JP2022542434A - 重水素化ｍｋ２経路阻害剤およびその使用方法 - Google Patents

重水素化ｍｋ２経路阻害剤およびその使用方法 Download PDF

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JP2022542434A
JP2022542434A JP2022506384A JP2022506384A JP2022542434A JP 2022542434 A JP2022542434 A JP 2022542434A JP 2022506384 A JP2022506384 A JP 2022506384A JP 2022506384 A JP2022506384 A JP 2022506384A JP 2022542434 A JP2022542434 A JP 2022542434A
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fibrosis
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JP2022542434A5 (enExample
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デイヴィッド ランドルフ アンダーソン
ゲイリー アンソニー デクレシェンツォ
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アクラリス セラピューティクス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022506384A 2019-07-31 2020-07-31 重水素化ｍｋ２経路阻害剤およびその使用方法 Ceased JP2022542434A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962881026P 2019-07-31 2019-07-31
US62/881,026 2019-07-31
PCT/US2020/044558 WO2021022186A1 (en) 2019-07-31 2020-07-31 Deuterated mk2 pathway inhibitors and methods of using the same

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JP2022542434A true JP2022542434A (ja) 2022-10-03
JP2022542434A5 JP2022542434A5 (enExample) 2023-07-19

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US (1) US12403141B2 (enExample)
EP (1) EP4003344A4 (enExample)
JP (1) JP2022542434A (enExample)
KR (1) KR20220041180A (enExample)
CN (1) CN114206339A (enExample)
AU (1) AU2020319879A1 (enExample)
BR (1) BR112022001324A2 (enExample)
CA (1) CA3149304A1 (enExample)
IL (1) IL290045A (enExample)
MX (1) MX2022001151A (enExample)
PH (1) PH12022550029A1 (enExample)
WO (1) WO2021022186A1 (enExample)

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KR20220161396A (ko) * 2020-03-27 2022-12-06 어클라리스 쎄라퓨틱스, 인코포레이티드 치환된 피리디논-피리디닐 화합물의 제조, 조성물, 및 결정형
BR112023019861A2 (pt) 2021-03-31 2023-11-07 Xinthera Inc Inibidores de mk2 e usos dos mesmos
EP4367099A4 (en) 2021-07-09 2025-06-04 Xinthera, Inc. Pyridinone mk2 inhibitors and uses thereof
WO2023001282A1 (zh) * 2021-07-23 2023-01-26 南京明德新药研发有限公司 杂环取代的嘧啶衍生物
CN116444492B (zh) * 2021-12-29 2026-03-03 上海美悦生物科技发展有限公司 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途
CN116396274B (zh) * 2022-01-06 2025-11-11 深圳信立泰药业股份有限公司 一种取代的联吡啶酮类化合物及其制备方法与应用
EP4464694A4 (en) 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
CN116444493A (zh) * 2022-01-14 2023-07-18 上海翰森生物医药科技有限公司 含双并环类衍生物、其制备方法和应用
WO2023150709A2 (en) * 2022-02-04 2023-08-10 Aclaris Therapeutics, Inc. Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds
CN119384410A (zh) * 2022-03-03 2025-01-28 深圳信立泰药业股份有限公司 一种氘代三联吡啶二酮化合物或其盐及其制备方法与应用
EP4650347A1 (en) * 2023-01-13 2025-11-19 Shanghai Meiyue Biotech Development Co., Ltd. Phenyl-substituted heteroaryl compound and pharmaceutical composition comprising same, preparation method therefor and use thereof
JP2026504073A (ja) * 2023-01-13 2026-02-03 プールベグ ファーマ（ユーケー） リミテッド がん免疫療法関連サイトカイン放出症候群の軽減のための医薬品および方法
WO2025093869A1 (en) * 2023-11-01 2025-05-08 Poolbeg Pharma (UK) Limited P38 map kinase inhibitor for use in the treatment of inflammation

Citations (7)

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WO2008141057A1 (en) * 2007-05-08 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated pimavanserin 1- (4-flu0r0benzyl) -3- (4-isobutoxybenzyl) -1- ( l-methyl-piperidin-4-yl) -urea
US20110136861A1 (en) * 2009-07-28 2011-06-09 Auspex Pharmaceuticals, Inc. Quinolone inhibitors of lipoprotein-associated phospholipase a2
JP2012528107A (ja) * 2009-05-28 2012-11-12 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP2013544889A (ja) * 2010-12-06 2013-12-19 コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド 置換ピリジノンピリジニル化合物
JP2016520654A (ja) * 2013-06-07 2016-07-14 コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物
WO2017036432A1 (en) * 2015-09-02 2017-03-09 Zentiva, K.S. A production method of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin- 4— yl)urea and its deuterated analogs not containing dimeric impurities
WO2018229683A1 (en) * 2017-06-15 2018-12-20 Novartis Ag 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases

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* Cited by examiner, † Cited by third party
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US9359300B2 (en) * 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
EP3442940A1 (en) * 2016-04-11 2019-02-20 Clexio Biosciences Ltd. Deuterated ketamine derivatives
EP3720436A4 (en) 2017-12-06 2021-06-02 Lin Bioscience, Pty Ltd. TUBULIN INHIBITORS
US20230087078A1 (en) 2020-03-02 2023-03-23 Washington University Compositions and methods for the treatment of pancreatic cancer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141057A1 (en) * 2007-05-08 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated pimavanserin 1- (4-flu0r0benzyl) -3- (4-isobutoxybenzyl) -1- ( l-methyl-piperidin-4-yl) -urea
JP2012528107A (ja) * 2009-05-28 2012-11-12 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
US20110136861A1 (en) * 2009-07-28 2011-06-09 Auspex Pharmaceuticals, Inc. Quinolone inhibitors of lipoprotein-associated phospholipase a2
JP2013544889A (ja) * 2010-12-06 2013-12-19 コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド 置換ピリジノンピリジニル化合物
JP2016520654A (ja) * 2013-06-07 2016-07-14 コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物
WO2017036432A1 (en) * 2015-09-02 2017-03-09 Zentiva, K.S. A production method of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin- 4— yl)urea and its deuterated analogs not containing dimeric impurities
WO2018229683A1 (en) * 2017-06-15 2018-12-20 Novartis Ag 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases

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Publication number Publication date
IL290045A (en) 2022-03-01
WO2021022186A1 (en) 2021-02-04
CA3149304A1 (en) 2021-02-04
MX2022001151A (es) 2022-02-22
CN114206339A (zh) 2022-03-18
KR20220041180A (ko) 2022-03-31
EP4003344A4 (en) 2023-07-26
PH12022550029A1 (en) 2023-02-27
US20220288070A1 (en) 2022-09-15
US12403141B2 (en) 2025-09-02
AU2020319879A1 (en) 2022-02-03
BR112022001324A2 (pt) 2022-03-22
EP4003344A1 (en) 2022-06-01

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