CN114341618A - 生化物质分析系统、方法及装置 - Google Patents

生化物质分析系统、方法及装置 Download PDF

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CN114341618A
CN114341618A CN201980100118.2A CN201980100118A CN114341618A CN 114341618 A CN114341618 A CN 114341618A CN 201980100118 A CN201980100118 A CN 201980100118A CN 114341618 A CN114341618 A CN 114341618A
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flow cell
module
signal
fluid
detection
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CN114341618B (zh
Inventor
姜鹤鸣
邢楚填
梁埈模
隋相坤
刘健
拉兹万·奇里塔
王忠海
西蒙·罗伯特·亚当斯
王乐
马克·弗雷德里克·森科
克雷格·爱德华·乌里齐
文思成
高斌
牟峰
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MGI Tech Co Ltd
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MGI Tech Co Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0193—Arrangements or apparatus for facilitating the optical investigation the sample being taken from a stream or flow to the measurement cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/636—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited using an arrangement of pump beam and probe beam; using the measurement of optical non-linear properties
    • G01N2021/637—Lasing effect used for analysis
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

一种生化物质分析系统(3)，用于对流动池(38)内样品的生物特征的检测，包括检测系统(31)、调度系统、生化反应系统及控制系统(36)。调度系统用于将流动池(38)在不同位点进行调度，位点包括位于检测系统(31)的位点与位于生化反应系统的位点，生化反应系统用于使流动池(38)内的样品发生反应，检测系统(31)用于对已发生反应的样品执行信号检测以获得代表样品的生物特征的信号，控制系统(36)用于控制检测系统(31)、调度系统与生化反应系统的协同作业。该系统提高了生化物质分析的自动化程度和通量。

Description

PCT国内申请，说明书已公开。

Claims (39)

  1. PCT国内申请，权利要求书已公开。
CN201980100118.2A 2019-09-24 2019-09-24 生化物质分析系统、方法及装置 Active CN114341618B (zh)

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PCT/CN2019/107593 WO2021056208A1 (zh) 2019-09-24 2019-09-24 生化物质分析系统、方法及装置

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EP (1) EP4036554A4 (zh)
JP (2) JP7457798B2 (zh)
KR (1) KR20220066162A (zh)
CN (1) CN114341618B (zh)
AU (2) AU2019467369B2 (zh)
CA (1) CA3151328A1 (zh)
WO (1) WO2021056208A1 (zh)

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
WO2021056445A1 (zh) * 2019-09-27 2021-04-01 深圳华大智造科技有限公司 流动池及应用所述流动池的生化物质反应装置

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032072A1 (en) * 2003-08-08 2005-02-10 Perlegen Sciences, Inc. Fragmentation and labelling with a programmable temperature control module
CN101004423A (zh) * 2006-01-19 2007-07-25 博奥生物有限公司 流体样品分析用卡盒系统
CN102703312A (zh) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 一种dna测序仪
CN103336130A (zh) * 2013-06-21 2013-10-02 嘉善加斯戴克医疗器械有限公司 一种全血免疫分析装置及使用此装置的血液分析仪
CN104569462A (zh) * 2013-10-15 2015-04-29 深圳迈瑞生物医疗电子股份有限公司 一种样本容器的搬送装置及方法
CN106967600A (zh) * 2016-01-13 2017-07-21 深圳华大基因研究院 芯片座、芯片固定构件及样品加载仪
CN107828641A (zh) * 2017-08-23 2018-03-23 苏州思维医疗科技有限公司 一种基因测序仪
CN208857264U (zh) * 2018-08-16 2019-05-14 深圳华大智造科技有限公司 加载装置及基因测序系统
CN110161003A (zh) * 2019-05-17 2019-08-23 深圳市刚竹医疗科技有限公司 光学检测装置及实时荧光定量核酸扩增检测系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6814933B2 (en) * 2000-09-19 2004-11-09 Aurora Biosciences Corporation Multiwell scanner and scanning method
JP2006038881A (ja) 2005-10-20 2006-02-09 Hitachi Ltd 生体サンプルの自動分析システム
WO2007123744A2 (en) 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
US20170022558A1 (en) * 2007-10-30 2017-01-26 Complete Genomics, Inc. Integrated system for nucleic acid sequence and analysis
MX337140B (es) 2012-04-03 2016-02-12 Illumina Inc Cabazal integrado de lectura optoelectrónica y cartucho fluído útil para secuenciación de ácidos nucleicos.
JP5978147B2 (ja) 2013-02-12 2016-08-24 株式会社日立ハイテクノロジーズ 生体物質分析装置
PT3030645T (pt) 2013-08-08 2023-02-16 Illumina Inc Sistema de fluidos para entrega de reagente a uma célula de fluxo

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032072A1 (en) * 2003-08-08 2005-02-10 Perlegen Sciences, Inc. Fragmentation and labelling with a programmable temperature control module
CN101004423A (zh) * 2006-01-19 2007-07-25 博奥生物有限公司 流体样品分析用卡盒系统
CN102703312A (zh) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 一种dna测序仪
CN103336130A (zh) * 2013-06-21 2013-10-02 嘉善加斯戴克医疗器械有限公司 一种全血免疫分析装置及使用此装置的血液分析仪
CN104569462A (zh) * 2013-10-15 2015-04-29 深圳迈瑞生物医疗电子股份有限公司 一种样本容器的搬送装置及方法
CN106967600A (zh) * 2016-01-13 2017-07-21 深圳华大基因研究院 芯片座、芯片固定构件及样品加载仪
CN107828641A (zh) * 2017-08-23 2018-03-23 苏州思维医疗科技有限公司 一种基因测序仪
CN208857264U (zh) * 2018-08-16 2019-05-14 深圳华大智造科技有限公司 加载装置及基因测序系统
CN110161003A (zh) * 2019-05-17 2019-08-23 深圳市刚竹医疗科技有限公司 光学检测装置及实时荧光定量核酸扩增检测系统

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AU2019467369A1 (en) 2022-04-21
JP7457798B2 (ja) 2024-03-28
AU2019467369B2 (en) 2023-10-19
KR20220066162A (ko) 2022-05-23
US20220341848A1 (en) 2022-10-27
AU2023266236A1 (en) 2023-12-07
WO2021056208A1 (zh) 2021-04-01
JP2022550706A (ja) 2022-12-05
EP4036554A4 (en) 2023-05-24
EP4036554A1 (en) 2022-08-03
CN114341618B (zh) 2024-05-14
CA3151328A1 (en) 2021-04-01
JP2024075643A (ja) 2024-06-04

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