CN114344431A - 一种治疗抑郁症的中药组合物及其制备方法 - Google Patents
一种治疗抑郁症的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗抑郁症的中药组合物,由柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏加水熬制而成,对于抑郁症患者具有调节体质、平衡阴阳气血、祛除痰邪的治疗作用并且对患者的生活质量有明显的改善。
Description
技术领域
本发明属于中药领域,具体涉及一种治疗抑郁症的中药组合物。
背景技术
据有关资料报道,目前抑郁、焦虑等症的发病率占人群总数的15.96~30%,按流行病学研究表明,人群中有13%~20%的发病率,其中严重占发病人群的2%~5%。且逐年升高,仅美国每年就有1500万人患有此病,目前,抑郁症患病人群逐年上升,随着快节奏的生活深入日常,抑郁症的预防以及治疗显得尤为重要,研究显示,很多中药副作用较小,具有多种途径、多方效应、多个靶点的综合抗抑郁的功效,不容易使患者产生耐受性、依赖性,还可以提高机体免疫力。中医治病强调并重视整体观念,遵循“辨证论治”的治疗原则,利用药物之间相互配伍炮制的增效减毒关系,能较明显地改善患者临床症状和生存质量并延长其生存时间,近年来有许多中药已发现有显著抗抑郁和焦虑活性的单体成分,中药在抗抑郁的疗效方面有其独特的优势,并且目前对此已经开展大量临床研究,但各研究样本量有限,质量不一,仍然缺乏可靠的循证医学证据,这给临床决策带来困难。
发明内容:
针对现有技术的不足,本发明提供了一种治疗抑郁症的中药组合物,以疏肝解郁、理气化痰为主,副作用较小,具有多种途径、多方效应、多个靶点的抗抑郁功效。
本发明具体的技术方案是这样实现的:
一种治疗抑郁症的中药组合物,由以下重量份组成:柴胡50-250份、厚朴30-170份、茯苓30-170份、枳实30-170份、合欢花30-170份、远志40-200份、郁金30-170份、龙骨100-300份、牡蛎100-300份、首乌藤100-300份、黄芩40-200份、半夏40-200份。
优选地,所述治疗抑郁症的中药组合物,由以下重量份组成:柴胡100-200份、厚朴50-100份、茯苓50-100份、枳实50-100份、合欢花50-120份、远志90-150份、郁金90-150份、龙骨150-250份、牡蛎150-250份、首乌藤150-250份、黄芩90-150份、半夏90-150份。
优选地,所述治疗抑郁症的中药组合物,由以下重量份组成:柴胡150份、厚朴80份、茯苓80份、枳实80份、合欢花90份、远志120份、郁金120份、龙骨200份、牡蛎200份、首乌藤200份、黄芩120份、半夏120份。
所述配方中,
柴胡,性微寒,味苦。归肝经、胆经、肺经。和解表里、疏肝、升阳。
厚朴,性温,味苦、辛。归脾经、胃经、肺经、大肠经。燥湿消痰、下气除满。
茯苓,性平,味甘、淡。归心经、肺经、脾经、肾经。利水渗湿、健脾宁心。
枳实,性微寒,味苦、辛、酸。归脾经、胃经。破气消积、化痰散痞。
合欢花,性平,味甘。归心经、肝经。解郁安神。
远志,性温,味苦、辛。归心经、肾经、肺经。安神益智、祛痰、消肿。
郁金,性寒,味辛、苦。归肝经、心经、肺经。活血止痛、行气化疥、清心解郁、利胆退黄。
龙骨,性平,味涩、甘。归心经、肝经、肾经、大肠经。镇心安神,平肝潜阳,固涩,收敛。
牡蛎,性微寒,味咸。归肝经、胆经、肾经。重镇安神,潜阳补阴,软坚散结,煅牡蛎收敛固涩。
首乌藤,性平,味甘。归心经、肝经。养血安神、祛风通络。
黄芩,性寒,味苦。归肺经、胆经、脾经、大肠经、小肠经。清热燥湿、泻火解毒、止血、安胎。
半夏,性温,味辛,有毒。归脾经、胃经、肺经。燥湿化痰、降逆止呕、消痞散结。
所述配方中龙骨、牡蛎、首乌藤,疏肝解郁,为君药;合欢花、远志、郁金,活血安神,为臣药;柴胡、厚朴、茯苓、枳实、黄芩、半夏,化瘀通络,清心解郁,调和诸药,共为佐使药。因此,本发明中的中药能安神解郁、缓解患者心情、调节气机失调,对抑郁症患者的焦躁不安、悲观消极、肝郁气滞等症状有明显改善,以此达到控制抑郁症发展的作用。
