CN114246923A

CN114246923A - Zhuang medicine compound medicine for treating infantile eczema and preparation and use methods thereof

Info

Publication number: CN114246923A
Application number: CN202111662333.7A
Authority: CN
Inventors: 邹敏; 翟阳; 梅小平; 刘红娟
Original assignee: International Zhuang Medical Hospital Of Guangxi
Current assignee: International Zhuang Medical Hospital Of Guangxi
Priority date: 2021-12-30
Filing date: 2021-12-30
Publication date: 2022-03-29

Abstract

The invention discloses a Zhuang medicine compound medicine for treating infantile eczema, which is prepared from the following raw materials in parts by weight: 8-25 parts of pseudotea pepper, 8-25 parts of moschus, 10-40 parts of pittosporum tobira stem, 20-60 parts of purslane, 5-40 parts of radix sophorae flavescentis, 8-25 parts of coptis chinensis, 10-30 parts of motherwort, 5-25 parts of folium artemisiae argyi, 10-35 parts of radix stemonae, 10-30 parts of fructus kochiae and 10-30 parts of cortex dictamni. The preparation method of the Zhuang medicine compound medicine comprises the following steps: s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water; s2: and after soaking, heating and extracting for 1-3 times, and combining filtrates to obtain the tea. The using method of the Zhuang medicine compound medicine comprises the following steps: and cooling the liquid medicine to 37-44 ℃ and then using the liquid medicine for bathing or cooling the liquid medicine to room temperature and then applying the liquid medicine to the affected part. The Zhuang medicine compound medicine can effectively treat infantile eczema and has the advantages of obvious curative effect and small toxic and side effects.

Description

Zhuang medicine compound medicine for treating infantile eczema and preparation and use methods thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly relates to a Zhuang medicine compound medicine for treating infantile eczema and a preparation method and a using method thereof.

Background

Infantile eczema is one of common diseases in pediatrics, and is an inflammatory and allergic skin disease of epidermis and superficial dermis caused by various internal and external factors. It is often manifested as erythema, papules, blisters, erosion of exudate, dry desquamation, severe itching, persistent itching. The clinical treatment is difficult to obtain a satisfactory result, and can be said to be a difficult disease among the infantile diseases.

The traditional Chinese medicine and Zhuang medicine have long-flowing knowledge of infantile eczema and good clinical curative effect, and the medical books of the traditional Chinese medicine and Zhuang medicine have related records of infantile eczema as early as thousands of years. Infantile eczema belongs to the categories of 'sores due to external invasion' and 'eczema' in the traditional Chinese medicine, in the 'jin Kui Yao, sores and carbuncles on intestines due to external invasion and pulse syndrome treatment', the 'sores due to external invasion and principal of coptis powder' exist, and in the Ming dynasty 'Youbu general treatise' the 'psoriasis and eczema' are the symptoms of dampness going out of spleen and dispersion and transformation of dampness. Clinically, infantile eczema is common in damp-heat type, and is vigorous, and has more food essence required by growth and development, but the internal organs of infants are delicate and tender, the spleen is often deficient, the spleen and the stomach are formed but not integrated, the spleen and the stomach are formed but not strong, and if people drink food inefficiently, the spleen qi is weak, and the transportation and transformation are insufficient to remove dampness and generate heat; the infantile eczema is formed by the body of the young yin and yang, the qi of the lung and the kidney is often insufficient, the striae of the skin is loose and the pathogenic factor is weakened, the skin is easily infected by wind, dampness and heat, and the internal and external pulsation is caused to be knotted on the skin.

The pathogenic mechanism of infantile eczema in modern medicine is not completely elucidated. But are closely related to allergic factors, immune factors, genetic factors, infection factors, skin barrier function defects and the like. The immunological research finds that the occurrence of eczema is closely related to type I and type IV allergic reactions, and is also related to the participation of mediators such as histamine, 5-hydroxytryptamine, cytokines and the like. Modern medicine is mostly symptomatic treatment for eczema, and mainly takes antihistaminic preparation, glucocorticoid, antibiotic and other medicines, while hormone medicine and antihistaminic preparation can quickly relieve symptoms, but after long-term use, the eczema has adverse effects of skin pigmentation, drying atrophy, local telangiectasia and the like, and the curative effect is also reduced.

With the development of society, the dietary structure is gradually changed, and the excessive consumption of fat, sweet and thick products increases the wet-heat constitution of children patients, the improvement of substance level changes the living habits, the cold drinking and the cold drinking cause the stagnation of pathogenic qi in the interior, and the skin develops after a long time, forming eczema. According to data statistics, the incidence rate of eczema in children is up to 10% -20%. Therefore, a more effective treatment method is developed and innovated, so that the pain of the children patients is relieved and the children patients grow healthily. Zhuang Yi Zhuang Yao has long history, rich practical experience, complete syndrome differentiation and treatment system, and is generally advocated due to its advantages of good clinical effect, various treatment methods, less side effects, high safety, and low recurrence rate.

