CN114209631A - Anti-aging skin care mask and preparation process thereof - Google Patents
Anti-aging skin care mask and preparation process thereof Download PDFInfo
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- CN114209631A CN114209631A CN202210084693.1A CN202210084693A CN114209631A CN 114209631 A CN114209631 A CN 114209631A CN 202210084693 A CN202210084693 A CN 202210084693A CN 114209631 A CN114209631 A CN 114209631A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging skin-care mask and a preparation process thereof, wherein the anti-aging skin-care mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 15-17 parts of cycloastragenol, 10-15 parts of honeysuckle extract, 10-13 parts of white tea extract, 6-10 parts of yeast lysate extract, 3-6 parts of retinol, 5-15 parts of collagen, 3-6 parts of humectant, 0.5-1 part of preservative, 1-3 parts of emulsifier, 5-10 parts of nicotinamide, 35-90 parts of water, 20-35 parts of panthenol, 15-30 parts of butanediol, 2-3 parts of carbomer, 1-2 parts of dispersant and 0.5-1 part of EDTA disodium; because the relative molecular mass of the cycloastragenol is smaller, the cycloastragenol has better fat solubility than the astragaloside, so the cycloastragenol is easier to permeate cell membranes and be absorbed by organisms; and the cycloastragenol can improve the activity of telomerase so as to improve the proliferation capacity of CD3 and CD8T cells and play a role in delaying senescence.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and relates to an anti-aging skin-care mask and a preparation process thereof.
Background
Skin oxidation is mainly caused by that the skin generates a large amount of free radicals and excessive free radicals in the aerobic respiration process, attacks skin cells, deprives skin nutrition, and causes body aging, organ tissue mutation, skin aging and immunity reduction. The most important feature of skin oxidation is the yellowing of the face, the increased mottling and blemishes, which is similar to "yellowing" of apples after oxidation and "rusting" of steel after oxidation. This damage occurs to the skin, which causes relaxation and fragility of collagen and elastic fibers, and a slowing of epidermal cell neogenesis. In addition, the cell nucleus is damaged by free radicals, so that healthy cells cannot be divided, intercellular lipids are also destroyed, and moisture in the skin cannot be maintained.
The facial mask is a cosmetic skin care product applied on face, and has effects of cleaning, building body and protecting face. Moisturizing the skin is the basis of beauty and skin care, and the skin losing moisture is dry and rough, forms fine lines and pigmentation, and causes various skin problems.
The cycloastragenol and the honeysuckle extract have good moisture retention and anti-aging performance, and are good materials for preparing the facial mask.
Disclosure of Invention
The invention aims to provide an anti-aging skin care mask and a preparation process thereof.
The purpose of the invention can be realized by the following technical scheme:
the anti-aging skin care mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 15-17 parts of cycloastragenol, 10-15 parts of honeysuckle extract, 10-13 parts of white tea extract, 6-10 parts of yeast lysate extract, 3-6 parts of retinol, 5-15 parts of collagen, 3-6 parts of humectant, 0.5-1 part of preservative, 1-3 parts of emulsifier, 5-10 parts of nicotinamide, 35-90 parts of water, 20-35 parts of panthenol, 15-30 parts of butanediol, 2-3 parts of carbomer, 1-2 parts of dispersant and 0.5-1 part of EDTA disodium;
the preparation method of the honeysuckle extracting solution comprises the following steps:
crushing a honeysuckle medicinal material by using a high-speed crusher, extruding by using a plate-and-frame filter press after crushing to remove most of water in the honeysuckle medicinal material, drying at low temperature, placing in a stirring tank, adding 60% ethanol, uniformly mixing and stirring at the stirring speed of 300r/min, heating to 75-90 ℃, connecting a condenser pipe, placing in a water bath kettle at 80-100 ℃, continuously stirring for reacting for 2-3 hours, and taking supernatant by adopting a centrifugal technology while the reaction is hot to obtain a honeysuckle extracting solution.
As a preferred technical scheme of the anti-aging skin care mask, the preparation method of the cycloastragenol comprises the following steps:
s1: drying 85-95 parts of astragaloside to obtain dry granules, grinding and sieving, collecting sieved granules, adding the sieved granules into water, performing ultrasonic dispersion with a probe for 30-45min, adding a dispersant dissolved in absolute ethyl alcohol, and performing ultrasonic dispersion with the probe for 15-20min to obtain an astragaloside dispersion liquid stabilized by the dispersant; adding HCl solution into astragaloside IV dispersion, adjusting pH of the astragaloside IV dispersion to 4, adding 5-8 parts of KIO4Stirring and mixing, reacting at 20-22 deg.C for 48-49h, and sequentially adding ethylene glycol and Na2CO3Adjusting the pH value to 7, carrying out reduced pressure concentration, adding n-butanol, extracting for 3 times, and then washing with water to obtain an intermediate A;
s2: adding 30% methanol aqueous solution to intermediate A, and adding BH4Reducing Na for 4-6h, adding acetic acid to adjust the pH value to 5, adding a sulfuric acid solution, reacting at 48-52 ℃ for 24-26h to obtain an intermediate B;
s3: addition of K to intermediate B2CO3Adjusting pH to 7, extracting with ethyl acetate to obtain extractive solution, concentrating under reduced pressure, and oven drying to obtain cycloastragenol crude product;
s4: placing the crude cycloastragenol in CH2Cl2Soaking in acetone for 24 hr to separate out crystal, filtering, and oven drying at low temperature to obtain cycloastragenol.
