CN114376060A - Probiotics stachyose tablet candy and preparation method thereof - Google Patents
Probiotics stachyose tablet candy and preparation method thereof Download PDFInfo
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- CN114376060A CN114376060A CN202011124945.6A CN202011124945A CN114376060A CN 114376060 A CN114376060 A CN 114376060A CN 202011124945 A CN202011124945 A CN 202011124945A CN 114376060 A CN114376060 A CN 114376060A
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- stachyose
- probiotic
- coating
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Links
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- 235000018291 probiotics Nutrition 0.000 title claims abstract description 57
- 235000009508 confectionery Nutrition 0.000 title claims abstract description 51
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- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
- A23G3/54—Composite products, e.g. layered, coated, filled
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/173—Reuteri
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/519—Breve
Abstract
The invention provides a probiotic stachyose tablet candy which has a strong discharge promoting function by combining composite probiotics and stachyose. The oral administration product can promote intestinal flora to reach a healthy flora structure, increase small intestine peristalsis capability, accelerate small intestine evacuation, and prevent excessive nutrition absorption. In addition, the product can improve the water and electrolyte absorption in colon, effectively promote excretion, and prevent and treat constipation. In addition, the tablet candy comprises a pill core and a coating layer, and the effective components are positioned in the pill core, so that the composite probiotics and stachyose in the small intestine part can be released, and the loss of the probiotics under the action of gastric acid can be prevented.
Description
Technical Field
The invention relates to the technical field of food industry, in particular to a probiotic stachyose tablet candy and a preparation method thereof.
Background
The probiotics are active microorganisms beneficial to a host, can be planted in the intestinal tract and the reproductive system of a human body, can generate exact health efficacy, thereby improving the micro-ecological balance of the host and playing a beneficial role. The main probiotics in human bodies are as follows: butyric acid bacillus, lactic acid bacteria, bifidobacteria, acidophilic lactobacillus, actinomycetes, saccharomycetes, etc. The probiotic has the effects of preventing or improving diarrhea, relieving lactose intolerance symptoms, preventing reproductive system infection, enhancing human immunity, promoting intestinal tract digestive system health, reducing serum cholesterol, and helping nutrient absorption.
Currently, the most productive and marketable active probiotic products in the world are mainly probiotic dairy products. With the development of modern technology level and food processing technology, in order to meet the requirements of consumers on probiotic products, the forms of probiotic products are continuously and diversely developed. The probiotic tablet has the characteristics of prolonging the survival period of live bacteria, being directly swallowed for drinking and being convenient to carry, thereby being concerned by people.
The tablet candy is a mixture which is prepared by using sugar as main body, adding various fillers and binders, granulating and tabletting, and can be made into tablet candy without heating and boiling, and is called cold-processing candy. However, most of the existing production processes of tabletted candies are to mix sweeteners, probiotic powder and other raw and auxiliary materials and then granulate, dry, granulate and tablet, and the long-time high-temperature drying procedure after granulation can cause reduction or damage of the quantity and activity of probiotics.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a probiotic stachyose tablet candy.
The second purpose of the invention is to provide a preparation method of the tabletting candy.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the invention relates to a probiotic stachyose tablet candy which comprises a pill core and a coating layer, wherein the pill core contains composite probiotics and stachyose, and the composite probiotics comprise lactobacillus rhamnosus, bifidobacterium lactis, bifidobacterium breve, lactobacillus reuteri and lactobacillus plantarum.
Preferably, the pill core further comprises navy bean extract, fructus cannabis, fructo-oligosaccharide, konjac powder and magnesium stearate.
Preferably, the pellet core comprises the following raw materials in parts by weight: 1.5-2.5 parts of lactobacillus rhamnosus, 1.5-2.5 parts of bifidobacterium lactis, 1.5-2.5 parts of bifidobacterium breve, 1.5-2.5 parts of lactobacillus reuteri, 1.5-2.5 parts of lactobacillus plantarum and 25-35 parts of stachyose.
