CN116211985B - Traditional Chinese medicine composition for treating flat wart, traditional Chinese medicine preparation and application thereof - Google Patents
Traditional Chinese medicine composition for treating flat wart, traditional Chinese medicine preparation and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating verruca plana, a traditional Chinese medicine preparation and application thereof. The Chinese medicinal composition comprises rhizoma Polygoni Cuspidati, herba Hedyotidis Diffusae, concha Ostreae, radix Isatidis, radix Arnebiae, carthami flos, curcumae rhizoma, radix Curcumae and Glycyrrhrizae radix. The traditional Chinese medicine formula disclosed by the invention is not only small in medicinal flavor, but also is all common traditional Chinese medicines, is easy to take, is low in price, can effectively reduce the treatment expense of a patient, is prepared by arranging various medicines, has the advantages of thorough treatment of flat warts, no recurrence, obvious treatment effect, no obvious adverse reaction and the like, is especially suitable for patients with long disease course, difficult recovery after long time, more skin damage, poor treatment effect of external medicines, qi stagnation and blood stasis, and can be popularized and used on a large scale.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a traditional Chinese medicine composition for treating verruca plana, a traditional Chinese medicine preparation and application thereof.
Background
Flat wart is a common viral skin disease caused by human papilloma virus infection, has the characteristics of repeated attack, persistent difficult healing and the like, and is usually easy for trauma patients with low body immunity. The disease is particularly well developed in the exposed parts of the face, back, neck, arms, etc. of women, most distressing young women. The incidence rate of flat warts is high, the treatment difficulty is high, and the flat warts are always headache of dermatologists. The needles which are clinically shown as skin or light brown are round, oval or polygonal, and can be densely distributed or linearly arranged due to local scratching, and generally have no obvious subjective symptoms or slight itching. The course of the disease is chronic and can last for months or years. Infection may be by direct or indirect contact. The current systemic treatment methods of flat warts by western medicine mainly comprise antiviral drugs (acyclovir, famciclovir, ganciclovir, valacyclovir and the like), retinoids and various immunomodulators (thymus peptide, interferon, transfer factors and the like). The commonly used topical western medicines include imiquimod, tretinoin, etc. External Western medicine treatment methods comprise liquid nitrogen freezing treatment, laser treatment, photodynamic therapy and the like.
The existing Western medicine has small virus inhibition and virus resistance effects; physical therapy is prone to relapse; some patients have sequelae such as scars, pigmentation and the like after treatment, and the treatment effect is poor. The traditional Chinese medicine brings flat wart into the category of 'flat wart', and the theory of traditional Chinese medicine considers that the disease is mainly formed by spleen dysfunction and transportation, damp-heat endogenous accumulation as toxin, re-sense wind evil and skin coagulation. The striae and striae are not firm, damp-heat toxin invades the skin and evil toxin is blocked on the surface of the muscle, and after long-term depression, toxin is transformed into blood stasis, which leads to stagnation of qi and blood. Flat warts are common in young people, and they are caused by excessive stagnation of qi and blood, so this disease is usually seen in clinic. The accumulation of heat-toxin, no dissipation in the day, blood vessel blockage, and accumulation of heat-accumulation in collaterals, blood stasis, heat and toxin can be avoided. At present, traditional Chinese medicine formulas are also used for treating flat warts, such as:
chinese patent CN105079603A discloses a traditional Chinese medicine composition for treating verruca plana and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from cortex mori, honeysuckle, fructus forsythiae, radix adenophorae, radix ophiopogonis, platycodon grandiflorum, radix scutellariae, fructus Gardeniae, liquorice, radix rehmanniae, cortex moutan, radix isatidis, myotonin, bighead atractylodes rhizome, dandelion, wild chrysanthemum flower, radix scrophulariae, poria cocos, peach kernels and almonds according to a certain proportion.