As the preferred technical scheme of the anti-aging skin care mask, the preparation method of the white tea extract comprises the following steps: adding the white tea into an extraction tank, adding dichloromethane, controlling the reaction pressure at 0-0.4MPa, the extraction temperature at 108-.
As the preferred technical scheme of the anti-aging skin care mask, the preparation method of the yeast lysate extract comprises the following steps:
s1, filtering the beer waste yeast liquid by using gauze, centrifugally separating, removing supernatant of yeast, taking filter residue, adding sodium bicarbonate, stirring and mixing at 55-60 ℃ for 30-40min, sieving by using a 100-mesh sieve, and sequentially adding water and sodium bicarbonate to respectively wash the filter residue to obtain an intermediate A;
s2, adding 5-10 parts of boiling ethanol into the intermediate A, carrying out heavy suspension quenching on the yeast, placing the yeast into a water bath pot for heat preservation for 10-15min, then placing the yeast into the ice bath for cooling for 10-15min at the temperature of-5-0 ℃, then carrying out centrifugation, sucking supernatant, carrying out freeze drying, drying at-15-5 ℃, and cooling to obtain the yeast lysate extract with the water content of less than or equal to 5%.
As a preferred technical scheme of the anti-aging skin-care mask, the humectant is one or a combination of more of sodium hyaluronate, polyethylene glycol, propylene glycol, glycerol, 1, 3-butanediol, diglycerol, dipropylene glycol, trimethylolpropane, xylitol, sorbitol and maltitol.
As a preferred technical scheme of the anti-aging skin care mask, the preservative is at least one of potassium sorbate, imidazolidinyl urea and hydantoin.
The preparation process of the anti-aging skin care mask comprises the following steps:
s1: mixing cycloastragenol, white tea extract and emulsifier, stirring, adding water to obtain emulsion A, sterilizing the emulsion A in a high temperature and high pressure sterilization tank for 40-45min, and cooling the emulsion A to below 50 deg.C after sterilization;
s2: adding flos Lonicerae extract, yeast cell lysate extract, retinol, protoprotein, nicotinamide, and panthenol into emulsifier, stirring to dissolve completely, steam sterilizing, and cooling to room temperature to obtain emulsion B;
s3: adding the emulsion A and the emulsion B into a stirring kettle, stirring, adding butanediol, carbomer, a dispersing agent, EDTA disodium, a preservative and a humectant, uniformly stirring, filtering by using a filter with the pore diameter of 0.65 micrometer, and filtering impurities to obtain a mask liquid;
s4: placing the facial mask bag filled with facial mask paper into a sterilization box for sterilizing the facial mask bag for 25-35min, and placing into a drying box; spraying the mask liquid on one surface of the mask paper, attaching a protective film on the back surface, injecting the mask liquid into the mask bag, and sealing the mask bag filled with the mask liquid:
as the preferable technical scheme of the preparation process of the anti-aging skin-care facial mask, the quantitative amount of the facial mask liquid filled into the facial mask bag is 30ml-35 ml.
The water bath kettle comprises a water bath kettle placing frame, wherein supporting seats are symmetrically fixed on the lower surface of the water bath kettle placing frame, the number of the supporting seats is arranged, a groove is formed in the water bath kettle placing frame, a water bath kettle body is fixed in the groove, a kettle cover is arranged above the water bath kettle body, a heat insulation layer is arranged between the water bath kettle body and the water bath kettle placing frame, a heating plate is arranged on the inner side of the heat insulation layer, a water outlet is formed in the right side of the water bath kettle placing frame, and the water outlet is communicated with the inside of the water bath kettle body after sequentially penetrating through the water outlet, the heat insulation layer and the heating plate;
a placing plate is transversely arranged in the water bath kettle body, two sides of the placing plate are fixedly connected with two side walls of the water bath kettle body, a fixing rod penetrates through the middle of the water bath kettle body, one end of the fixing rod is fixedly connected with the lower wall of the water bath kettle body, a cavity is formed in the left side of the placing plate, an inclined groove plate is arranged on the lower wall of the cavity, the inclined groove plate is triangular, and two inclined groove plates are clamped with the clamping rod;
the upper end of the clamping rod is fixedly connected with the sliding rod, a sleeve is arranged on the outer side of the sliding rod, the sliding rod is sleeved in the sleeve, the upper end of the sliding rod is fixedly connected with the inner wall of the sleeve through a limiting spring, the sleeve penetrates through the upper wall of the placing plate, clamping blocks are fixed on two side walls of the sleeve positioned in the cavity, an operating rod is arranged on the left side of the sleeve, the operating rod penetrates through the left side wall of the sleeve and is fixedly connected with the sliding rod, and the operating rod is slidably connected with the side wall of the sleeve;
the right side wall of the sleeve is fixedly connected with a first fixing plate through a first connecting rod, the right side of the first fixing plate is arc-shaped, an installation rod is fixed on the upper surface of the right side of the placing plate, the side wall of the installation rod is fixedly connected with a second fixing plate through a second connecting rod, the left side of the second fixing plate is arc-shaped, and the circle center of the second fixing plate is opposite to that of the first fixing plate; the placing plate is provided with a plurality of through holes.
The working method of the water bath pot specifically comprises the following steps: the pot cover is opened, the container is placed in the water bath pot placing frame, the operating rod is pulled to enable the sliding rod to move upwards, the position of the clamping rod and the inclined groove plate is adjusted, the sleeve pipe is made to move, the position between the first fixing plate and the second fixing plate is adjusted to fix the container, meanwhile, the heating plate is started to heat water in the water bath pot body, the pot cover is covered, and the container is taken out after the reaction is completed.