Preferably, the pellet core also comprises the following raw materials in parts by weight: 5-15 parts of white kidney bean extract, 5-15 parts of fructus cannabis, 15-25 parts of fructo-oligosaccharide, 5-15 parts of konjac flour and 0.5-1.5 parts of magnesium stearate.
Preferably, the coating layer contains hydroxypropyl methylcellulose and aloe vera gel.
Preferably, the coating layer comprises the following raw materials in parts by weight: 0.5-1.5 parts of hydroxypropyl methyl cellulose and 3.5-7.5 parts of aloe gel.
The invention also relates to a preparation method of the tablet candy, which comprises the following steps:
(1) preparing a pill core: uniformly mixing the compound probiotics, stachyose, white kidney bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate, adding an organic solvent aqueous solution to obtain a soft material, preparing the soft material into a strip, shearing and rounding the strip to prepare spherical pellets, and drying the spherical pellets to obtain pellet cores;
(2) preparing a coating solution: uniformly mixing and stirring the hydroxypropyl methyl cellulose, the aloe gel and an organic solvent aqueous solution to obtain a coating solution;
(3) preparing a coating layer: and (3) placing the pellet cores obtained in the step (1) into a fluidized bed coating machine or a coating pan, adding the coating liquid obtained in the step (2), and drying after coating to obtain the tablet candy.
Preferably, in the step (1), the soft material is extruded by a sieve plate with the aperture of 0.8-1 mm to obtain a strip-shaped object, and then the strip-shaped object is sheared and rounded by a rounding machine, wherein the rotating speed of the rounding machine is 800-1000 r/min, the rounding time is 3-7 min, and the drying temperature of the spherical pellets is 45-55 ℃.
Preferably, the organic solvent aqueous solution in the steps (1) and (2) is ethanol solution with the volume content of 80-95%.
The invention has the beneficial effects that:
the invention provides a probiotic stachyose tablet candy which has a strong discharge promoting function by combining composite probiotics and stachyose. The oral administration product can promote intestinal flora to reach a healthy flora structure, increase small intestine peristalsis capability, accelerate small intestine evacuation, and prevent excessive nutrition absorption. In addition, the product can improve the water and electrolyte absorption in colon, effectively promote excretion, and prevent and treat constipation.
In addition, the tablet candy comprises a pill core and a coating layer, and the effective components are positioned in the pill core, so that the composite probiotics and stachyose in the small intestine part can be released, and the probiotics can be prevented from being lost under the action of gastric acid.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The invention relates to a probiotic stachyose tablet candy, which comprises a pill core and a coating layer. Wherein the pill core contains composite probiotics and stachyose, and the composite probiotics comprise Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium breve, Lactobacillus reuteri and Lactobacillus plantarum.
The composite probiotics and stachyose are used together, and have strong excretion promoting function. Stachyose can reduce the metabolic activity of harmful enzymes in intestines by influencing the metabolic activity of certain enzymes in the intestines, so that putrefying products such as methyl phenol and the like in the intestines are reduced, the discharge of the putrefying products out of the body is accelerated, the reabsorption of toxic metabolites is reduced, and the burden of decomposing toxins by the liver is lightened. And stachyose has excellent effect of relaxing bowel, reduces the retention time of food residues in intestinal tracts and reduces the possibility of lead absorption in the intestinal tracts. At the same time, lead secreted into intestinal tract by bile can be removed by stachyose to block its reabsorption.
The lactobacillus rhamnosus has the functions of reducing cholesterol, regulating flora balance, expelling toxin, preventing dental caries and improving immunity. The bifidobacterium lactis has the functions of promoting intestinal peristalsis, relieving constipation, inhibiting cancer and promoting the absorption of lactose by a human body. The Bifidobacterium breve has the functions of improving immunity, resisting allergy and oxidation. The Lactobacillus reuteri has the functions of improving immunity and inhibiting bacteria in oral cavity. The lactobacillus plantarum has the functions of relieving lactose intolerance, reducing lipid substance absorption and promoting micro-ecological balance.
In one embodiment of the invention, the pellet core further comprises navy bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate.
