CN114129835B

CN114129835B - Nebulization catheter for multiphase fluids, nebulization dosing system, control method, computer device and dosing device

Info

Publication number: CN114129835B
Application number: CN202111314163.3A
Authority: CN
Inventors: 徐宏; 王茂强; 徐鹏威; 关玉
Original assignee: Hangzhou Kunbo Biotechnology Co Ltd
Current assignee: Hangzhou Kunbo Biotechnology Co Ltd
Priority date: 2021-05-26
Filing date: 2021-11-08
Publication date: 2024-05-28
Anticipated expiration: 2041-11-08
Also published as: CN114129834B; CN114129836A; CN218739765U; CN217162788U; CN115177823B; CN115177823A; CN217489465U; CN216934313U; CN115177822A; CN217489464U; CN217489461U; CN114129835A; CN114129836B; CN216934312U; CN114129837B; CN114129837A; CN115177822B; CN114129834A; CN217489463U

Abstract

The application discloses an atomization catheter suitable for multiphase fluid, which comprises a tube body, wherein one end of the tube body is a proximal end, the other end of the tube body is a distal end which can extend into a bronchus, a channel capable of conveying the fluid from the proximal end to the distal end is arranged in the tube body, an atomization head is arranged at the distal end of the tube body, and the fluid in the channel is atomized by the atomization head and then is output; the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, and the fluid is atomized through the atomizing chamber. The diameter of the atomization catheter is smaller, the atomization catheter can be inserted into a lung section which cannot be accessed by an endoscope to perform accurate atomization drug delivery, and the drug effect is faster and more accurate to act on an affected part of a patient through targeted atomization drug delivery, so that the drug liquid is prevented from remaining in the oral cavity and the nasal cavity.

Description

Nebulization catheter for multiphase fluids, nebulization dosing system, control method, computer device and dosing device

Technical Field

The application relates to the field of medical equipment, in particular to an atomization catheter, an atomization drug delivery system, a control method, computer equipment and drug delivery equipment which can be used for treating bronchial diseases and are suitable for multiphase fluid.

Background

In clinical endoscopic treatment, an atomization administration mode is generally required to be matched, so that the injected medicine liquid can be uniformly distributed, the uniformity degree of the combination of related tissues (such as bronchial mucosa and gastrointestinal mucosa) and the medicine is improved, and the impact injury to the tissues possibly caused by the traditional direct injection is reduced to the greatest extent.

Current nebulizers are used to administer drugs by inhalation, where the liquid drug is broken down into an aerosol of tiny particles or droplets, and the patient using the drug can get more efficient inhalation and absorption.

The existing atomization equipment is single in administration form, poor in atomization effect and still further improved in treatment effect.

Disclosure of Invention

The application provides an atomization catheter which can be inserted into bronchus and release therapeutic substances, the atomization effect is better, the administration mode is flexible, the targeted administration can be carried out aiming at a small-area focus, and the administration efficiency and the therapeutic effect are further improved.

The application relates to an atomization catheter suitable for multiphase fluid, which comprises a tube body, wherein one end of the tube body is a proximal end, the other end of the tube body is a distal end which can extend into a bronchus, a channel capable of conveying the fluid from the proximal end to the distal end is arranged in the tube body, an atomization head is arranged at the distal end of the tube body, and the fluid in the channel is atomized by the atomization head and then is output;

The atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, and the fluid is atomized through the atomizing chamber.

Compared with the traditional atomizer, the atomization catheter provided by the application has smaller outer diameter of the catheter body, has certain flexibility, and can enter the deep part of the lung for accurate administration. The external diameter, length and other dimensional parameters of the tube body are not strictly limited, but can at least extend into the bronchus to reach the focus.

The following provides several alternatives, but not as additional limitations to the above-described overall scheme, and only further additions or preferences, each of which may be individually combined for the above-described overall scheme, or may be combined among multiple alternatives, without technical or logical contradictions.

Optionally, the tube body adopts a multi-tube form, at least two tubes are arranged side by side or nested inside and outside, and each tube can be independently configured or an integrated multi-cavity tube can be adopted.

The atomizing conduit can convey multiphase fluid, each phase of fluid is correspondingly provided with a fluid channel, and each fluid channel extends independently.