The invention has the beneficial effects that:
(1) because the relative molecular mass of the cycloastragenol is smaller, the cycloastragenol has better fat solubility than the astragaloside, so the cycloastragenol is easier to permeate cell membranes and be absorbed by organisms; and the cycloastragenol can improve the activity of telomerase so as to improve the proliferation capacity of CD3 and CD8T cells and play a role in delaying senescence.
(2) The yeast lysate extract contains rich yeast nutritional active substances such as small molecular peptides, free amino acids, vitamins, nucleic acids, nucleotides and the like, has the nutritional performance of yeast degradation products, has high solubility in a mask, has excellent dispersion uniformity, is beneficial to uniform and effective absorption of skin, and has excellent oxidation resistance.
(3) Compared with artificially synthesized antioxidant substances such as BHA, BHT, PG, TBHQ and the like, the natural antioxidant substances such as tea polyphenol, flavone, catechin and the like contained in the white tea extract have higher use safety, and can effectively remove free radicals to reduce functional damage to cells caused by oxidative stress damage.
Drawings
In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic view of the exterior of a water bath according to the present invention;
FIG. 2 is a schematic view of the interior of the water bath of the present invention;
FIG. 3 is a schematic view of the attachment of the mounting plate to the mounting bar of the present invention;
FIG. 4 is a top plan view of the subject holding board;
fig. 5 is an enlarged view of fig. 2 at a.
In the figure: 1. placing a water bath pot rack; 2. a supporting seat; 3. a water outlet; 4. a pot cover; 5. heating plates; 6. a thermal insulation layer; 7. a water bath kettle body; 8. placing the plate; 9. fixing the rod; 10. a through hole; 11. a slide bar; 12. mounting a rod; 13. a cavity; 14. a chute plate; 15. a clamping rod; 16. a second connecting rod; 17. an operating lever; 18. a limiting spring; 19. a first fixing plate; 20. a second fixing plate; 21. a clamping block; 22. a sleeve; 23. a first connecting rod.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The anti-aging skin care mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 15 parts of cycloastragenol, 10 parts of honeysuckle extract, 10 parts of white tea extract, 6 parts of yeast lysate extract, 3 parts of retinol, 5 parts of collagen, 3 parts of humectant, 0.5 part of preservative, 1 part of emulsifier, 5 parts of nicotinamide, 35 parts of water, 20 parts of panthenol, 15 parts of butanediol, 2 parts of carbomer, 1 part of dispersant and 0.5 part of EDTA disodium;
the preparation method of the honeysuckle extracting solution comprises the following steps:
crushing a honeysuckle medicinal material by using a high-speed crusher, extruding by using a plate-and-frame filter press after crushing, removing most of water in the honeysuckle medicinal material, drying at low temperature, placing in a stirring tank, adding 60% ethanol, uniformly mixing and stirring, wherein the stirring speed is 300r/min, heating to 75 ℃, connecting a condensation pipe, placing in a water bath kettle at 80 ℃, continuously stirring for reacting for 2 hours, and taking supernatant by using a centrifugal technology while the reaction is hot after the reaction is finished to obtain a honeysuckle extracting solution.
Specifically, the preparation method of the cycloastragenol comprises the following steps:
s1: drying 85 parts of astragaloside to obtain dry granules, grinding and sieving, collecting sieved granules, adding the sieved granules into water, performing ultrasonic dispersion for 30min by using a probe, adding a dispersing agent dissolved in absolute ethyl alcohol, and performing ultrasonic dispersion for 15min by using the probe to obtain an astragaloside dispersion liquid stabilized by the dispersing agent; adding HCl solution into astragaloside IV dispersion, adjusting pH of the astragaloside IV dispersion to 4, adding 5 parts of KIO4Stirring and mixing the mixture, reacting at the temperature of 20 ℃ for 48 hours, and then sequentially adding ethylene glycol and Na2CO3Adjusting the pH value to 7, carrying out reduced pressure concentration, adding n-butanol, extracting for 3 times, and then washing with water to obtain an intermediate A;
s2: adding 30% methanol aqueous solution to intermediate A, and adding BH4Reducing Na for 4-6h, adding acetic acid to adjust the pH value to 5, adding a sulfuric acid solution, reacting at 48 ℃ for 24h to obtain an intermediate B;
s3: addition of K to intermediate B2CO3Adjusting pH to 7, extracting with ethyl acetate to obtain extractive solution, concentrating under reduced pressure, and oven drying to obtain cycloastragenol crude product;
s4: placing the crude cycloastragenol in CH2Cl2Soaking in acetone for 24 hr, and separatingAnd filtering the crystal, and drying at low temperature to obtain the cycloastragenol.
Specifically, the preparation method of the white tea extract comprises the following steps: adding white tea into an extraction tank, adding dichloromethane, controlling the reaction pressure at 0MPa, the extraction temperature at 108 ℃, extracting for 3h, introducing nitrogen for 90s after extraction is finished, removing air, keeping the temperature for reaction after the introduction is finished, standing and cooling to room temperature, reducing the pressure to 0MPa, collecting extract liquor, adding anhydrous sodium sulfate, standing the extract liquor for 24h at the temperature of-5 ℃, taking out the extract liquor, filtering, and performing negative pressure concentration to obtain the white tea extract.