制备所述治疗抑郁症的中药组合物的方法:
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水煎煮,煮至水剩四分之一时,滤过,得药汤。
服用方法:成人每次500ml,一日三次。
本发明所述中药组合物治疗抑郁症,能安神解郁、缓解患者心情、调节气机失调,对抑郁症患者的焦躁不安、悲观消极、肝郁气滞等症状有明显改善,有调节体质、平衡阴阳气血、祛除痰邪之功效,以此达到控制抑郁症发展的作用。
附图说明
图1是抑郁建模后旷场实验结果图;
图2是抑郁建模后高架十字迷宫实验结果图;
图3是给药后21d后高架十字迷宫实验结果图。
具体实施方式
实施例1
治疗抑郁症的中药组合物,由以下重量份组成:柴胡150份、厚朴80份、茯苓80份、枳实80份、合欢花90份、远志120份、郁金120份、龙骨200份、牡蛎200份、首乌藤200份、黄芩120份、半夏120份;
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤;
所述药汤的服用方法:成人每次500ml,一日三次。
实施例2
治疗抑郁症的中药组合物,由以下重量份组成:柴胡100份、厚朴50份、茯苓50份、枳实50份、合欢花50份、远志90份、郁金90份、龙骨150份、牡蛎150份、首乌藤150份、黄芩90份、半夏90份;
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤;
所述药汤的服用方法:成人每次500ml,一日三次。
实施例3
治疗抑郁症的中药组合物,由以下重量份组成:柴胡200份、厚朴100份、茯苓100份、枳实100份、合欢花120份、远志150份、郁金150份、龙骨250份、牡蛎250份、首乌藤250份、黄芩150份、半夏150份;
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤;
所述药汤的服用方法:成人每次500ml,一日三次。
实施例4
治疗抑郁症的中药组合物,由以下重量份组成:柴胡50份、厚朴30份、茯苓30份、枳实30份、合欢花30份、远志40份、郁金30份、龙骨100份、牡蛎100份、首乌藤100份、黄芩40份、半夏40份;
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤;
所述药汤的服用方法:成人每次500ml,一日三次。
实施例5
治疗抑郁症的中药组合物,由以下重量份组成:柴胡250份、厚朴170份、茯苓170份、枳实170份、合欢花170份、远志200份、郁金170份、龙骨300份、牡蛎300份、首乌藤300份、黄芩200份、半夏200份;
称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤;
所述药汤的服用方法:成人每次500ml,一日三次。
试验例
1.针对小鼠构建抑郁模型进行旷场实验和十字迷宫实验:
旷场实验:
(1)实验箱底部平均划为25格,中央9格为中央区域,其余16格为外周区域;
(2)在安静且昏暗的房间,捏住大鼠尾巴(距根部1/3处)轻放入实验箱中央,观察其在5min内总活动路程和中央区域停留时间,红外照明,摄像头记录过程;
(3)1次实验后清理箱内粪便等残留物,喷洒酒精并用纱布拭擦干净,以除去上一只大鼠的气昧,避免影响下一只大鼠实验结果。
抑郁模型组的穿越方格的总数、直立次数、穿过中央格的次数、中央格的停留时间都明显低于空白对照组(P<0.05),表明抑郁模型构建成功,如图1显示:抑郁建模成功。
十字迷宫实验:
实验前先将小鼠置于开场中活动5min,然后将小鼠置于迷宫中央,使其头部正对其中一个开放臂,用计算机跟踪记录小鼠在高架十字迷宫上的活动情况,记录时间为5min。以小鼠开臂进入次数百分比(OE%)即开臂进入次数/(开臂进入次数+封臂进入次数)和开臂滞留时间百分比(OT%)即开臂滞留时间/(开臂滞留时间+封臂滞留时间)作为评价药物抗焦虑作用的指标。