Wherein the white kidney bean extract has the effects of reducing glucose absorption, and reducing postprandial blood glucose rise and fat synthesis. Fructus Cannabis has the effect of loosening bowel to relieve constipation. The fructo-oligosaccharide keeps the good sweet taste characteristic of the sucrose, has excellent indigestible water-soluble dietary fiber and can bidirectionally regulate the micro-ecological balance of the human body. The rhizoma Amorphophalli powder has effects of reducing blood lipid, lowering blood sugar, and relaxing bowels. Magnesium stearate is used as a tabletting auxiliary material.
In one embodiment of the invention, the pellet core comprises the following raw materials in parts by weight: 1.5-2.5 parts of lactobacillus rhamnosus, 1.5-2.5 parts of bifidobacterium lactis, 1.5-2.5 parts of bifidobacterium breve, 1.5-2.5 parts of lactobacillus reuteri, 1.5-2.5 parts of lactobacillus plantarum and 25-35 parts of stachyose.
In one embodiment of the invention, the pellet core further comprises the following raw materials in parts by weight: 5-15 parts of white kidney bean extract, 5-15 parts of fructus cannabis, 15-25 parts of fructo-oligosaccharide, 5-15 parts of konjac flour and 0.5-1.5 parts of magnesium stearate.
In one embodiment of the invention, the coating layer comprises hydroxypropyl methylcellulose and aloe vera gel.
Wherein, the hydroxypropyl methyl cellulose as a coating layer has toughness and can be used as a binder and a film forming agent. Aloe vera gel is used as a lubricant and binder.
In one embodiment of the invention, the coating layer comprises the following raw materials in parts by weight: 0.5-1.5 parts of hydroxypropyl methyl cellulose and 3.5-7.5 parts of aloe gel.
The invention also relates to a preparation method of the tablet candy, which comprises the following steps:
(1) preparing a pill core: uniformly mixing the compound probiotics, stachyose, white kidney bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate, adding an organic solvent aqueous solution to obtain a soft material, preparing the soft material into strips, shearing and rounding the strips to prepare spherical pellets, and drying the spherical pellets to obtain pellet cores;
(2) preparing a coating solution: mixing hydroxypropyl methylcellulose, aloe gel and organic solvent water solution, and stirring to obtain coating solution;
(3) preparing a coating layer: and (3) placing the pellet cores obtained in the step (1) into a fluidized bed coating machine or a coating pan, adding the coating liquid prepared in the step (2), and drying after coating to obtain the tablet candy.
In one embodiment of the invention, in the step (1), the soft material is extruded through a sieve plate with the aperture of 0.8-1 mm to obtain a strip-shaped object, and then is sheared and rounded through a rounding machine, wherein the rotating speed of the rounding machine is 800-1000 r/min, the rounding time is 3-7 min, and the drying temperature of the spherical pellets is 45-55 ℃.
In one embodiment of the present invention, the organic solvent aqueous solution in steps (1) and (2) is an ethanol solution with a volume content of 80-95%.
In one embodiment of the present invention, in step (3), if the coating is performed by using a coating pan, the quality-required cores may be preheated at 40 ℃ in the coating pan. Then the coating pan is started, the compression pump is started, and the air injection pressure is controlled to be 0.4-1.2 kg/cm2The coating pan speed was adjusted to 70 rpm. And spraying the prepared coating liquid on the surface of the rotating pill core by using a spray gun, and drying by hot air at 40-50 ℃ after uniform coating. And repeatedly spraying the coating liquid on the surface of the pellet core until the required coating weight gain is achieved. And (3) after coating, putting the coated granules into a drying oven for drying for 2-3 hours to volatilize the solvent soaked in the granules, thus obtaining the tablet candy.
If a fluidized bed coating machine is adopted for coating, the pellet cores meeting the quality requirement can be placed in an air flow coating device. Coating parameters: the blower frequency is (40 +/-2) Hz; the fluidization temperature is (38 +/-1) DEG C; the flow rate of the coating liquid is 0.2-0.3 mL/min; the atomization pressure was 0.15 MPa.
