CN1142939C - 类皮质激素化合物的硝酸酯及其药物应用 - Google Patents

类皮质激素化合物的硝酸酯及其药物应用 Download PDF

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Publication number
CN1142939C
CN1142939C CNB97180284XA CN97180284A CN1142939C CN 1142939 C CN1142939 C CN 1142939C CN B97180284X A CNB97180284X A CN B97180284XA CN 97180284 A CN97180284 A CN 97180284A CN 1142939 C CN1142939 C CN 1142939C
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group
application
medicine
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Expired - Fee Related
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CNB97180284XA
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Chinese (zh)
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CN1253563A (zh
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P
P·德索尔达托
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB97180284XA 1996-10-04 1997-10-02 类皮质激素化合物的硝酸酯及其药物应用 Expired - Fee Related CN1142939C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei
ITMI96A002048 1996-10-04

Publications (2)

Publication Number Publication Date
CN1253563A CN1253563A (zh) 2000-05-17
CN1142939C true CN1142939C (zh) 2004-03-24

Family

ID=11374972

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB97180284XA Expired - Fee Related CN1142939C (zh) 1996-10-04 1997-10-02 类皮质激素化合物的硝酸酯及其药物应用

Country Status (18)

Country Link
US (8) US6610676B1 (https=)
EP (1) EP0929565B1 (https=)
JP (1) JP4388600B2 (https=)
KR (1) KR100487898B1 (https=)
CN (1) CN1142939C (https=)
AT (1) ATE218142T1 (https=)
AU (1) AU719250B2 (https=)
BR (1) BR9711586A (https=)
CA (1) CA2267630C (https=)
DE (1) DE69712900T2 (https=)
DK (1) DK0929565T3 (https=)
ES (1) ES2177952T3 (https=)
HU (1) HUP9904149A3 (https=)
IT (1) IT1285770B1 (https=)
PT (1) PT929565E (https=)
RU (1) RU2186781C2 (https=)
SI (1) SI0929565T1 (https=)
WO (1) WO1998015568A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
WO2003029268A1 (en) 2001-10-03 2003-04-10 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
RU2261481C2 (ru) * 2003-03-26 2005-09-27 ФГУ Омская государственная медицинская академия Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
EP1940863B1 (en) * 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy derivatives of glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
BRPI0807078A2 (pt) * 2007-02-05 2014-04-08 Nicox Sa Composto, e, formulação farmacêutica
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
ES2442720T3 (es) * 2008-07-31 2014-02-13 Nicox S.A. Glucocorticoides unidos a ésteres de nitrato por medio de un enlazador aromático en posición 21 y su uso en oftalmología
CN102186874A (zh) * 2008-08-05 2011-09-14 尼科克斯公司 新的释放no的类固醇衍生物
CN102186873A (zh) 2008-08-05 2011-09-14 尼科克斯公司 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
US8716268B2 (en) * 2010-06-07 2014-05-06 Chao Liu Nitrate esters of corticoid compounds useful as diuretics
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN108191938B (zh) * 2018-01-11 2019-07-05 湖南新合新生物医药有限公司 9,11烯烃甾族化合物的制备方法
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (https=) * 1963-05-01
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (https=) * 1971-05-07 1973-12-28
NZ177056A (en) * 1974-03-27 1978-09-20 Plurichemie Anstalt Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
CA1058161A (en) * 1975-09-08 1979-07-10 Ravi K. Varma 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en) 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
DE69412109T2 (de) 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
SI0759899T1 (en) 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途

Also Published As

Publication number Publication date
US7368442B2 (en) 2008-05-06
DE69712900D1 (de) 2002-07-04
EP0929565A2 (en) 1999-07-21
US20060270644A1 (en) 2006-11-30
WO1998015568A3 (en) 1998-06-18
US7160871B2 (en) 2007-01-09
PT929565E (pt) 2002-10-31
US20060154905A1 (en) 2006-07-13
CN1253563A (zh) 2000-05-17
BR9711586A (pt) 1999-08-24
KR20000048911A (ko) 2000-07-25
AU719250B2 (en) 2000-05-04
US7605151B2 (en) 2009-10-20
KR100487898B1 (ko) 2005-05-09
US7157450B2 (en) 2007-01-02
IT1285770B1 (it) 1998-06-18
CA2267630A1 (en) 1998-04-16
HUP9904149A3 (en) 2001-03-28
DE69712900T2 (de) 2002-12-12
SI0929565T1 (en) 2002-08-31
US7196075B2 (en) 2007-03-27
US20050004089A1 (en) 2005-01-06
ATE218142T1 (de) 2002-06-15
JP4388600B2 (ja) 2009-12-24
CA2267630C (en) 2008-01-08
US7056905B2 (en) 2006-06-06
HUP9904149A2 (hu) 2000-04-28
US7205288B2 (en) 2007-04-17
ES2177952T3 (es) 2002-12-16
US20070161612A1 (en) 2007-07-12
US20060160780A1 (en) 2006-07-20
AU4780397A (en) 1998-05-05
RU2186781C2 (ru) 2002-08-10
WO1998015568A2 (en) 1998-04-16
US6610676B1 (en) 2003-08-26
US20080234242A1 (en) 2008-09-25
ITMI962048A1 (it) 1998-04-04
US20060160781A1 (en) 2006-07-20
JP2001501637A (ja) 2001-02-06
DK0929565T3 (da) 2002-09-09
EP0929565B1 (en) 2002-05-29

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Granted publication date: 20040324

Termination date: 20131002