CN114190543B - 一种低渗透压特殊医学用途婴儿无乳糖配方食品 - Google Patents
一种低渗透压特殊医学用途婴儿无乳糖配方食品 Download PDFInfo
- Publication number
- CN114190543B CN114190543B CN202111566836.4A CN202111566836A CN114190543B CN 114190543 B CN114190543 B CN 114190543B CN 202111566836 A CN202111566836 A CN 202111566836A CN 114190543 B CN114190543 B CN 114190543B
- Authority
- CN
- China
- Prior art keywords
- parts
- compound
- maltodextrin
- lactose
- ascorbyl palmitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003204 osmotic effect Effects 0.000 title claims abstract description 29
- 235000013305 food Nutrition 0.000 title claims abstract description 18
- 235000020214 lactose-free milk formula Nutrition 0.000 title claims abstract description 18
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 30
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 30
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 30
- 201000010538 Lactose Intolerance Diseases 0.000 claims abstract description 19
- 235000000346 sugar Nutrition 0.000 claims abstract description 17
- 239000007787 solid Substances 0.000 claims abstract description 16
- 229920002472 Starch Polymers 0.000 claims abstract description 15
- 235000019698 starch Nutrition 0.000 claims abstract description 15
- 239000008107 starch Substances 0.000 claims abstract description 15
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 13
- 235000021119 whey protein Nutrition 0.000 claims abstract description 13
- 235000021552 granulated sugar Nutrition 0.000 claims abstract description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 6
- 239000008103 glucose Substances 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 50
- 150000001875 compounds Chemical class 0.000 claims description 38
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 26
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 26
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 26
- -1 compound potassium citrate Chemical class 0.000 claims description 25
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 15
- 239000004519 grease Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 229940032147 starch Drugs 0.000 claims description 14
- 102000007544 Whey Proteins Human genes 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- 229960001295 tocopherol Drugs 0.000 claims description 12
- 235000010384 tocopherol Nutrition 0.000 claims description 12
- 229930003799 tocopherol Natural products 0.000 claims description 12
- 239000011732 tocopherol Substances 0.000 claims description 12
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 12
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 11
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 11
- 229930195729 fatty acid Natural products 0.000 claims description 11
- 239000000194 fatty acid Substances 0.000 claims description 11
- 235000019871 vegetable fat Nutrition 0.000 claims description 11
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Inorganic materials [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 8
- 229960000367 inositol Drugs 0.000 claims description 8
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 8
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 8
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims description 7
- 235000019743 Choline chloride Nutrition 0.000 claims description 7