Chinese patent CN105079603a discloses a traditional Chinese medicine for treating flat wart, which is prepared from the following medicinal materials in parts by weight: 8 parts of fringed pink, 5 parts of bamboo shavings, 5 parts of Japanese ampelopsis root, 7 parts of radix peucedani, 15 parts of honeysuckle stem, 12 parts of ash bark, 3 parts of campsis grandiflora, 10 parts of drynaria rhizome, 5 parts of stachys, 4 parts of large-leaf gentian root, 5 parts of scandent hop, 3 parts of apocynum venetum, 10 parts of glabrous sarcandra herb and 12 parts of eucalyptus leaf.
However, the traditional Chinese medicine has more traditional Chinese medicine taste, some raw materials are not easy to obtain, and the cost is high.
Giant knotweed, also called giant knotweed, male coptis, blood-activating dragon and the like, is a herb of diuresis and dampness-excreting, has the functions of clearing heat and detoxicating, excreting dampness and eliminating jaundice, dispersing blood stasis and relieving pain, relieving cough and reducing sputum, but the prior art does not use the giant knotweed as a monarch drug for treating flat warts.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a traditional Chinese medicine composition for treating flat warts, a traditional Chinese medicine preparation and application thereof, the traditional Chinese medicine composition takes giant knotweed rhizome as a monarch drug, focuses on the comprehensive application of the clearing method, the eliminating method and the regulating method in eight methods, carries out overall differentiation treatment from viscera and six excesses, grasps the characteristics of flat warts, not only clears heat and cools blood, dehumidifies and detoxifies, but also does not forget to activate blood and remove stasis and software to remove stasis according to the appearance of warts and the basic evolution rule of long-term diseases, focuses on treating the root cause, and combines the symptoms and the exterior and interior, and finally leads wind-break, evil heat clearing, toxicity relieving, liver qi dredging, blood self-harmonizing, stasis and dispersing warts.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the first aspect of the invention provides a traditional Chinese medicine composition for treating flat wart, which comprises the following components: herba Hedyotidis Diffusae, concha Ostreae, radix Isatidis, rhizoma Polygoni Cuspidati, radix Arnebiae, carthami flos, curcumae rhizoma, radix Curcumae and Glycyrrhrizae radix.
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-30 parts of giant knotweed, 20-40 parts of oldenlandia diffusa, 20-40 parts of oyster, 10-30 parts of radix isatidis, 5-20 parts of lithospermum, 8-18 parts of safflower, 5-30 parts of curcuma zedoary, 5-20 parts of radix curcumae and 1-5 parts of liquorice.
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of giant knotweed, 30 parts of oldenlandia diffusa, 30 parts of oyster, 15 parts of radix isatidis, 10 parts of lithospermum, 12 parts of safflower, 10 parts of curcuma zedoary, 10 parts of radix curcumae and 3 parts of liquorice.
The second aspect of the invention provides a traditional Chinese medicine preparation for treating verruca plana, which is prepared from the raw materials comprising the traditional Chinese medicine composition.
Further, the traditional Chinese medicine preparation is in the form of granules, tablets, capsules, pills or decoction.
In a third aspect, the invention provides a pharmaceutical composition for treating flat warts, which comprises the traditional Chinese medicine preparation and vitamin A acid cream.
Further, the traditional Chinese medicine preparation is decoction.
The fourth aspect of the invention provides application of the traditional Chinese medicine composition in preparation of a medicine for treating flat wart.
Further, the flat wart is a flat wart with qi stagnation and blood stasis.