The administration mode of the probiotic stachyose tablet candy provided by the invention is as follows: for the tabletted candy with the weight of single granule of 1.0g, 2-3 granules are taken with warm water 30 minutes before meal twice a day. Preferably, two tablets are taken 30 minutes before breakfast, 3 tablets are taken 30 minutes before supper, and 2 tablets can be taken in case of hyperphagia.
Example 1
A probiotic stachyose tablet candy comprises a pill core and a coating layer. Wherein the pill core comprises the following raw materials in parts by weight: 2 parts of lactobacillus rhamnosus, 2 parts of bifidobacterium lactis, 2 parts of bifidobacterium breve, 2 parts of lactobacillus reuteri, 2 parts of lactobacillus plantarum, 30 parts of stachyose, 10 parts of white kidney bean extract, 10 parts of fructus cannabis, 20 parts of fructo-oligosaccharide, 10 parts of konjac flour and 1.0 part of magnesium stearate.
The coating layer comprises the following raw materials in parts by weight: 1.0 part of hydroxypropyl methyl cellulose and 5 parts of aloe gel.
The probiotics are all freeze-dried powder and purchased from Jiangsu Yuanshen health industry Limited company. Wherein the typical collection number of the strain of the lactobacillus rhamnosus is TR08/TR09, the typical collection number of the strain of the bifidobacterium lactis is TR10/TR101, the typical collection number of the strain of the bifidobacterium breve is TR-R03, the typical collection number of the strain of the lactobacillus reuteri is TR02, and the typical collection number of the strain of the lactobacillus plantarum is TR 22. Stachyose, fructo-oligosaccharide, konjac flour, white kidney bean extract, fructus cannabis, hydroxypropyl methylcellulose and aloe gel are all purchased from Jiangsu Yuanshen Sen health industry Co.
The preparation method of the tabletting candy comprises the following steps:
(1) preparing a pill core: uniformly mixing the composite probiotics, stachyose, white kidney bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate, and adding 95% ethanol water solution by volume to obtain a soft material with viscoelasticity and plasticity. Extruding the soft material through a sieve plate with the aperture of 0.8mm to obtain strips, shearing and rounding by a rounding machine to prepare spherical pellets, wherein the rotation speed of the rounding machine is 960r/min, and the rounding time is 5 min. Drying the spherical pellets at 50 ℃ to obtain pellet cores.
(2) Preparing a coating solution: mixing hydroxypropyl methylcellulose, aloe gel and 80% ethanol water solution, stirring, and swelling to obtain coating solution;
(3) preparing a coating layer: placing the pellet core obtained in the step (1) in a coating pan to preheat at 40 ℃. Then the coating pan is started, the compression pump is started, and the air injection pressure is controlled at 1.0kg/cm2The coating pan speed was adjusted to 70 rpm. And spraying the prepared coating liquid on the surface of the rotating pill core by using a spray gun, and drying by hot air at 40-50 ℃ after uniform coating. And repeatedly spraying the coating liquid on the surface of the pellet core until the required coating weight gain is 4 percent. After coating, the coated granules are put into a drying oven to be dried for 2 hours, so that the solvent soaked in the drying oven is volatilized, and the tabletting candy is obtained. The weight of the single tabletted candy was 1.0 g.
Example 2
A probiotic stachyose tablet candy comprises a pill core and a coating layer. Wherein the pill core comprises the following raw materials in parts by weight: 1.5 parts of lactobacillus rhamnosus, 1.5 parts of bifidobacterium lactis, 1.5 parts of bifidobacterium breve, 1.5 parts of lactobacillus reuteri, 1.5 parts of lactobacillus plantarum, 25 parts of stachyose, 5 parts of white kidney bean extract, 5 parts of fructus cannabis, 15 parts of fructo-oligosaccharide, 5 parts of konjac flour and 0.5 part of magnesium stearate.
The coating layer comprises the following raw materials in parts by weight: 0.5 part of hydroxypropyl methyl cellulose and 3.5 parts of aloe gel. The procedure was as in example 1.
