CN114159366B - Composition for repairing facial flushing and telangiectasis and preparation method thereof - Google Patents
Composition for repairing facial flushing and telangiectasis and preparation method thereof Download PDFInfo
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- CN114159366B CN114159366B CN202111624673.0A CN202111624673A CN114159366B CN 114159366 B CN114159366 B CN 114159366B CN 202111624673 A CN202111624673 A CN 202111624673A CN 114159366 B CN114159366 B CN 114159366B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention provides a composition for repairing facial flushing and telangiectasis and a preparation method thereof, wherein the composition comprises 50-80 parts of water, 1-20 parts of sophora flower extract, 1-20 parts of Ophicalcitum, 1-20 parts of azelaic acid, 1-10 parts of propylene glycol, 1-10 parts of glycerol, 1-10 parts of polyethylene glycol-8 1-10 parts of methyl glucoside sesquistearate, 1-10 parts of methyl glucoside sesquistearate EO-20, 1-10 parts of enzyme-cleaved oligopeptide hyaluronic acid, 1-10 parts of monoglycoside and 1-10 parts of simethicone. The composition provided by the invention not only comprises moisturizing and repairing, anti-inflammatory and antibacterial components, but also mainly comprises components for improving capillary functions, can gradually reduce vascular permeability, increase vascular elasticity, maintain normal resistance of capillary, prevent excessive fragility of the capillary, can enable facial paroxysmal flushing and persistent flushing to subside, and has obvious effect of relieving the true telangiectasis which occurs.
Description
Technical Field
The invention relates to the technical field of facial nursing, in particular to a composition for repairing facial flushing and telangiectasia and a preparation method thereof.
Background
Facial telangiectasis is often caused by a plurality of diseases, including rosacea, facial eczema, hormone-dependent dermatitis and the like, mainly shows paroxysmal flushing (dynamic erythema), persistent flushing (static erythema), red blood streak and the like, and is accompanied by uncomfortable symptoms such as intermittent burning of the face, burning pain, itching and the like, and the chronic repeated attacks cause serious influence on life treatment of patients.
At present, products, medicines and treatment methods for repairing and treating facial flushing and facial erythema are relatively lacking in the market, and some skin care products or external preparations for comfort and repair, such as mikania special cream, mainly comprise Shu Minbao wet, have a temporary relieving effect on mild paroxysmal flushing, and are ineffective on facial persistent erythema and already formed telangiectasia.
Other laser therapeutic instruments such as photon skin tendering, 980 laser and the like can improve facial flushing and red blood streaks to different degrees, but require multiple treatments to a professional medical institution, have high treatment cost and are easy to cause skin injury.
Disclosure of Invention
The object of the present invention is to solve at least one of the technical drawbacks.
Therefore, an object of the present invention is to propose a composition for repairing facial flushing and telangiectasia and a preparation method thereof, which solve the problems mentioned in the background art and overcome the disadvantages of the prior art.
To achieve the above object, an embodiment of an aspect of the present invention provides a composition for repairing facial flushing, telangiectasia, comprising the following components in parts by weight: 50-80 parts of water, 1-20 parts of pagodatree flower extract, 1-20 parts of Ophicalcitum, 1-20 parts of azelaic acid, 1-10 parts of propylene glycol, 1-10 parts of glycerin, 1-10 parts of polyethylene glycol-8 1-10 parts of methyl glucoside sesquistearate, 1-10 parts of methyl glucoside sesquistearate EO-20, 1-10 parts of enzyme-cut oligopeptide hyaluronic acid, 1-10 parts of monoglycoside ester and 1-10 parts of dimethyl silicone oil.
The invention also provides a preparation method of the composition for repairing facial flushing and telangiectasia, which comprises the following steps in sequence:
(1) Grinding Ophicalcitum into powder, sieving, adding into boiling water, cooling, filtering, passing through macroporous resin column, washing with water, eluting with 30% alcohol, concentrating the eluate on rotary evaporator under reduced pressure to remove alcohol, and standing to obtain Ophicalcitum precipitate;
(2) Mixing azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8, stirring uniformly, reacting under the protection of nitrogen, washing the product with distilled water after the reaction is completed, putting the washed particles into ethanol solution for fully swelling, and reacting under the protection of nitrogen to form inclusion;
(3) Adding water into the inclusion, and adding enzyme-cleaved oligopeptide hyaluronic acid and flos Sophorae Immaturus extract to form water phase;
(4) Mixing methyl glucoside sesquistearate, methyl glucoside sesquistearate EO-20, monoglycoside ester and simethicone, and heating to form oil phase;
(5) Homogenizing the water phase at high speed with a homogenizer, adding the oil phase into the water phase under nitrogen protection, homogenizing at high speed with a homogenizer, cooling to room temperature, and stopping homogenizing.