Compared with the prior art, the invention has the following technical effects:
the traditional Chinese medicine formula provided by the invention has the advantages of few medicinal herbs, common traditional Chinese medicines, easiness in taking, low price, capability of effectively reducing the treatment expense of patients, thorough treatment, no recurrence, obvious treatment effect, no obvious adverse reaction and the like, and is especially suitable for patients with long disease course, difficult recovery, more skin damage, poor treatment effect of external medicines, qi stagnation and blood stasis.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating verruca plana, which comprises the following components: the traditional Chinese medicine composition comprises polygonum cuspidatum, oldenlandia diffusa, oyster, radix isatidis, lithospermum, safflower, curcuma zedoary, radix curcumae and liquorice, and preferably comprises the following raw materials in parts by weight: 10-30 parts of giant knotweed, 20-40 parts of oldenlandia diffusa, 20-40 parts of oyster, 10-30 parts of radix isatidis, 5-20 parts of lithospermum, 158-18 parts of safflower, 205-30 parts of curcuma zedoary, 5-20 parts of radix curcumae and 1-5 parts of liquorice. The traditional Chinese medicine composition provided by the invention is prepared according to the characteristics of clinical flat wart patients by the inventor, and has better curative effect in clinical use. In the formula, giant knotweed rhizome has the effects of clearing heat and detoxicating, promoting diuresis and treating stranguria, is used as a monarch drug, and radix isatidis, oldenlandia diffusa and lithospermum have the effects of clearing heat and detoxicating and promoting diuresis, and is used as ministerial drug, and safflower, rhizoma curcumae and radix curcumae are used as assistant drugs to promote qi circulation and promote blood circulation to remove blood stasis, and oyster has the effects of softening hardness and dissipating stagnation; so that the licorice can regulate the medicines, protect the stomach and regulate the middle warmer. The medicines in the recipe are arranged to supplement each other, so that qi and blood are smooth, blood stasis is eliminated, stagnation is eliminated, and toxin is eliminated. The invention has no serious adverse reaction to the treatment of flat wart and good patient compliance. The traditional Chinese medicine composition has remarkable effect of treating flat wart and is worthy of popularization.
The present invention will be described in detail and in detail by way of the following examples, which are not intended to limit the scope of the invention, for better understanding of the invention.
The methods described in the examples are carried out using conventional methods, if not specified, and the reagents used are, if not specified, conventional commercially available reagents or reagents formulated by conventional methods.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating flat warts, which comprises the following raw materials in parts by weight:
15 parts of giant knotweed, 30 parts of oldenlandia diffusa, 30 parts of oyster, 15 parts of radix isatidis, 10 parts of lithospermum, 12 parts of safflower, 10 parts of curcuma zedoary, 10 parts of radix curcumae and 3 parts of liquorice.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating flat warts, which comprises the following raw materials in parts by weight:
20 parts of giant knotweed, 35 parts of oldenlandia diffusa, 35 parts of oyster, 20 parts of radix isatidis, 15 parts of lithospermum, 15 parts of safflower, 15 parts of curcuma zedoary, 15 parts of radix curcumae and 5 parts of liquorice.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating flat warts, which comprises the following raw materials in parts by weight:
10 parts of giant knotweed, 25 parts of oldenlandia diffusa, 25 parts of oyster, 10 parts of radix isatidis, 8 parts of lithospermum, 10 parts of safflower, 8 parts of curcuma zedoary, 8 parts of radix curcumae and 2 parts of liquorice.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating flat warts, which comprises the following raw materials in parts by weight:
20 parts of giant knotweed, 40 parts of oldenlandia diffusa, 40 parts of oyster, 20 parts of radix isatidis, 15 parts of lithospermum, 15 parts of safflower, 15 parts of curcuma zedoary, 15 parts of radix curcumae and 5 parts of liquorice.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating flat warts, which comprises the following raw materials in parts by weight:
10 parts of giant knotweed, 20 parts of oldenlandia diffusa, 20 parts of oyster, 10 parts of radix isatidis, 5 parts of lithospermum, 8 parts of safflower, 5 parts of curcuma zedoary, 5 parts of radix curcumae and 2 parts of liquorice.
Example 6 clinical efficacy experiment
1. Data and method
1.1 general data
The patients with 100 cases of verruca plana, which are treated by the treatment of the verruca plana in the hospital, are collected from 7 months in 2019 and 7 months in 2022, the random digital meter method is divided into a control group and an observation group, 2 cases of the control group are required to exit the treatment due to the self reasons, the observation group has no falling cases, and finally the 2 cases are respectively included in 48 cases and 50 cases. The two general data were compared, the differences were statistically significant (P > 0.05), and were comparable. General data for both groups of patients are shown in Table 1.