Optionally, the proximal end of the tube body is fixed with a tube joint, and the tube joint includes:

A manifold having a plurality of inputs and an output, the outputs being in communication with respective fluid passages within the tube;

and each joint is communicated with one input end of the confluence piece.

Each input end corresponds to a phase of fluid, the converging piece receives multiphase fluid, but the fluids of the phases are not mixed, and the fluid after passing through the converging piece still circulates in the pipe body along the respective channel.

Optionally, the confluence piece has two input ends, wherein one input end is communicated with a first connector for being connected with a gas phase or a liquid phase, and the other input end is communicated with a second connector for being connected with the liquid phase or the gas phase.

The fluids at the two inputs are different, one being in the gas phase and the other being in the liquid phase, or both being in the liquid phase.

Optionally, inside the busbar, a first branch and a second branch extend from each input end, respectively, and when adjacent to the output end, the two branches gather together and remain isolated from each other.

The converging members are used to concentrate the fluid channels at each input end, but do not mix.

Optionally, the first branch and the second branch are adjacent to the output end of the confluence member, wherein one branch is distributed on the periphery of the other branch.

One branch is positioned at the center position, and the other branch is distributed around the branch, so that the structure is more compact.

The present application also provides an aerosolized drug delivery system comprising:

A perfusion device for supplying a fluid containing a therapeutic substance;

an atomization catheter which is communicated with the perfusion device and is used for receiving fluid and outputting the fluid into bronchus after atomization;

the sampling device is used for collecting the state parameters of the fluid;

And the control device is connected with the sampling device and is used for receiving the state parameters and correspondingly controlling the perfusion device.

The aerosolized drug delivery system may employ the aerosolized catheter of the various embodiments described above, with the fluid containing the therapeutic substance entering the aerosolized catheter through the infusion device until applied to the focal site.

The present application also provides a control method of an aerosolized drug delivery system for aerosolizing and delivering a fluid containing a therapeutic substance into a bronchus, the control method comprising:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

Driving a perfusion device by the control signal to regulate the supply of the fluid.

The control method of the atomized medicine delivery system is characterized in that the state parameters of the fluid are monitored to adjust the state parameters of the fluid to be optimal.

The present application also provides a control device of an aerosolized drug delivery system for aerosolizing and delivering a fluid containing a therapeutic substance into a bronchus, the control device comprising:

a first module for acquiring a state parameter of the fluid;

The second module is used for generating corresponding control signals according to the state parameters;

A third module for driving the perfusion device by the control signal to adjust the supply of the fluid.

The respective modules in the above-described control device may be implemented in whole or in part by software, hardware, and combinations thereof. The above modules may be embedded in hardware or may be independent of a processor in the computer device, or may be stored in software in a memory in the computer device, so that the processor may call and execute operations corresponding to the above modules.

The present application also provides a computer device configured for use in a nebulized delivery system for nebulizing a fluid comprising a therapeutic substance and outputting the fluid into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor performing the following steps when the computer program is executed:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

The application also provides a drug delivery device for treating lung diseases, which is the atomizing catheter.

The atomization catheter disclosed by the application has a better atomization effect, is flexible in administration mode, can go deep into a lung section which cannot be accessed by an endoscope to carry out accurate atomization administration, and can be used for carrying out targeted atomization administration, so that the drug effect acts on an affected part of a patient faster and more accurately, and the drug liquid is prevented from remaining in an oral cavity and a nasal cavity.

Drawings

FIG. 1 is a schematic view of a fogging catheter according to an embodiment of the application;

FIG. 2 is a schematic view of the proximal pipe joint of FIG. 1;

FIG. 3 is an exploded view of the pipe joint of FIG. 2;

FIG. 4 is a schematic view showing the internal structure of the pipe joint part of FIG. 1;

FIG. 5 is a schematic view of the structure of the butt end of the pipe joint with the pipe body;

FIG. 6 is a schematic view of the structure of the butt end of the pipe body with the pipe joint;

FIG. 7 is a schematic view of the distal atomizing head of FIG. 1;

FIG. 8 is a schematic view of the atomizing head of FIG. 7 at another angle;

FIG. 9 is an exploded view of the atomizing head of FIG. 8;

