CN114159346A - Bacteriostatic composition for daily life and preparation method thereof - Google Patents
Bacteriostatic composition for daily life and preparation method thereof Download PDFInfo
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- CN114159346A CN114159346A CN202010948429.9A CN202010948429A CN114159346A CN 114159346 A CN114159346 A CN 114159346A CN 202010948429 A CN202010948429 A CN 202010948429A CN 114159346 A CN114159346 A CN 114159346A
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- oil
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- bacteriostatic
- emulsifier
- daily life
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- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 45
- 239000003921 oil Substances 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 22
- 241000196324 Embryophyta Species 0.000 claims abstract description 21
- 239000003974 emollient agent Substances 0.000 claims abstract description 16
- 239000003906 humectant Substances 0.000 claims abstract description 14
- 239000010642 eucalyptus oil Substances 0.000 claims abstract description 10
- 229940044949 eucalyptus oil Drugs 0.000 claims abstract description 10
- 239000010677 tea tree oil Substances 0.000 claims abstract description 9
- 229940111630 tea tree oil Drugs 0.000 claims abstract description 9
- 239000010668 rosemary oil Substances 0.000 claims abstract description 7
- 229940058206 rosemary oil Drugs 0.000 claims abstract description 7
- 239000010661 oregano oil Substances 0.000 claims abstract description 5
- 229940111617 oregano oil Drugs 0.000 claims abstract description 5
- 235000019198 oils Nutrition 0.000 claims description 39
- 239000002994 raw material Substances 0.000 claims description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- 239000002085 irritant Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 4
- 241001529744 Origanum Species 0.000 claims description 4
- 235000011203 Origanum Nutrition 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 2
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 claims description 2
- 240000007817 Olea europaea Species 0.000 claims description 2
- 244000170916 Paeonia officinalis Species 0.000 claims description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- 239000012874 anionic emulsifier Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 150000002430 hydrocarbons Chemical class 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000012875 nonionic emulsifier Substances 0.000 claims description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 2
- 229940049964 oleate Drugs 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 229940100460 peg-100 stearate Drugs 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 230000008719 thickening Effects 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 230000006378 damage Effects 0.000 abstract description 10
- 230000003020 moisturizing effect Effects 0.000 abstract description 6
- 230000001681 protective effect Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 3
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 10
- 239000003205 fragrance Substances 0.000 description 6
- 230000007794 irritation Effects 0.000 description 5
- 230000002147 killing effect Effects 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000003467 diminishing effect Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 229910001385 heavy metal Inorganic materials 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 241000238876 Acari Species 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 244000166124 Eucalyptus globulus Species 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 241000607762 Shigella flexneri Species 0.000 description 2
- 241000607626 Vibrio cholerae Species 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000010773 plant oil Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 229940118696 vibrio cholerae Drugs 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic composition for daily life, which comprises the following components in part by weight: emulsifier, plant bacteriostatic oil, emollient, humectant and water; the plant antibacterial oil is at least one of tea tree oil, rosemary oil, oregano oil and eucalyptus oil. The invention solves the problem that the Chinese character 'xiao' product in the prior art has large skin irritation. The antibacterial composition not only has antibacterial and bactericidal effects, but also does not harm and stimulate the skin, and also has moistening and moisturizing effects on the skin, and has a protective effect on the skin.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic composition for daily life and a preparation method thereof.
Background
At present, people have more and more requirements on human skin disinfection during epidemic situations, and a plurality of word eliminating products with bacteriostatic and bactericidal effects are widely popularized and applied and popularized as daily killing products. The products with such effects in cosmetics and scratch cards are mainly the following:
1. and (3) disinfecting alcohol: 75% alcohol can inhibit and kill pathogenic organisms by changing the permeability of microbial cell membranes, interfering and destroying the enzyme system of pathogenic microorganisms, and enabling the protein of the pathogenic microorganisms to be coagulated and denatured. The alcohol disinfectant products are mainly in the form of a spray or gel pack.