Example 3
A probiotic stachyose tablet candy comprises a pill core and a coating layer. Wherein the pill core comprises the following raw materials in parts by weight: 2.5 parts of lactobacillus rhamnosus, 2.5 parts of bifidobacterium lactis, 2.5 parts of bifidobacterium breve, 2.5 parts of lactobacillus reuteri, 2.5 parts of lactobacillus plantarum, 35 parts of stachyose, 15 parts of white kidney bean extract, 15 parts of fructus cannabis, 25 parts of fructo-oligosaccharide, 15 parts of konjac flour and 1.5 parts of magnesium stearate.
The coating layer comprises the following raw materials in parts by weight: 1.5 parts of hydroxypropyl methyl cellulose and 7.5 parts of aloe gel. The procedure was as in example 1.
Comparative example 1
A probiotic stachyose tablet candy comprises a pill core and a coating layer. The pill core does not contain stachyose. The stachyose part is supplemented with rhizoma Amorphophalli powder, and other materials and preparation process are the same as example 1.
Comparative example 2
A probiotic stachyose tablet candy comprises a pill core and a coating layer. The pill core does not contain Lactobacillus rhamnosus and Lactobacillus plantarum. The lactobacillus rhamnosus and lactobacillus plantarum parts were supplemented with bifidobacterium lactis, and the other materials and preparation were the same as in example 1.
Comparative example 3
A probiotic stachyose tablet candy comprises a pill core and a coating layer. The pill core does not contain semen Phaseoli vulgaris extract and fructus Cannabis. The white kidney bean extract and the hemp seed were partially supplemented with konjac flour, and other raw materials and preparation processes were the same as in example 1.
Comparative example 4
A probiotic stachyose tablet candy contains only pill core and no coating layer. The raw materials in the pellet core and the preparation process are the same as in example 1.
Viable count and tableting quality testing
Each of the tabletted confectionery obtained in the above examples and comparative examples was packed in 100 tablets and stored in a cool and dry place at room temperature of 20. + -. 5 ℃. Viable cell count test was conducted before and after 3 months of storage, and the effect of tabletting quality was visually observed, and the results are shown in table 1.
TABLE 1
As can be seen from Table 1, in examples 1 to 3, the composition of the raw materials was changed within the scope of the present invention, and in comparative examples 1 to 3, the number of live bacteria before and after storage did not change much by replacing the species of probiotic bacteria or other active ingredients, and the survival rate of probiotic bacteria was about 88%. The split and moisture rates after storage of examples 1-3 and comparative examples 1-3 were close to 0. The tabletted confectionery product prepared in comparative example 4 did not contain a coating layer and could not insulate the core layer from air and moisture, the number of viable bacteria was significantly reduced after storage and some cracking and deliquescence occurred.
Animal model test
80 clean-grade Kunming mice were selected and randomly divided into 8 groups. The adaptive feeding is carried out in a ventilated, clean, quiet and appropriate temperature and humidity environment for one week, and water and food are freely drunk in the period.
A week later, the mice were gavaged with sucralfate in an amount of 2.0g/kg 1 time a day for 3 consecutive days. The mice all have the conditions of delayed first defecation time, obviously reduced defecation grain number and weakened intestinal propulsion activity.
Stopping the intragastric administration of sucralfate on day 4, and performing intragastric administration of the pulverized candy pieces with an amount of 1.0g/kg for 3 consecutive days 1 time per day. The administration pattern and the defecation status of the mice on day 7 are shown in table 2.
TABLE 2
As can be seen from Table 2, the tabletted candies prepared in examples 1-3 significantly improved constipation in mice. In comparative examples 1 to 4, it was found that, in the case of replacing the probiotic species or other active ingredients and removing the coating layer, the tabletted confectionery improved constipation in mice, but to a lesser extent.
The stomach filling amount of the tabletted candy is 1.0g/kg, the dosage of the adult is 5 tablets per day, and the dosage of the tabletted candy/the adult is 5g/50 kg-1.0 g/kg, which is calculated by taking the adult weight as 50kg, and is the same as the stomach filling amount of a mouse. The experimental results show that the tabletted candy provided by the invention also has a positive effect on improving the constipation of a human body.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The probiotic stachyose tabletted candy is characterized by comprising a pill core and a coating layer, wherein the pill core contains composite probiotics and stachyose, and the composite probiotics comprise lactobacillus rhamnosus, bifidobacterium lactis, bifidobacterium breve, lactobacillus reuteri and lactobacillus plantarum.