Disclosure of Invention

The invention aims to provide a Zhuang medicine compound for treating infantile eczema, aiming at the defects of various conventional western medicines for treating infantile eczema, the Zhuang medicine compound for effectively treating infantile eczema has the advantages of remarkable curative effect and small toxic and side effects.

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 8-25 parts of pseudotea pepper, 8-25 parts of moschus, 10-40 parts of pittosporum tobira stem, 20-60 parts of purslane, 5-40 parts of radix sophorae flavescentis, 8-25 parts of coptis chinensis, 10-30 parts of motherwort, 5-25 parts of folium artemisiae argyi, 10-35 parts of radix stemonae, 10-30 parts of fructus kochiae, 10-30 parts of cortex dictamni, 5-25 parts of radix sileris, 5-25 parts of schizonepeta and 5-30 parts of mahonia fortunei.

Further, the feed comprises the following raw materials in parts by weight: 10-20 parts of pseudotea pepper, 10-20 parts of moschus, 20-30 parts of pittosporum tobira stem, 30-40 parts of purslane, 10-20 parts of radix sophorae flavescentis, 10-20 parts of coptis chinensis, 15-25 parts of motherwort, 10-20 parts of folium artemisiae argyi, 15-25 parts of radix stemonae, 15-25 parts of fructus kochiae, 15-25 parts of cortex dictamni, 10-20 parts of radix sileris, 10-20 parts of schizonepeta and 10-20 parts of mahonia fortunei.

Further comprises 8-25 parts of Dafeiyang and 8-25 parts of lantana camara.

The invention also provides a preparation method of the Zhuang medicine compound medicine for treating infantile eczema, which comprises the following steps:

s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water;

s2: and after soaking, adding water, heating and extracting for 1-3 times, and combining filtrates to obtain the traditional Chinese medicine composition.

Further, in step S1, the ratio of the material to the liquid is 1: 12-15.

Further, in step S1, the soaking time is 20-40 min.

Further, in step S2, the extraction temperature is 80-100 ℃.

Furthermore, in step S2, the time for each extraction is 0.5-1.5 h.

Further, in step S2, the amount of the obtained chemical solution is 0.5 to 0.7 times the amount of the water added.

The invention also provides a using method of the Zhuang medicine compound medicine for treating infantile eczema, which comprises the following steps: and cooling the liquid medicine to 37-44 ℃ and then using the liquid medicine for bathing or cooling the liquid medicine to room temperature and then applying the liquid medicine to the affected part.

The raw materials of the invention have the following sources and effects:

pseudo tea peppery: is root or leaf of Meliaceae plant, Cipadessa cinerascens (Pell.) hand. Slightly warm, bitter, numb and spicy. The efficacy is as follows: miao Xiao Duan, the air duct, resolve dampness, move qi and alleviate pain. The main treatment is as follows: malaria, cold, rheumatic arthralgia, dysentery, abdominal pain, burn and scald, and skin pruritus.

Moschus: is the whole herb of Adenosma glutinosum (L) Druce of Scrophulariaceae. Warm, sweet and spicy; the efficacy is as follows: dispel wind-toxin, unblock Longlu and Luo, alleviate pain and relieve itching. The main treatment is as follows: rheumatic osteodynia, poliomyelitis sequelae, abdominal pain, carbuncle, furuncle, eczema, traumatic injury, and bite.

Red back pith rod: the roots and leaves of Alchoronea trewiides (Benh.) Muell. Cool, sweet and astringent. The efficacy is as follows: clearing away heat and toxic materials, removing dampness and toxic materials, regulating functions of LONGLUO, killing parasites, and relieving itching. The main treatment is as follows: dysentery, stranguria syndrome, urolithic stranguria, hematuria, metrorrhagia, leukorrhagia, rubella, eczema, pyocutaneous disease, hemorrhoid, and traumatic hemorrhage.

Flying greatly: is whole plant or rooted whole plant of Euphorbia hirta L. Cool, spicy and sour. The efficacy is as follows: clearing away heat and toxic materials, regulating water flow, relieving itching, and promoting lactation. The main treatment is as follows: carbuncle and sore, furuncle, diarrhea, dysentery, edema, stranguria syndrome, eczema , skin pruritus, periodontitis, and puerperal hypogalactia.

Lantana camara: is the whole plant of Lantana camara L. And (5) cultivating. Cool, sweet, spicy and numb. The efficacy is as follows: clearing away heat and toxic materials, removing dampness and toxic materials, and relieving swelling and pain. The main treatment is as follows: common cold, high fever, influenza, gill disease, rheumatic arthralgia, traumatic injury, pulmonary tuberculosis, hemoptysis, scrofula, eczema and skin pruritus.

