Medicine Bioengineering Co ltd
Priority date: 2022-01-26
Filing date: 2022-01-26
Publication date: 2022-04-26

Abstract

The invention discloses a traditional Chinese medicine oral liquid for expelling parasites and a production process thereof, belonging to the field of traditional Chinese medicines and comprising the following raw materials: 8-16 parts of betel nut, 4-10 parts of agrimony bud, 3-9 parts of stone-like omphalia, 2-8 parts of cortex meliae, 3-9 parts of carpesium, 5-10 parts of torreya grandiflorum, 6-13 parts of rangooncreeper fruit, 2-6 parts of cyrtomium rhizome, 3-5 parts of elecampane, 6-12 parts of pumpkin seed, 4-9 parts of dark plum fruit, 1-7 parts of golden cypress, 2-6 parts of Chinese pulsatilla root, 6-12 parts of pomegranate bark, 4-8 parts of negundo chastetree root and 3-9 parts of aloe. The invention selects natural Chinese herbal medicines, has no toxic and side effects and has good insect expelling effect.

Description

A Chinese medicinal oral liquid for expelling parasites, and its preparation method

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine oral liquid for expelling parasites and a production process thereof.

Background

Anthelmintics are drugs that kill or expel parasites in the intestinal tract. Such drugs are mainly used for diseases caused by intestinal parasites (e.g., roundworms, tapeworms, hookworms, pinworms, etc.), and the drugs can be selected according to the type of parasite. The anthelmintic can be administered to paralyze or kill the insect body, so that the insect is discharged out of the body and can be cured radically. With the development of animal husbandry and the improvement of living standard of people, the quality requirements of people on animal food are higher and higher, and the requirements on drug residue, sanitary quality and the like are higher.

Animal parasitic diseases are generally treated by adopting chemically synthesized medicines, namely western medicines, and after administration, residual substances of the medicines are left on organisms, so that meat products and human health are affected. The traditional Chinese medicine has little toxicity and side effect, weak drug property, but lasting drug effect, more comprehensive effect and no residue in the body. In addition, the production process of antibiotics and chemical synthesizers is complex, the production cost is high, serious environmental pollution is caused, the traditional Chinese medicine is natural, most of the traditional Chinese medicine is wild, the source is wide, the cost is low, the preparation process is simple, and the traditional Chinese medicine is convenient to store and is not easy to deteriorate. The common traditional Chinese medicine has slower drug effect and is not convenient to take

Gastrointestinal disease is one of the major factors affecting the development, growth and physical condition of young animals. In addition, infection of tapeworm, roundworm, hookworm and other intestinal parasites is also the most common disease in the animal kingdom, which seriously affects the normal growth and physical condition of animals, and general traditional Chinese medicines have slow drug action and are not convenient to take, so that the development of a safe and effective drug for expelling parasites is an urgent technical problem to be solved at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine oral liquid for expelling parasites and a production process thereof, which are used for solving the problems in the prior art, and all natural Chinese herbal medicines are selected, so that the traditional Chinese medicine oral liquid has no toxic or side effect and good parasite expelling effect.

In order to achieve the purpose, the invention provides the following scheme:

the invention provides a traditional Chinese medicine oral liquid for expelling parasites, which is prepared from the following raw material medicines in parts by weight:

8-16 parts of betel nut, 4-10 parts of agrimony bud, 3-9 parts of stone-like omphalia, 2-8 parts of cortex meliae, 3-9 parts of carpesium, 5-10 parts of torreya grandiflorum, 6-13 parts of rangooncreeper fruit, 2-6 parts of cyrtomium rhizome, 3-5 parts of elecampane, 6-12 parts of pumpkin seed, 4-9 parts of dark plum fruit, 1-7 parts of golden cypress, 2-6 parts of Chinese pulsatilla root, 6-12 parts of pomegranate bark, 4-8 parts of negundo chastetree root and 3-9 parts of aloe.