- 229940114079 arachidonic acid Drugs 0.000 claims description 7
- 235000021342 arachidonic acid Nutrition 0.000 claims description 7
- 239000001506 calcium phosphate Substances 0.000 claims description 7
- 229960003178 choline chloride Drugs 0.000 claims description 7
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 7
- 239000001103 potassium chloride Substances 0.000 claims description 7
- 235000011164 potassium chloride Nutrition 0.000 claims description 7
- 239000001508 potassium citrate Substances 0.000 claims description 7
- 229960002635 potassium citrate Drugs 0.000 claims description 7
- 235000011082 potassium citrates Nutrition 0.000 claims description 7
- 239000001509 sodium citrate Substances 0.000 claims description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 7
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 7
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 7
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 7
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
- 235000010755 mineral Nutrition 0.000 claims description 6
- 239000011707 mineral Substances 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 6
- 229960005055 sodium ascorbate Drugs 0.000 claims description 6
- 229940080313 sodium starch Drugs 0.000 claims description 6
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 5
- 239000000828 canola oil Substances 0.000 claims description 5
- 235000019519 canola oil Nutrition 0.000 claims description 5
- 239000003240 coconut oil Substances 0.000 claims description 5
- 235000019864 coconut oil Nutrition 0.000 claims description 5
- 239000002285 corn oil Substances 0.000 claims description 5
- 235000005687 corn oil Nutrition 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 235000019198 oils Nutrition 0.000 claims description 5
- 239000003549 soybean oil Substances 0.000 claims description 5
- 235000012424 soybean oil Nutrition 0.000 claims description 5
- 235000020238 sunflower seed Nutrition 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 150000003904 phospholipids Chemical class 0.000 claims description 4
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 4
- 239000011755 sodium-L-ascorbate Substances 0.000 claims description 4
- 235000019187 sodium-L-ascorbate Nutrition 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 235000019192 riboflavin Nutrition 0.000 claims description 3
- 239000002151 riboflavin Substances 0.000 claims description 3
- 229960003080 taurine Drugs 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 claims description 2
- UPJKSWLLCONYMW-UHFFFAOYSA-N 5'-Adenosine monophosphate Natural products COc1cc(O)c(C(=O)C)c(OC2OC(COC3OC(C)C(O)C(O)C3O)C(O)C(O)C2O)c1 UPJKSWLLCONYMW-UHFFFAOYSA-N 0.000 claims description 2
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims description 2
- 239000011665 D-biotin Substances 0.000 claims description 2
- 235000000638 D-biotin Nutrition 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 2
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 2
- SLIUELDPAPMQIB-IDIVVRGQSA-N [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C=NC=2C(O)=NC=NC12 Chemical compound [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C=NC=2C(O)=NC=NC12 SLIUELDPAPMQIB-IDIVVRGQSA-N 0.000 claims description 2