Specifically, the preparation method of the yeast lysate extract comprises the following steps:
s1, filtering the beer waste yeast liquid by using gauze, centrifugally separating, removing supernatant of yeast, taking filter residue, adding sodium bicarbonate, stirring and mixing for 30min at 55 ℃, sieving by using a 100-mesh sieve, and sequentially adding water and the sodium bicarbonate to respectively wash the filter residue to obtain an intermediate A;
s2, adding 5-10 parts of boiling ethanol into the intermediate A, carrying out heavy suspension quenching on the yeast, placing the yeast into a water bath pot for heat preservation for 10min, then placing the yeast into an ice bath for cooling for 10min at the temperature of-5 ℃, then carrying out centrifugation, absorbing supernatant, carrying out freeze drying, drying at-15 ℃, and cooling to obtain the yeast lysate extract with the water content of less than or equal to 5%.
Specifically, the humectant is one or more of sodium hyaluronate, polyethylene glycol, propylene glycol, glycerol, 1, 3-butanediol, diglycerol, dipropylene glycol, trimethylolpropane, xylitol, sorbitol and maltitol.
Specifically, the preservative is one of potassium sorbate, imidazolidinyl urea and hydantoin.
The preparation process of the anti-aging skin care mask comprises the following steps:
s1: mixing cycloastragenol, white tea extract and emulsifier, stirring, adding water to obtain emulsion A, sterilizing the emulsion A in a high temperature and high pressure sterilization tank for 40min, and cooling the emulsion A to below 50 deg.C after sterilization;
s2: adding flos Lonicerae extract, yeast cell lysate extract, retinol, protoprotein, nicotinamide, and panthenol into emulsifier, stirring to dissolve completely, steam sterilizing, and cooling to room temperature to obtain emulsion B;
s3: adding the emulsion A and the emulsion B into a stirring kettle, stirring, adding butanediol, carbomer, a dispersing agent, EDTA disodium, a preservative and a humectant, uniformly stirring, filtering by using a filter with the pore diameter of 0.65 micrometer, and filtering impurities to obtain a mask liquid;
s4: placing the facial mask bag filled with facial mask paper into a sterilization box for sterilizing the facial mask bag for 25min, and placing into a drying box; spraying the mask liquid on one surface of the mask paper, attaching a protective film on the back surface, injecting the mask liquid into the mask bag, and sealing the mask bag filled with the mask liquid:
specifically, the quantitative amount of the facial mask liquid filled into the facial mask bag is 30 ml.
Example 2
The anti-aging skin care mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 16 parts of cycloastragenol, 13 parts of honeysuckle extract, 12 parts of white tea extract, 8 parts of yeast lysate extract, 4 parts of retinol, 10 parts of collagen, 4 parts of humectant, 0.8 part of preservative, 2 parts of emulsifier, 8 parts of nicotinamide, 50 parts of water, 27 parts of panthenol, 23 parts of butanediol, 2.5 parts of carbomer, 1.5 parts of dispersant and 0.8 part of EDTA disodium;
the preparation method of the honeysuckle extracting solution comprises the following steps:
crushing a honeysuckle medicinal material by using a high-speed crusher, extruding by using a plate-and-frame filter press after crushing, removing most of water in the honeysuckle medicinal material, drying at low temperature, placing in a stirring tank, adding 60% ethanol, uniformly mixing and stirring, wherein the stirring speed is 300r/min, heating to 72 ℃, connecting a condenser pipe, placing in a water bath kettle at 90 ℃, continuously stirring for reacting for 2.5 hours, and taking supernatant by using a centrifugal technology while the reaction is hot after the reaction is finished to obtain a honeysuckle extracting solution.
Specifically, the preparation method of the cycloastragenol comprises the following steps:
s1: drying 90 parts of astragaloside to obtain dry granules, grinding and sieving, collecting sieved granules, adding the sieved granules into water, performing ultrasonic dispersion for 40min by using a probe, adding a dispersing agent dissolved in absolute ethyl alcohol, and performing ultrasonic dispersion for 17min by using the probe to obtain an astragaloside dispersion liquid stabilized by the dispersing agent; adding HCl solution into astragaloside IV dispersion, adjusting pH of the astragaloside IV dispersion to 4, adding 6 parts of KIO4Stirring and mixing the mixture, reacting at 21 ℃ for 48.5 hours, and then sequentially adding ethylene glycol and Na2CO3Adjusting the pH value to 7, carrying out reduced pressure concentration, adding n-butanol, extracting for 3 times, and then washing with water to obtain an intermediate A;
s2: adding 30% methanol aqueous solution to intermediate A, and adding BH4Reducing Na for 5 hours, adding acetic acid to adjust the pH value to 5, adding a sulfuric acid solution, reacting at the temperature of 50 ℃ for 25 hours to obtain an intermediate B;
s3: addition of K to intermediate B2CO3Adjusting pH to 7, extracting with ethyl acetate to obtain extractive solution, concentrating under reduced pressure, and oven drying to obtain cycloastragenol crude product;
s4: placing the crude cycloastragenol in CH2Cl2Soaking in acetone for 24 hr to separate out crystal, filtering, and oven drying at low temperature to obtain cycloastragenol.
Specifically, the preparation method of the white tea extract comprises the following steps: adding white tea into an extraction tank, adding dichloromethane, controlling the reaction pressure at 0.2MPa, the extraction temperature at 109 ℃, the extraction time at 3.5h, introducing nitrogen for 95s after the extraction is finished, removing air, preserving heat for reaction after the introduction is finished, standing and cooling to room temperature, reducing the pressure to 0MPa, collecting extract liquor, adding anhydrous sodium sulfate, standing the extract liquor for 24.5h at the temperature of-3 ℃, taking out the extract liquor, filtering, and performing negative pressure concentration to obtain the white tea extract.