Purslane: aerial parts of Portulaca oleracea L of Portulacaceae family. Sour in taste, cold in nature; it enters large intestine meridian and liver meridian. The efficacy is as follows: clearing away heat and toxic material, cooling blood and stopping bleeding. The main treatment is as follows: treating enteritis, bacillary dysentery, furuncle, toxic swelling, snake and insect bite, hemorrhoid with swelling and pain, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoidal bleeding, metrorrhagia, acute dermatitis, subacute dermatitis, herpes zoster, puerperal and functional facial hemorrhage, appendicitis, and ancylostomiasis.

Flavescent sophora root: is processed product of dried root of Sophora flavescens ait (Sophora flavescens) belonging to Leguminosae. Bitter taste and cold nature; it enters heart, liver, stomach, large intestine and bladder meridians. The efficacy is as follows: clear heat and dry dampness, kill parasites and induce diuresis. The main treatment is as follows: can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis.

Coptis chinensis: is rhizome of Coptis chinensis Franch of Ranunculaceae. Cold in nature, bitter in taste; they enter heart, spleen, stomach, liver, gallbladder and large intestine meridians. The efficacy is as follows: clear heat and dry dampness, purge fire and remove toxicity. The main treatment is as follows: dampness-heat, abdominal fullness, emesis, acid regurgitation, dysentery, jaundice, high fever, coma, hyperactivity of heart-fire, blood heat, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle. It is indicated for eczema, eczema and purulence in ear canal by proper dosage for external application.

Motherwort: is aerial part of Leonurus japonicus sweet. Slightly cold in nature, bitter and pungent in flavor; it enters liver meridian, heart meridian and bladder meridian. The efficacy is as follows: promoting blood circulation, regulating menstruation, inducing diuresis, and relieving swelling. The main treatment is as follows: dysmenorrhea, amenorrhea, unsmooth menstruation, postpartum abdominal pain due to blood stasis; edema, dysuria, etc.

Folium artemisiae argyi: is leaf of Artemisia argyi Levl. et Vant. Warm in nature, bitter and pungent in flavor; it enters liver, spleen and kidney meridians. The efficacy is as follows: dispel cold, alleviate pain, warm meridians and stop bleeding. The main treatment is as follows: cold pain in lower abdomen, irregular menstruation, infertility due to cold womb, hematemesis, epistaxis, metrorrhagia, metrostaxis, and pregnancy bleeding; it can be used for treating skin pruritus.

Stemona root: is root tuber of Stemona sessilifolia (Miq.) Miq, Stemona Stemona sessilifolia (Bl.) Miq. Slightly warm in nature, sweet and bitter in taste; it enters lung meridian. The efficacy is as follows: moisten lung to arrest cough, kill parasites and kill lice. The main treatment is as follows: cough due to new or old age, cough due to tuberculosis, and cough due to tussis; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus.

The preparation method comprises the following steps of (1) preparing broom cypress fruit: is a pilus of Kochia scoparia (L.) Schrad. Cold in nature, sweet and bitter in taste; it enters kidney and bladder meridians. The efficacy is as follows: clear damp-heat and relieve itching. The main treatment is as follows: skin pruritus, urticaria, eczema and dysuria.

And (3) preparing cortex dictamni: is root bark of Dictamnus dasycarpus Turcz. Cold in nature, bitter in taste; it enters spleen and stomach meridians. The efficacy is as follows: clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substance. The main treatment is as follows: sore due to damp-heat, impetigo, eczema, rubella, scabies, rheumatism, jaundice, dark urine, etc.

Wind prevention: root of Saposhnikovia divaricata (Turcz.) Schischk. Warm in nature, sweet and pungent in flavor; it enters bladder meridian, liver meridian and spleen meridian. The efficacy is as follows: relieving exterior syndrome, dispelling pathogenic wind, and removing dampness. The main treatment is as follows: cold, headache, fever, anhidrosis, rheumatic arthralgia, spasm of limbs, skin pruritus due to wind-damp, tetanus, etc.

Herba schizonepetae: is aerial part of Schizonepeta tenuifolia Briq. of Labiatae. Mild in nature and pungent in flavor; it enters lung and liver meridians. The efficacy is as follows: relieving exterior syndrome, dispelling pathogenic wind and promoting eruption. The main treatment is as follows: common cold, headache, measles, rubella, and pyocutaneous disease.

Chinese Mahonia: stem and leaf of plant (Mahonia fortunei (Lindl.) Fedde) of Mahonia of berberidaceae. Bitter and cool. The efficacy is as follows: clear heat, tonify deficiency, relieve cough and resolve phlegm. The main treatment is as follows: it is indicated for pulmonary tuberculosis, hemoptysis, hectic fever, dizziness, tinnitus, soreness of waist and knees, vexation, and conjunctival congestion.