In any of the above embodiments, it is preferable that in the step (1), the screen plate is selected to have a size of 100 mesh.
In any of the above-mentioned modes, in the step (1), the specification of the macroporous resin column is preferably 10 cm. Times.50 cm.
In any of the above embodiments, it is preferable that in the step (1), the ratio of the Ophicalcitum powder to the boiling water is 1:5.
It is preferable from any of the above aspects that the detailed steps of step (2) are: azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8 are mixed, nitrogen is introduced after uniform stirring for 15 minutes, static reaction is carried out at 60 ℃ for 1-2 hours under the protection of nitrogen, after the reaction is finished, products are washed for multiple times by distilled water, inorganic salts, unreacted monomers and soluble polymers are removed, the washed particles are put into ethanol solution for fully swelling for 24 hours, nitrogen is introduced for 15 minutes, and static reaction is carried out at 81 ℃ for 24 hours under the protection of nitrogen, so as to form inclusion bodies.
It is preferable from any of the above aspects that the detailed steps of step (5) are: homogenizing the water phase at a high speed with a homogenizer at 5000 rpm, introducing nitrogen for 15 min, adding the oil phase into the water phase under nitrogen protection, homogenizing for 30min, gradually cooling to room temperature, and stopping homogenizing.
In any of the above schemes, preferably, in the step (3), the preparation method of the sophora flower extract comprises the following steps: (1) Sun drying flos Sophorae Immaturus, removing impurities, pulverizing, and sieving with 100-200 mesh sieve to obtain flos Sophorae Immaturus powder; (2) Adding flos Sophorae Immaturus powder into ethanol, reflux extracting for 1-2 hr, and filtering to obtain solid and ethanol extractive solution; (3) Adding the solid obtained by filtering in the step (2) into 10-20wt% sodium carbonate solution, carrying out reflux leaching for 1-2h, and filtering to obtain sodium carbonate leaching solution; (4) Mixing the ethanol extract and sodium carbonate extract, concentrating under reduced pressure to obtain concentrated solution; and (5) evaporating and drying the concentrated solution at 40-60 ℃ to obtain the product.
The pagodatree flower extract is derived from dried flower buds and flowers of pagodatree flower of leguminous plants, the former is known as pagodatree flower bud, the latter is known as pagodatree flower, the pagodatree flower has long medication history, and the medication is carried in Japanese materia medica of Tang Dynasty. The main components are rutin, quercetin, brass, pagodatree flower active polysaccharide, various minerals and various amino acids. Has effects of clearing heat and detoxicating, relieving inflammation and pain, improving capillary function, reducing vascular permeability, increasing vascular elasticity, maintaining normal resistance of capillary vessel, and preventing capillary vessel fragility. The rutin is a main chemical component, and is mainly used for clinically assisting in treating capillary hemorrhage with increased fragility, purpura and various hemorrhagic diseases.
The pistil Dan Huarui stone is a common traditional Chinese medicine carried by pharmacopoeia, the original name of the pistil Dan Huarui stone is also known as dolomite, and is firstly carried in Song of Jia you Ben Cao, which is a marble with different serpentine content in metamorphic rocks. Compendium of materia Medica: the Ophicalcitum is specially used for stopping bleeding, and can make blood into water and acid. "; blood theory (treatise on syndrome): this herb is used to treat bleeding due to its unique qi bias. He can move blood and all herbs can damage qi, so it can self-transform blood without damaging qi, and remove blood stasis. "; the He Ji Ju Fang (He Ji Ju Fang): for all kinds of blood and injury of golden sore and embryo, there is a powder of Ophicalcitum, all of which can transform blood into water, so this stone also covers the ratio of unusual vegetation. The Ophicalcitum is carbonate containing large amount of calcium and magnesium, small amount of ferric salt, aluminum salt and acid insoluble substance, and can increase calcium ion concentration in blood, densify vessel wall, prevent blood plasma exudation, and promote blood coagulation.