抑郁模型组的开臂进入次数百分比和滞留次数百分比明显低于空白对照组(P<0.05),表明抑郁模型构建成功,如图2所示。并且给药后开臂进入次数百分比和滞留次数百分比明显高于抑郁模型组(P<0.05),图3表明,构建该配方具有良好治愈抑郁的效果。
2.临床疗效研究
(1)随机选择临床确诊的抑郁症患者200例,主要表现为心情低落,活力体力的下降以及兴趣减退,同时伴随其他的症状,如食欲下降、脑力下降,注意力记忆力衰退,严重的患者会产生自杀的想法,借助抑郁自评量表、伯恩斯抑郁症清单等确诊为抑郁症。
(2)用药方法:
成人每次500ml,一日三次。
(3)疗效:有效(症状消失,心态积极);无效(症状无改善)。具体临床效果见表1。
表1治疗抑郁症临床效果
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | |
病例数 | 50 | 50 | 50 | 50 | 50 |
有效 | 46 | 45 | 44 | 45 | 44 |
无效 | 4 | 5 | 6 | 5 | 6 |
本发明临床实验证明,本发明所提供的中药组方对抑郁症的总有效率为90%,其中实施例1所述中药组方效果最好,服用半年以上该中药组方能够使得抑郁症症状消失,心态积极向上。
治疗抑郁症实例:
1.张XX,女,52岁,多思虑,精神倦怠,情志抑郁,偶尔大脑空白,2017年来中医门诊就诊,按中医辨证,为郁症,连续服用该汤药和手法导引五个月以上,经检查,症状消失。
2.张XX,男,54岁,精神抑郁、多愁善感、失眠多梦、头晕目眩、体乏无力、记忆力减退,经中医诊断为抑郁症,连续服用该汤药4个月以上,症状逐渐缓解,随访3个月未见复发。
3.李XX,女,28岁,情绪低落、兴趣丧失、行动迟滞、入睡困难、早醒多梦、急躁易怒,中医诊断为抑郁症,嘱保持心理平衡,连续服用该汤药4个月以上,症状消失,随访3个月未见复发。
4.谢XX,男,30岁,严重失眠、胸闷、对生活失去兴趣和信心、偶有轻生念头,经中医诊断为中度抑郁,连续服用该汤药4个月以上,病情痊愈,后随访3个月生活正常,未见复发。
以上实例表明:本发明所述的中药组合物,能安神解郁、缓解患者心情、调节气机失调,对抑郁症患者的症状有明显改善。
Claims (6)
1.一种治疗抑郁症的中药组合物,其特征在于:由以下重量份组成:柴胡50-250份、厚朴30-170份、茯苓30-170份、枳实30-170份、合欢花30-170份、远志40-200份、郁金30-170份、龙骨100-300份、牡蛎100-300份、首乌藤100-300份、黄芩40-200份、半夏40-200份。
2.根据权利要求1所述治疗抑郁症的中药组合物,其特征在于:由以下重量份组成:柴胡100-200份、厚朴50-100份、茯苓50-100份、枳实50-100份、合欢花50-120份、远志90-150份、郁金90-150份、龙骨150-250份、牡蛎150-250份、首乌藤150-250份、黄芩90-150份、半夏90-150份。
3.根据权利要求1所述治疗抑郁症的中药组合物,其特征在于:由以下重量份组成:柴胡150份、厚朴80份、茯苓80份、枳实80份、合欢花90份、远志120份、郁金120份、龙骨200份、牡蛎200份、首乌藤200份、黄芩120份、半夏120份。
4.制备如权利要求1-3所述中药组合物的方法,其特征在于:称取处方量的柴胡、厚朴、茯苓、枳实、合欢花、远志、郁金、龙骨、牡蛎、首乌藤、黄芩、半夏,加入6倍水量煎煮,煮至水剩下四分之一时,滤过得药汤。
5.制备如权利要求4所述中药组合物的方法,其特征在于:所述药汤的服用方法:成人每次500ml,一日三次。
6.如权利要求1-3所述中药组合物的应用,其特征在于:治疗抑郁症的应用。
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