Specifically, the preparation method of the yeast lysate extract comprises the following steps:
s1, filtering the beer waste yeast liquid by using gauze, centrifugally separating, removing supernatant of yeast, taking filter residue, adding sodium bicarbonate, stirring and mixing at 57 ℃ for 35min, sieving by using a 100-mesh sieve, and sequentially adding water and the sodium bicarbonate to respectively wash the filter residue to obtain an intermediate A;
s2, adding 8 parts of boiling ethanol into the intermediate A, carrying out heavy suspension quenching on the yeast, placing the yeast in a water bath for heat preservation for 12min, then placing the yeast in an ice bath for cooling for 12min at the temperature of-3 ℃, then carrying out centrifugation, absorbing supernatant, carrying out freeze drying, drying at-5 ℃, and obtaining the yeast lysate extract with the water content of less than or equal to 5% after cooling.
Specifically, the humectant is a combination of sodium hyaluronate, polyethylene glycol, propylene glycol, glycerin, 1, 3-butanediol, diglycerin, dipropylene glycol, trimethylolpropane, xylitol, sorbitol and maltitol.
Specifically, the preservative is two of potassium sorbate, imidazolidinyl urea and hydantoin.
The preparation process of the anti-aging skin care mask comprises the following steps:
s1: mixing cycloastragenol, white tea extract and emulsifier, stirring, adding water to obtain emulsion A, sterilizing the emulsion A in a high temperature and high pressure sterilization tank for 43min, and cooling the emulsion A to below 50 deg.C after sterilization;
s2: adding flos Lonicerae extract, yeast cell lysate extract, retinol, protoprotein, nicotinamide, and panthenol into emulsifier, stirring to dissolve completely, steam sterilizing, and cooling to room temperature to obtain emulsion B;
s3: adding the emulsion A and the emulsion B into a stirring kettle, stirring, adding butanediol, carbomer, a dispersing agent, EDTA disodium, a preservative and a humectant, uniformly stirring, filtering by using a filter with the pore diameter of 0.65 micrometer, and filtering impurities to obtain a mask liquid;
s4: placing the facial mask bag filled with facial mask paper into a sterilization box for sterilizing the facial mask bag for 30min, and placing into a drying box; spraying the mask liquid on one surface of the mask paper, attaching a protective film on the back surface, injecting the mask liquid into the mask bag, and sealing the mask bag filled with the mask liquid:
specifically, the quantitative amount of the facial mask liquid filled into the facial mask bag is 32 ml.
Example 3
The anti-aging skin care mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 17 parts of cycloastragenol, 15 parts of honeysuckle extract, 13 parts of white tea extract, 10 parts of yeast lysate extract, 6 parts of retinol, 15 parts of collagen, 6 parts of humectant, 1 part of preservative, 3 parts of emulsifier, 10 parts of nicotinamide, 90 parts of water, 35 parts of panthenol, 30 parts of butanediol, 3 parts of carbomer, 2 parts of dispersant and 1 part of EDTA disodium;
the preparation method of the honeysuckle extracting solution comprises the following steps:
crushing a honeysuckle medicinal material by using a high-speed crusher, extruding by using a plate-and-frame filter press after crushing, removing most of water in the honeysuckle medicinal material, drying at low temperature, placing in a stirring tank, adding 60% ethanol, uniformly mixing and stirring, wherein the stirring speed is 300r/min, heating to 90 ℃, connecting a condensation pipe, placing in a water bath kettle at 100 ℃, continuously stirring for reacting for 3 hours, and taking supernatant by using a centrifugal technology while the reaction is hot after the reaction is finished to obtain a honeysuckle extracting solution.
Specifically, the preparation method of the cycloastragenol comprises the following steps:
s1: drying 95 parts of astragaloside IV to obtain dry granules, grinding and sieving, collecting sieved granules, adding the sieved granules into water, performing ultrasonic dispersion for 45min by using a probe, adding a dispersing agent dissolved in absolute ethyl alcohol, and performing ultrasonic dispersion for-20 min by using the probe to obtain an astragaloside IV dispersion liquid stabilized by the dispersing agent; adding HCl solution into astragaloside IV dispersion, adjusting pH of the astragaloside IV dispersion to 4, and adding 8 parts of KIO4Stirring and mixing the mixture, reacting at the temperature of 22 ℃ for 49 hours, and then sequentially adding ethylene glycol and Na2CO3Adjusting the pH value to 7, carrying out reduced pressure concentration, adding n-butanol, extracting for 3 times, and then washing with water to obtain an intermediate A;
s2: in the intermediateAdding 30% methanol water solution into A, and adding BH4Reducing Na for 6 hours, adding acetic acid to adjust the pH value to 5, adding a sulfuric acid solution, reacting at 52 ℃ for 26 hours to obtain an intermediate B;
s3: addition of K to intermediate B2CO3Adjusting pH to 7, extracting with ethyl acetate to obtain extractive solution, concentrating under reduced pressure, and oven drying to obtain cycloastragenol crude product;
s4: placing the crude cycloastragenol in CH2Cl2Soaking in acetone for 24 hr to separate out crystal, filtering, and oven drying at low temperature to obtain cycloastragenol.