Azelaic acid is derived from grains such as wheat, rye, barley, etc. The main effects include broad spectrum antibiosis, anti-inflammatory, melanin inhibition, cell hyperproliferation inhibition and epidermal cell maturation and differentiation promotion. Azelaic acid anti-inflammatory reduces expression of kallikrein (KLK 5) and antibacterial peptides, KLK5 and antibacterial peptides (especially LL-37 fragment) stimulate capillary formation and azelaic acid can block continued telangiectasia. Meanwhile, the composition has good permeability to skin, and can increase the absorption function of the skin to moisture-preserving components.
The enzyme-cleaved oligopeptide hyaluronic acid belongs to small molecule hyaluronic acid, and can obviously reduce the damaged percutaneous water loss rate and gradually repair the damaged skin barrier when acting on the skin.
The composition provided by the invention not only comprises moisturizing and repairing, anti-inflammatory and antibacterial components, but also mainly comprises components for improving capillary functions, can gradually reduce vascular permeability, increase vascular elasticity, maintain normal resistance of capillary, prevent excessive fragility of the capillary, can enable facial paroxysmal flushing and persistent flushing to subside, and has obvious effect of relieving the true telangiectasis which occurs.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The foregoing and/or additional aspects and advantages of the invention will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
FIG. 1 is a graph of the effect of using a composition for repairing facial flushing and telangiectasia according to an embodiment of the present invention;
fig. 2 is a graph of another effect of using a composition for repairing facial flushing and telangiectasia according to an embodiment of the present invention.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative and intended to explain the present invention and should not be construed as limiting the invention.
Example 1
The invention provides a composition for repairing facial flushing and telangiectasia, which comprises the following components in parts by weight: 50 parts of water, 1 part of pagodatree flower extract, 1 part of Ophicalcitum, 1 part of azelaic acid, 1 part of propylene glycol, 1 part of glycerol, 5 parts of polyethylene glycol-8 1 parts of methyl glucoside sesquistearate, 1 part of methyl glucoside sesquistearate EO-20 parts of enzyme-cleaved oligopeptide hyaluronic acid, 1 part of monoglycoside ester and 1 part of simethicone.
The invention also provides a preparation method of the composition for repairing facial flushing and telangiectasia, which comprises the following steps in sequence:
(1) Grinding Ophicalcitum into powder, sieving with 100 mesh sieve, and mixing at a ratio of 1:5, pouring into boiling water and cooling. The filtrate was slowly passed through a treated macroporous resin column (10 cm. Times.50 cm) and washed with water. Washing the resin column with water, eluting the target compound with 30% alcohol, concentrating the eluate on a rotary evaporator under reduced pressure to remove ethanol, and standing to obtain Ophicalcitum precipitate;
(2) Mixing azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8, stirring uniformly, introducing nitrogen for 15 minutes, statically reacting at 60 ℃ for 1-2 hours under the protection of nitrogen, washing the product for multiple times by distilled water after the reaction is finished, removing inorganic salt, unreacted monomers and soluble polymers, putting the washed particles into ethanol solution to fully swell for 24 hours, introducing nitrogen for 15 minutes, and statically reacting at 81 ℃ for 24 hours under the protection of nitrogen to form inclusion;
(3) Adding water into the inclusion, and adding enzyme-cleaved oligopeptide hyaluronic acid and flos Sophorae Immaturus extract to form water phase;
(4) Mixing methyl glucoside sesquistearate, methyl glucoside sesquistearate EO-20, monoglycoside ester and simethicone, and heating to form oil phase;
(5) Homogenizing the water phase at a high speed with a homogenizer at 5000 rpm, introducing nitrogen for 15 min, adding the oil phase into the water phase under nitrogen protection, homogenizing for 30min, gradually cooling to room temperature, and stopping homogenizing.
The preparation method of the sophora flower extract comprises the following steps: (1) Sun drying flos Sophorae Immaturus, removing impurities, pulverizing, and sieving with 100-200 mesh sieve to obtain flos Sophorae Immaturus powder; (2) Adding flos Sophorae Immaturus powder into ethanol, reflux extracting for 1-2 hr, and filtering to obtain solid and ethanol extractive solution; (3) Adding the solid obtained by filtering in the step (2) into 10-20wt% sodium carbonate solution, carrying out reflux leaching for 1-2h, and filtering to obtain sodium carbonate leaching solution; (4) Mixing the ethanol extract and sodium carbonate extract, concentrating under reduced pressure to obtain concentrated solution; and (5) evaporating and drying the concentrated solution at 40-60 ℃ to obtain the product.
