CN114146147A - 一种强力枇杷露混合均匀的方法 - Google Patents
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Abstract
本发明公开了一种强力枇杷露混合均匀的方法，涉及中药制药技术领域。本发明一种强力枇杷露混合均匀的方法，每1000ml强力枇杷露由以下各原料及重量份制备而成：桔梗6‑8、白前9‑11、桑白皮3‑5、枇杷叶70‑72、百部15‑16、罂粟壳50‑52、蔗糖500‑580、蜂蜜58‑60、防腐剂2‑3、香精0.10‑0.12、薄荷脑0.15‑0.17，加纯化水定容。本发明一种强力枇杷露混合均匀的方法，首先将浸膏浓缩，提高浸膏的相对密度至1.25‑1.35，再将浸膏、稠膏、蔗糖、蜂蜜等进行混合，并分步用纯化水稀释，不仅能充分混匀，还使混合液中关键质量指标吗啡的含量控制在0.02‑0.15mg/ml，且不易产生沉淀，有效去除强力枇杷露中的沉淀物，保证强力枇杷露的澄清度，有效降低强力枇杷露中微生物风险，提高强力枇杷露的临床疗效，利于推广使用。
Description
技术领域
本发明属于中药制药技术领域，特别是涉及一种强力枇杷露混合均匀的方法。
背景技术
强力枇杷露为内科咳嗽类非处方药药品。强力枇杷露主要成分有枇杷叶，罂粟壳，百部，白前，桑白皮，桔梗，薄荷脑；辅料有蔗糖、蜂蜜、枸橼酸、香精、防腐剂(苯甲酸钠)。用于治疗痰热伤肺所致的咳嗽经久不愈，痰少而黄或干咳无痰者。西医临床应用，现代医学明确诊断为急、慢性支气管炎等。
现有的原强力枇杷露工艺中，先在由罂粟壳与酸水煎煮的稠膏中加入蔗糖、蜂蜜进行溶糖操作，再与浸膏进行混匀制备而成，这种混合方式存在混合不均匀的弊端，根据相似相溶原理，溶糖液含糖量高(相对密度1.20-1.35)，浸膏的浓度低(相对密度1.05-1.10)，两者混合后，一方面，浸膏的相对密度低，量大，不易混匀；另一方面混合溶液易产生沉淀，影响强力枇杷露的口感和质量。故此，我们提出一种强力枇杷露混合均匀的方法。
发明内容
本发明的目的在于提供一种强力枇杷露混合均匀的方法，为解决上述技术问题，本发明是通过以下技术方案实现的：
一种强力枇杷露混合均匀的方法，每1000ml强力枇杷露由以下各原料及重量份制备而成：桔梗6-8、白前9-11、桑白皮3-5、枇杷叶70-72、百部15-16、罂粟壳50-52、蔗糖500-580、蜂蜜58-60、防腐剂2-3、香精0.10-0.12、薄荷脑0.15-0.17，加纯化水定容；
制备方法如下：
步骤一、前处理；将桔梗、白前、桑白皮、枇杷叶、百部五味中药材拣选，洗切，得净药材；
步骤二、一次煎煮：将步骤一中桔梗、白前、桑白皮、枇杷叶、百部五味药加水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，浓缩至浸膏状，备用；
步骤三、二次煎煮：取配方量的罂粟壳加6.5-10倍药材总重量的酸水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，滤液浓缩至稠膏，备用；
步骤四、真空浓缩：将步骤二的浸膏置于浓缩罐中，控制真空度在0.08MPa，温度≧80℃，减压浓缩，提高浸膏相对密度至1.25-1.35；
步骤五、分步混合：向步骤三的稠膏中加入配方量的防腐剂，搅拌溶解，再加入配方量的蔗糖、蜂蜜和步骤四中的浓缩后的浸膏，分步加入适量纯化水稀释，搅拌混匀，加热至沸腾，保持沸腾20-30分钟；
步骤六、配制：向步骤五中的混合液加入枸橼酸调节PH值至3.0-4.0，静置过滤，向滤液中加入配方量的香精和薄荷脑，搅拌均匀，静置过滤，收集滤液；
步骤七、罐装：将步骤六中的滤液灭菌，并要求装瓶。
优选的，所述步骤三中的酸水可以是枸橼酸水溶液、磷酸水溶液、盐酸溶液、10％乙酸溶液中的一种。
优选的，所述步骤五中防腐剂为苯甲酸钠。
优选的，所述步骤六中香精为使用乙醇进行溶解的香蕉香精。
本发明具有以下有益效果：
1、本发明首先将浸膏浓缩，提高浸膏的相对密度至1.25-1.35，再将浸膏、稠膏、蔗糖、蜂蜜等进行混合，并分步用纯化水稀释，不仅能充分混匀，还使混合液中关键质量指标吗啡的含量控制在0.02-0.15mg/ml，且不易产生沉淀；
2、本发明经过一次煎煮、二次煎煮、分步混合、配制等步骤中多次过滤，有效去除强力枇杷露中的沉淀物，保证强力枇杷露的澄清度，再通过多次高温蒸煮有效降低强力枇杷露中微生物风险；
3、本发明制备方法简单，提高强力枇杷露的临床疗效，利于推广使用。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例一