Compared with the prior art, the invention has the beneficial effects that:

1. the invention starts from the pathology of infantile eczema, is prepared by using the Zhuang medicine components with unique curative effect by combining the physiological and pathological characteristics of infants, overcomes the defects of large side effect and easy generation of drug resistance of western medicines by utilizing the advantages of Zhuang medicine, small side effect of traditional Chinese medicines and difficult generation of drug resistance, and has the characteristics of low cost, convenient use, obvious curative effect, heat clearing, dampness eliminating, detoxification, itching relieving and small toxic and side effect, and the preparation process is simple.

2. The compound of the invention can strengthen the spleen and the stomach, nourish qi and blood, improve the frequent insufficiency of the spleen of children, strengthen the body of the spleen and the stomach, nourish the qi of the spleen and the stomach, treat the weakness of the spleen and the qi of the children, and eliminate dampness and generate heat due to insufficient transportation and transformation; it also has effects in invigorating kidney, moistening lung, treating deficiency of lung and kidney qi, loosening striae, and resisting pathogenic factors, and preventing eczema due to affection of wind, dampness and heat. The medicines are reasonably compatible and the curative effect is obvious. Clinical practices show that the traditional Chinese medicine and Zhuang medicine for treating infantile eczema has the effects of clearing heat, drying dampness, detoxifying and relieving itching, can improve symptoms of children with eczema, and has the advantages of definite and stable curative effect and no toxic or side effect.

3. The invention aims at the physiological and pathological characteristics of eczema considered by traditional Chinese medicine, and uses 14 medicines of pseudotea pepper, moschus, lindera glauca stem, euphorbia hirta, lantana camara, purslane, radix sophorae flavescentis, coptis chinensis, motherwort herb, folium artemisiae argyi, radix stemonae, fructus kochiae, cortex dictamni, radix sileris, herba schizonepetae and Chinese mahonia. In the formula, the pittosporum tobira stem, the fleabane, the broom cypress fruit and the cortex dictamni are combined into monarch drugs to play the effects of clearing heat, drying dampness, detoxifying and relieving itching; the pseudotea pepper, the moschus, the lantana camara, the purslane, the radix sophorae flavescentis and the radix stemonae are combined into ministerial medicines to assist monarch medicines in strengthening the effects of clearing heat and drying dampness, detoxifying, killing parasites and relieving itching; the coptis, the motherwort, the folium artemisiae argyi and the Chinese mahonia are combined as adjuvant drugs and matched with monarch drugs and ministerial drugs to play the roles of clearing heat, promoting diuresis and tonifying deficiency. Ledebouriella root, radix Saposhnikoviae and Schizonepeta tenuifolia are used as guiding drugs to reach the skin striae and striae, and they also have the actions of dispelling wind, relieving itching and promoting eruption. The whole formula is used together, and the effects of clearing heat, eliminating dampness, detoxifying and relieving itching are achieved. The radix linderae rubra stem and the motherwort are used together, so that the dragon road and the qi circulation can be adjusted, the spleen and lung qi can be smooth, the transportation and the transformation can be smooth, the motherwort can activate blood and remove stasis to help to dissipate evil, the radix linderae rubra stem can dispel wind, clear heat and promote diuresis, the two medicines are used together to dispel wind and remove dampness, and the qi and the blood are smooth; the mahonia fortunei and the radix linderae rubra are used together, so that the dampness and the toxicity can be removed, the pathogenic heat can be cleared, and the pathogenic heat can be cleared; the motherwort herb and the Chinese mahonia are used together, and can tonify the lung and qi, clear heat and promote diuresis and activate blood circulation, and eliminate dampness and remove heat stasis. The combination of the three can effectively treat the infantile eczema.

Detailed Description

Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.

Example 1

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 10 parts of pseudotea pepper, 25 parts of moschus, 40 parts of pittosporum rubrum, 20 parts of euphorbia hirta, 8 parts of lantana camara, 40 parts of purslane, 10 parts of radix sophorae flavescentis, 20 parts of coptis chinensis, 15 parts of motherwort, 20 parts of folium artemisiae argyi, 15 parts of radix stemonae, 25 parts of fructus kochiae, 15 parts of cortex dictamni, 5 parts of radix sileris, 20 parts of schizonepeta and 10 parts of mahonia fortunei.

The preparation method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps:

s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water at a material-liquid ratio of 1:12 for 20 min;

s2: after soaking, extracting for the first time, heating to 80 deg.C, extracting for 0.5h, and filtering to obtain medicinal liquid; extracting for the second time, heating to 90 ℃, extracting for 1h, and filtering; and mixing the filtrates.

The using method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps: after the liquid medicine is cooled to room temperature, the liquid medicine is applied to the affected part.