Example two
The invention provides a composition for repairing facial flushing and telangiectasia, which comprises the following components in parts by weight: 60 parts of water, 10 parts of pagodatree flower extract, 10 parts of Ophicalcitum, 10 parts of azelaic acid, 5 parts of propylene glycol, 5 parts of glycerol, 5 parts of polyethylene glycol-8 5 parts of methyl glucoside sesquistearate, 5 parts of methyl glucoside sesquistearate EO-20 parts of enzyme-cleaved oligopeptide hyaluronic acid, 5 parts of monoglycoside ester and 5 parts of simethicone.
The invention also provides a preparation method of the composition for repairing facial flushing and telangiectasia, which comprises the following steps in sequence:
(1) Grinding Ophicalcitum into powder, sieving with 100 mesh sieve, and mixing at a ratio of 1:5, pouring into boiling water and cooling. The filtrate was slowly passed through a treated macroporous resin column (10 cm. Times.50 cm) and washed with water. Washing the resin column with water, eluting the target compound with 30% alcohol, concentrating the eluate on a rotary evaporator under reduced pressure to remove ethanol, and standing to obtain Ophicalcitum precipitate;
(2) Mixing azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8, stirring uniformly, introducing nitrogen for 15 minutes, statically reacting at 60 ℃ for 1-2 hours under the protection of nitrogen, washing the product for multiple times by distilled water after the reaction is finished, removing inorganic salt, unreacted monomers and soluble polymers, putting the washed particles into ethanol solution to fully swell for 24 hours, introducing nitrogen for 15 minutes, and statically reacting at 81 ℃ for 24 hours under the protection of nitrogen to form inclusion;
(3) Adding water into the inclusion, and adding enzyme-cleaved oligopeptide hyaluronic acid and flos Sophorae Immaturus extract to form water phase;
(4) Mixing methyl glucoside sesquistearate, methyl glucoside sesquistearate EO-20, monoglycoside ester and simethicone, and heating to form oil phase;
(5) Homogenizing the water phase at a high speed with a homogenizer at 5000 rpm, introducing nitrogen for 15 min, adding the oil phase into the water phase under nitrogen protection, homogenizing for 30min, gradually cooling to room temperature, and stopping homogenizing.
The preparation method of the sophora flower extract comprises the following steps: (1) Sun drying flos Sophorae Immaturus, removing impurities, pulverizing, and sieving with 100-200 mesh sieve to obtain flos Sophorae Immaturus powder; (2) Adding flos Sophorae Immaturus powder into ethanol, reflux extracting for 1-2 hr, and filtering to obtain solid and ethanol extractive solution; (3) Adding the solid obtained by filtering in the step (2) into 10-20wt% sodium carbonate solution, carrying out reflux leaching for 1-2h, and filtering to obtain sodium carbonate leaching solution; (4) Mixing the ethanol extract and sodium carbonate extract, concentrating under reduced pressure to obtain concentrated solution; and (5) evaporating and drying the concentrated solution at 40-60 ℃ to obtain the product.
Example III
The invention provides a composition for repairing facial flushing and telangiectasia, which comprises the following components in parts by weight: 80 parts of water, 20 parts of pagodatree flower extract, 20 parts of Ophicalcitum, 20 parts of azelaic acid, 10 parts of propylene glycol, 10 parts of glycerol, 10 parts of polyethylene glycol-8 parts of methyl glucoside sesquistearate, 10 parts of methyl glucoside sesquistearate EO-2010 parts of enzyme-cleaved oligopeptide hyaluronic acid, 10 parts of monoglycoside ester and 10 parts of simethicone.
The invention also provides a preparation method of the composition for repairing facial flushing and telangiectasia, which comprises the following steps in sequence:
(1) Grinding Ophicalcitum into powder, sieving with 100 mesh sieve, and mixing at a ratio of 1:5, pouring into boiling water and cooling. The filtrate was slowly passed through a treated macroporous resin column (10 cm. Times.50 cm) and washed with water. Washing the resin column with water, eluting the target compound with 30% alcohol, concentrating the eluate on a rotary evaporator under reduced pressure to remove ethanol, and standing to obtain Ophicalcitum precipitate;
(2) Mixing azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8, stirring uniformly, introducing nitrogen for 15 minutes, statically reacting at 60 ℃ for 1-2 hours under the protection of nitrogen, washing the product for multiple times by distilled water after the reaction is finished, removing inorganic salt, unreacted monomers and soluble polymers, putting the washed particles into ethanol solution to fully swell for 24 hours, introducing nitrogen for 15 minutes, and statically reacting at 81 ℃ for 24 hours under the protection of nitrogen to form inclusion;
(3) Adding water into the inclusion, and adding enzyme-cleaved oligopeptide hyaluronic acid and flos Sophorae Immaturus extract to form water phase;
(4) Mixing methyl glucoside sesquistearate, methyl glucoside sesquistearate EO-20, monoglycoside ester and simethicone, and heating to form oil phase;
(5) Homogenizing the water phase at a high speed with a homogenizer at 5000 rpm, introducing nitrogen for 15 min, adding the oil phase into the water phase under nitrogen protection, homogenizing for 30min, gradually cooling to room temperature, and stopping homogenizing.