Further, the raw material medicines are in parts by weight as follows:

10-14 parts of betel nut, 6-8 parts of agrimony bud, 5-7 parts of stone-like omphalia, 4-6 parts of cortex meliae, 4-7 parts of carpesium, 6-8 parts of torreya grandiflorum, 8-11 parts of rangooncreeper fruit, 3-5 parts of cyrtomium rhizome, 3-5 parts of elecampane, 7-10 parts of pumpkin seed, 5-8 parts of dark plum fruit, 2-5 parts of golden cypress, 3-5 parts of Chinese pulsatilla root, 7-10 parts of pomegranate bark, 5-7 parts of negundo chastetree root and 4-7 parts of aloe.

Furthermore, the raw material medicines are as follows in parts by weight:

12 parts of betel nut, 7 parts of agrimony bud, 6 parts of Omphalia, 5 parts of chinaberry bark, 5 parts of carpesium, 7 parts of Chinese torreya seed, 10 parts of rangooncreeper fruit, 4 parts of cyrtomium rhizome, 4 parts of costustoot, 8 parts of pumpkin seed, 6 parts of dark plum fruit, 3 parts of amur corktree bark, 4 parts of Chinese pulsatilla root, 8 parts of pomegranate bark, 6 parts of negundo chastetree root and 5 parts of aloe.

The invention also provides a production process of the traditional Chinese medicine oral liquid, which comprises the following steps:

(1) weighing the areca, the agrimony bud, the stone-like omphalia, the chinaberry bark, the carpesium, the Chinese torreya seed, the rangooncreeper fruit, the cyrtomium rhizome, the elecampane, the pumpkin seed, the dark plum fruit, the amur corktree bark, the Chinese pulsatilla root, the pomegranate bark, the negundo chastetree root and the aloe according to the weight part ratio, and soaking in water;

(2) adding water into the raw materials soaked in the step (1) for decoction, filtering, and collecting filtrate and filter residues;

(3) adding water into the filter residue obtained in the step (2) for decoction, filtering and collecting filtrate;

(4) and (3) mixing the filtrates collected in the steps (2) and (3), centrifuging, collecting supernate, and concentrating to obtain the compound.

Further, the temperature of the water for soaking in the step (1) is normal temperature, and the soaking time is 20-40 min.

Furthermore, the mass of the water added in the step (2) and the step (3) is 8-10 times of the total weight of the raw materials.

Further, the step (2) is carried out by boiling with strong fire and then slowly decocting with slow fire for 20-40 min.

Further, the step (3) is carried out by boiling with strong fire and then slowly decocting with slow fire for 30-50 min.

Further, the centrifugation in the step (4) is performed for 10-15min at the rotation speed of 15000-.

Further, the step (4) is concentrated to a relative density of 1.00-1.20.

The invention is based on the pathogenesis of traditional Chinese medicine and the theory of nature, flavor and channel tropism. The traditional Chinese medicine disclosed by the invention is bitter and cold in nature and mostly enters lung, stomach and kidney channels, and has the effects of clearing heat and removing toxicity, cooling blood, promoting the production of body fluid and quenching thirst. Wherein, the components are as follows:

betel nut, bitter, pungent and warm in nature and flavor, enters stomach and large intestine meridians, and has the following main functions: kill parasites, remove food retention, descend qi, promote diuresis and check malaria. Can be used for treating tapeworm, ascariasis, fasciolopsiasis, abdominal pain due to parasitic infestation, dysentery, tenesmus, edema, tinea pedis, and malaria. The Arecae semen contains alkaloid, condensed tannin, fat and Arecae semen red pigment. Arecoline in the alkaloids is an effective insect repellent ingredient.

The agrimony bud is bitter, astringent and mild in nature and taste, enters liver, small intestine and large intestine channels, and has the following main functions: and (4) expelling insects. Taenia disease is treated. The bud of Agrimonia pilosa contains agrimophol, agrimonol, apigenin, catechol, tannin, etc. Agrimophol is a phloroglucinol derivative which can be synthesized artificially at present and is an effective component for killing tapeworm.

