CN114302883A - Vmat2抑制剂及其制备方法和应用 - Google Patents
Vmat2抑制剂及其制备方法和应用 Download PDFInfo
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- CN114302883A CN114302883A CN202080052104.0A CN202080052104A CN114302883A CN 114302883 A CN114302883 A CN 114302883A CN 202080052104 A CN202080052104 A CN 202080052104A CN 114302883 A CN114302883 A CN 114302883A
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
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Abstract
本发明涉及一类作为VMAT2抑制剂的化合物，具体涉及式(I)所述的化合物或其立体异构体或其药学上可接受的盐及其制备方法，以及在制备治疗与VMAT2相关疾病的药物的应用。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210968124.3A CN115260186B (zh) | 2019-08-12 | 2020-08-11 | Vmat2抑制剂及其制备方法和应用 |
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| CN201910739845 | 2019-08-12 | ||
| CN2019107398455 | 2019-08-12 | ||
| CN201911094084 | 2019-11-11 | ||
| CN2019110940849 | 2019-11-11 | ||
| PCT/CN2020/108314 WO2021027792A1 (zh) | 2019-08-12 | 2020-08-11 | Vmat2抑制剂及其制备方法和应用 |
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| CN202210968124.3A Division CN115260186B (zh) | 2019-08-12 | 2020-08-11 | Vmat2抑制剂及其制备方法和应用 |
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| CN114302883B CN114302883B (zh) | 2022-09-06 |
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| CN202210968124.3A Active CN115260186B (zh) | 2019-08-12 | 2020-08-11 | Vmat2抑制剂及其制备方法和应用 |
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| EP (1) | EP4015517A4 (zh) |
| JP (1) | JP2022547390A (zh) |
| KR (1) | KR20220035204A (zh) |
| CN (2) | CN114302883B (zh) |
| AU (1) | AU2020327501A1 (zh) |
| BR (1) | BR112022002107A2 (zh) |
| CA (1) | CA3148302A1 (zh) |
| WO (1) | WO2021027792A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115260186A (zh) * | 2019-08-12 | 2022-11-01 | 山东绿叶制药有限公司 | Vmat2抑制剂及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023010566A (es) * | 2021-03-22 | 2023-09-21 | Neurocrine Biosciences Inc | Inhibidores de proteina transportadora vesicular monoaminotransportadora-2 (vmat2) y metodos de uso. |
| TW202421131A (zh) * | 2022-09-21 | 2024-06-01 | 美商紐羅克里生物科學有限公司 | Vmat2抑制劑及其使用方法 |
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| CN101484190A (zh) * | 2006-05-02 | 2009-07-15 | 宾夕法尼亚大学理事会 | 放射性标记的二氢丁苯那嗪衍生物及其作为显像剂的用途 |
| WO2010026436A2 (en) * | 2008-09-08 | 2010-03-11 | Biovail Laboratories International (Barbados) Srl | Pharmaceutical compounds |
| CN102120742A (zh) * | 2010-01-08 | 2011-07-13 | 中国药科大学 | 1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-(2-甲基丙基)-2H-苯并[a]喹嗪-2-酮的制备方法 |
| WO2018222549A1 (en) * | 2017-05-31 | 2018-12-06 | Five Eleven Pharma Inc. | Novel deuterium substituted positron emission tomography (pet) imaging agents and their pharmacological application |
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| CN101553487B (zh) * | 2006-11-08 | 2012-06-13 | 纽罗克里生物科学有限公司 | 取代的3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-吡啶并[2,1-a]异喹啉-2-醇化合物和与其相关的方法 |
| US8008500B2 (en) * | 2007-06-08 | 2011-08-30 | General Electric Company | Intermediates useful for making tetrabenazine compounds |
| CN102285984B (zh) * | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| US11306082B2 (en) * | 2017-11-08 | 2022-04-19 | Foresee Pharmaceuticals Co., Ltd. | Esters of dihydrotetrabenazine |
| CA3086611C (en) * | 2017-12-26 | 2023-07-25 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | A crystalline form of valbenazine ditosylate, processes for preparation thereof and use thereof |
| CA3148302A1 (en) * | 2019-08-12 | 2021-02-18 | Shandong Luye Pharmaceutical Co., Ltd. | Vmat2 inhibitor and preparation method therefor and use thereof |
-
2020
- 2020-08-11 CA CA3148302A patent/CA3148302A1/en active Pending
- 2020-08-11 CN CN202080052104.0A patent/CN114302883B/zh active Active
- 2020-08-11 CN CN202210968124.3A patent/CN115260186B/zh active Active
- 2020-08-11 KR KR1020227005179A patent/KR20220035204A/ko not_active Application Discontinuation
- 2020-08-11 US US17/634,977 patent/US20220340562A1/en active Pending
- 2020-08-11 BR BR112022002107A patent/BR112022002107A2/pt unknown
- 2020-08-11 WO PCT/CN2020/108314 patent/WO2021027792A1/zh unknown
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| CN101484190A (zh) * | 2006-05-02 | 2009-07-15 | 宾夕法尼亚大学理事会 | 放射性标记的二氢丁苯那嗪衍生物及其作为显像剂的用途 |
| WO2010026436A2 (en) * | 2008-09-08 | 2010-03-11 | Biovail Laboratories International (Barbados) Srl | Pharmaceutical compounds |
| CN102120742A (zh) * | 2010-01-08 | 2011-07-13 | 中国药科大学 | 1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-(2-甲基丙基)-2H-苯并[a]喹嗪-2-酮的制备方法 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115260186A (zh) * | 2019-08-12 | 2022-11-01 | 山东绿叶制药有限公司 | Vmat2抑制剂及其制备方法和应用 |
| CN115260186B (zh) * | 2019-08-12 | 2024-05-28 | 山东绿叶制药有限公司 | Vmat2抑制剂及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
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| BR112022002107A2 (pt) | 2022-04-12 |
| KR20220035204A (ko) | 2022-03-21 |
| EP4015517A4 (en) | 2023-10-18 |
| CA3148302A1 (en) | 2021-02-18 |
| CN114302883B (zh) | 2022-09-06 |
| JP2022547390A (ja) | 2022-11-14 |
| WO2021027792A1 (zh) | 2021-02-18 |
| CN115260186B (zh) | 2024-05-28 |
| CN115260186A (zh) | 2022-11-01 |
| EP4015517A1 (en) | 2022-06-22 |
| AU2020327501A1 (en) | 2022-02-24 |
| US20220340562A1 (en) | 2022-10-27 |
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