The preparation method of the sophora flower extract comprises the following steps: (1) Sun drying flos Sophorae Immaturus, removing impurities, pulverizing, and sieving with 100-200 mesh sieve to obtain flos Sophorae Immaturus powder; (2) Adding flos Sophorae Immaturus powder into ethanol, reflux extracting for 1-2 hr, and filtering to obtain solid and ethanol extractive solution; (3) Adding the solid obtained by filtering in the step (2) into 10-20wt% sodium carbonate solution, carrying out reflux leaching for 1-2h, and filtering to obtain sodium carbonate leaching solution; (4) Mixing the ethanol extract and sodium carbonate extract, concentrating under reduced pressure to obtain concentrated solution; and (5) evaporating and drying the concentrated solution at 40-60 ℃ to obtain the product.
And (3) effect verification:
effect case one
As shown in fig. 1, patients had persistent facial flushes for more than 2 years with intermittent facial burning and burning pain. The hot and cold air stimulation or the eating of spicy food is easy to aggravate, and the season is easy to aggravate when flowering in spring. The facial erythema aggravates in the last month, the skin is dry with itching, the erythema telangiectasis type rose acne is diagnosed, the ebastine tablet is orally taken, the composition cream is externally used for 2 times a day, the erythema obviously subsides after 14 days of treatment, and the patient continues to use the composition cream without recrudescence basically within three months.
Effect case two
As shown in fig. 2, the patient intermittently flushes the face for more than 5 years, and cold and hot stimulation is easily aggravated. Various hormone ointments such as fluocinolone acetonide, you Zhuoer, picokangwang and other unknown commercial traditional Chinese medicine ointments can be used for 5 years, and the temporary relief and aggravation of drug withdrawal can be realized. The facial flooding and swelling, burning itching, diagnosis of telangiectasia-like hormone dermatitis, and administration of the topical composition cream for 3-4 times a day, with gradual regression of erythema, are suggested to be used for a long period of time, and no recurrence is suggested for 6 months.
Table 1 effect comparison
As can be seen from Table 1, the compositions prepared according to the present invention have the following advantages:
the composition has the advantages of relaxing sensitization, moisturizing, repairing, improving capillary function, reducing vascular permeability, increasing vascular elasticity, keeping normal resistance of capillary vessels, preventing excessive fragility of the capillary vessels, relieving telangiectasia symptoms after long-term use, no hormone, no damage to skin barrier components and low cost.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
It will be readily understood by those skilled in the art that the present invention, including any combination of parts described in the summary and detailed description of the invention above and shown in the drawings, is limited in scope and does not constitute a complete description of the various aspects of these combinations for the sake of brevity. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Although embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the invention, and that variations, modifications, alternatives, and variations may be made in the above embodiments by those skilled in the art without departing from the spirit and principles of the invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. A composition for repairing facial flushing and telangiectasia, comprising the following components in parts by weight: 50-80 parts of water, 1-20 parts of pagodatree flower extract, 1-20 parts of Ophicalcitum, 1-20 parts of azelaic acid, 1-10 parts of propylene glycol, 1-10 parts of glycerin, 81-10 parts of polyethylene glycol, 1-10 parts of methyl glucoside sesquistearate EO-201-10 parts, 1-10 parts of enzyme-cleaved oligopeptide hyaluronic acid, 1-10 parts of monoglyceride and 1-10 parts of simethicone.