Omphalia, bitter and cold in nature and flavor, enters stomach and large intestine channels, and mainly treats the following functions: remove food retention and kill parasites. It can be used for treating abdominal pain due to parasitic infestation, infantile malnutrition, and epilepsy. Water content, ash content, ether extract and alcohol extract. The main component is a protease called omphalin, which is an effective component for expelling tapeworm.

Ku Lian Pi, bitter and cold in nature, enters liver, spleen and stomach meridians. The functional indications are as follows: clear heat, dry dampness and kill parasites. It is indicated for ascaris, pinworm, rubella and scabies. The melia azedarach contains various bitter triterpenes, the main bitter component is margosine, and the margosine has the function of expelling ascaris.

The carpesium arvense, bitter in nature, pungent and mild in flavor, enters spleen, stomach and liver meridians and has the following main functions: killing parasites, clearing away heat and toxic material, and invigorating spleen and stomach. Contains lactone compounds such as valeric acid, n-hexanoic acid, oleic acid, D-linolenic acid, methylene, stigmasterol, carpesin lactone, and carpesin ketone. Contains volatile oil containing carpesin lactone and carpesin ketone; contains n-hexanoic acid, stigmasterol, triacontane and hentriacontane, etc. Radix Carpesii has anthelmintic effect.

The semen torreyae, sweet in nature and taste, is neutral and enters lung, stomach and large intestine channels, and has the main functions: kill parasites, remove food retention and moisten dryness. It can be used for treating abdominal pain due to parasitic infestation, infantile malnutrition, dry cough, constipation, and hemorrhoid. The fatty oil contains glyceride and sterol of palmitic acid, stearic acid, oleic acid and linoleic acid. It also contains oxalic acid, glucose, polysaccharide, volatile oil, tannin, etc.

Rangooncreeper fruit, sweet in nature and taste, warm in nature, and capable of entering spleen and stomach meridians, has the main functions: kill parasites, remove food retention and invigorate the spleen. It is indicated for abdominal pain due to ascarid, infantile malnutrition, food stagnation, abdominal distention, and dysentery. The main component contains potassium quisqualis and fatty oil. The oil contains oleic acid, palmitic acid, stearic acid, linoleic acid, myristic acid, arachidic acid, and sterol.

Cyrtomium fortunei, nature and taste: bitter and slightly cold, entering liver and stomach meridians, with functions: clear heat and dissipate blood stasis, remove toxicity and kill parasites. The main treatment is as follows: the fever is manifested by macula, hematemesis, epistaxis, metrorrhagia, hematochezia, dysentery with bloody stool, abdominal pain due to parasitic infestation, etc.

Radix aucklandiae is bitter, pungent and warm in nature and has the functions of entering spleen, large intestine and triple energizer meridians: move qi, alleviate pain, invigorate spleen and promote digestion. The main treatment is as follows: distending pain in the chest and abdomen, vomiting with diarrhea, tenesmus, dyspepsia. The main components are as follows: contains volatile oil, saussurea lappa base, resin, and inulin. The efficacy and the effect are as follows: move qi and regulate intestine to stop pain and diarrhea.

The pumpkin seeds are sweet and neutral in nature and taste, enter spleen and stomach meridians, and have the following effects: and (4) expelling insects. Chemical components: contains cucurbitine, fatty oil, protein, vitamins A, B1, B2, C, and carotene. The main component of the fatty oil is glyceride of linoleic acid, oleic acid, stearic acid, etc.

Dark plum, nature and taste: sour, astringent and warm, entering lung, spleen and large intestine meridians, with functions: astringe lung and intestines, produce fluid to relieve thirst, and relieve ascaris. The main treatment is as follows: chronic cough, chronic diarrhea, chronic dysentery, hematochezia, ascariasis, polydipsia, emesis, etc. The main components are as follows: contains citric acid, sterol black and oleanolic acid-like substance.