Example 2

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 25 parts of pseudotea pepper, 20 parts of moschus, 20 parts of pittosporum tobira stem, 8 parts of euphorbia hirta, 25 parts of lantana camara, 20 parts of purslane, 5 parts of radix sophorae flavescentis, 8 parts of coptis chinensis, 30 parts of motherwort, 25 parts of folium artemisiae argyi, 35 parts of radix stemonae, 10 parts of fructus kochiae, 20 parts of cortex dictamni, 25 parts of radix sileris, 10 parts of herba schizonepetae and 20 parts of mahonia fortunei.

s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water at a material-liquid ratio of 1:15 for 30 min;

s2: after soaking, extracting for the first time, heating to 90 ℃, extracting for 1h, and filtering to obtain a liquid medicine; extracting for the second time, heating to 90 ℃, extracting for 1h, and filtering; and mixing the filtrates.

The using method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps: cooling the medicinal liquid to 37 deg.C, and bathing.

Example 3

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 15 parts of pseudotea pepper, 8 parts of moschus, 25 parts of pittosporum rubrum, 25 parts of euphorbia hirta, 15 parts of lantana camara, 35 parts of purslane, 20 parts of radix sophorae flavescentis, 15 parts of coptis chinensis, 10 parts of motherwort, 10 parts of folium artemisiae argyi, 20 parts of radix stemonae, 20 parts of fructus kochiae, 10 parts of cortex dictamni, 15 parts of radix sileris, 15 parts of herba schizonepetae and 15 parts of mahonia fortunei.

s2: after soaking, extracting for the first time, heating to 100 ℃, extracting for 1h, and filtering to obtain a liquid medicine; extracting for the second time, heating to 100 ℃, extracting for 1h, and filtering; and mixing the filtrates.

The using method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps: cooling the medicinal liquid to 42 deg.C, and bathing.

Example 4

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 8 parts of pseudotea pepper, 15 parts of moschus, 10 parts of pittosporum tobira stem, 30 parts of purslane, 30 parts of radix sophorae flavescentis, 25 parts of coptis chinensis, 25 parts of motherwort, 15 parts of folium artemisiae argyi, 10 parts of radix stemonae, 15 parts of fructus kochiae, 25 parts of cortex dictamni, 20 parts of radix sileris, 5 parts of herba schizonepetae and 20 parts of Chinese mahonia stem.

s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water at a material-liquid ratio of 1:13 for 35 min;

s2: after soaking, extracting for the first time, heating to 100 ℃, extracting for 1h, and filtering to obtain a liquid medicine; extracting for the second time, heating to 100 ℃, extracting for 1h, and filtering; extracting for the third time, heating to 100 ℃, extracting for 1h, and filtering; and mixing the filtrates.

The using method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps: cooling the medicinal liquid to 40 deg.C, and bathing.

Example 5

The Zhuang medicine compound medicine for treating infantile eczema comprises the following raw materials in parts by weight: 20 parts of pseudotea pepper, 10 parts of moschus, 30 parts of pittosporum tobira stem, 60 parts of purslane, 40 parts of radix sophorae flavescentis, 10 parts of coptis chinensis, 20 parts of motherwort, 5 parts of folium artemisiae argyi, 25 parts of radix stemonae, 30 parts of fructus kochiae, 30 parts of cortex dictamni, 10 parts of radix sileris, 25 parts of herba schizonepetae and 5 parts of Chinese mahonia stem.

s1: cleaning all the raw materials, filtering to remove impurities, and soaking in cold water at a material-liquid ratio of 1:14 for 25 min;

s2: after soaking, extracting for the first time, heating to 80 ℃, extracting for 1.5h, and filtering to obtain a liquid medicine; extracting for the second time, heating to 90 deg.C, extracting for 1.5h, and filtering; extracting for the third time, heating to 100 ℃, extracting for 1h, and filtering; and mixing the filtrates.

The using method of the Zhuang medicine compound medicine for treating infantile eczema comprises the following steps: cooling the medicinal liquid to 44 deg.C, and bathing.

Comparative example 1

The preparation method is basically the same as the embodiment 3, except that the raw materials are not added with the shanma yunnanensis stem, the motherwort and the mahonia fortunei, and the mixture ratio of the other components is unchanged.

Comparative example 2

The preparation method is basically the same as the embodiment 3, except that the prepared raw materials are not added with the kenaf raspberry stem and the motherwort, and the mixture ratio of the other components is unchanged.

Comparative example 3

The procedure of example 3 was repeated except that the materials were not supplemented with kenaf raspberry stem and mahonia, and the proportions of the other ingredients were not changed.

Comparative example 4

The preparation method is basically the same as the embodiment 3, except that motherwort and Chinese mahonia are not added into the prepared raw materials, and the mixture ratio of the other components is unchanged.

