CN114209732B - 诺卡氏菌病的防治药物及其应用 - Google Patents
诺卡氏菌病的防治药物及其应用 Download PDFInfo
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- CN114209732B CN114209732B CN202210129154.5A CN202210129154A CN114209732B CN 114209732 B CN114209732 B CN 114209732B CN 202210129154 A CN202210129154 A CN 202210129154A CN 114209732 B CN114209732 B CN 114209732B
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- nocardia
- magnolol
- honokiol
- magnolia
- magnolia officinalis
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
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Abstract
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105726522A (zh) * | 2016-01-28 | 2016-07-06 | 西北农林科技大学 | 厚朴酚在杀灭鱼类寄生原虫中的应用及其制剂 |
CN108578476A (zh) * | 2018-05-31 | 2018-09-28 | 广州市普精生物科技有限公司 | 一种防治鱼类诺卡氏菌病的组合物及其制备方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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Non-Patent Citations (1)
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---|
厚朴总酚对几种病原菌的抑菌作用;郭冰玉 等;《河南水产》;20211231(第3期);22-25 * |
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