Specifically, the preparation method of the white tea extract comprises the following steps: adding white tea into an extraction tank, adding dichloromethane, controlling the reaction pressure at 0.4MPa, the extraction temperature at 110 ℃, extracting for 4h, introducing nitrogen for 100s after extraction is finished, removing air, preserving heat for reaction after the introduction is finished, standing and cooling to room temperature, reducing the pressure to 0MPa, collecting extract liquor, adding anhydrous sodium sulfate, standing the extract liquor for 25h at the temperature of 0 ℃, taking out the extract liquor, filtering, and performing negative pressure concentration to obtain the white tea extract.
Specifically, the preparation method of the yeast lysate extract comprises the following steps:
s1, filtering the beer waste yeast liquid by using gauze, centrifugally separating, removing supernatant of yeast, taking filter residue, adding sodium bicarbonate, stirring and mixing at 60 ℃ for 40min, sieving by using a 100-mesh sieve, and sequentially adding water and the sodium bicarbonate to respectively wash the filter residue to obtain an intermediate A;
s2, adding 10 parts of boiling ethanol into the intermediate A, carrying out heavy suspension quenching on the yeast, placing the yeast in a water bath pot for heat preservation for 15min, then placing the yeast in an ice bath for cooling for 15min at the temperature of 0 ℃, then carrying out centrifugation, absorbing supernatant, carrying out freeze drying, drying at the temperature of 5 ℃, and obtaining the yeast lysate extract with the water content of less than or equal to 5% after cooling.
Specifically, the humectant is a combination of sodium hyaluronate, polyethylene glycol, propylene glycol, glycerin, 1, 3-butanediol, diglycerin, dipropylene glycol, trimethylolpropane, xylitol, sorbitol and maltitol.
Specifically, the preservative is two of potassium sorbate, imidazolidinyl urea and hydantoin.
The preparation process of the anti-aging skin care mask comprises the following steps:
s1: mixing cycloastragenol, white tea extract and emulsifier, stirring, adding water to obtain emulsion A, sterilizing the emulsion A in a high temperature and high pressure sterilization tank for 45min, and cooling the emulsion A to below 50 deg.C after sterilization;
s2: adding flos Lonicerae extract, yeast cell lysate extract, retinol, protoprotein, nicotinamide, and panthenol into emulsifier, stirring to dissolve completely, steam sterilizing, and cooling to room temperature to obtain emulsion B;
s3: adding the emulsion A and the emulsion B into a stirring kettle, stirring, adding butanediol, carbomer, a dispersing agent, EDTA disodium, a preservative and a humectant, uniformly stirring, filtering by using a filter with the pore diameter of 0.65 micrometer, and filtering impurities to obtain a mask liquid;
s4: placing the facial mask bag filled with facial mask paper into a sterilization box for sterilizing the facial mask bag for 35min, and placing into a drying box; and spraying the facial mask liquid on one surface of the facial mask paper, attaching a protective film on the back surface, injecting the facial mask liquid into the facial mask bag, and sealing the facial mask bag filled with the facial mask liquid.
Specifically, the quantitative amount of the facial mask liquid filled into the facial mask bag is 35 ml.
Referring to fig. 1-5, the water bath includes a water bath rack 1, support seats 2 are symmetrically fixed on the lower surface of the water bath rack 1, the number of the support seats 2 is 4, a groove is formed in the water bath rack 1, a water bath pot body 7 is fixed in the groove, a pot cover 4 is arranged above the water bath pot body 7, a heat insulation layer 6 is arranged between the water bath pot body 7 and the water bath rack 1, a heating plate 5 is arranged on the inner side of the heat insulation layer 6, a water outlet 3 is formed in the right side of the water bath rack 1, and the water outlet 3 is communicated with the inside of the water bath pot body 7 after sequentially penetrating through the water outlet 3, the heat insulation layer 6 and the heating plate 5;
a placing plate 8 is transversely arranged in the water bath kettle body 7, two sides of the placing plate 8 are fixedly connected with two side walls of the water bath kettle body 7, a fixing rod 9 penetrates through the middle of the water bath kettle body 7, one end of the fixing rod 9 is fixedly connected with the lower wall of the water bath kettle body 7, a cavity 13 is formed in the left side of the placing plate 8, an inclined groove plate 14 is arranged on the lower wall of the cavity 13, the inclined groove plate 14 is triangular, and two inclined groove plates 14 are clamped with a clamping rod 15;
the upper end of the clamping rod 15 is fixedly connected with the sliding rod 11, a sleeve 22 is arranged on the outer side of the sliding rod 11, the sliding rod 11 is sleeved in the sleeve 22, the upper end of the sliding rod 11 is fixedly connected with the inner wall of the sleeve 22 through a limiting spring 18, the sleeve 22 penetrates through the upper wall of the placing plate 8, clamping blocks 21 are fixed on two side walls of the sleeve 22 in the cavity 13, an operating rod 17 is arranged on the left side of the sleeve 22, the operating rod 17 penetrates through the left side wall of the sleeve 22 and then is fixedly connected with the sliding rod 11, and the operating rod 17 is slidably connected with the side wall of the sleeve 22;
the right side wall of the sleeve 22 is fixedly connected with a first fixing plate 19 through a first connecting rod 23, the right side of the first fixing plate 19 is arc-shaped, the upper surface of the right side of the placing plate 8 is fixedly provided with an installation rod 12, the side wall of the installation rod 12 is fixedly connected with a second fixing plate 20 through a second connecting rod 16, the left side of the second fixing plate 20 is arc-shaped, and the circle center of the second fixing plate 20 is opposite to that of the first fixing plate 19; the placing plate 8 is provided with a plurality of through holes 10.