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 2
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 2
- 239000011666 cyanocobalamin Substances 0.000 claims description 2
- PVBRXXAAPNGWGE-LGVAUZIVSA-L disodium 5'-guanylate Chemical compound [Na+].[Na+].C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O PVBRXXAAPNGWGE-LGVAUZIVSA-L 0.000 claims description 2
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 2
- 229940117373 dl-alpha tocopheryl acetate Drugs 0.000 claims description 2
- 239000011790 ferrous sulphate Substances 0.000 claims description 2
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 2
- 229960000304 folic acid Drugs 0.000 claims description 2
- 235000019152 folic acid Nutrition 0.000 claims description 2
- 239000011724 folic acid Substances 0.000 claims description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229940099596 manganese sulfate Drugs 0.000 claims description 2
- 239000011702 manganese sulphate Substances 0.000 claims description 2
- 235000007079 manganese sulphate Nutrition 0.000 claims description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 2
- 239000001230 potassium iodate Substances 0.000 claims description 2
- 235000006666 potassium iodate Nutrition 0.000 claims description 2
- 229940093930 potassium iodate Drugs 0.000 claims description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 2
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 2
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 2
- 229960000342 retinol acetate Drugs 0.000 claims description 2
- 235000019173 retinyl acetate Nutrition 0.000 claims description 2
- 239000011770 retinyl acetate Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 239000011781 sodium selenite Substances 0.000 claims description 2
- 235000015921 sodium selenite Nutrition 0.000 claims description 2
- 229960001471 sodium selenite Drugs 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 2
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 2
- 229940045145 uridine Drugs 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 235000005282 vitamin D3 Nutrition 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- 229940021056 vitamin d3 Drugs 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- 229960001518 levocarnitine Drugs 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 abstract description 22
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract description 16
- 239000008101 lactose Substances 0.000 abstract description 16
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 8
- 235000018102 proteins Nutrition 0.000 abstract description 8
- 108090000623 proteins and genes Proteins 0.000 abstract description 8
- 102000004169 proteins and genes Human genes 0.000 abstract description 8
- 230000009286 beneficial effect Effects 0.000 abstract description 6
- 238000011084 recovery Methods 0.000 abstract description 4
- 230000029087 digestion Effects 0.000 abstract description 3
- 235000013350 formula milk Nutrition 0.000 description 32
- 239000000047 product Substances 0.000 description 25
- 235000015097 nutrients Nutrition 0.000 description 15
- 230000012010 growth Effects 0.000 description 8
- 235000013336 milk Nutrition 0.000 description 8
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 102100026189 Beta-galactosidase Human genes 0.000 description 6