Huang Bai, bitter and cold in nature and entering kidney and bladder meridians. The functions are as follows: purging kidney fire, clearing damp-heat, and relieving sore-toxin. The main treatment is as follows: bone steaming, fatigue heat, night sweat, spermatorrhea, jaundice, anuresis, stranguria with turbid urine, and leukorrhagia. Swelling and pain of foot and knee, carbuncle, swelling, sore and ulcer. The main components are as follows: contains berberine, cortex Phellodendri and tung tree, phellodendron lactone, and dictamnolide.

Pulsatilla root, radix Pulsatillae, bitter and cold in nature, enters stomach and large intestine meridians. The functions are as follows: cool blood, clear heat and remove toxicity. The main treatment is as follows: dysentery due to heat and toxic materials, warm malaria, epistaxis, hemorrhoid hemorrhage, etc. Has special effect on amebic dysentery. Can inhibit the growth of amebic protozoa, and contains saponin as effective component. In addition, it has antifungal and antibacterial effects.

Pomegranate rind, sour, astringent and warm in nature and flavor, enters large intestine, lung and kidney meridians. The functions are as follows: chronic diarrhea and dysentery, hematochezia, rectocele, spermatorrhea, leucorrhea, abdominal pain due to parasitic infestation. The functional indications are as follows: astringe intestines, stop bleeding, expel parasites. The main components are as follows: contains tannin, mucus, and bitter.

The negundo chastetree roots, pungent and warm in nature and flavor, enter the shaoyin meridian of hand, and have the following main functions: relieving exterior syndrome, expelling wind-damp, regulating qi-flowing for relieving pain, checking malaria, expelling parasites. It is used to treat common cold, cough, asthma, rheumatism, stomachache, eruptive disease, abdominal pain, and malaria. Enterobiasis.

Aloe, bitter and cold in nature and flavor, enters liver, heart and spleen meridians, and has the following main functions: clear heat, relieve constipation and kill parasites. It is indicated for constipation due to heat accumulation, malnutrition heat, parasites accumulation, tinea, hemorrhoids and fistula, atrophic rhinitis, scrofula. The main components are as follows: barbaloin, isobarbaloin, resin, aloe-emodin. The efficacy and the effect are as follows: clear heat, cool liver, purge and kill parasites. In addition, it has bitter taste and stomach-invigorating effect.

The invention discloses the following technical effects:

the invention combines the sixteen ingredients, so that the drug effects of the raw materials are played together, and the effects of promoting digestion, removing food stagnation, regulating qi, tonifying spleen, warming middle-jiao, dispelling cold, breaking qi, widening intestines and expelling and treating gastrointestinal nematodes are synergistically realized, thereby achieving the purposes of treating digestive diseases of animals caused by various reasons, gastrointestinal type cold, expelling and treating intestinal parasites and other diseases in animals. The insect-expelling traditional Chinese medicine oral liquid has the characteristics of naturalness and no pollution, has no drug resistance, no harmful residue, small toxic and side effects and good insect-expelling effect when being used as a medicine in an animal body,

the Chinese medicinal composition contains alkaloid, glycosides, phenols, tannin, organic acid, polysaccharide, chlorogenic acid and other substances with the functions of sterilizing, resisting virus, expelling parasites and the like. Therefore, the traditional Chinese medicine composition for expelling the parasites from the animals not only can effectively expel and kill the parasites inside and outside the animals, but also provides certain nutrient substances for animal organisms. The Chinese herbal medicine for expelling parasites has multiple treatment functions, can expel and kill parasites, and can also treat certain diseases.

The traditional Chinese medicine composition with good insect expelling effect is prepared by analyzing the medicinal properties and pharmacological effects of the components and combining the components, and each traditional Chinese medicine in the traditional Chinese medicine composition can effectively exert the respective function and has the mutual synergistic effect. The medicines are combined to play the roles of clearing heat, eliminating dampness and promoting the production of body fluid. The invention conforms to the modern drug property and pharmacological action mechanism, and the compatibility of the Chinese medicinal materials can effectively expel parasites from the modern medicine.