The working method of the water bath pot specifically comprises the following steps: the pot cover 4 is opened to place the container into the water bath pot placing frame 1, the operating rod 17 is pulled to enable the sliding rod 11 to move upwards, the clamping position of the clamping rod 15 and the inclined groove plate 14 is adjusted, the sleeve 22 moves, the position between the first fixing plate 19 and the second fixing plate 20 is adjusted to fix the container, meanwhile, the heating plate 5 is started to heat water in the water bath pot body 7, the pot cover 4 is covered, and after the reaction is completed, the container is taken out.
Comparative example
15 volunteers with the age of 30-60 years are selected from each experimental group; the comparative group uses anti-aging skin care facial masks purchased from supermarkets; the using method comprises the following steps: the product is administered for 3 months, 3 times per week, and continuously for 8 weeks. Using an MPA580 skin elasticity tester and an OBSERV comprehensive part skin image analyzer to respectively test and evaluate volunteers before use of the product and at the 4 th week and the 8 th week after use of the product, wherein the highest score is 5, and the lowest score is 0;
volunteers were asked about the feeling of use and scored, including the smoothness, smoothness of the facial skin and improvement of fine lines. Each score was evaluated on a 1-5 point basis, with 1 being no improvement, 2 being uncertain, 3 being slight improvement, 4 being slight improvement, and 5 being significant improvement, and the improvement rates for each index after the subjects used the product were counted, with the results shown in table 1:
TABLE 1
As shown in Table 1, the addition of cycloastragenol can play a role in delaying aging to a certain extent; the yeast lysate extract has high solubility in the facial mask, excellent dispersion uniformity, contribution to uniform skin and effective absorption of the yeast lysate extract, and excellent anti-aging effect.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (10)
1. An anti-aging skin care mask is characterized in that: the mask comprises mask paper and mask liquid, wherein the mask liquid is prepared from the following raw materials in parts by weight: 15-17 parts of cycloastragenol, 10-15 parts of honeysuckle extract, 10-13 parts of white tea extract, 6-10 parts of yeast lysate extract, 3-6 parts of retinol, 5-15 parts of collagen, 3-6 parts of humectant, 0.5-1 part of preservative, 1-3 parts of emulsifier, 5-10 parts of nicotinamide, 35-90 parts of water, 20-35 parts of panthenol, 15-30 parts of butanediol, 2-3 parts of carbomer, 1-2 parts of dispersant and 0.5-1 part of EDTA disodium;
the preparation method of the honeysuckle extracting solution comprises the following steps:
crushing a honeysuckle medicinal material by using a high-speed crusher, extruding by using a plate-and-frame filter press after crushing to remove most of water in the honeysuckle medicinal material, drying at low temperature, placing in a stirring tank, adding 60% ethanol, uniformly mixing and stirring at the stirring speed of 300r/min, heating to 75-90 ℃, connecting a condenser pipe, placing in a water bath kettle at 80-100 ℃, continuously stirring for reacting for 2-3 hours, and taking supernatant by adopting a centrifugal technology while the reaction is hot to obtain a honeysuckle extracting solution.
2. The anti-aging skin care mask according to claim 1, wherein: the preparation method of the cycloastragenol comprises the following steps:
s1: drying 85-95 parts of astragaloside to obtain dry granules, grinding and sieving, collecting sieved granules, adding the sieved granules into water, performing ultrasonic dispersion with a probe for 30-45min, adding a dispersant dissolved in absolute ethyl alcohol, and performing ultrasonic dispersion with the probe for 15-20min to obtain an astragaloside dispersion liquid stabilized by the dispersant; adding HCl solution into astragaloside IV dispersion, adjusting pH of the astragaloside IV dispersion to 4, adding 5-8 parts of KIO4Stirring and mixing, reacting at 20-22 deg.C for 48-49h, and sequentially adding ethylene glycol and Na2CO3Adjusting the pH value to 7, carrying out reduced pressure concentration, adding n-butanol, extracting for 3 times, and then washing with water to obtain an intermediate A;
s2: adding 30% methanol aqueous solution to intermediate A, and adding BH4Reducing Na for 4-6h, adding acetic acid to adjust the pH value to 5, adding a sulfuric acid solution, reacting at 48-52 ℃ for 24-26h to obtain an intermediate B;
s3: addition of K to intermediate B2CO3Adjusting pH to 7, extracting with ethyl acetate to obtain extractive solution, concentrating under reduced pressure, and oven drying to obtain cycloastragenol crude product;
s4: placing the crude cycloastragenol in CH2Cl2Soaking in acetone for 24 hr to separate out crystal, filtering, and oven drying at low temperature to obtain cycloastragenol.
3. The anti-aging skin care mask according to claim 1, wherein: the preparation method of the white tea extract comprises the following steps: adding the white tea into an extraction tank, adding dichloromethane, controlling the reaction pressure at 0-0.4MPa, the extraction temperature at 108-.
4. The anti-aging skin care mask according to claim 1, wherein: the preparation method of the yeast lysate extract comprises the following steps:
s1, filtering the beer waste yeast liquid by using gauze, centrifugally separating, removing supernatant of yeast, taking filter residue, adding sodium bicarbonate, stirring and mixing at 55-60 ℃ for 30-40min, sieving by using a 100-mesh sieve, and sequentially adding water and sodium bicarbonate to respectively wash the filter residue to obtain an intermediate A;
s2, adding 5-10 parts of boiling ethanol into the intermediate A, carrying out heavy suspension quenching on the yeast, placing the yeast into a water bath pot for heat preservation for 10-15min, then placing the yeast into the ice bath for cooling for 10-15min at the temperature of-5-0 ℃, then carrying out centrifugation, sucking supernatant, carrying out freeze drying, drying at-15-5 ℃, and cooling to obtain the yeast lysate extract with the water content of less than or equal to 5%.