Table 1 comparison of general data for two groups of patients
1.2 diagnostic criteria
(1) Western medicine diagnosis standard refers to diagnosis of flat wart in Chinese clinical dermatology: the skin injury, the itching feeling and the chronic disease course are usually seen for young men and women, the face, the forearm, the back of the hand and the like, and the skin injury, the itching feeling and the chronic disease course can be resolved by oneself, and the skin injury can be continued for many years without healing and the skin injury is repeated.
(2) The traditional Chinese medicine refers to flat warts (qi stagnation and blood stasis type) in diagnosis and treatment guidelines for common diseases of traditional Chinese medicine dermatology: longer course, different forms and sizes of warts, pale and hard, yellow brown or dark red. The rash is not eliminated for a long time, but no new rash appears, and the disease condition is relatively stable. Patients often have distending pain in chest and hypochondrium, irregular menstruation, dysmenorrhea and the like. A pale or purple tongue with ecchymosis and ecchymosis on the side of the tongue, a thin and white coating, and a wiry or astringent pulse.
1.3 inclusion criteria
(1) Patients aged 18-75 years old;
(2) Meets the Western diagnosis of flat wart and the diagnosis of flat wart caused by qi stagnation and blood stasis in traditional Chinese medicine;
(3) No other medication was given for nearly 4 weeks;
(4) The study is agreed to participate and an informed consent form is signed, and the medicine can be taken according to the doctor's advice and the consultation can be carried out on time.
1.4 exclusion criteria
(1) Patients with allergic constitution;
(2) Acupuncture patients;
(3) Patients with scar physique;
(4) Patients with mental disorder and confusion;
(5) Pregnant or lactating women.
1.5 methods of treatment
The control group is treated with vitamin A acid cream (manufacturer: chongqing Huabang pharmaceutical Co., ltd., approval mark: national drug standard character H50021816), and after the affected part is cleaned before sleeping every night, a proper amount of finger and abdomen massage is applied to the affected part. The observation group is treated by adding traditional Chinese medicines on the basis of the control group, and the prescription comprises the following medicines: 15g of giant knotweed, 30g of oldenlandia diffusa, 30g of oyster, 15g of radix isatidis, 10g of lithospermum, 12g of safflower, 10g of curcuma zedoary, 10g of radix curcumae and 3g of liquorice. The decoction is 320mL and is taken at the morning and evening with 1 dose/day. Both groups were treated continuously for 6 weeks.
1.6 observations index and method
(1) The two groups of clinical efficacy were compared. Clinical efficacy decision criteria: the skin damage is resolved, and no new rash appears as a cure; the skin loss is resolved by more than or equal to 30 percent, the skin rash is flattened, and only individual new rash appears to be improved; skin lesions resolved < 30% and skin rash did not change to unhealed. Total effective = cure + improvement. (2) Comparing the skin damage scores before and after the two groups of treatments, including skin damage quantity, pruritus degree, skin damage size and skin damage thickness, wherein the skin damage quantity is respectively 0, 1, 2 and 3 according to none, 1-10, 11-20 and more than 20; the degree of itching was counted as O, 1, 2, 3 respectively, according to no, occasional itching, itching but tolerable and intolerable; the skin damage is calculated to be 0, 1, 2 and 3 respectively according to the thickness of no skin damage, less than 2mm, 2-5 mm and more than 5 mm; the thickness of the skin loss is calculated to be O, 1, 2 and 3 respectively according to the thickness of no skin loss which is less than 0.5mm, 0.5-1 mm and more than 1 mm. (3) Systemic and local adverse reactions (erythema, scaling, oedema, blisters, pigmentation, etc.) were observed and recorded during the course of treatment in the patients.
1.7 statistical analysis
Data were processed by GraphPad Prism 5 software, metering data were all recordedThe comparison between the two groups is shown by t test; count data is expressed as a rate (%), and χ is used for comparison between two groups 2 And (5) checking. The difference of P < 0.05 is statistically significant.
2. Results
2.1 comparison of two groups of clinical efficacy
The total effective rate of the observed group is significantly higher than that of the control group, and the difference is statistically significant (P < 0.05), as shown in Table 2.