- 108010059881 Lactase Proteins 0.000 description 6
- 108010005774 beta-Galactosidase Proteins 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 6
- 229940116108 lactase Drugs 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 210000001503 joint Anatomy 0.000 description 4
- 239000011812 mixed powder Substances 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 208000019902 chronic diarrheal disease Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000007580 dry-mixing Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000020256 human milk Nutrition 0.000 description 3
- 210000004251 human milk Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 206010053759 Growth retardation Diseases 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 201000009840 acute diarrhea Diseases 0.000 description 2
- 208000005161 congenital lactase deficiency Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 2
- 150000003271 galactooligosaccharides Chemical class 0.000 description 2
- 231100000001 growth retardation Toxicity 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 235000013618 yogurt Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012742 Diarrhoea infectious Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 1
- 206010023648 Lactase deficiency Diseases 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000052708 Recessive Genes Human genes 0.000 description 1
- 108700005079 Recessive Genes Proteins 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- PNPLHKHBANFGMS-WFIJOQBCSA-N [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 PNPLHKHBANFGMS-WFIJOQBCSA-N 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 229940127282 angiotensin receptor antagonist Drugs 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000037817 intestinal injury Diseases 0.000 description 1
- NNIPDXPTJYIMKW-UHFFFAOYSA-N iron tin Chemical compound [Fe].[Sn] NNIPDXPTJYIMKW-UHFFFAOYSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000020190 lactose-free milk Nutrition 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000006180 nutrition needs Nutrition 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- 235000019175 phylloquinone Nutrition 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- 229960001898 phytomenadione Drugs 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- 229940091251 zinc supplement Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本申请提供了一种适用于乳糖不耐症的低渗透压特殊医学用途婴儿无乳糖配方食品，其中用麦芽糊精、葡萄糖、固体淀粉糖、白砂糖代替乳糖，乳糖含量小于0.5g/100g，蛋白质全部由乳清蛋白提供；本申请的食品属于无乳糖配方，适合患有乳糖不耐受婴儿食用，可以减轻肠道的消化负担，有利于腹泻的恢复。
Description
技术领域
本申请属于食品领域，特别是婴幼儿食品领域，具体地，本申请提供了一种低渗透压特殊医学用途婴儿无乳糖配方食品及其制备方法。
背景技术
特殊医学用途婴儿配方食品，是针对患有特殊紊乱、疾病或医学状况等特殊医学状况婴儿的营养需求而设计制成的粉状或液态配方食品。在医生或临床营养师指导下，单独食用或与其它食物配合食用时，其能量和营养成分能满足特殊医学状况婴儿的生长发育需求。
特殊医学用途婴儿无乳糖配方食品主要技术要求为配方中以其它碳水化合物完全或部分代替乳糖；蛋白质由乳蛋白提供。根据《预包装食品营养标签通则》（GB28050）规定，粉状无乳糖配方食品中乳糖含量应低于0.5克/100克。
乳糖主要存在于人和哺乳动物乳汁中，是婴儿的主要能量来源。婴儿摄入乳糖后需在乳糖酶作用下水解为葡萄糖和半乳糖才可以被小肠吸收。新生儿和婴儿可能存在先天性乳糖不耐受或继发性乳糖不耐受：先天性乳糖不耐受是指自出生时机体乳糖酶活性即低下或缺乏，是机体常染色体上隐性基因所致；继发性乳糖不耐受是指因各种原因（如：感染性腹泻、局限性回肠炎等疾病）导致小肠上皮损伤，出现暂时性乳糖酶活性低下。乳糖不耐症出现的关键原因是乳糖酶的相对或绝对缺乏，导致婴儿进食的母乳或普通婴儿配方粉中乳糖无法被消化吸收。
中国婴幼儿中乳糖不耐受发病率较高，可达46.9%-70.0%。婴儿肠道中的乳糖酶活性下降或完全停止分泌，会导致乳糖无法被乳糖酶水解，没有被水解的乳糖在大肠被细菌产酸产气，从而引起肠胃胀气、胀痛，过量的乳糖还会升高肠道内部的渗透压，阻止对水分吸收而导致腹泻。长时间腹泻还将继续导致体内渗透压增高，破坏体内水和酸碱平衡，出现肠腔高渗透压的状况，继而引发更严重的腹痛、腹泻症状。