First, animal experiment

1. Animal(s) production

160 healthy and clean BALB/c mice, 6-8 weeks old and 20-30g of body mass, provided by animal laboratories of Guangxi university of traditional Chinese medicine.

2. Method of producing a composite material

2.1 establishment of mouse eczema model

The specific operation method for constructing the mouse eczema model comprises the following steps: 160 mice are taken, the backs and the abdomens of the mice are shaved by electric clippers, the area of the shaved backs and the abdomens of the mice is cut to be in the range of 2.0cm x 2.0cm for standby, 50 mul of 7% DNCB (2, 4-dinitrochlorobenzene) solution is coated on the shaved parts of the mice for sensitization, sensitization is enhanced once again on the 2 nd day, 30 mul of 0.1% DNCB solution is coated on the shaved back areas for excitation on the 4 th day and excitation is carried out once every 3d, the skin properties of the backs and the abdomens of the mice are observed by naked eyes after the 4 th time, if the skins of the backs and the abdomens are dry and rough, dark red spots and brown scabs, and the mice frequently lick and scratch and restless, the molding success is indicated.

2.2 administration by groups

Mice successfully modeled were randomly divided into an eczema model group, a pediatric eczema Zhuang medicine compound drug group, a positive control group (dexamethasone positive control group) and a comparative example group, wherein 20 mice in each group were treated with corresponding drugs respectively on the 2 nd day after the excitation was stopped.

Respectively adopting 2000mL of the children eczema strengthening medicine compound medicine in the embodiment 3 and the medicine solution in the comparative examples 1-4 to soak and bathe the mice for 7 days, wherein the soaking and bathing are carried out 1 time per day and 10 minutes per time; the positive control group is administered dexamethasone 0.65 mg/kg^-1Dissolving the extract in normal saline to prepare 2000mL of solution, and soaking the solution in the normal saline for 7 days 1 time per day and 10 minutes per time; model (model)The mice were bathed with an equal amount of 0.9% physiological saline 1 time per day for 10 minutes each time for 7 days.

3. Degree score of eczema skin damage of abdomen and back of each group of mice

Observing skin condition before and after each administration, such as erythema degree, edema or pimple, epidermal exfoliation or scratch degree, wound exudation or scabbing degree, and horny layer moss degree

And (4) grading the skin damage according to the sample variation degree, and preparing 0-5 parts. The score 0 is asymptomatic, the score 5 is highly marked, and the score increases in units of 0.5.

4. Criteria for efficacy assessment

(1) The evaluation standard of the curative effect of the disease is drawn up according to the clinical research guiding principle of the new traditional Chinese medicine, and the calculation method adopts the nimodipine method: [ (before treatment score for SCORAD-after treatment score for SCORAD)/before treatment score for SCORAD ] 100%.

The clinical cure is as follows: the skin lesions are completely removed, the symptoms disappear, and the integral value is reduced by more than or equal to 90 percent;

the effect is shown: the skin lesion is mostly removed, the symptom is obviously relieved, and the integral value is reduced by more than or equal to 70 percent when the integral value is more than 90 percent;

the method has the following advantages: the skin lesion is partially removed, the symptom is improved, and the integral value is reduced by more than or equal to 50 percent when the ratio is 70 percent;

and (4) invalidation: the skin lesions are not obviously removed, the symptoms are not relieved or worsened reversely, and the integral value is reduced by less than 50 percent.

(2) Total effective rate ═ [ (number of clinical recovery cases + number of significant cases + number of effective cases)/total number of cases in this group ]. 100%.

5. Statistical method

SPSS22.0 software is adopted for data processing, the measured data is expressed by mean +/-standard deviation (x- +/-s), variance analysis is adopted for comparison among groups, LSD-t test is adopted for pairwise comparison among groups, and the difference P < 0.05 has statistical significance.

6. Results

1. The results of skin lesion scoring for each group of mice are shown in table 1.

TABLE 1 evaluation results of the degree of eczema of abdomen and back of each group of mice (point, x)^-±s，n＝20)

Compared with the model group, P is less than 0.05, and the difference has statistical significance.

2. The therapeutic effect of each group of mice is shown in Table 2

Table 2 curative effect (example) of each group of mice (n ═ 20)

As can be seen from table 2:

(1) before administration, 3 groups have erythema, pimple, scratch/exfoliation, and comparative difference of skin damage scores has no statistical significance (P is more than 0.05); compared with the eczema model group, the skin damage score of the positive control group is reduced after 1 day (P is less than 0.05), and the skin damage score of the children eczema Zhuang medicine compound medicine group is reduced after 3 days (P is less than 0.05).

(2) The total effective rate of the embodiments 3-4 of the invention is above 90%, and the cure rate is above 60%; example 4 compared with example 3, the two medicines of Dafeiyang and lantana camara are omitted, and the total effective rate and the cure rate are both reduced by 5%.