2. The probiotic stachyose tableted candy according to claim 1, wherein the pellet core further comprises navy bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate.
3. The probiotic stachyose tabletted candy according to claim 1, wherein the pellet core comprises the following raw materials in parts by weight: 1.5-2.5 parts of lactobacillus rhamnosus, 1.5-2.5 parts of bifidobacterium lactis, 1.5-2.5 parts of bifidobacterium breve, 1.5-2.5 parts of lactobacillus reuteri, 1.5-2.5 parts of lactobacillus plantarum and 25-35 parts of stachyose.
4. The probiotic stachyose tabletted candy according to claim 3, wherein the pellet core further comprises the following raw materials in parts by weight: 5-15 parts of white kidney bean extract, 5-15 parts of fructus cannabis, 15-25 parts of fructo-oligosaccharide, 5-15 parts of konjac flour and 0.5-1.5 parts of magnesium stearate.
5. The probiotic stachyose tableted candy according to claim 1, wherein the coating layer comprises hydroxypropyl methylcellulose and aloe vera gel.
6. The probiotic stachyose tableted candy according to claim 5, wherein the coating layer comprises the following raw materials in parts by weight: 0.5-1.5 parts of hydroxypropyl methyl cellulose and 3.5-7.5 parts of aloe gel.
7. The method of preparing a probiotic stachyose tabletted candy according to any one of claims 1 to 6, comprising the steps of:
(1) preparing a pill core: uniformly mixing the compound probiotics, stachyose, white kidney bean extract, fructus cannabis, fructo-oligosaccharide, konjac flour and magnesium stearate, adding an organic solvent aqueous solution to obtain a soft material, preparing the soft material into a strip, shearing and rounding the strip to prepare spherical pellets, and drying the spherical pellets to obtain pellet cores;
(2) preparing a coating solution: uniformly mixing and stirring the hydroxypropyl methyl cellulose, the aloe gel and an organic solvent aqueous solution to obtain a coating solution;
(3) preparing a coating layer: and (3) placing the pellet cores obtained in the step (1) into a fluidized bed coating machine or a coating pan, adding the coating liquid obtained in the step (2), and drying after coating to obtain the tablet candy.
8. The method for preparing a probiotic stachyose tabletted candy according to claim 7, wherein in the step (1), the soft material is extruded through a sieve plate with the aperture of 0.8-1 mm to obtain a strip, and then the strip is cut and rounded through a rounding machine.
9. The method for preparing a probiotic stachyose tabletted candy according to claim 7, wherein in the step (1), the rotation speed of a spheronizer is 800-1000 r/min, the spheronization time is 3-7 min, and the drying temperature of spherical pellets is 45-55 ℃.
10. The method for preparing a probiotic stachyose tabletted candy according to claim 7, wherein the organic solvent aqueous solution in steps (1) and (2) is an ethanol solution with a volume content of 80-95%.
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| CN108740251A (en) * | 2018-06-15 | 2018-11-06 | 广东燕岭生命科技股份有限公司 | A kind of probiotic gel candy and preparation method thereof improving constipation |
| CN110574916A (en) * | 2018-06-11 | 2019-12-17 | 江苏帝尔生物科技有限公司 | nutritional meal replacement product with fat reducing and bowel relaxing effects and preparation method thereof |
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| CN110574916A (en) * | 2018-06-11 | 2019-12-17 | 江苏帝尔生物科技有限公司 | nutritional meal replacement product with fat reducing and bowel relaxing effects and preparation method thereof |
| CN108740251A (en) * | 2018-06-15 | 2018-11-06 | 广东燕岭生命科技股份有限公司 | A kind of probiotic gel candy and preparation method thereof improving constipation |
| CN111493322A (en) * | 2020-05-15 | 2020-08-07 | 苏州普瑞森基因科技有限公司 | Microencapsulated probiotic bacteria and preparation method and application thereof |
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