乳糖不耐受的长期危害表现为钙吸收不良、腹泻、软骨病、体重低下及生长发育迟缓、营养不良、贫血等，尤其先天性和继发性乳糖酶缺乏可导致婴幼儿难治性腹泻和慢性腹泻。
目前国产低渗透压的特殊医学用途无乳糖婴儿配方食品少之又少，大多患病婴儿只能购买类似的进口配方食品，但进口配方食品存在供货不稳定，价格高等劣势，因此开发一种符合中国国情的此类产品是十分有必要的。
原发性或继发性乳糖不耐受婴儿易出现的难治性腹泻和慢性腹泻，一般会伴随婴儿肠腔渗透压增高，体内水平衡和酸碱平衡紊乱，针对此病症，一则通过喂食低渗透压补液盐、补锌、思密达等药物治疗腹泻症状，这种治疗方法不仅费用高，而且婴儿会有生长发育迟缓、营养不良的风险。二则通过喂养不含乳糖的配方粉，但通常市面上的无乳糖配方粉渗透压较高，不利于出现腹泻症状的婴儿较快恢复。
现有类似产品的主要缺点还包括：
1）产品冲调液渗透压较高，不利于缓解腹泻婴儿肠腔内高渗透压状况，不能及时调整婴儿体内水平衡和酸碱平衡；2) 湿法工艺生产，整个工艺流程涉及设备较多，成本较高，工艺相对复杂，热敏性和光敏性营养素容易损失；3）大多只属于普通婴配粉、乳制品等，不符合《GB25596 食品安全国家标准 特殊医学用途婴儿配方食品通则》中对营养素指标的规定。
例如：目前公开的专利中涉及无乳糖配方的大多为牛奶、发酵乳、孕产妇奶粉等，如公开号：113016884缓解乳糖不耐受的孕产妇配方奶粉、公开号：112868764一种无乳糖常温酸奶及其制备方法 、公开号：112715659一种无乳糖常温酸奶及其制备方法、公开号：112616918一种无乳糖微发酵牛乳及其制备方法 、公开号：112042741一种采用复合酶制备无乳糖奶制品的方法等。此类产品虽然也属于无乳糖，但是不符合GB25596中对营养素的规定，不适合婴儿食用，无法满足有乳糖不耐症婴儿的生长发育需求。公开的专利中有些虽属于特殊医学用途婴儿无乳糖配方食品，符合GB25596中对营养素的规定，但并未提到配方渗透压的问题，冲调液渗透压不确定，可能无法快速缓解婴儿肠腔高渗透压腹泻的状况，如公开号：109156817一种无乳糖婴儿配方食品及其制备方法、公开号：110419579 一种特殊医学用途婴儿配方奶粉。公开的专利中有部分是采用湿法工艺生产，但湿法工艺复杂，设备投入和生产成本比干法工艺要高许多，热敏性和光敏性营养素容易损失，如公开号：103598353乳基无乳糖婴儿配方粉。
发明内容
有鉴于此，通过让婴儿食用具有低渗透压特征的特殊医学用途婴儿无乳糖配方食品，是缓解因乳糖不耐受导致的腹泻腹胀病症最简而有效的方法。对于其它婴幼儿急性腹泻，食用此产品可使病程明显缩短，说明具有低渗透压特征的特殊医学用途婴儿无乳糖配方食品治疗婴幼儿急性腹泻也值得在临床推广应用。
本发明要解决的技术问题为在于提供一种适用于因先天性或继发性乳糖不耐症婴儿的低渗透压特殊医学用途无乳糖婴儿配方食品，减轻肠道负担，缓解婴儿乳糖不耐受、急性腹泻、慢性腹泻和难治性腹泻。本发明碳水化合物用麦芽糊精、葡萄糖、固体淀粉糖、白砂糖代替乳糖，乳糖含量小于0.5g/100g，属于无乳糖配方，适合患有乳糖不耐受婴儿食用，可以减轻肠道的消化负担，有利于腹泻的恢复。蛋白质全部由乳清蛋白提供，乳清蛋白属于一种优质蛋白，所含必需氨基酸种类齐全、数量充足、比例适当，容易被人体吸收利用。其它维生素、矿物质也均符合GB25596中的规定。
一方面，本申请提供了一种适用于乳糖不耐症的低渗透压特殊医学用途婴儿无乳糖配方食品，包含如下质量份的组份：
植物脂肪粉1 657～803份、植物脂肪粉2 108～132份、复配柠檬酸钾 39.2～58.8份、复配柠檬酸钠 20～30份、复配磷酸氢钙 9.6～14.4份、复配二十二碳六烯酸油脂 8.4～12.6份、白砂糖 8～12份、复配氯化钾 8～12份、复配花生四烯酸油脂 7.2～10.8份、复配氯化胆碱 7.2～10.8份、复配矿物质 4～6份、复配肌醇 2.8～4.2份、复配维生素 2.4～3.6份、磷酸三钙 2.4～3.6份、碳酸钙 0.4～0.6份、复配核苷酸 0.4～0.6份、复配左旋肉碱 0.296～0.444份。
进一步的，所述植物脂肪粉1由包括以下质量份的原料制备而成：
麦芽糊精 168.4～205.9份、复合植物油107.7～131.6份、分离乳清蛋白粉102.5～125.3份、固体淀粉糖86～105.2份、无水奶油86～105.2份、食用葡萄糖65.7～80.3份、辛烯基琥珀酸淀粉钠34.2～41.8份、单，双甘油脂肪酸酯4.5～5.5份、L-抗坏血酸钠1.4～1.7份、抗坏血酸棕榈酸酯0.203～0.249份、混合生育酚浓缩物0.158～0.193份、磷脂0.112～0.136份。
所述的复合植物油包括玉米油 26.9～32.9份、葵花籽油 24.8～30.3份、大豆油23.7～28.9份、低芥酸菜籽油 21.5～26.3份、椰子油 10.8～13.2份、混合生育酚浓缩物0.032～0.039份、抗坏血酸棕榈酸酯 0.022～0.026份。
进一步的，所述植物脂肪粉2由包括以下质量份的原料制备而成：
麦芽糊精 45～55份、复合植物油25.9～31.7份、固体淀粉糖 18.8～23份、分离乳清蛋白粉 17.1～20.9份、单，双甘油脂肪酸酯 0.747～0.913份、L-抗坏血酸钠 0.405～0.495份、抗坏血酸棕榈酸酯 0.036～0.044份、混合生育酚浓缩物 0.036～0.044份、磷脂0.018～0.022份。
其中，所述的复合植物油包括玉米油 6.5～7.9份、葵花籽油 6.0～7.3份、大豆油5.7～7.0份、低芥酸菜籽油5.2～6.3份、椰子油 2.6～3.2份、混合生育酚浓缩物 0.008～0.009份、抗坏血酸棕榈酸酯 0.005～0.006份。
进一步的，所述的复配柠檬酸钾包括麦芽糊精 34.5～51.7份、柠檬酸钾 4.7～7.1份、抗坏血酸棕榈酸酯 0.004～0.006份；
所述的复配柠檬酸钠包括麦芽糊精 17.6～26.4份、柠檬酸钠 2.4～3.6份、抗坏血酸棕榈酸酯 0.002～0.003份。
所述的复配磷酸氢钙包括磷酸氢钙9.6～14.4份、麦芽糊精 0.001～0.0014份、抗坏血酸棕榈酸酯 0.001～0.0014份。
所述的复配二十二碳六烯酸油脂包括麦芽糊精 2.7～4.0份、固体淀粉糖1.5～2.3份、二十二碳六烯酸油脂 1.4～2.1份、分离乳清蛋白粉1.3～1.9份、白砂糖0.76～1.14份、辛烯基琥珀酸淀粉钠 0.648～0.972份、L-抗坏血酸钠 0.058～0.086份、单，双甘油脂肪酸酯 0.05～0.076份、磷酸三钙 0.046～0.07份、卡拉胶 0.01～0.014份、混合生育酚浓缩物0.002～0.003份、抗坏血酸棕榈酸酯 0.002～0.003份。
所述的复配氯化钾包括氯化钾 6.4～9.6份、麦芽糊精 1.6～2.4份、抗坏血酸棕榈酸酯 0.0008～0.0012份
所述的复配花生四烯酸油脂包括麦芽糊精 2～2.9份、花生四烯酸油脂 1.6～2.4份、固体淀粉糖1.3～2.0份、分离乳清蛋白粉1.1～1.6份、白砂糖 0.664～0.996份、辛烯基琥珀酸淀粉钠 0.400～0.600份、单，双甘油脂肪酸酯 0.063～0.095份、磷酸三钙 0.061～0.091份、L-抗坏血酸钠 0.050～0.076份、卡拉胶 0.008～0.012份、混合生育酚浓缩物0.001～0.002份、抗坏血酸棕榈酸酯 0.001～0.002份。
所述的复配氯化胆碱包括麦芽糊精 6.3～9.5份、氯化胆碱0.9～1.3份、抗坏血酸棕榈酸酯 0.0007～0.0011份。