2. Adding a chlorine bactericide: chlorine gas is combined with water to form hypochlorous acid, the molecular weight is small, the hypochlorous acid easily penetrates through pathogen cell membranes, the strong oxidizing property is provided, substances such as protein, RNA, DNA and the like are separated out by damaging cell models, and a biological enzyme system is influenced, so that the purpose of killing pathogens is achieved. Common products such as 84 disinfectant.
3. Cationic surfactant: the cationic hydrophilic group adsorbs negatively charged bacteria, and the negatively charged bacteria are gathered on cell walls to generate a chamber resistance effect, so that the bacteria are inhibited in growth and die; at the same time, the hydrophobic alkyl can also act with the hydrophilic group of bacteria to change the permeability of the membrane, so that the lysis is generated, the cell structure is damaged, and the cell is dissolved and killed.
4. Other classes of heavy metal ions, such as silver ions, have pathogen killing effects.
Because the alcohol has degreasing property and volatility, normal cutin of the skin is easy to dissolve and lose water on the surface of the skin, the high-concentration alcohol (75% -80%) has large influence on the skin (especially the young skin of infants) after being used for a long time, and is easy to dry and crack. The chlorine bactericide has high irritation, and is difficult to be used as hand or skin disinfection products. Cationic antiseptic agents, which are highly irritating to the skin, can cause intense irritation if accumulated and retained on the skin for extended periods of time. In addition, the products are all the vanishing character sizes, and the makeup character size factories are difficult to realize and sell.
Disclosure of Invention
In view of the disadvantages of the prior art, the invention aims to provide a bacteriostatic composition for daily life, which is used for solving the problem that the Chinese character 'xiao' product in the prior art is large in skin irritation, and also provides a preparation method of the bacteriostatic composition for daily life. The antibacterial composition not only has antibacterial and bactericidal effects, but also does not harm and stimulate the skin, and also has moistening and moisturizing effects on the skin, and has a protective effect on the skin.
In order to attain the above and other related objects,
the invention provides a bacteriostatic composition for daily life, which comprises the following components in parts by weight: 2-4 parts of an emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of an emollient, 5-10 parts of a humectant and 50-80 parts of water;
wherein the plant antibacterial oil is at least one of tea tree oil, rosemary oil, oregano oil and eucalyptus oil.
The antibacterial composition not only eliminates the damage of a large amount of solvents to the skin, but also avoids the stimulation and harm of cationic surfactants or heavy metal ions to the skin. The antibacterial composition is used in the same way as common face cream and lotion, and is convenient to spread uniformly. The antibacterial composition not only has antibacterial and bactericidal effects, but also does not harm and stimulate the skin, and also has moistening and moisturizing effects on the skin, and has a protective effect on the skin.
The tea tree oil is a broad-spectrum antibacterial agent, has the effects of inhibiting bacteria, diminishing inflammation, expelling parasites and killing mites, and has unique fragrance, which is beneficial to refreshing. The essential oil component of rosemary has excellent antibacterial activity, wherein the essential oil component has good antibacterial effect on escherichia coli, staphylococcus aureus and vibrio cholerae, and can be used as an antioxidant to delay the oxidation rate of the antibacterial composition. The origanum oil is a broad-spectrum antibacterial agent, has the effects of inhibiting bacteria, diminishing inflammation and expelling parasites, and has good antibacterial activity on 31 common enteritis-causing bacteria and shigella flexneri. The eucalyptus oil has certain mildew-proof, bactericidal and antiseptic effects, has the special fragrance of the cool and refreshing eucalyptus spinosa leaves with a few of camphor smells, and has strong and non-lasting fragrance. The tea tree oil, the rosemary oil, the oregano oil and the eucalyptus oil are compounded to form the plant bacteriostatic oil, so that bacteriostasis can be performed on various germs, and the four kinds of plant oil have small irritation to the skin of a human body, so that the plant bacteriostatic oil can be used for disinfecting the skin of an infant.
In an embodiment of the invention, the bacteriostatic composition comprises the following components in parts by weight: 2-4 parts of an emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of an emollient, 5-10 parts of a humectant, 0.5-1 part of an anti-irritant, 0.2-0.6 part of a preservative, 0.1-0.5 part of a pH regulator, 0.1-0.2 part of an aromatic and 50-80 parts of water.