一种强力枇杷露混合均匀的方法，每1000ml强力枇杷露由以下各原料及重量份制备而成：桔梗7、白前10、桑白皮4、枇杷叶71、百部15、罂粟壳51、蔗糖550、蜂蜜58、防腐剂2、香精0.11、薄荷脑0.16，加纯化水定容：
制备方法如下：
步骤一、前处理；将桔梗、白前、桑白皮、枇杷叶、百部五味中药材拣选，洗切，得净药材；
步骤二、一次煎煮：将步骤一中桔梗、白前、桑白皮、枇杷叶、百部五味药加水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，浓缩至浸膏状，备用；
步骤三、二次煎煮：取配方量的罂粟壳加6.5-10倍药材总重量的酸水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，滤液浓缩至稠膏，备用；
步骤四、真空浓缩：将步骤二的浸膏置于浓缩罐中，控制真空度在0.08MPa，温度≧80℃，减压浓缩，提高浸膏相对密度至1.25-1.35；
步骤五、分步混合：向步骤三的稠膏中加入配方量的防腐剂，搅拌溶解，再加入配方量的蔗糖、蜂蜜和步骤四中的浓缩后的浸膏，分步加入适量纯化水稀释，搅拌混匀，加热至沸腾，保持沸腾20-30分钟；
步骤六、配制：向步骤五中的混合液加入枸橼酸调节PH值至3.0-4.0，静置过滤，向滤液中加入配方量的香精和薄荷脑，搅拌均匀，静置过滤，收集滤液；
步骤七、罐装：将步骤六中的滤液灭菌，并要求装瓶。
步骤三中的酸水可以是枸橼酸水溶液、磷酸水溶液、盐酸溶液、10％乙酸溶液中的一种，步骤三中的酸水为浓度1％的盐酸溶液。
步骤五中防腐剂为苯甲酸钠。
步骤六中香精为使用乙醇进行溶解的香蕉香精。
本发明首先将浸膏浓缩，提高浸膏的相对密度至1.25-1.35，再将浸膏、稠膏、蔗糖、蜂蜜进行混合，并分步用纯化水稀释，不仅能充分混匀，还使混合液中关键质量指标吗啡的含量控制在0.02-0.15mg/ml，且不易产生沉淀；本发明经过一次煎煮、二次煎煮、分步混合、配制等步骤中多次过滤，有效去除强力枇杷露中的沉淀物，保证强力枇杷露的澄清度，再通过多次高温蒸煮有效降低强力枇杷露中微生物风险；本发明制备方法简单，提高强力枇杷露的临床疗效，利于推广使用。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节，也不限制该发明仅为所述的具体实施方式。显然，根据本说明书的内容，可作很多的修改和变化。本说明书选取并具体描述这些实施例，是为了更好地解释本发明的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。
Claims (4)
1.一种强力枇杷露混合均匀的方法，其特征在于：每1000ml强力枇杷露由以下各原料及重量份制备而成：桔梗6-8、白前9-11、桑白皮3-5、枇杷叶70-72、百部15-16、罂粟壳50-52、蔗糖500-580、蜂蜜58-60、防腐剂2-3、香精0.10-0.12、薄荷脑0.15-0.17，加纯化水定容；
制备方法如下：
步骤一、前处理；将桔梗、白前、桑白皮、枇杷叶、百部五味中药材拣选，洗切，得净药材；
步骤二、一次煎煮：将步骤一中桔梗、白前、桑白皮、枇杷叶、百部五味药加水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，浓缩至浸膏状，备用；
步骤三、二次煎煮：取配方量的罂粟壳加6.5-10倍药材总重量的酸水煎煮3-4次，每次1.5-2.0小时，合并煎液，过滤，滤液浓缩至稠膏，备用；
步骤四、真空浓缩：将步骤二的浸膏置于浓缩罐中，控制真空度在0.08MPa，温度≧80℃，减压浓缩，提高浸膏相对密度至1.25-1.35；
步骤五、分步混合：向步骤三的稠膏中加入配方量的防腐剂，搅拌溶解，再加入配方量的蔗糖、蜂蜜和步骤四中的浓缩后的浸膏，分步加入适量纯化水稀释，搅拌混匀，加热至沸腾，保持沸腾20-30分钟；
步骤六、配制：向步骤五中的混合液加入枸橼酸调节PH值至3.0-4.0，静置过滤，向滤液中加入配方量的香精和薄荷脑，搅拌均匀，静置过滤，收集滤液；
步骤七、罐装：将步骤六中的滤液灭菌，并要求装瓶。
2.根据权利要求1所述的一种强力枇杷露混合均匀的方法，其特征在于：所述步骤三中的酸水可以是枸橼酸水溶液、磷酸水溶液、盐酸溶液、10％乙酸溶液中的一种。
3.根据权利要求1所述的一种强力枇杷露混合均匀的方法，其特征在于：所述步骤五中防腐剂为苯甲酸钠。
4.根据权利要求1所述的一种强力枇杷露混合均匀的方法，其特征在于：所述步骤六中香精为使用乙醇进行溶解的香蕉香精。
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