CN114206339A - 氘化mk2途径抑制剂及其使用方法 - Google Patents

氘化mk2途径抑制剂及其使用方法 Download PDF

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Publication number
CN114206339A
CN114206339A CN202080051376.9A CN202080051376A CN114206339A CN 114206339 A CN114206339 A CN 114206339A CN 202080051376 A CN202080051376 A CN 202080051376A CN 114206339 A CN114206339 A CN 114206339A
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China
Prior art keywords
disease
chronic
cancer
syndrome
vitiligo
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Pending
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CN202080051376.9A
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English (en)
Chinese (zh)
Inventor
D·R·安德森
G·A·德雷森佐
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Aclaris Therapeutics Inc
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Aclaris Therapeutics Inc
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Publication of CN114206339A publication Critical patent/CN114206339A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080051376.9A 2019-07-31 2020-07-31 氘化mk2途径抑制剂及其使用方法 Pending CN114206339A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962881026P 2019-07-31 2019-07-31
US62/881,026 2019-07-31
PCT/US2020/044558 WO2021022186A1 (en) 2019-07-31 2020-07-31 Deuterated mk2 pathway inhibitors and methods of using the same

Publications (1)

Publication Number Publication Date
CN114206339A true CN114206339A (zh) 2022-03-18

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CN202080051376.9A Pending CN114206339A (zh) 2019-07-31 2020-07-31 氘化mk2途径抑制剂及其使用方法

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US (1) US12403141B2 (enExample)
EP (1) EP4003344A4 (enExample)
JP (1) JP2022542434A (enExample)
KR (1) KR20220041180A (enExample)
CN (1) CN114206339A (enExample)
AU (1) AU2020319879A1 (enExample)
BR (1) BR112022001324A2 (enExample)
CA (1) CA3149304A1 (enExample)
IL (1) IL290045A (enExample)
MX (1) MX2022001151A (enExample)
PH (1) PH12022550029A1 (enExample)
WO (1) WO2021022186A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115666566A (zh) * 2020-03-27 2023-01-31 阿克拉瑞斯治疗股份有限公司 用于免疫病况的治疗的mk2途径抑制剂的口服组合物
WO2024149359A1 (zh) * 2023-01-13 2024-07-18 上海美悦生物科技发展有限公司 苯基取代的杂芳基类化合物及其药物组合物、制备方法和用途

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BR112023019861A2 (pt) 2021-03-31 2023-11-07 Xinthera Inc Inibidores de mk2 e usos dos mesmos
EP4367099A4 (en) 2021-07-09 2025-06-04 Xinthera, Inc. Pyridinone mk2 inhibitors and uses thereof
WO2023001282A1 (zh) * 2021-07-23 2023-01-26 南京明德新药研发有限公司 杂环取代的嘧啶衍生物
CN116444492B (zh) * 2021-12-29 2026-03-03 上海美悦生物科技发展有限公司 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途
CN116396274B (zh) * 2022-01-06 2025-11-11 深圳信立泰药业股份有限公司 一种取代的联吡啶酮类化合物及其制备方法与应用
EP4464694A4 (en) 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
CN116444493A (zh) * 2022-01-14 2023-07-18 上海翰森生物医药科技有限公司 含双并环类衍生物、其制备方法和应用
WO2023150709A2 (en) * 2022-02-04 2023-08-10 Aclaris Therapeutics, Inc. Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds
CN119384410A (zh) * 2022-03-03 2025-01-28 深圳信立泰药业股份有限公司 一种氘代三联吡啶二酮化合物或其盐及其制备方法与应用
JP2026504073A (ja) * 2023-01-13 2026-02-03 プールベグ ファーマ（ユーケー） リミテッド がん免疫療法関連サイトカイン放出症候群の軽減のための医薬品および方法
WO2025093869A1 (en) * 2023-11-01 2025-05-08 Poolbeg Pharma (UK) Limited P38 map kinase inhibitor for use in the treatment of inflammation

Citations (3)

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US20100305145A1 (en) * 2009-05-28 2010-12-02 Gary Mark Coppola Substituted Aminobutyric Derivatives as Neprilysin Inhibitors
CN105263326A (zh) * 2013-06-07 2016-01-20 汇合生命科学股份有限公司 甲基/氟-吡啶基-甲氧基取代的吡啶酮-吡啶基化合物及氟-嘧啶基-甲氧基取代的吡啶酮-吡啶基化合物
CN108884019A (zh) * 2016-04-11 2018-11-23 克雷西奥生物科技有限公司 氘代氯胺酮衍生物

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WO2008141057A1 (en) * 2007-05-08 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated pimavanserin 1- (4-flu0r0benzyl) -3- (4-isobutoxybenzyl) -1- ( l-methyl-piperidin-4-yl) -urea
US8575348B2 (en) * 2009-07-28 2013-11-05 Auspex Pharmaceuticals, Inc Quinolone inhibitors of lipoprotein-associated phospholipase A2
US9359300B2 (en) * 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
SI2648516T1 (sl) * 2010-12-06 2019-01-31 Aclaris Therapeutics, Inc. Substituirane spojine piridinon-piridinila
CZ2015601A3 (cs) * 2015-09-02 2017-03-15 Zentiva, K.S. Způsob výroby 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)močoviny a jejích deuterovaných analog neobsahujících dimerické nečistoty
WO2018229683A1 (en) * 2017-06-15 2018-12-20 Novartis Ag 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases
EP3720436A4 (en) 2017-12-06 2021-06-02 Lin Bioscience, Pty Ltd. TUBULIN INHIBITORS
US20230087078A1 (en) 2020-03-02 2023-03-23 Washington University Compositions and methods for the treatment of pancreatic cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100305145A1 (en) * 2009-05-28 2010-12-02 Gary Mark Coppola Substituted Aminobutyric Derivatives as Neprilysin Inhibitors
CN105263326A (zh) * 2013-06-07 2016-01-20 汇合生命科学股份有限公司 甲基/氟-吡啶基-甲氧基取代的吡啶酮-吡啶基化合物及氟-嘧啶基-甲氧基取代的吡啶酮-吡啶基化合物
CN108884019A (zh) * 2016-04-11 2018-11-23 克雷西奥生物科技有限公司 氘代氯胺酮衍生物

Non-Patent Citations (2)

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邵明莎等: "盐酸d3-Poziotinib的设计合成及体外肝微粒体稳定性研究", 《烟台大学学报》, vol. 32, no. 3, pages 220 - 225 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115666566A (zh) * 2020-03-27 2023-01-31 阿克拉瑞斯治疗股份有限公司 用于免疫病况的治疗的mk2途径抑制剂的口服组合物
WO2024149359A1 (zh) * 2023-01-13 2024-07-18 上海美悦生物科技发展有限公司 苯基取代的杂芳基类化合物及其药物组合物、制备方法和用途

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IL290045A (en) 2022-03-01
WO2021022186A1 (en) 2021-02-04
CA3149304A1 (en) 2021-02-04
MX2022001151A (es) 2022-02-22
JP2022542434A (ja) 2022-10-03
KR20220041180A (ko) 2022-03-31
EP4003344A4 (en) 2023-07-26
PH12022550029A1 (en) 2023-02-27
US20220288070A1 (en) 2022-09-15
US12403141B2 (en) 2025-09-02
AU2020319879A1 (en) 2022-02-03
BR112022001324A2 (pt) 2022-03-22
EP4003344A1 (en) 2022-06-01

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Application publication date: 20220318