所述的复配矿物质包括硫酸镁 2.6～3.9份、麦芽糊精 1.1～1.7份、硫酸亚铁0.147～0.221份、硫酸锌 0.119～0.179份、硫酸铜 0.008～0.012份、硫酸锰 0.006～0.009份、碘酸钾 0.001～0.002份、亚硒酸钠 0.0002～0.0004份。
所述的复配肌醇包括麦芽糊精 1.7～2.5份、肌醇 1.1～1.7份、抗坏血酸棕榈酸酯 0.0003～0.0004份。
所述的复配维生素包括麦芽糊精 1.4～2.0份、L-抗坏血酸钠 0.32～0.48份、牛磺酸 0.32～0.48份、50%的dl-α-醋酸生育酚 0.224～0.336份、D-泛酸钙 0.048～0.072份、11.5%的醋酸视黄酯 0.046～0.068份、烟酰胺 0.044～0.066份、0.25%的胆钙化醇0.029～0.043份、核黄素 0.007～0.011份、盐酸硫胺素 0.004～0.006份、盐酸吡哆醇0.004～0.006份、叶酸 0.001～0.002份、D-生物素 0.0003～0.0004份、植物甲萘醌0.0003～0.0004份、氰钴胺 0.000016～0.000024份。
所述的复配核苷酸包括5'-胞苷酸二钠 0.158～0.238份、5'-尿苷酸二钠 0.089～0.133份、5'单磷酸腺苷 0.076～0.114份、5'-肌苷酸二钠 0.050～0.076份、5'-鸟苷酸二钠 0.026～0.040份。
所述的复配左旋肉碱包括麦芽糊精 0.164～0.246份、左旋肉碱酒石酸盐 0.132～0.198份、抗坏血酸棕榈酸酯 0.00003～0.00004份。
进一步地，其中固体淀粉糖由40%的麦芽糖和60%的低聚异麦芽糖组成。
另一方面，本申请提供了上述一种适用于乳糖不耐症的低渗透压特殊医学用途无乳糖婴儿配方食品的制备方法，包括以下步骤：
步骤一，原料验收：将上述所有物料自行取样检验，合格后验收；
步骤二，备料：按照生产配方进行备料；
步骤三，脱外包：脱外包并用酒精擦拭内包装外表面；
步骤四，进料：将已脱外包的物料进入进粉间，经隧道式紫外线杀菌器，其中紫外线灯管数量≧18根，紫外线强度≧70uw/cm2，传输到清洁作业区倒粉间，粉袋间距≥10cm；
步骤五，分装配料：将上述所有物料按照生产配方进行分装；
步骤六，预混：将上述的磷酸三钙、碳酸钙、复配核苷酸、复配左旋肉碱预混2-4分钟，混合后的营养素为预混料包；
步骤七，称量：将上述的植物脂肪粉1和植物脂肪粉2按产品配方称量；
步骤八，投料：将上述的物料包括1、植物脂肪粉2、复配柠檬酸钾、复配柠檬酸钠、复配磷酸氢钙、复配二十二碳六烯酸油脂、白砂糖、复配氯化钾、复配花生四烯酸油脂、复配氯化胆碱、复配矿物质、预混料包、复配肌醇、复配维生素投入到系统；此投料过程没有严格的前后顺序；
骤九，过筛：投入到系统的各物料过10～24目振动粉筛，振动粉筛由电机驱使做水平振动，筛网上原料在水平运动时，依自身重力落入下方横搅龙，再经横搅龙匀速推至出口；
步骤十，输粉：输粉主要设备是压力仓；待压力仓内部压力值达到设定值0.3MPa后，压力仓打开，气流携带仓内物料经过不锈钢管道，一次性正压输送到干混机内；输粉结束前，洁净压缩空气延时吹扫仓内10～20s，可保证全部原料输送至干混机内；
步骤十一，干混：上述物料输送至干混机内，设定干混洁净压缩空气压力是0.4～0.5 MPa，干混时间是420～540s；
步骤十二，金属检测：金属检测仪可检出≥0.7mm的铁和≥1.0mm不锈钢，从而消除奶粉中的金属颗粒杂质；
步骤十三，接粉：干混机连接金检仪，再通过连接装置与移动式粉箱对接；对接前后，接粉口和对接口需用75%酒精清理消毒；干混机锥底的洁净压缩空气按照固定频率（吹0.3s，停3s）推动干混粉落入下方的横搅龙，再经横搅龙匀速输送，经过金检，落入移动式粉箱；
步骤十四，送粉、金属检测：接粉完成后，将移动式粉箱通过货运电梯，运送至粉仓间，移动式粉箱对接对应线别的下粉口，其中对接前后，接粉口和对接口需用75%酒精消毒，干混粉经金属检测仪进入包装机；金属检测仪可检出≥0.7mm的铁和≥1.0mm不锈钢；
步骤十五，内包装：干混粉经金属检测仪进入包装机中包装，包装机为自动充填、计量、充氮、封口；罐装机速为17-23罐/分钟，充氮后听中残氧量为≤3%；
空听经过铁听隧道式紫外线杀菌器杀菌至少10秒；底盖经过传递窗式紫外线杀菌器杀菌至少15分钟；
步骤十六，外包装：此过程包括日期打印、扫描剔除、扣塑盖、装箱、封箱、喷码、码垛；
步骤十七，成品出库：待检测中心检验合格后配货、发货。
有益效果：
本发明添加葵花籽油、大豆油、低芥酸菜籽油、椰子油、玉米油及无水奶油合理调整产品脂肪酸组成，该脂肪酸组成更为贴近母乳中脂肪酸的组成，保证了婴幼儿生长发育所需要营养，增强了新生儿的免疫力。
本发明完全符合《GB25596 食品安全国家标准 特殊医学用途婴儿配方食品通则》中对营养素指标的规定。
本发明碳水化合物用麦芽糊精、葡萄糖、固体淀粉糖、白砂糖代替乳糖，乳糖含量小于0.5g/100g，属于无乳糖配方，适合患有乳糖不耐受婴儿食用，可以减轻肠道的消化负担，有利于腹泻的恢复。蛋白质全部由乳清蛋白提供，乳清蛋白属于一种优质蛋白，所含必需氨基酸种类齐全、数量充足、比例适当，容易被人体吸收利用。
本配方冲调液体平均渗透压约为220 mOsm/kg，低渗透压可以有效缓解腹泻婴儿肠腔内高渗透压状况，能及时调整婴儿体内水平衡和酸碱平衡。
合理的蛋白质、钠、钾、氯、磷比例，使本无乳糖配配方食品的肾脏溶质负荷（23.3mOsm/100kcal）在合理的范围之内（10.5～29.3mOsm/100kcal），不会给婴儿的肾脏带来负担。
DHA、ARA、牛磺酸及胆碱组合搭配可改善宝宝脑部记忆力及视力。
肌醇可促进生长发育，预防湿疹。
核苷酸、烟酸 、锌、维生素A，能够加速肠道细胞的分化、生长与修复，促进小肠的成熟，显著提高小肠绒毛的高度，利于肠道受伤后的修复。并可刺激双歧杆菌生长，降低肠道pH、抑制有害菌生长，缓解婴儿腹泻症状并利于肠道修复。
本发明使用的植物脂肪粉是采用微胶囊包埋技术，利用先进的高压均质及干燥设备而制成的一种水溶性粉质油脂，大大提高了产品的稳定性和营养素有效性。
本发明采用干法工艺生产，采用进料隧道杀菌、营养素预混、一次投料、空气压力输粉、固定空气压力和空气频率及固定干混时间、二次金属检测的整体工艺生产，此工艺避免生产过程中的交叉污染、容易控制产品理化指标，减少微量成分损失，保证了产品的混合均匀性，同时节省能耗，降低成本，缩短生产时间，能保证此配方食品的全价营养效能。
附图说明
图1为本申请产品与母乳数据对比；
图2为本申请产品与GB25596最小值对比；
图3为本申请产品与GB25596最大值对比。
具体实施方式
实施例1 本申请产品的制备
按照发明内容部分的方法制备本申请产品：本发明为一种适用于乳糖不耐症婴儿的低渗透压无乳糖配方食品，每100mL冲调液提供250～295kJ能量，乳糖含量＜0.5g/100g，渗透压平均约为220mOsm/kg。其它营养素指标也均符合GB25596中对营养素的要求。
表1每100kJ该配方食品提供的营养成分：
通过图2及图3可知产品各营养素均在GB 25596要求范围内，作为单一营养来源可满足0-6月龄特殊医学状况婴儿的生长发育需要。图1则显示了产品各营养素与母乳类似。
实施例2 不同固体糖对产品渗透压的影响
在其他成分一致（原料同批次）的情况下，配制不同固体淀粉糖配方的产品，检测其渗透压：
配方1：40%的麦芽糖、60%的低聚异麦芽糖
配方2：50%的麦芽糖、50%的低聚异麦芽糖
配方3：30%的麦芽糖、70%的低聚异麦芽糖
配方4：60%的麦芽糖、40%的低聚异麦芽糖
配方5：40%的麦芽糖、60%的麦芽糊精
配方6：40%的麦芽糖、60%的低聚半乳糖
（实际实验室验证了大量配方，限于篇幅仅展示部分代表性配方的结果）
使用冰点渗透压仪（OM819，LOSER）检测这些产品的渗透压，结果如下表2：