The emulsifier, the emollient and the humectant are added into the antibacterial composition, so that the antibacterial composition not only has antibacterial and bactericidal effects, but also does not harm or stimulate the skin, and can also have the effects of moistening and moisturizing the skin, thereby having a protective effect on the skin. In addition, an anti-irritant is added to reduce the irritation of the plant bacteriostatic oil to the skin, a preservative is added to prolong the storage time of the bacteriostatic composition, a pH regulator is added to enable the pH of the bacteriostatic composition to be closer to the pH of the human skin, and an aromatic is added to cover the smell of the eucalyptus oil.
In an embodiment of the invention, the bacteriostatic composition comprises the following components in parts by weight: 2-4 parts of emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of emollient, 5-10 parts of humectant, 0.5-1 part of anti-irritant, 0.2-0.6 part of preservative, 0.1-0.5 part of pH regulator, 0.1-0.2 part of aromatic, 0.2-0.8 part of vitamin E, 0.1-0.5 part of excipient and 50-80 parts of water.
In an embodiment of the invention, the bacteriostatic composition comprises the following components in parts by weight: 2.5-3.5 parts of emulsifier, 8-15 parts of plant bacteriostatic oil, 8-15 parts of emollient, 6-8 parts of humectant, 0.5-1 part of anti-irritant, 0.2-0.6 part of preservative, 0.1-0.5 part of pH regulator, 0.1-0.2 part of aromatic, 0.2-0.8 part of vitamin E, 0.1-0.5 part of excipient and 50-80 parts of water.
In one embodiment of the present invention, the emulsifier is at least one of an anionic emulsifier, a cationic emulsifier, a nonionic emulsifier, a natural emulsifier, and a thickening emulsifier;
the emollient is at least one of silicone oil, animal and vegetable oil, higher alcohol, hydrocarbon and synthetic oil.
In an embodiment of the present invention, the emulsifier is at least one of glyceryl stearate citrate, cetearyl olive oleate, glyceryl stearate, PEG-100 stearate;
the emollient is at least one of polydimethylsiloxane, squalane, olive oil, cetostearyl alcohol and isohexadecane;
the humectant is at least one of polyalcohol, sodium hyaluronate and ceramide;
the anti-irritant is at least one of peony/radix Paeoniae extract, bisabolol, and radix Stephaniae Tetrandrae extract;
the preservative is at least one of methyl hydroxybenzoate, propyl hydroxybenzoate, bis (hydroxymethyl) imidazolidinyl urea and phenoxyethanol;
the pH regulator is arginine or triethanolamine;
the aromatic is essence;
the excipient is at least one of carbomer and hydroxyethyl cellulose.
In an embodiment of the invention, the plant bacteriostatic oil comprises the following components in parts by weight: 1.5-2.5 parts of tea tree oil, 0.3-0.7 part of rosemary oil, 1.0-2.0 parts of eucalyptus oil and 1.5-2.5 parts of origanum oil.
In a second aspect of the present invention, there is provided a method for preparing the above bacteriostatic composition for daily life, comprising the following steps:
step one, uniformly mixing a water-phase raw material and water at 70-80 ℃ to obtain a water-phase mixture, wherein the water-phase raw material comprises a humectant; uniformly mixing oil phase raw materials at 70-80 ℃ to obtain an oil phase mixture, wherein the oil phase raw materials comprise an emulsifier, plant bacteriostatic oil and an emollient;
and step two, adding the water phase mixture into an emulsifying pot, stirring at 70-80 ℃, adding the oil phase, homogenizing for 2-5 min, cooling to 45 ℃, adding the rest materials, uniformly mixing, and stopping the machine to discharge the materials.
The preparation method of the antibacterial composition is simple and is suitable for industrial large-scale production.
In an embodiment of the present invention, the mixing temperature in the first step is 75 ℃; and in the second step, the stirring temperature is 75 ℃, and the homogenization time is 3 min.
In an embodiment of the present invention, the water phase material further includes a pH adjuster, and the oil phase material further includes an anti-irritant.
In an embodiment of the present invention, the water phase material further includes an excipient, and the oil phase material further includes vitamin E.