5. The anti-aging skin care mask according to claim 1, wherein: the humectant is one or a combination of more of sodium hyaluronate, polyethylene glycol, propylene glycol, glycerin, 1, 3-butanediol, diglycerin, dipropylene glycol, trimethylolpropane, xylitol, sorbitol and maltitol.
6. The anti-aging skin care mask according to claim 1, wherein: the preservative is at least one of potassium sorbate, imidazolidinyl urea and hydantoin.
7. The preparation process of the anti-aging skin care mask according to any one of claims 1 to 6, characterized in that: the method comprises the following steps:
s1: mixing cycloastragenol, white tea extract and emulsifier, stirring, adding water to obtain emulsion A, sterilizing the emulsion A in a high temperature and high pressure sterilization tank for 40-45min, and cooling the emulsion A to below 50 deg.C after sterilization;
s2: adding flos Lonicerae extract, yeast cell lysate extract, retinol, protoprotein, nicotinamide, and panthenol into emulsifier, stirring to dissolve completely, steam sterilizing, and cooling to room temperature to obtain emulsion B;
s3: adding the emulsion A and the emulsion B into a stirring kettle, stirring, adding butanediol, carbomer, a dispersing agent, EDTA disodium, a preservative and a humectant, uniformly stirring, filtering by using a filter with the pore diameter of 0.65 micrometer, and filtering impurities to obtain a mask liquid;
s4: placing the facial mask bag filled with facial mask paper into a sterilization box for sterilizing the facial mask bag for 25-35min, and placing into a drying box; and spraying the facial mask liquid on one surface of the facial mask paper, attaching a protective film on the back surface, injecting the facial mask liquid into the facial mask bag, and sealing the facial mask bag filled with the facial mask liquid.
8. The preparation process of the anti-aging skin care mask according to claim 7, characterized in that: the quantitative amount of the facial mask liquid filled into the facial mask bag is 30ml-35 ml.
9. The anti-aging skin care mask according to claim 1 or 4, wherein: the water bath comprises a water bath rack (1), wherein supporting seats (2) are symmetrically fixed on the lower surface of the water bath rack (1), 4 supporting seats (2) are arranged, a groove is formed in the water bath rack (1), a water bath pot body (7) is fixed in the groove, a pot cover (4) is arranged above the water bath pot body (7), a heat insulation layer (6) is arranged between the water bath pot body (7) and the water bath rack (1), a heating plate (5) is arranged on the inner side of the heat insulation layer (6), a water outlet (3) is formed in the right side of the water bath rack (1), and the water outlet (3), the heat insulation layer (6) and the heating plate (5) are sequentially arranged in a penetrating manner and then communicated with the interior of the water bath pot body (7);
a placing plate (8) is transversely arranged in the water bath pot body (7), two sides of the placing plate (8) are fixedly connected with two side walls of the water bath pot body (7), a fixing rod (9) penetrates through the middle of the water bath pot body (7), one end of the fixing rod (9) is fixedly connected with the lower wall of the water bath pot body (7), a cavity (13) is formed in the left side of the placing plate (8), an inclined groove plate (14) is arranged on the lower wall of the cavity (13), the inclined groove plate (14) is triangular, and the two inclined groove plates (14) are clamped with a clamping rod (15);
the upper end of the clamping rod (15) is fixedly connected with the sliding rod (11), a sleeve (22) is arranged on the outer side of the sliding rod (11), the sliding rod (11) is sleeved in the sleeve (22), the upper end of the sliding rod (11) is fixedly connected with the inner wall of the sleeve (22) through a limiting spring (18), the sleeve (22) penetrates through the upper wall of the placing plate (8), clamping blocks (21) are fixed on two side walls of the sleeve (22) in the cavity (13), an operating rod (17) is arranged on the left side of the sleeve (22), the operating rod (17) penetrates through the left side wall of the sleeve (22) and then is fixedly connected with the sliding rod (11), and the operating rod (17) is in sliding connection with the side wall of the sleeve (22);
the right side wall of the sleeve (22) is fixedly connected with a first fixing plate (19) through a first connecting rod (23), the right side of the first fixing plate (19) is arc-shaped, an installation rod (12) is fixed on the upper surface of the right side of the placing plate (8), the side wall of the installation rod (12) is fixedly connected with a second fixing plate (20) through a second connecting rod (16), the left side of the second fixing plate (20) is arc-shaped, and the circle center of the second fixing plate (20) is opposite to that of the first fixing plate (19); the placing plate (8) is provided with a plurality of through holes (10).
10. The anti-aging skin care mask as set forth in claim 9, wherein: the working method of the water bath pot specifically comprises the following steps: open pot cover (4) and put into water-bath kettle rack (1) with the container in, pulling action bars (17), make slide bar (11) upward movement, adjust the position of kelly (15) and chute board (14) block, make sleeve pipe (22) remove, and thus adjust the position between first fixed plate (19) and second fixed plate (20) and fix the container, start hot plate (5) simultaneously and heat the water in the water-bath kettle body (7), cover pot cover (4), treat the reaction and accomplish the back, take out the container.
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