The medicine prepared by the preparation method has small toxic and side effects, wide medicine source of each component, strong practicability and simple and easily-controlled preparation process; obviously reduces the production cost and enlarges the popularization and application range of the medicine.

Detailed Description

Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.

It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference herein for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.

It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The specification and examples are exemplary only.

As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.

The "parts" in the present invention are all parts by mass unless otherwise specified.

Example 1

A traditional Chinese medicine oral liquid for expelling parasites is composed of the following raw material medicines in parts by weight:

8 parts of areca-nut, 4 parts of agrimony bud, 3 parts of Omphalia, 2 parts of chinaberry bark, 3 parts of common carpesium fruit, 5 parts of Chinese torreya seed, 6 parts of rangoon creeper fruit, 2 parts of cyrtomium rhizome, 3 parts of costustoot, 6 parts of pumpkin seed, 4 parts of dark plum fruit, 1 part of amur corktree bark, 2 parts of Chinese pulsatilla root, 6 parts of pomegranate bark, 4 parts of negundo chastetree root and 3 parts of aloe.

Example 2

16 parts of betel nut, 10 parts of agrimony bud, 9 parts of Omphalia, 8 parts of cortex meliae, 9 parts of carpesium, 10 parts of Chinese torreya seed, 13 parts of rangooncreeper fruit, 6 parts of cyrtomium rhizome, 5 parts of costustoot, 12 parts of pumpkin seed, 9 parts of dark plum fruit, 7 parts of phellodendron, 6 parts of Chinese pulsatilla root, 12 parts of pomegranate bark, 8 parts of negundo chastetree root and 9 parts of aloe.

Example 3

Example 4

The process for preparing the above-mentioned examples 1 to 3 of the oral liquid of Chinese traditional medicine for expelling parasites includes the following steps:

(1) weighing the areca, the gemma agrimoninae, the stone-like omphalia, the cortex meliae, the carpesium, the Chinese torreya, the quisqualis, the cyrtomium rhizome, the elecampane, the pumpkin seed, the dark plum, the phellodendron, the Chinese pulsatilla root, the pomegranate rind, the negundo chastetree root and the aloe according to the weight parts, and soaking in water at normal temperature for 20 min;

(2) adding water into the raw materials soaked in the step (1) for decocting, wherein the weight of the added water is 8 times of that of the raw materials, boiling with strong fire, then slowly decocting with slow fire for 20min, filtering, and collecting filtrate and filter residue;

(3) decocting the filter residue obtained in the step (2) with water, wherein the weight of the water is 8 times of the weight of each raw material, boiling with strong fire, slowly decocting with slow fire for 30-50min, filtering, and collecting filtrate;

(4) mixing the filtrates collected in steps (2) and (3), centrifuging at 15000r/min for 10min, collecting supernatant, and concentrating to relative density of 1.00.

Example 5

The difference from example 4 is that the soaking time in step (1) was 40 min.

Example 6

The difference from example 4 is that the weight of water added in step (2) was 10 times the weight of each raw material.

Example 7

The difference from example 4 is that in step (2), the decoction is carried out slowly for 40min with slow fire.

Example 8

The difference from example 4 is that the weight of water added in step (3) is 10 times the weight of each raw material.

Example 9

The difference from example 4 is that in step (3), the decoction is carried out slowly with slow fire for 50 min.

Example 10

The difference from example 4 is that the centrifugation in step (4) is carried out at a speed of 20000r/min for 15 min.

Example 11

The difference from example 4 is that the concentrate in step (4) was concentrated to a relative density of 1.20.

Comparative example 1

The differences from the embodiment 1 are that 8-16 parts of areca, 4-10 parts of agrimony bud, 3-9 parts of stone-like omphalia, 2-8 parts of chinaberry bark, 3-9 parts of common carpesium fruit, 5-10 parts of Chinese torreya seed, 6-13 parts of rangoon creeper fruit, 2-6 parts of cyrtomium rhizome, 3-5 parts of costustoot, 6-12 parts of pumpkin seed, 4-9 parts of dark plum fruit, 1-7 parts of amur corktree bark, 2-6 parts of Chinese pulsatilla root, 6-12 parts of pomegranate bark, 4-8 parts of negundo chastetree root and 3-9 parts of aloe.