FIG. 10 is a schematic view of the atomizing head of FIG. 9 at another angle;

FIG. 11 is an exploded view of the atomizing head of FIG. 10;

FIG. 12 is a schematic view of the atomizing head of FIG. 11 at another angle;

FIG. 13 is a perspective view of a diverter in an atomizing head;

FIG. 14 is a perspective view of an atomizing chamber in an atomizing head;

FIG. 15 is a front view of the atomizing head;

FIG. 16 is a cross-sectional view A-A of FIG. 15;

FIG. 17 is an enlarged view of the portion B of FIG. 16;

FIG. 18 is a block diagram of a aerosolized drug delivery system in accordance with an embodiment of the present application;

FIG. 19 is a flow chart of a control method according to an embodiment of the application;

FIG. 20 is a schematic block diagram of a control device according to an embodiment of the present application;

FIG. 21 is a block diagram of a computer device in accordance with an embodiment of the present application.

Reference numerals in the drawings are described as follows:

100. a tube body; 110. an outer tube; 120. an inner tube; 130. a first channel; 140. a second channel;

200. a pipe joint; 210. a first joint; 220. a second joint; 230. a confluence member; 231. a first branch; 231', a first leg; 232. a second branch; 232', a second leg; 233. an output end; 234. a first branch pipe; 235. a second branch pipe;

400. An atomizing head; 410. a first cannula; 420. a second cannula; 430. a first communication pipe; 440. a second communicating pipe; 450. an atomizing chamber; 451. an inner cavity; 452. an outer chamber wall; 453. a distal chamber wall; 454. an inner chamber wall; 460. a first spout; 470. a second spout; 480. a shunt; 481. a cover body; 482. an opening; 483. and a diversion hole.

Detailed Description

The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

The existing oral cavity or nasal cavity atomization administration mode is difficult to reach the far end of the lung due to long human airway, most of atomized particles are deposited on the oral cavity, the nose and the main bronchus, and accurate administration cannot be performed; in addition, the drug cannot be deeply administered into the airway due to the limitation of the mechanical size, the treatment effect is poor, and improvement is still needed.

Referring to fig. 1 to 17, in an embodiment of the present application, an atomization catheter is provided, which includes a tube body 100, wherein one end of the tube body 100 is a proximal end, the other end is a distal end that can extend into a bronchus, a channel capable of conveying fluid from the proximal end to the distal end is provided in the tube body 100, an atomization head 400 is provided at the distal end of the tube body 100, and the fluid in the channel is atomized by the atomization head 400 and then output;

The atomizing head 400 has an atomizing chamber 450 therein for mixing multiphase fluid, which is atomized via the atomizing chamber 450.

Compared with the traditional atomizer, the atomization catheter of the embodiment has smaller outer diameter of the tube body 100, has certain flexibility, and can enter deep lung for accurate administration. The outer diameter, length, etc. of the tube 100 are not critical, but may extend into at least the bronchus to reach the lesion, and the preferred embodiments described below are also intended to achieve the desired effect.

Depending on the therapeutic purpose, the fluid may be pre-dispersed with the therapeutic substance, and depending on the nature of the therapeutic substance, the fluid itself may be a liquid or gas phase, or a more complex mixture, with the purpose of further dispersing the fluid to produce smaller particles to promote absorption and uniform administration.

The tube body 100 can be made of metal or synthetic materials, provides necessary mechanical properties and intervention safety, can be in the form of a single tube, multiple tubes or the like according to the requirement of fluid delivery, and can be at least two tubes arranged side by side or nested inside and outside when multiple tubes are adopted, and each tube can be independently configured or an integrated multi-cavity tube is adopted.

In order to facilitate passage within the finer bronchi, the outer diameter of the tube body 100 is generally no greater than 1.2mm to 2.0mm, for example, the outer diameter of the nebulizing catheter is 1.8mm, enabling accurate nebulization delivery to be achieved to a section of the lung that is not reached by the endoscope.

Since the inventive nebulizing catheter can extend into the bronchi, its length is correspondingly matched, for example, the length of the tube body 100 is 800 mm-1200 mm.

Multiphase fluids such as gases and liquids, and at least one of which may carry a therapeutic substance, are determined in particular by the physicochemical properties of the therapeutic substance. The gas and the liquid can form tiny bubbles after being mixed and converged, the bubbles carry liquid drops to be sprayed out, and the atomization effect is achieved as a whole.