表2结果表明，除低聚半乳糖由于其中不可避免的大量乳糖杂质造成效果不佳外，其余的固体淀粉糖配方都能取得明显的降低渗透压效果。其中40%的麦芽糖和60%的低聚异麦芽糖提供了良好的低渗效果，不仅优于其他配方，而且优于其他比例的麦芽糖和低聚异麦芽糖组合，推测这种情况与糖和蛋白/氨基酸在溶液中复杂氢键、范德华力和疏水作用造成的凝聚相关。
此外麦芽糖和低聚异麦芽糖甜度较低，有助于调整奶粉的口味（低渗奶粉中单糖二糖和聚糖一般种类多、用量多，造成味道混杂难以调和），低聚异麦芽糖还有防止褐变的效果。
Claims (2)
1.一种适用于乳糖不耐症的低渗透压特殊医学用途婴儿无乳糖配方食品，其特征在于，所述食品由如下质量份的组份制备而成： 植物脂肪粉1 657～803份、植物脂肪粉2 108～132份、复配柠檬酸钾39.2～58.8份、复配柠檬酸钠20～30份、复配磷酸氢钙9.6～14.4份、复配二十二碳六烯酸油脂8.4～12.6份、白砂糖8～12份、复配氯化钾8～12份、复配花生四烯酸油脂7.2～10.8份、复配氯化胆碱7.2～10.8份、复配矿物质4～6份、复配肌醇2.8～4.2份、复配维生素2.4～3.6份、磷酸三钙2.4～3.6份、碳酸钙0.4～0.6份、复配核苷酸0.4～0.6份、复配左旋肉碱0.296～0.444份；
其中所述植物脂肪粉1由以下质量份的原料制备而成：麦芽糊精168.4～205.9份、复合植物油107.7～131.6份、分离乳清蛋白粉102.5～125.3份、固体淀粉糖86～105.2份、无水奶油86～105.2份、食用葡萄糖65.7～80.3份、辛烯基琥珀酸淀粉钠34.2～41.8份、单，双甘油脂肪酸酯4.5～5.5份、L-抗坏血酸钠1.4～1.7份、抗坏血酸棕榈酸酯0.203～0.249份、混合生育酚浓缩物0.158～0.193份、磷脂0.112～0.136份； 所述的复合植物油包括玉米油26.9～32.9份、葵花籽油24.8～30.3份、大豆油23.7～28.9份、低芥酸菜籽油21.5～26.3份、椰子油10.8～13.2份、混合生育酚浓缩物0.032～0.039份、抗坏血酸棕榈酸酯0.022～0.026份；
其中所述植物脂肪粉2由以下质量份的原料制备而成：麦芽糊精45～55份、复合植物油25.9～31.7份、固体淀粉糖18.8～23份、分离乳清蛋白粉17.1～20.9份、单，双甘油脂肪酸酯0.747～0.913份、L-抗坏血酸钠0.405～0.495份、抗坏血酸棕榈酸酯0.036～0.044份、混合生育酚浓缩物0.036～0.044份、磷脂0.018～0.022份； 其中，所述的复合植物油包括玉米油6.5～7.9份、葵花籽油6.0～7.3份、大豆油5.7～7.0份、低芥酸菜籽油5.2～6.3份、椰子油2.6～3.2份、混合生育酚浓缩物0.008～0.009份、抗坏血酸棕榈酸酯0.005～0.006份；
其中固体淀粉糖由40％的麦芽糖和60％的低聚异麦芽糖组成；
其中所述的复配柠檬酸钾包括麦芽糊精34.5～51.7份、柠檬酸钾4.7～7.1份、抗坏血酸棕榈酸酯0.004～0.006份； 所述的复配柠檬酸钠包括麦芽糊精17.6～26.4份、柠檬酸钠2.4～3.6份、抗坏血酸棕榈酸酯0.002～0.003份； 所述的复配磷酸氢钙包括磷酸氢钙9.6～14.4份、麦芽糊精0.001～0.0014份、抗坏血酸棕榈酸酯0.001～0.0014份； 所述的复配二十二碳六烯酸油脂包括麦芽糊精2.7～4.0份、固体淀粉糖1.5～2.3份、二十二碳六烯酸油脂1.4～2.1份、分离乳清蛋白粉1.3～1.9份、白砂糖0.76～1.14份、辛烯基琥珀酸淀粉钠0.648～0.972份、L-抗坏血酸钠0.058～0.086份、单，双甘油脂肪酸酯0.05～0.076份、磷酸三钙0.046～0.07份、卡拉胶0.01～0.014份、混合生育酚浓缩物0.002～0.003份、抗坏血酸棕榈酸酯0.002～0.003份； 所述的复配氯化钾包括氯化钾6.4～9.6份、麦芽糊精1.6～2.4份、抗坏血酸棕榈酸酯0.0008～0.0012份； 所述的复配花生四烯酸油脂包括麦芽糊精2～2.9份、花生四烯酸油脂1.6～2.4份、固体淀粉糖1.3～2.0份、分离乳清蛋白粉1.1～1.6份、白砂糖0.664～0.996份、辛烯基琥珀酸淀粉钠0.400～0.600份、单，双甘油脂肪酸酯0.063～0.095份、磷酸三钙0.061～0.091份、L-抗坏血酸钠0.050～0.076份、卡拉胶0.008～0.012份、混合生育酚浓缩物0.001～0.002份、抗坏血酸棕榈酸酯0.001～0.002份； 所述的复配氯化胆碱包括麦芽糊精6.3～9.5份、氯化胆碱0.9～1.3份、抗坏血酸棕榈酸酯0.0007～0.0011份； 所述的复配矿物质包括硫酸镁2.6～3.9份、麦芽糊精1.1～1.7份、硫酸亚铁0.147～0.221份、硫酸锌0.119～0.179份、硫酸铜0.008～0.012份、硫酸锰0.006～0.009份、碘酸钾0.001～0.002份、亚硒酸钠0.0002～0.0004份； 所述的复配肌醇包括麦芽糊精1.7～2.5份、肌醇1.1～1.7份、抗坏血酸棕榈酸酯0.0003～0.0004份； 所述的复配维生素包括麦芽糊精1.4～2.0份、L-抗坏血酸钠0.32～0.48份、牛磺酸0.32～0.48份、50％的dl-α-醋酸生育酚0.224～0.336份、D-泛酸钙0.048～0.072份、11.5％的醋酸视黄酯0.046～0.068份、烟酰胺0.044～0.066份、0.25％的胆钙化醇0.029～0.043份、核黄素0.007～0.011份、盐酸硫胺素0.004～0.006份、盐酸吡哆醇0.004～0.006份、叶酸0.001～0.002份、D-生物素0.0003～0.0004份、植物甲萘醌0.0003～0.0004份、氰钴胺0.000016～0.000024份； 所述的复配核苷酸包括5'-胞苷酸二钠0.158～0.238份、5'-尿苷酸二钠0.089～0.133份、5'单磷酸腺苷0.076～0.114份、5'-肌苷酸二钠0.050～0.076份、5'-鸟苷酸二钠0.026～0.040份； 所述的复配左旋肉碱包括麦芽糊精0.164～0.246份、左旋肉碱酒石酸盐0.132～0.198份、抗坏血酸棕榈酸酯0.00003～0.00004份。
2.根据权利要求1所述食品的制备方法，其特征在于，所述制备方法包括以下步骤： 步骤一，原料验收；步骤二，备料；步骤三，脱外包；步骤四，进料；步骤五，分装配料；步骤六，预混；步骤七，称量；步骤八，投料；步骤九，过筛；步骤十，输粉；步骤十一，干混；步骤十二，金属检测；步骤十三，接粉；步骤十四，送粉、金属检测；步骤十五，内包装；步骤十六，外包装。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111566836.4A CN114190543B (zh) | 2021-12-20 | 2021-12-20 | 一种低渗透压特殊医学用途婴儿无乳糖配方食品 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111566836.4A CN114190543B (zh) | 2021-12-20 | 2021-12-20 | 一种低渗透压特殊医学用途婴儿无乳糖配方食品 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114190543A CN114190543A (zh) | 2022-03-18 |
| CN114190543B true CN114190543B (zh) | 2023-05-26 |
Family