As described above, the bacteriostatic composition for daily life and the preparation method thereof of the invention have the following beneficial effects:
1. the antibacterial composition not only eliminates the damage of a large amount of solvents to the skin, but also avoids the stimulation and harm of cationic surfactants or heavy metal ions to the skin. The antibacterial composition is used in the same way as common face cream and lotion, and is convenient to spread uniformly. The antibacterial composition not only has antibacterial and bactericidal effects, but also does not harm and stimulate the skin, and also has moistening and moisturizing effects on the skin, and has a protective effect on the skin.
2. The tea tree oil is a broad-spectrum antibacterial agent, has the effects of inhibiting bacteria, diminishing inflammation, expelling parasites and killing mites, and has unique fragrance, which is beneficial to refreshing. The essential oil component of rosemary has excellent antibacterial activity, wherein the essential oil component has good antibacterial effect on escherichia coli, staphylococcus aureus and vibrio cholerae, and can be used as an antioxidant to delay the oxidation rate of the antibacterial composition. The origanum oil is a broad-spectrum antibacterial agent, has the effects of inhibiting bacteria, diminishing inflammation and expelling parasites, and has good antibacterial activity on 31 common enteritis-causing bacteria and shigella flexneri. The eucalyptus oil has certain mildew-proof, bactericidal and antiseptic effects, has the special fragrance of the cool and refreshing eucalyptus spinosa leaves with a few of camphor smells, and has strong and non-lasting fragrance. The tea tree oil, the rosemary oil, the oregano oil and the eucalyptus oil are compounded to form the plant bacteriostatic oil, so that bacteriostasis can be performed on various germs, and the four kinds of plant oil have small irritation to the skin of a human body, so that the plant bacteriostatic oil can be used for disinfecting the skin of an infant.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
Example 1
A bacteriostatic composition for daily life is shown in table 1:
table 1
The preparation method of the bacteriostatic composition in the example 1 comprises the following steps:
(1) uniformly mixing the raw materials in the water phase with pure water and heating to 75 ℃;
(2) mixing and heating the raw materials in the oil phase to 75 ℃, and uniformly mixing;
(3) pumping the water phase into an emulsifying pot, pumping the oil phase into the water phase under the condition of keeping the temperature (75 ℃) and continuously stirring, homogenizing for 3 minutes after pumping, continuously stirring, and cooling;
(4) the raw materials in other phases are added at 45 ℃;
(5) stopping the machine below 40 ℃ and discharging to obtain the material.
Example 2
A bacteriostatic composition for daily life is shown in Table 2:
table 2
The bacteriostatic composition of example 2 was prepared in the same manner as in example 1.
Example 3
A bacteriostatic composition for daily life is shown in Table 3:
table 3
The bacteriostatic composition of example 3 was prepared in the same manner as in example 1.
Example 4
A bacteriostatic composition for daily life is shown in Table 4:
table 4
The bacteriostatic composition of example 4 was prepared in the same manner as in example 1.
The bacteriostatic compositions of examples 1 to 4 were tested as follows, and the test results are shown in table 5:
table 5
As can be seen from the data in Table 5, the bacteriostatic composition has very good bacteriostatic effect, and the bacteriostatic effect on Escherichia coli, Staphylococcus aureus and Candida albicans reaches 100%. In addition, the antibacterial composition also has good moisture retention, so that the antibacterial composition can achieve the effects of moistening and preserving the skin and has the effect of protecting the skin. In conclusion, the antibacterial composition disclosed by the invention not only has antibacterial and bactericidal effects, but also does not harm or stimulate the skin, and also has the effects of moistening and moisturizing the skin, and has a protective effect on the skin. Therefore, the invention effectively overcomes various defects in the prior art and has high industrial utilization value.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The bacteriostatic composition for daily life is characterized by comprising the following components in parts by weight: 2-4 parts of an emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of an emollient, 5-10 parts of a humectant and 50-80 parts of water;
wherein the plant antibacterial oil is at least one of tea tree oil, rosemary oil, oregano oil and eucalyptus oil.