The atomizing chamber 450 has at least a first fluid inlet, a second fluid inlet, and a spray orifice for the atomized fluid, although the first and second fluid inlets may be pre-joined adjacent the atomizing chamber 450, i.e., share a common fluid inlet.

To optimize the dosing area, in one embodiment, the nebulization chamber 450 has a plurality of jets of nebulized fluid and at least two jets are oriented differently.

The spout may be oriented axially and distally, radially outward, tangentially with respect to the direction of extension of the tubular body 100, or may be angled slightly from each of the above.

For atomization effect, the atomization chamber 450 is provided in plurality and extends along the circumference of the tube 100. The respective atomizing chambers 450 are radially disposed at the peripheral region of the axis of the tube body 100.

To facilitate interventional delivery, in one embodiment, the atomizing head 400 is of radially compressible construction, having opposed compressed and released states. The compressible structure can adopt a net cage structure, a winding structure and the like.

The spray head 400 is convenient to pass through in the body in a compressed state, can be released as required after being adjacent to a focus, can finish the drug delivery at one time especially aiming at a focus with a large area, does not need to adjust the position for multiple times, compresses the spray head 400 when the spray head needs to be recovered, and is loaded on other pipe fittings to be withdrawn out of the body.

For multiple atomizing chambers 450, for fluid delivery, a manifold delivery may be used, with branches adjacent to the atomizing chambers 450 to distribute into each of the atomizing chambers 450, or multiple-line parallel delivery may be used.

Of course, in order to facilitate the arrangement of the pipes, a main pipe conveying mode is generally adopted between the atomization pipes, and after the pipes 100 are conveyed, multiple pipes can be adopted in parallel according to requirements.

The proximal end of the tube 100 is typically connected to a fluid-carrying infusion device or a storage device, and a tube connector 200, such as a conventional luer connector, may be fixed to the proximal end of the tube 100 in advance for easy assembly, and a threaded or snap-fit manner may be used to facilitate quick connection to an external conduit.

The pipe joint 200 may adopt a single interface or multiple interfaces in parallel according to different fluids, and when the interfaces are used, the pipe joint 200 may adopt a three-way, four-way or other modes, and a control valve may be configured for at least one interface, or of course, the control valve may also adopt an external or detachable mode, and be connected with the pipe joint 200 only when needed.

Referring to fig. 2 to 6, when a multiphase fluid is used, the pipe joint 200 includes:

A junction element 230 having a plurality of input ends and an output end 233, said output end 233 being in communication with a corresponding fluid passage in said tubular body 100;

a plurality of connectors, each connector communicating with one of the inputs of the manifold 230.

For example, when two-phase fluid input is used, the manifold 230 has two inputs, one of which is connected to the first connector 210 for accessing the gas or liquid phase and the other of which is connected to the second connector 220 for accessing the liquid or gas phase.

The fluid to which the two connectors are connected, one of which is in a liquid phase and the other of which is in a gas phase, for example, the first connector 210 is connected to the gas phase and the second connector 220 is connected to the liquid phase, and vice versa.

Inside the junction element 230, a first branch 231 and a second branch 232 extend from each input end, respectively, and when adjacent to the output end 233, the two branches gather together and remain isolated from each other. And after being gathered together, the pipe body 100 is more convenient to be butted with.

In one embodiment, the first leg 231 'and the second leg 232' are adjacent to the output end 233 of the junction 230, wherein one leg is distributed around the periphery of the other leg.

For example, the second legs 232 'are distributed around the outer circumference of the first legs 231'. The distribution may be a full circle around the periphery or a spaced distribution around the periphery.

The use of a spacing means is more advantageous for transporting the fluid transported by the second branch 232' in a multichannel parallel manner within the tubular body 100, for example at the output 233 of said junction 230, provided with:

A first branch pipe 234, the first branch pipe 231' is communicated with the first branch pipe 234,

The second branch lines 232' are connected to all the second branch lines 235, and the second branch lines 235 are arranged around the first branch line 234.

The first branch pipe 234 and the plurality of second branch pipes 235 integrally form a plug structure, which facilitates rapid assembly with the pipe body 100.