(3) Compared with the eczema model group, the comparative example 1, the comparative example 2, the comparative example 3 and the comparative example 4, the total effective rate and the cure rate of the example 3 are superior to those of the eczema model group, the comparative example 1, the comparative example 2, the comparative example 3 and the comparative example 4, and the difference has statistical significance (P is less than 0.05); compared with the positive control group, the total effective rate and the cure rate of the example 3 are equivalent, and the difference has no statistical significance (P is more than 0.05). Therefore, the compound medicine can effectively treat the eczema.

(4) The treatment effects of the comparative examples 1 to 4 are lower than those of the example 3, and the effect of the example 3 relative to the comparative example 1 is better than the sum of the effects of the comparative examples 2 to 4 relative to the comparative example 1, so that the pseudotea peppers, the moschus and the kenaf stems in the raw materials can generate a synergistic effect, and the treatment effect of treating infantile eczema is improved. Comparative example 2 and comparative example 4, although showing the same total effective rate, the cure rate of comparative example 4 is higher than comparative example 2.

Second, clinical research

1. Medical record data

1.1 number of selected persons

The Zhuang nationality medicine compound of infantile eczema in example 3 was applied to 60 children patients with infantile eczema, and was randomized between men and women.

1.2 diagnostic criteria

1.2.1 diagnostic criteria for Western medical conditions

According to the diagnosis standard of eczema in Chinese clinical dermatology compiled by Zhao dialectic main, the method comprises the following steps:

(1) the rash is dense papule-sized papule, herpes simplex or vesicle, and basal flushing;

(2) the papules, the papules or the papules have obvious punctate exudation and small erosion surfaces after the tips are scratched, the serous fluid continuously exudes, the centers of lesions are often heavier and gradually spread to the periphery, and the peripheries of the lesions are scattered on the papules or the papules, so that the boundaries are unclear;

(3) it can occur on any part of the body surface, and most of the skin lesions are distributed symmetrically and usually appear on the exposed parts of the head, face, behind the ears, at the distal ends of the limbs, hands and feet, etc.

1.2.2 Chinese medicine syndrome diagnostic standard

Referring to the syndrome and expression of damp-heat type in the traditional Chinese medicine syndrome diagnosis curative effect standard issued by the State administration of traditional Chinese medicine and pharmacy and the practical traditional Chinese medicine pedigree compiled by Zhang Qiwen and Zhu jin, the formulated diagnosis standard is as follows:

syndrome of dampness-heat:

the main symptoms are: it is clustered or scattered on the head, face, limbs, buttocks, etc. to form erythema, pimple, local flush and burning, exudation and juice, and pruritus.

The secondary symptoms are as follows: thirst, restlessness, poor appetite, dry stools, shortness of urine and reddening of urine. Red tongue with thin yellow or white coating, purple red fingerprint, and slippery or rapid pulse.

Those with more than 2 major and minor symptoms can be diagnosed by combining the tongue pulse.

1.3 case inclusion criteria

(1) The diagnosis standard of the infantile eczema western medicine disease is met;

(2) the diagnosis standard of infantile eczema (damp-heat syndrome) is met;

(3) the age is 2 months to 12 years;

(4) children who have not been treated with other oral or topical drugs within 1 week;

(5) the legal guardian signs an informed consent and actively cooperates.

1.4 case exclusion criteria

(1) Does not meet the inclusion criteria;

(2) patients with severe eczema, patients with skin lesions locally complicated with bacterial, viral or fungal infections;

(3) simultaneously, other skin diseases such as seborrheic dermatitis, stasis dermatitis, neurodermatitis and the like are suffered;

(4) severe primary diseases such as severe heart, liver, kidney, digestive and hematopoietic diseases are combined;

(5) those allergic to the test drugs or their components.

1.5 rejection and shedding Standard

(1) Cases that do not meet inclusion criteria or are mistakenly entered;

(2) the disease condition of the subject does not reach the expected control degree within a period of time;

(3) if the judgment of curative effect is affected, the medicine is not taken according to the regulation or clinical data is incomplete;

(4) for various reasons, the subject himself requires to quit the test;

(5) serious other complications occur during the study;

(6) other drugs that may affect the efficacy assessment are taken during the study.

2. Method of producing a composite material

2.1 methods of treatment

The treatment with the drug of example 3 of the present invention was once a day. The diet should be light during the treatment period, and spicy food should not be stimulated; all drugs that might interfere with the results of the study were banned.

2.2 Observation indicators and Scoring standards

2.2.1 safety Observation indicators

(1) Blood routine, urine analysis, and stool routine examination (one test before and after treatment).

(2) Examination of heart, liver and kidney functions (one test before and after treatment).

(3) Adverse reactions that may occur (recorded over time).

2.2.2 therapeutic efficacy side-viewing indices

2.2.2.1 indexes of curative effect of diseases: the efficacy of the treatment was assessed by using the score of SCORAD as proposed by the European atopic dermatitis research group, and scoring before and after treatment.