2. Bacteriostatic composition for daily life according to claim 1, characterized in that: the antibacterial composition comprises the following components in parts by weight: 2-4 parts of an emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of an emollient, 5-10 parts of a humectant, 0.5-1 part of an anti-irritant, 0.2-0.6 part of a preservative, 0.1-0.5 part of a pH regulator, 0.1-0.2 part of an aromatic and 50-80 parts of water.
3. Bacteriostatic composition for daily life according to claim 2, characterized in that: the antibacterial composition comprises the following components in parts by weight: 2-4 parts of emulsifier, 5-15 parts of plant bacteriostatic oil, 5-20 parts of emollient, 5-10 parts of humectant, 0.5-1 part of anti-irritant, 0.2-0.6 part of preservative, 0.1-0.5 part of pH regulator, 0.1-0.2 part of aromatic, 0.2-0.8 part of vitamin E, 0.1-0.5 part of excipient and 50-80 parts of water.
4. Bacteriostatic composition for daily life according to claim 3, characterized in that: the antibacterial composition comprises the following components in parts by weight: 2.5-3.5 parts of emulsifier, 8-15 parts of plant bacteriostatic oil, 8-15 parts of emollient, 6-8 parts of humectant, 0.5-1 part of anti-irritant, 0.2-0.6 part of preservative, 0.1-0.5 part of pH regulator, 0.1-0.2 part of aromatic, 0.2-0.8 part of vitamin E, 0.1-0.5 part of excipient and 50-80 parts of water.
5. Bacteriostatic composition for daily life according to claim 3 or 4, characterized in that: the emulsifier is at least one of an anionic emulsifier, a cationic emulsifier, a nonionic emulsifier, a natural emulsifier and a thickening emulsifier; the emollient is at least one of silicone oil, animal and vegetable oil, higher alcohol, hydrocarbon and synthetic oil.
6. Bacteriostatic composition for daily life according to claim 3 or 4, characterized in that: the emulsifier is at least one of glyceryl stearate citrate, cetearyl olive oleate, glyceryl stearate and PEG-100 stearate;
the emollient is at least one of polydimethylsiloxane, squalane, olive oil, cetostearyl alcohol and isohexadecane;
the humectant is at least one of polyalcohol, sodium hyaluronate and ceramide;
the anti-irritant is at least one of peony/radix Paeoniae extract, bisabolol, and radix Stephaniae Tetrandrae extract;
the preservative is at least one of methyl hydroxybenzoate, propyl hydroxybenzoate, bis (hydroxymethyl) imidazolidinyl urea and phenoxyethanol;
the pH regulator is arginine or triethanolamine;
the aromatic is essence;
the excipient is at least one of carbomer and hydroxyethyl cellulose.
7. A bacteriostatic composition for daily life according to any one of claims 1-4, wherein: the plant bacteriostatic oil comprises the following components in parts by weight: 1.5-2.5 parts of tea tree oil, 0.3-0.7 part of rosemary oil, 1.0-2.0 parts of eucalyptus oil and 1.5-2.5 parts of origanum oil.
8. A method for preparing a bacteriostatic composition for daily life as defined in any one of claims 1 to 7, which comprises the following steps:
step one, uniformly mixing a water-phase raw material and water at 70-80 ℃ to obtain a water-phase mixture, wherein the water-phase raw material comprises a humectant; uniformly mixing oil phase raw materials at 70-80 ℃ to obtain an oil phase mixture, wherein the oil phase raw materials comprise an emulsifier, plant bacteriostatic oil and an emollient;
and step two, adding the water phase mixture into an emulsifying pot, stirring at 70-80 ℃, adding the oil phase, homogenizing for 2-5 min, cooling to 45 ℃, adding the rest materials, uniformly mixing, and stopping the machine to discharge the materials.
9. A method of preparing a bacteriostatic composition for use in daily life according to claim 8, characterized in that: the water phase raw material also comprises a pH regulator, and the oil phase raw material also comprises an anti-irritant.
10. A method of preparing a bacteriostatic composition for use in daily life according to claim 9, characterized in that: the water phase raw material also comprises an excipient, and the oil phase raw material also comprises vitamin E.
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