Accordingly, the tube body 100 employs a multi-lumen tube, and each lumen (i.e., fluid passage) within the multi-lumen tube communicates with a corresponding branch tube on the manifold 230. Each branch pipe on the confluence member 230 can be inserted into the corresponding cavity to be communicated when in butt joint. Can be relatively fixed by bonding or interference fit after insertion.

The number of lumens in the multi-lumen tube and the distribution characteristics of the interface portions should be matched with the branch tubes on the junction element 230, and if necessary, a matched foolproof structure can be arranged, so that the positioning and the plugging are convenient.

In the illustration, 7 channels are provided in the multilumen tubing, centered for gas delivery and 6 surrounding channels for liquid delivery.

Each lumen in the tube 100 extends distally and communicates with a corresponding fluid inlet on the atomizing head 400. In one embodiment, a first channel 130 is included that is centered, and a plurality of second channels 140 are located at the periphery of the first channel 130.

To accommodate the design of multiphase fluids, the atomizing head 400 in one embodiment includes:

a plurality of atomizing chambers 450, each atomizing chamber 450 having a plurality of fluid inlets, and a spray of atomized fluid;

A plurality of cannulas, each cannula being in plug-in communication with a corresponding fluid channel within the tube body 100;

and a plurality of communicating pipes, each cannula is connected to a corresponding fluid inlet in the atomizing chamber 450 through a corresponding communicating pipe.

The cross-sectional shapes of the respective cannulas and the communicating pipes are not strictly limited, such as a circle, a rectangle, etc., and the regulation and control of the fluid state can be realized by reasonable configuration of the cross-sectional areas.

One of the plurality of cannulas is a first cannula 410, and the rest is a plurality of second cannulas 420 distributed on the outer periphery of the first cannula 410.

A corresponding first cannula 410 interfaces with first channel 130 and a plurality of second cannulas 420 correspond with each of second channels 140.

To facilitate fluid distribution, in one embodiment, the first cannula 410 is connected to all of the nebulization chambers 450 via a first communication tube 430 of radiation distribution, and each second cannula 420 is connected to at least one nebulization chamber 450 via a corresponding second communication tube 440.

In one embodiment, the plurality of atomizing chambers 450 are distributed in a ring shape, and each second cannula 420 is connected to two circumferentially adjacent atomizing chambers 450.

Each second cannula 420 is distributed between two circumferentially adjacent nebulization chambers 450.

In one embodiment, there are two second communication tubes 440 for each second cannula 420 that are matched to each other, each of which is connected to a respective side of the nebulization chamber 450. The fluid distribution is more uniform and reasonable, the interference of each cannula and the communicating pipe can be avoided as much as possible, and the occupied space is saved.

In order to optimize the structure, in an embodiment, the first communicating tube 430 includes a plurality of branch tubes according to the radiation direction, one branch tube is connected to the atomizing chamber 450 for the same atomizing chamber 450, two second communicating tubes 440 are connected to the atomizing chamber 450 and come from different second cannulas 420, and the two second communicating tubes 440 are located at two sides of the branch tube connected to the atomizing chamber 450.

The plurality of branches is preferably evenly distributed in a circumferential direction. Furthermore, the atomizing head 400 is integrally rotationally symmetrical, and because of the 6 atomizing chambers 450 in the drawing, the included angle between the adjacent atomizing chambers 450 is 60 degrees, and other components are the same.

To further optimize the distribution, an included angle area is formed between two adjacent branch pipes, and each second insertion pipe 420 of the plurality of second insertion pipes 420 is arranged in a corresponding included angle area.

For each second cannula 420, two mating second communicating tubes 440 are generally V-shaped and extend from the second cannula 420 toward an atomizing chamber 450 radially outward of the tube body 100.

The communication position between the two second communication pipes 440 and the second insertion pipe 420 is preferably on the side of the second insertion pipe 420 facing the first insertion pipe 410, i.e., on the radially inner side of the pipe body 100.

The number of branches is the same as the number of second cannula 420 and nebulization chamber 450, thus providing a one-to-one match, 6 in the figure, and 2 to 10, e.g., 4 to 8, in other embodiments.