TABLE 3 SCORAD scoring table

2.2.2.2 Chinese medicine syndrome therapeutic index

The Chinese medicine syndrome scoring table formulated by the clinical test design and evaluation technical guideline for new Chinese medicine for infantile eczema department of the pediatrics division of the Chinese medical society is referred to, and the scoring is respectively carried out before and after the treatment so as to evaluate the curative effect of the medicine.

TABLE 4 Chinese medicine syndrome scoring table

2.2.2.3 Observation day

The observation days are before the administration and 3 rd and 7 th days after the administration. The treatment was recorded once before and after treatment.

2.3 evaluation criteria

2.3.1 therapeutic efficacy assessment criteria

3 results

See table 5.

TABLE 5 eczema treatment

Cure of disease	Show effect	Is effective	Invalidation	The cure rate is%	High efficiency
						25	20	11	4	41.7	93.3％

As can be seen from Table 5, the compound medicine of the embodiment 3 of the invention can effectively treat infantile eczema, the cure rate reaches 41.7%, and the total effective rate reaches 93.3%.

Third, clinical application

Certain Luoyangqi, male, 1 year old 3 months old, Nanning people, infants with pruritus on the back and cheek, papules, local flushing and burning heat, liquid seepage and juice flowing, and clinical diagnosis of infantile eczema, the medicine is administered to the patient in the embodiment 3 according to the invention for treatment, and the medicine is used once a day, and seven days are 1 course of treatment. After 1 treatment course, the pimple on the affected part disappeared without itching.

In Zhongzhi, maid, 3 months, Bai chou city people, infant buttocks and face, erythema and pimple, local flushing and burning, partial effusion and clinical diagnosis of infantile eczema, the medicine is administered to the patient in example 2 according to the invention, and the medicine is used once a day, and seven days are 1 course of treatment. After 1 treatment course, erythema disappeared, pimple decreased, and no itching.

A certain child suffers from pruritus capitis, pruritus of the face and the limbs of the child, and is scattered on the papulopapule, the clinical diagnosis is infantile eczema, the drug is given to the child in the embodiment 4 for treatment according to the invention, the drug is used once a day, and seven days are 1 course of treatment. After 1 treatment course, symptoms disappeared and pimples disappeared.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. The Zhuang medicine compound medicine for treating infantile eczema is characterized by comprising the following raw materials in parts by weight: 8-25 parts of pseudotea pepper, 8-25 parts of moschus, 10-40 parts of pittosporum tobira stem, 20-60 parts of purslane, 5-40 parts of radix sophorae flavescentis, 8-25 parts of coptis chinensis, 10-30 parts of motherwort, 5-25 parts of folium artemisiae argyi, 10-35 parts of radix stemonae, 10-30 parts of fructus kochiae, 10-30 parts of cortex dictamni, 5-25 parts of radix sileris, 5-25 parts of schizonepeta and 5-30 parts of mahonia fortunei.

2. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-20 parts of pseudotea pepper, 10-20 parts of moschus, 20-30 parts of pittosporum tobira stem, 30-40 parts of purslane, 10-20 parts of radix sophorae flavescentis, 10-20 parts of coptis chinensis, 15-25 parts of motherwort, 10-20 parts of folium artemisiae argyi, 15-25 parts of radix stemonae, 15-25 parts of fructus kochiae, 15-25 parts of cortex dictamni, 10-20 parts of radix sileris, 10-20 parts of schizonepeta and 10-20 parts of mahonia fortunei.

3. The Zhuang nationality medicine compound for treating infantile eczema according to claim 1 or 2, which is characterized by further comprising 8-25 parts of Dafeiyang and 8-25 parts of lantana camara.

4. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 1 or 2, wherein the preparation method comprises the following steps:

s2: and after soaking, heating and extracting for 1-3 times, and combining filtrates to obtain the tea.

5. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 4, which is characterized in that: in step S1, the ratio of the material to the liquid is 1: 12-15.

6. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 4, which is characterized in that: in step S1, the soaking time is 20-40 min.

7. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 4, which is characterized in that: in step S2, the extraction temperature is 80-100 ℃.

8. The Zhuang nationality medicine compound for treating infantile eczema as claimed in claim 4, which is characterized in that: in the step S2, the time for each extraction is 0.5-1.5 h.

9. The Zhuang nationality medicine compound for treating infantile eczema as claimed in any one of claims 1-8, which is used by the following steps: and cooling the liquid medicine to 37-44 ℃ and then using the liquid medicine for bathing.

10. The Zhuang nationality medicine compound for treating infantile eczema as claimed in any one of claims 1-8, which is used by the following steps: after the liquid medicine is cooled to room temperature, the liquid medicine is applied to the affected part.