2. A method for preparing a composition for repairing facial flushing and telangiectasia, comprising the following steps in order of sequence:
(1) Grinding Ophicalcitum into powder, sieving, adding into boiling water, cooling, filtering, passing through macroporous resin column, washing with water, eluting with 30% alcohol, concentrating the eluate on rotary evaporator under reduced pressure to remove alcohol, and standing to obtain Ophicalcitum precipitate;
(2) Mixing azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8, stirring uniformly, reacting under the protection of nitrogen, washing the product with distilled water after the reaction is completed, putting the washed particles into ethanol solution for fully swelling, and reacting under the protection of nitrogen to form inclusion;
(3) Adding water into the inclusion, and adding enzyme-cleaved oligopeptide hyaluronic acid and flos Sophorae Immaturus extract to form water phase;
(4) Methyl glucoside sesquistearate, methyl glucoside sesquistearate EO-20, monoglyceride,
Mixing dimethyl silicone oil and heating to form an oil phase;
(5) Homogenizing the water phase at high speed with a homogenizer, adding the oil phase into the water phase under nitrogen protection, homogenizing at high speed with a homogenizer, cooling to room temperature, and stopping homogenizing.
3. The method for producing a composition for repairing facial flushing and telangiectasia according to claim 2, wherein in the step (1), the screen plate size is selected to be 100 mesh.
4. The method for producing a composition for repairing facial flushing and telangiectasia according to claim 2, wherein in the step (1), the specification of the macroporous resin column is 10cm x 50cm.
5. The method of preparing a composition for repairing facial flushes and telangiectasias claimed in claim 2, wherein in step (1), the ratio of the marmorite powder to the boiling water is 1:5.
6. The method of preparing a composition for repairing facial flushes, telangiectasia according to claim 2, characterized in that the detailed steps of step (2) are: azelaic acid, a Ophicalcitum precipitate, poloxamer 407, propylene glycol and polyethylene glycol-8 are mixed, nitrogen is introduced after uniform stirring for 15 minutes, static reaction is carried out at 60 ℃ for 1-2 hours under the protection of nitrogen, after the reaction is finished, products are washed for multiple times by distilled water, inorganic salts, unreacted monomers and soluble polymers are removed, the washed particles are put into ethanol solution for fully swelling for 24 hours, nitrogen is introduced for 15 minutes, and static reaction is carried out at 81 ℃ for 24 hours under the protection of nitrogen, so as to form inclusion bodies.
7. A method of preparing a composition for repairing facial flushes, telangiectasia according to claim 2, characterized in that the detailed steps of step (5) are: homogenizing the water phase at a high speed with a homogenizer at 5000 rpm, introducing nitrogen for 15 min, adding the oil phase into the water phase under nitrogen protection, homogenizing for 30min, gradually cooling to room temperature, and stopping homogenizing.
8. The method for preparing a composition for repairing facial flushing and telangiectasia according to claim 2, wherein in the step (3), the preparation method of the sophora flower extract comprises the following steps: (1) Sun drying flos Sophorae Immaturus, removing impurities, pulverizing, and sieving with 100-200 mesh sieve to obtain flos Sophorae Immaturus powder; (2) Adding flos Sophorae Immaturus powder into ethanol, reflux extracting for 1-2 hr, and filtering to obtain solid and ethanol extractive solution; (3) Adding the solid obtained by filtering in the step (2) into 10-20wt% sodium carbonate solution, carrying out reflux leaching for 1-2h, and filtering to obtain sodium carbonate leaching solution; (4) Mixing the ethanol extract and sodium carbonate extract, concentrating under reduced pressure to obtain concentrated solution; and (5) evaporating and drying the concentrated solution at 40-60 ℃ to obtain the product.
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| CN108465061A (en) * | 2018-06-01 | 2018-08-31 | 四川省中医药科学院 | It is a kind of to be used to treat pharmaceutical composition of Facial Recurrent Dermatitis and its preparation method and application |
| CN113197804A (en) * | 2021-04-29 | 2021-08-03 | 钟意生物技术(广州)有限公司 | Plant repair factor and application thereof |
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| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
| US10596090B2 (en) * | 2016-05-27 | 2020-03-24 | Jan Marini Skin Research | Cosmetic formulation to reduce facial flushing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108465061A (en) * | 2018-06-01 | 2018-08-31 | 四川省中医药科学院 | It is a kind of to be used to treat pharmaceutical composition of Facial Recurrent Dermatitis and its preparation method and application |
| CN113197804A (en) * | 2021-04-29 | 2021-08-03 | 钟意生物技术(广州)有限公司 | Plant repair factor and application thereof |
Non-Patent Citations (1)
| Title |
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| 周剑.中医对糖尿病视网膜病变的认识.中医杂志.1990,(第第12期期),第45-47页. * |
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