ID=80655506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111566836.4A Active CN114190543B (zh) | 2021-12-20 | 2021-12-20 | 一种低渗透压特殊医学用途婴儿无乳糖配方食品 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114190543B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117378756A (zh) * | 2023-12-07 | 2024-01-12 | 四平君乐宝乳业有限公司 | 低渗透压特殊医学用途婴儿配方食品及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101233876B (zh) * | 2008-02-02 | 2011-11-02 | 内蒙古蒙牛乳业（集团）股份有限公司 | 一种适用于0-12个月的低乳糖婴儿液态乳 |
| CN101904362B (zh) * | 2010-08-10 | 2013-03-20 | 河北三元食品有限公司 | 一种豆基婴儿粉及制备方法 |
| CN103598353B (zh) * | 2013-11-07 | 2015-11-18 | 河北三元食品有限公司 | 乳基无乳糖婴儿配方粉 |
| CN105831253A (zh) * | 2016-03-23 | 2016-08-10 | 无锡超科食品科技有限公司 | 一种无乳糖婴幼儿配方奶粉及其制备方法 |
| CN109007794A (zh) * | 2018-06-11 | 2018-12-18 | 河北健素临床营养有限公司 | 增加肠道耐受性的全营养食品 |
| CN109156817A (zh) * | 2018-08-01 | 2019-01-08 | 贝因美（杭州）食品研究院有限公司 | 一种无乳糖婴儿配方食品及其制备方法 |
| CN109497533A (zh) * | 2019-01-03 | 2019-03-22 | 贝因美（杭州）食品研究院有限公司 | 一种适用于食物蛋白过敏婴儿的无乳糖氨基酸婴儿配方食品及其制备方法 |
| CN110269101A (zh) * | 2019-06-07 | 2019-09-24 | 宁波特壹食品有限公司 | 一种无乳糖配方粉及其制造方法 |
| CN111955554A (zh) * | 2020-06-05 | 2020-11-20 | 广州翼酵堂生物科技有限公司 | 一种孕产妇驼乳粉及其生产工艺 |
| CN112602782A (zh) * | 2020-12-15 | 2021-04-06 | 安徽月半湾商贸有限公司 | 一种药食同源的奶粉 |
| CN113785972B (zh) * | 2021-09-17 | 2023-10-24 | 江苏冬泽特医食品有限公司 | 用于罕见病苯丙酮尿症的营养粉、制备方法及用途 |
-
2021
- 2021-12-20 CN CN202111566836.4A patent/CN114190543B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN114190543A (zh) | 2022-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8747939B2 (en) | Nutrient composition | |
| EP2658405B1 (en) | Nutritional products including a fat system including free fatty acids | |
| CN105724584A (zh) | 一种含益生元和益生菌的婴幼儿配方奶粉及其制备方法 | |
| KR102285373B1 (ko) | 소화관 운동성을 유지하는 항-역류 조성물 | |
| CN107927754A (zh) | 一种产时供能专用型临床营养配方及其制备方法 | |
| CN101427783A (zh) | 一种添加植物脂肪粉的孕产妇型液态奶及其制备方法 | |
| JP2010527590A (ja) | 酸性の液体母乳栄養補助食品 | |
| CN108013453A (zh) | 小儿乳糖不耐受专用型临床营养配方及其制备方法 | |
| CN114190543B (zh) | 一种低渗透压特殊医学用途婴儿无乳糖配方食品 | |
| US20140377404A1 (en) | Use of specific carbohydrate systems during pregnancy for effecting the offspring | |
| EP2614724A1 (en) | Use of specific carbohydrate systems during pregnancy for reducing adverse health effects later in life in offspring | |
| EP2614725A1 (en) | Use of specific carbohydrate systems during pregnancy for improving lean body mass development and formation and reducing adverse health effects later in life in offspring | |
| EP2777404A1 (en) | Use of specific carbohydrate systems during pregnancy for preventing fat accumulation in pregnant women | |
| US20220248740A1 (en) | Food compositions for weight management | |
| EP2428217A1 (en) | Composition based on docosahexaenoic acid (dha) for use in the treatment of cystic fibrosis and non-alcoholic hepatic steatosis | |
| CN118489750A (zh) | 一种适用于乳糖不耐受的特殊医学用途无乳糖婴儿配方食品及其制备方法 | |
| WO2024201522A1 (en) | Nutraceutical composition for oral administration | |
| WO2022118270A1 (en) | Human milk oligosaccharides for use in supporting night sleep duration | |
| CN116528695A (zh) | 用于支持睡眠模式的成熟或改善的人乳寡糖 | |
| CN117598475A (zh) | 一种成人特殊医学用途全营养配方食品及其制备方法 | |
| TW201244642A (en) | Methods for improving bone health in infants using prebiotics | |
| CN103564428A (zh) | 一种包含生物素和叶酸的复合营养剂组合方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |