CN114174335A - 一种人源化vegfr2抗体及其应用 - Google Patents
一种人源化vegfr2抗体及其应用 Download PDFInfo
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- CN114174335A CN114174335A CN202080045177.7A CN202080045177A CN114174335A CN 114174335 A CN114174335 A CN 114174335A CN 202080045177 A CN202080045177 A CN 202080045177A CN 114174335 A CN114174335 A CN 114174335A
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Abstract
本发明属于肿瘤免疫治疗领域，涉及一种重组人源化的抗VEGFR2抗体药物。本发明公开编码所述抗体的核酸序列(包括重/轻链可变区)、含有所述核酸序列的载体、药物组合物和试剂盒。本发明公开的抗体能与肿瘤细胞特异性结合，并同时阻断VEGF‑A，VEGF‑C和VEGF‑D的作用，因而具有更佳的抑制血管生成作用。所述抗体还能激活NK细胞发生抗体依赖性细胞毒性(ADCC)反应，抑制肿瘤的生长和转移，可用于临床治疗黑色素瘤。
Description
PCT国内申请，说明书已公开。
Claims (24)
- PCT国内申请，权利要求书已公开。
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| CN2019106566665 | 2019-07-19 | ||
| CN201910656666 | 2019-07-19 | ||
| PCT/CN2020/102559 WO2021013064A1 (zh) | 2019-07-19 | 2020-07-17 | 一种人源化vegfr2抗体及其应用 |
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| CN114174335A true CN114174335A (zh) | 2022-03-11 |
| CN114174335B CN114174335B (zh) | 2023-12-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110382540A (zh) * | 2017-01-05 | 2019-10-25 | 赫利克斯生物药品公司 | Vegfr-2抗体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20240209099A1 (en) * | 2021-04-14 | 2024-06-27 | Suzhou Transcenta Therapeutics Co., Ltd. | Novel anti-hvegfr2 antibodies |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110076279A1 (en) * | 2006-10-20 | 2011-03-31 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| WO2013067098A1 (en) * | 2011-11-02 | 2013-05-10 | Apexigen, Inc. | Anti-kdr antibodies and methods of use |
| CN105646710A (zh) * | 2014-11-17 | 2016-06-08 | 四川科伦药物研究院有限公司 | 一种全人源化抗vegfr-2单克隆抗体及其制备方法 |
| CN106188296A (zh) * | 2016-07-19 | 2016-12-07 | 中山康方生物医药有限公司 | 一类抗血管内皮生长因子受体vegfr2的单克隆抗体及其编码基因和应用 |
| CN106892980A (zh) * | 2017-01-25 | 2017-06-27 | 长春金赛药业有限责任公司 | 抗vegfr2单克隆抗体及其应用 |
-
2020
- 2020-07-17 WO PCT/CN2020/102559 patent/WO2021013064A1/zh active Application Filing
- 2020-07-17 CN CN202080045177.7A patent/CN114174335B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110076279A1 (en) * | 2006-10-20 | 2011-03-31 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| WO2013067098A1 (en) * | 2011-11-02 | 2013-05-10 | Apexigen, Inc. | Anti-kdr antibodies and methods of use |
| CN105646710A (zh) * | 2014-11-17 | 2016-06-08 | 四川科伦药物研究院有限公司 | 一种全人源化抗vegfr-2单克隆抗体及其制备方法 |
| CN106188296A (zh) * | 2016-07-19 | 2016-12-07 | 中山康方生物医药有限公司 | 一类抗血管内皮生长因子受体vegfr2的单克隆抗体及其编码基因和应用 |
| CN106892980A (zh) * | 2017-01-25 | 2017-06-27 | 长春金赛药业有限责任公司 | 抗vegfr2单克隆抗体及其应用 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110382540A (zh) * | 2017-01-05 | 2019-10-25 | 赫利克斯生物药品公司 | Vegfr-2抗体 |
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