Comparative example 2

The difference from the production process of the traditional Chinese medicine oral liquid for expelling the parasites in the embodiment 1 is that the method comprises the following steps:

(1) weighing the areca, the gemma agrimoninae, the stone-like omphalia, the cortex meliae, the carpesium, the Chinese torreya, the quisqualis, the cyrtomium rhizome, the elecampane, the pumpkin seed, the dark plum, the phellodendron, the Chinese pulsatilla root, the pomegranate rind, the negundo chastetree root and the aloe according to the weight parts;

(2) decocting the raw materials weighed in the step (1) with water, wherein the weight of the water is 14 times of that of the raw materials, boiling with strong fire, slowly decocting with slow fire for 60min, filtering, and collecting filtrate and filter residue;

(3) adding water into the filter residue obtained in the step (2) for decoction, wherein the weight of the added water is 13 times of the weight of each raw material, boiling with strong fire, then slowly decocting with slow fire for 70min, filtering, and collecting filtrate;

(4) mixing the filtrates collected in steps (2) and (3), centrifuging at 10000r/min for 10min, collecting supernatant, and concentrating to relative density of 1.90.

Comparative example 3

The difference from example 1 is that betel nut and quisqualis are not contained.

Effect verification

Animal experiments:

70 mice with parasites, weighing 18-24g, were randomly divided into 7 groups of 10, 6 groups were fed with the Chinese medicinal oral liquid prepared in examples 1-3 and comparative examples 1-3 according to examples 1-3 and comparative examples 1-3, respectively, 1.5mL/kg of mice per day, 1 group of control group was given distilled water in equal amount once per day for 30 days.

The test results show that the mice taking the traditional Chinese medicine oral liquid (examples 1-3) prepared by the invention are completely cured, while the cure rate of comparative examples 1-3 is only 50-60% of that of the traditional Chinese medicine oral liquid, and the cure rate of a control group is 0. The insect repellent effect of the traditional Chinese medicine oral liquid is obvious, the effect is obviously superior to that of a comparative example 1 (the raw material proportion is different) and a comparative example 2 (the production process of the traditional Chinese medicine oral liquid is different) and that of a comparative example 3 (no betel nut and rangooncreeper fruit are added in the raw materials), and the raw material proportion, the production process of the traditional Chinese medicine oral liquid and the raw material components have influence on the curative effect of the prepared product.

The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.

Claims

1. A traditional Chinese medicine oral liquid for expelling parasites is characterized in that: the traditional Chinese medicine oral liquid is prepared from the following raw material medicines in parts by weight:

2. The traditional Chinese medicine oral liquid for expelling parasites according to claim 1, which is characterized in that: the weight parts of the raw materials are as follows:

3. The traditional Chinese medicine oral liquid for expelling parasites according to claim 2, which is characterized in that: the weight parts of the raw materials are as follows:

4. A process for producing the traditional Chinese medicine oral liquid for expelling parasites according to any one of claims 1 to 3, which is characterized in that: the method comprises the following steps:

5. The production process according to claim 4, characterized in that: the temperature of the water for soaking in the step (1) is normal temperature, and the soaking time is 20-40 min.

6. The production process according to claim 4, characterized in that: the mass of the water added in the step (2) and the step (3) is 8-10 times of the total weight of the raw materials.

7. The production process according to claim 4, characterized in that: and (3) boiling with strong fire when decocting in the step (2), and then slowly decocting with slow fire for 20-40 min.

8. The production process according to claim 4, characterized in that: and (3) boiling with strong fire when decocting, and slowly decocting with slow fire for 30-50 min.

9. The production process according to claim 4, characterized in that: the centrifugation in the step (4) is performed for 10-15min under the condition that the rotating speed is 15000-20000 r/min.

10. The process according to claim 4, wherein the step (4) is carried out to a relative density of 1.00 to 1.20.