Table 2 comparative clinical efficacy of the two groups (%)
2.2 comparison of the scores of the skin lesions before and after treatment of the two groups
Before treatment, the control group and the observation group have no statistical significance (P is more than 0.05) on the skin damage quantity, the pruritus degree, the skin damage size score and the skin damage thickness score; after treatment, the scores of the observed groups were lower than those of the control groups, and the differences were statistically significant (P < 0.05). See table 3.
Table 3 comparison of skin loss scores before and after treatment for both groups
2.3 comparing the occurrence of two adverse reactions
Neither group of patients had severe systemic and local adverse reactions during the treatment period. The control group has 2 patients with desquamation at the administration position, 1 patient with erythema at the administration position, the observation group has 1 patient with pigment increase at the administration position, 1 patient with swelling at the administration position, 1 patient with diarrhea, and the occurrence rate of adverse reaction of the two groups of medicines is compared, and the difference has no statistical significance (P is more than O.05).
3. Clinical typical cases
(1) The patient, female, age 23, has flat wart on face, and it is not effective to treat for many years. After taking the traditional Chinese medicine prescription of the invention for 2 weeks, the flat wart is gradually reduced, and the flat wart falls off cleanly after 5 weeks. Follow-up for 1 year without recurrence.
(2) The patients, the women, the ages of 58, have flat warts on the neck, and the treatment of the patients with flat warts by adopting Chinese and western medicines for many years is ineffective. After taking the traditional Chinese medicine prescription provided by the invention for 1 week, the flat wart is gradually shrunken, and falls off cleanly after 4 weeks. Follow-up for 1 year without recurrence.
The above description of the specific embodiments of the present invention has been given by way of example only, and the present invention is not limited to the above described specific embodiments. It will be apparent to those skilled in the art that any equivalent modifications and substitutions of the present invention are intended to be within the scope of the present invention. Accordingly, equivalent changes and modifications are intended to be included within the scope of the present invention without departing from the spirit and scope thereof.
Claims (8)
1. The traditional Chinese medicine composition for treating flat wart is characterized by being prepared from the following raw materials in parts by weight: 10-30 parts of giant knotweed, 20-40 parts of oldenlandia diffusa, 20-40 parts of oyster, 10-30 parts of radix isatidis, 5-20 parts of lithospermum, 8-18 parts of safflower, 5-30 parts of curcuma zedoary, 5-20 parts of radix curcumae and 1-5 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 15 parts of giant knotweed, 30 parts of oldenlandia diffusa, 30 parts of oyster, 15 parts of radix isatidis, 10 parts of lithospermum, 12 parts of safflower, 10 parts of curcuma zedoary, 10 parts of radix curcumae and 3 parts of liquorice.
3. A traditional Chinese medicine preparation for treating verruca plana, which is characterized by being prepared from raw materials comprising the traditional Chinese medicine composition as claimed in claim 1 or 2.
4. The Chinese medicinal preparation according to claim 3, wherein the Chinese medicinal preparation is in the form of granule, tablet, capsule, pill or decoction.
5. A pharmaceutical composition for the treatment of flat warts, comprising a traditional Chinese medicine formulation according to claim 3 or 4 and a vitamin a acid cream.
6. The pharmaceutical composition of claim 5, wherein the traditional Chinese medicine preparation is a decoction.
7. The use of a Chinese medicinal composition according to claim 1 or 2 for the preparation of a medicament for the treatment of flat warts.
8. The use according to claim 7, wherein the flat wart is a qi stagnation and blood stasis type flat wart.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645213A (en) * | 2013-11-18 | 2015-05-27 | 姜丹宁 | External traditional Chinese medicine for treating warts |
| CN107648553A (en) * | 2017-09-25 | 2018-02-02 | 汪杰峰 | Treat the Chinese medicine and preparation technology of flat wart |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645213A (en) * | 2013-11-18 | 2015-05-27 | 姜丹宁 | External traditional Chinese medicine for treating warts |
| CN107648553A (en) * | 2017-09-25 | 2018-02-02 | 汪杰峰 | Treat the Chinese medicine and preparation technology of flat wart |
Non-Patent Citations (1)
| Title |
|---|
| 灭疣汤治疗扁平疣;江海燕, 袁菊芬;四川中医;-(第11期);41 * |
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