CN114224995A - Production process of traditional Chinese medicine composition for treating epigastric pain - Google Patents

Production process of traditional Chinese medicine composition for treating epigastric pain Download PDF

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Publication number
CN114224995A
CN114224995A CN202111533899.XA CN202111533899A CN114224995A CN 114224995 A CN114224995 A CN 114224995A CN 202111533899 A CN202111533899 A CN 202111533899A CN 114224995 A CN114224995 A CN 114224995A
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concentration tank
medicine composition
product
chinese medicine
production process
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杨飞
杨周显
白禾叶
张吉刚
张亚兰
唐秋菊
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HUNAN JINGHETANG PHARMACEUTICAL CO Ltd
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HUNAN JINGHETANG PHARMACEUTICAL CO Ltd
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Abstract

A production process of a traditional Chinese medicine composition for treating epigastric pain comprises the following steps: 1) selecting eighteen medicines of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, dried ginger, cinnamon, angelica sinensis, wolfberry, white paeony root, ligusticum wallichii, pseudo-ginseng, pawpaw, mangnolia officinalis, fructus amomi, elecampane, fennel, obscured homalomena rhizome, teasel root, liquorice and the like, cleaning, cutting and drying the medicines, and finally storing the medicines in a material cleaning warehouse; 2) coarsely crushing the bighead atractylodes rhizome, the pseudo-ginseng, the costustoot, the fructus amomi, the dried ginger, the cinnamon, the mangnolia officinalis, the ligusticum wallichii and the fennel in a material cleaning warehouse, then crushing, sterilizing and grinding medicinal materials into fine powder to obtain a product A, and storing the product A in a raw and auxiliary material warehouse for later use; the production process of the traditional Chinese medicine composition is reasonable in design, the prepared medicine composition has high qualification rate, and the double concentration technology of high-temperature evaporation and low-temperature extraction is adopted, so that the utilization rate of the extracting solution is improved, and the cost is saved.

Description

Production process of traditional Chinese medicine composition for treating epigastric pain
Technical Field
The invention relates to the technical field of production of gastrointestinal pharmaceutical compositions, in particular to a production process of a traditional Chinese medicine composition for treating epigastric pain.
Background
At present, the traditional Chinese medicine composition for treating epigastric pain is mainly a gastrointestinal health capsule, which is prepared from eighteen medicines such as codonopsis pilosula, bighead atractylodes rhizome, poria cocos, dried ginger, cinnamon, angelica sinensis, wolfberry fruit, white paeony root, ligusticum wallichii, pseudo-ginseng, pawpaw, mangnolia officinalis, fructus amomi, elecampane, fennel, obscured homalomena rhizome, teasel root, liquorice and the like by adding and reducing ancient formula Sijunzi soup and mangnolia officinalis middle-warming soup, and is prepared by utilizing ancestral medicine formula and adopting a most scientific and preferred fermentation method in recent times, and has the effects of warming middle-jiao to dispel cold, regulating vital energy and relieving pain; it is suitable for treating stomach ache, anorexia, abdominal distention, hypoqi, no speaking desire, loose stool, etc. caused by deficiency-cold of spleen and stomach, and can be used for adjuvant treatment of chronic superficial gastritis and peptic ulcer with the above symptoms.
However, the existing production process is still a process of many years ago, and has a plurality of defects, in the production process, the drug effects of the traditional Chinese medicine components cannot be well extracted and maintained, the quality of the finished product cannot be easily controlled, and the requirements of modern production cannot be met.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the existing defects and provide a production process of a traditional Chinese medicine composition for treating epigastric pain, the design is reasonable, the qualification rate of the prepared medicine composition is high, and the double concentration technology of high-temperature evaporation and low-temperature extraction is adopted, so that the utilization rate of an extracting solution is improved, the cost is saved, and the problems in the background technology can be effectively solved.
In order to realize the purpose, the invention adopts the following technical scheme:
a production process of a traditional Chinese medicine composition for treating epigastric pain comprises the following steps:
1) selecting eighteen medicines of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, dried ginger, cinnamon, angelica sinensis, wolfberry, white paeony root, ligusticum wallichii, pseudo-ginseng, pawpaw, mangnolia officinalis, fructus amomi, elecampane, fennel, obscured homalomena rhizome, teasel root, liquorice and the like, cleaning, cutting and drying the medicines, and finally storing the medicines in a material cleaning warehouse;
2) coarsely crushing the bighead atractylodes rhizome, the pseudo-ginseng, the costustoot, the fructus amomi, the dried ginger, the cinnamon, the mangnolia officinalis, the ligusticum wallichii and the fennel in a material cleaning warehouse, then crushing, sterilizing and grinding medicinal materials into fine powder to obtain a product A, and storing the product A in a raw and auxiliary material warehouse for later use;
3) decocting radix Codonopsis, Poria, radix Angelicae sinensis, fructus Lycii, radix Paeoniae alba, fructus Chaenomelis, fructus Amomi, radix aucklandiae and Glycyrrhrizae radix in water twice, mixing decoctions, filtering to obtain water extractive solution and residue, concentrating the water extractive solution with water extractive solution concentrating device to obtain fluid extract, collecting the fluid extract, and storing the water extractive fluid extract in a cold storage;
4) inspecting the product A and the water extract, adding fresh yeast and table vinegar after the product A and the water extract are qualified to obtain an ingredient B, and fermenting, drying, sterilizing, crushing, sieving and totally mixing the ingredient B to obtain a product C:
5) and (4) inspecting the product C, filling the qualified product C into a gelatin hollow capsule, inspecting again, then carrying out inner packaging, outer packaging and inspection, and finally warehousing the finished product.
Further, in the step 2), the product A is sieved by a 80-mesh sieve when being crushed.
Further, in the step 3), the first decoction is 6 times of water and is carried out for 2 hours; the second decoction is 4 times of water and is decocted for 1.5 hours.
Further, in the step 3), the relative density of the clear paste is 1.15-1.18 when measured at 60 ℃.
Further, in the step 4), the adding amount of the fresh yeast is 0.5g, and the adding amount of the vinegar is 0.1 g.
Further, in the step 4), the fermentation temperature is 30 +/-4 ℃, and the fermentation time is 24 hours.
Further, in step 4), the product C is sterilized at 110 ℃ for 30 minutes at the time of total mixing.
The water extract concentrating device comprises an evaporation concentrating tank and a low-temperature concentrating tank;
an evaporation and concentration tank: a liquid inlet pipe is fixedly communicated with the top of the evaporation concentration tank, a discharge unit is fixedly communicated with the bottom of the evaporation concentration tank, an electromagnetic heater is installed at the bottom of the evaporation concentration tank, and a spiral channel communicated with the inside of the evaporation concentration tank is arranged in an interlayer of the evaporation concentration tank;
a low-temperature concentration tank: the low-temperature concentration device is communicated with the inside of the spiral channel through a steam conveying pipe, a condenser is installed on the side surface of the low-temperature concentration tank, a condensing pipe is fixedly communicated with the condenser and sleeved on the low-temperature concentration tank, a stepping motor is installed at the bottom of the low-temperature concentration tank, spiral blades are fixed on an output shaft of the stepping motor and distributed on the inner side of the low-temperature concentration tank, a low-temperature discharge pipe is fixedly communicated with the bottom of the low-temperature concentration tank, and a filter is assembled on the low-temperature discharge pipe;
the stepping motor, the condenser and the electromagnetic heater are all electrically connected with an external PLC controller.
Furthermore, the discharging unit comprises a discharging pipe and a switch valve, the discharging pipe is communicated and fixed at the bottom of the evaporation concentration tank, and the switch valve is assembled on the discharging pipe.
Compared with the prior art, the invention has the beneficial effects that: the production process of the medicinal composition for treating the intestines and stomach has the following advantages: the design is reasonable, the prepared pharmaceutical composition has high qualification rate, and the dual concentration technology of high-temperature evaporation and low-temperature extraction is adopted, so that the utilization rate of the extracting solution is improved, and the cost is saved.
Drawings
FIG. 1 is a process flow diagram of the present invention;
FIG. 2 is a schematic perspective view of a concentrator according to the present invention;
fig. 3 is a schematic perspective sectional view of the concentrating device of the present invention.
In the figure: 1 evaporation concentration tank, 2 liquid inlet pipe, 3 steam delivery pipe, 4 discharging units, 41 discharging pipe, 42 on-off valve, 5 condenser, 6 condenser pipe, 7 low temperature concentration tank, 8 low temperature discharging pipe, 9 filter, 10 stepping motor, 11 helical blade, 12 electromagnetic heater, 13 helical channel.
Detailed Description
The present invention will be explained in detail by the following examples, which are disclosed for the purpose of protecting all technical improvements within the scope of the present invention.
Referring to fig. 1-3, a process for preparing a Chinese medicinal composition for treating epigastric pain comprises the following steps:
1) selecting eighteen medicines of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, dried ginger, cinnamon, angelica sinensis, wolfberry fruit, white paeony root, ligusticum wallichii, pseudo-ginseng, pawpaw, mangnolia officinalis, fructus amomi, elecampane, fennel, homalomena occulta, teasel root, liquorice and the like, carrying out the processing method and the operation process of the eighteen medicines according to the part of the 2020 edition of Chinese pharmacopoeia, cleaning, cutting and drying the medicines, and finally storing the medicines in a material purification library;
2) coarsely crushing the bighead atractylodes rhizome, the pseudo-ginseng, the costustoot, the fructus amomi, the dried ginger, the cinnamon, the mangnolia officinalis, the ligusticum wallichii and the fennel in a material cleaning warehouse, then crushing, sterilizing and grinding medicinal materials into fine powder, sieving by a 80-mesh sieve during crushing to obtain a product A, and storing the product A in a raw and auxiliary material warehouse for later use;
3) decocting radix Codonopsis, Poria, radix Angelicae sinensis, fructus Lycii, radix Paeoniae alba, fructus Chaenomelis, fructus Amomi, radix aucklandiae and Glycyrrhrizae radix in water twice, the first time is 6 times of water, and decocting for 2 hr; decocting for 1.5 hours with 4 times of water for the second time, combining the decoctions, filtering to obtain water extract and dregs of a decoction respectively, concentrating the water extract by using a water extract concentrating device to obtain clear paste, measuring at 60 ℃, wherein the relative density of the clear paste is 1.15-1.18, collecting the paste, and storing the water extract in a refrigerator;
4) and (3) inspecting the product A and the water extract, adding fresh yeast and vinegar after the product A and the water extract are qualified, wherein the adding amount of the fresh yeast is 0.5g, the adding amount of the vinegar is 0.1g, the fermentation temperature is 30 +/-4 ℃, fermenting for 24 hours to obtain a material B, fermenting, drying, sterilizing, crushing, sieving and totally mixing the material B, and sterilizing a product C for 30 minutes at 110 ℃ during the total mixing to obtain a product C:
5) and (4) inspecting the product C, filling the qualified product C into a gelatin hollow capsule, inspecting again, then carrying out inner packaging, outer packaging and inspection, and finally warehousing the finished product.
The water extract concentrating device comprises an evaporation concentrating tank 1 and a low-temperature concentrating tank 7;
evaporation and concentration tank 1: a liquid inlet pipe 2 is fixedly communicated with the top of the evaporation concentration tank 1, a discharging unit 4 is fixedly communicated with the bottom of the evaporation concentration tank 1, an electromagnetic heater 12 is arranged at the bottom of the evaporation concentration tank 1, and a spiral channel 13 communicated with the inside of the evaporation concentration tank 1 is arranged in an interlayer of the evaporation concentration tank 1;
low-temperature concentration tank 7: the steam delivery pipe 3 is communicated with the inside of the spiral channel 13, the condenser 5 is installed on the side surface of the low-temperature concentration tank 7, the condenser 5 is fixedly communicated with the condenser pipe 6, the condenser pipe 6 is sleeved on the low-temperature concentration tank 7, the bottom of the low-temperature concentration tank 7 is provided with the stepping motor 10, the output shaft of the stepping motor 10 is fixedly provided with the spiral blades 11, the spiral blades 11 are distributed on the inner side of the low-temperature concentration tank 7, the bottom of the low-temperature concentration tank 7 is fixedly communicated with the low-temperature discharge pipe 8, and the low-temperature discharge pipe 8 is provided with the filter 9;
wherein, step motor 10, condenser 5 and electromagnetic heater 12 all electric connection outside PLC controller, add the water extract to evaporative concentration jar 1 through feed liquor pipe 2, then, electromagnetic heater 12 heats the water extract, the water extract heats and evaporates and forms the clear paste, heating steam enters into spiral channel 13, thus keep warm to evaporative concentration jar 1, steam is carried to low temperature concentration jar 7 through delivery pipe 3, condenser 5 inputs cooling liquid to condenser pipe 6, cooling liquid cools down cryogenic concentration jar 7, steam forms liquid under the low temperature environment, the output shaft of step motor 10 drives helical blade 11 to rotate, helical blade 11 stirs the liquid in cryogenic concentration jar 7, thus make the liquid separate out the ice crystal, the ice crystal liquid discharges through low temperature discharging pipe 8, filter 9 filters the crystal, the clear paste discharges through low temperature discharging pipe 8, the method adopts double concentration technology of high-temperature evaporation and low-temperature extraction, thereby improving the utilization rate of the extracting solution and saving the cost.
Further, the discharging unit 4 comprises a discharging pipe 41 and a switch valve 42, the discharging pipe 41 is communicated and fixed at the bottom of the evaporation concentration tank 1, the switch valve 42 is assembled on the discharging pipe 41, the switch valve 42 is opened, and the clear paste is discharged from the discharging pipe 41, so that the reasonability of design is guaranteed.
The working principle of the water extract concentrating device is as follows: adding water extract into an evaporation concentration tank 1 through a liquid inlet pipe 2, then heating the water extract by an electromagnetic heater 12, heating and evaporating the water extract to form clear paste, opening a switch valve 42, discharging the clear paste from a discharge pipe 41, and allowing heating steam to enter a spiral channel 13, thereby preserving heat of the evaporation concentration tank 1, conveying the steam into a low-temperature concentration tank 7 through a steam conveying pipe 3, inputting cooling liquid into a condenser pipe 6 by a condenser 5, cooling the low-temperature concentration tank 7 by the cooling liquid, allowing the steam to form liquid in a low-temperature environment, driving a spiral blade 11 to rotate by an output shaft of a stepping motor 10, stirring the liquid in the low-temperature concentration tank 7 by the spiral blade 11, and accordingly separating out ice crystals from the liquid, discharging the ice crystal liquid through a low-temperature discharge pipe 8, filtering the crystals by a filter 9, and discharging the clear paste through the low-temperature discharge pipe 8.
It should be noted that, in the process flow diagram disclosed in the above embodiment, the dashed line frame is a D-level clean zone, and the rest is a general production zone, and the stepping motor 10, the condenser 5, and the electromagnetic heater 12 are all configured according to actual application scenarios.
While the invention has been particularly shown and described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (9)

1. A production process of a traditional Chinese medicine composition for treating epigastric pain is characterized by comprising the following steps: the method comprises the following steps:
1) selecting eighteen medicines of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, dried ginger, cinnamon, angelica sinensis, wolfberry, white paeony root, ligusticum wallichii, pseudo-ginseng, pawpaw, mangnolia officinalis, fructus amomi, elecampane, fennel, obscured homalomena rhizome, teasel root, liquorice and the like, cleaning, cutting and drying the medicines, and finally storing the medicines in a material cleaning warehouse;
2) coarsely crushing the bighead atractylodes rhizome, the pseudo-ginseng, the costustoot, the fructus amomi, the dried ginger, the cinnamon, the mangnolia officinalis, the ligusticum wallichii and the fennel in a material cleaning warehouse, then crushing, sterilizing and grinding medicinal materials into fine powder to obtain a product A, and storing the product A in a raw and auxiliary material warehouse for later use;
3) decocting radix Codonopsis, Poria, radix Angelicae sinensis, fructus Lycii, radix Paeoniae alba, fructus Chaenomelis, fructus Amomi, radix aucklandiae and Glycyrrhrizae radix in water twice, mixing decoctions, filtering to obtain water extractive solution and residue, concentrating the water extractive solution with water extractive solution concentrating device to obtain fluid extract, collecting the fluid extract, and storing the water extractive fluid extract in a refrigerator;
4) inspecting the product A and the water extract, adding fresh yeast and table vinegar after the product A and the water extract are qualified to obtain an ingredient B, and fermenting, drying, sterilizing, crushing, sieving and totally mixing the ingredient B to obtain a product C:
5) and (4) inspecting the product C, filling the qualified product C into a gelatin hollow capsule, inspecting again, then carrying out inner packaging, outer packaging and inspection, and finally warehousing the finished product.
2. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: in step 2), the product A is sieved by a 80-mesh sieve when being crushed.
3. The process for the manufacture of a pharmaceutical composition for the gastrointestinal treatment according to claim 1, wherein: in the step 3), the first decoction is 6 times of water and is carried out for 2 hours; the second decoction is 4 times of water and is decocted for 1.5 hours.
4. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: in the step 3), the relative density of the clear paste is 1.15-1.18 when measured at 60 ℃.
5. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: in the step 4), the adding amount of the fresh yeast is 0.5g, and the adding amount of the vinegar is 0.1 g.
6. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: in the step 4), the fermentation temperature is 30 +/-4 ℃, and the fermentation is carried out for 24 hours.
7. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: in step 4), the product C is sterilized at 110 ℃ for 30 minutes during the total mixing.
8. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 1, is characterized in that: the water extract concentrating device comprises an evaporation concentrating tank (1) and a low-temperature concentrating tank (7);
evaporation concentration tank (1): a liquid inlet pipe (2) is fixedly communicated with the top of the evaporation concentration tank (1), a discharging unit (4) is fixedly communicated with the bottom of the evaporation concentration tank (1), an electromagnetic heater (12) is installed at the bottom of the evaporation concentration tank (1), and a spiral channel (13) communicated with the inside of the evaporation concentration tank (1) is arranged in an interlayer of the evaporation concentration tank (1);
low-temperature concentration tank (7): the device is characterized by being communicated with the interior of a spiral channel (13) through a steam conveying pipe (3), a condenser (5) is installed on the side face of a low-temperature concentration tank (7), a condensing pipe (6) is fixedly communicated on the condenser (5), the condensing pipe (6) is sleeved on the low-temperature concentration tank (7), a stepping motor (10) is installed at the bottom of the low-temperature concentration tank (7), spiral blades (11) are fixedly arranged on an output shaft of the stepping motor (10), the spiral blades (11) are distributed on the inner side of the low-temperature concentration tank (7), a low-temperature discharging pipe (8) is fixedly communicated with the bottom of the low-temperature concentration tank (7), and a filter (9) is assembled on the low-temperature discharging pipe (8);
the stepping motor (10), the condenser (5) and the electromagnetic heater (12) are all electrically connected with an external PLC.
9. The production process of the traditional Chinese medicine composition for treating epigastric pain according to claim 8, is characterized in that: the discharging unit (4) comprises a discharging pipe (41) and a switch valve (42), the discharging pipe (41) is communicated and fixed at the bottom of the evaporation and concentration tank (1), and the switch valve (42) is assembled on the discharging pipe (41).
CN202111533899.XA 2021-12-15 2021-12-15 Production process of traditional Chinese medicine composition for treating epigastric pain Pending CN114224995A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723943A (en) * 2005-07-06 2006-01-25 湖南敬和堂制药有限公司 Preparation method of traditional Chinese medicine composition for treating gastritis and peptic ulcer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723943A (en) * 2005-07-06 2006-01-25 湖南敬和堂制药有限公司 Preparation method of traditional Chinese medicine composition for treating gastritis and peptic ulcer

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