The direction in which each communicating tube is connected to the corresponding atomizing chamber 450 affects the atomization effect to some extent, and in turn, in the embodiment, all communicating tubes for the same atomizing chamber 450 are connected to the atomizing chamber 450 along the same direction.

In a preferred embodiment, all communication tubes for the same nebulization chamber 450 extend radially outward of the tube body 100 and access the respective nebulization chamber 450.

I.e. radial to the tube 100, all fluid inlets of the atomizing chamber 450 are on the inside. The structure is also more compact.

Along the axial direction of the tube 100, all of the cannulas are on the proximal side of the atomizing chamber 450. After each cannula has been inserted into the lumen of the tube 100, the communication tubes and the atomizing chamber 450 are on the distal side of the exterior of the tube 100, for the atomizing head 400 as a whole.

All the branch pipes and the communicating pipes are arranged substantially coplanar and abut against the distal end face of the pipe body 100.

For proper distribution of the drug delivery, in one embodiment, the atomizing chamber 450 has two nozzles facing each, a first nozzle 460 facing distally in the axial direction of the tube 100 and a second nozzle 470 facing radially outward in the tube 100.

The atomizing chamber 450 includes walls defining an interior 451 with the walls defining respective side walls, for example, a first orifice 460 defined by the distal wall 453, a second orifice 470 defined by the outer wall 452, and respective fluid inlets defined by the inner wall 454. The fluids of different phases are atomized and ejected after being mixed in the cavity 451.

In order to improve the mixing and atomizing effect, a flow divider 480 is disposed in the atomizing chamber 450, wherein one fluid is mixed with the other fluid after passing through the flow divider 480.

In one embodiment, the flow divider 480 is a cover 481 with an opening 482 at one side, and the cover 481 is provided with a plurality of flow dividing holes 483, and one of the fluid inlets communicating with the atomizing chamber 450 is in butt joint with the opening 482 of the cover 481.

In one embodiment, the cover 481 has a hollow cube structure, and a plurality of diversion holes 483 are distributed on the five side walls except for the opening 482.

The size of the diversion holes 483 should be determined according to the material to be sprayed, such as fluid viscosity, dispersion of the therapeutic material, or particle size, such as typically between 5 microns and 100 microns.

The interior of the atomizing chamber 450 is divided by the cover 481 into an inner chamber into which one phase of fluid is introduced and an outer chamber into which the other phase of fluid is introduced.

Referring to fig. 17, in one embodiment, the first communication tube 430 interfaces with the opening 482 of the flow divider 480, i.e., communicates with the inner chamber, and the second communication tube 440 is connected to the outer chamber.

The fluid (for example, gas) output from the first communication pipe 430 enters the outer chamber through the plurality of flow dividing holes 483 on the cover 481 to be mixed with the liquid, so as to form bubbles, and the bubbles carry the liquid drops to be output through the nozzles on the wall of the atomizing chamber 450. Because the nozzles with a plurality of directions are arranged, when the focus of the lung is arranged on the two sides of the bronchus wall, the liquid medicine can be accurately sprayed.

Referring to fig. 18, in some embodiments, there is also provided an aerosolized drug delivery system comprising:

A perfusion device for supplying a fluid containing a therapeutic substance;

the sampling device is used for collecting the state parameters of the fluid;

The aerosolized drug delivery system of this embodiment may employ the aerosolized catheter of each of the embodiments described above, with the fluid containing the therapeutic substance entering the aerosolized catheter through the infusion device until applied to the focal site.

The perfusion device mainly provides fluid power, obtains a certain flow rate and can be adjusted according to the needs, for example, a controllable fluid delivery pump and the like are adopted, and the prior art can also be adopted in terms of the structure and the control mode of the pump.

The perfusion device is correspondingly configured according to the state and the type of the fluid, and can be generally in butt joint with the pipe joint 200 at the proximal end side of the atomizing catheter in a flexible connection mode, and a regulating device and the like are arranged at the position to be controlled.

The sampling device can acquire relevant parameters as required as a control basis, wherein the state parameters of the fluid comprise at least one of temperature, pressure and flow.

In order to assist operation, the sampling device also collects image signals of the focus part and/or state signals of the focus part.

The image signal is convenient for visual operation, can be used as real-time reference and comparison, and the state signal of the focus part can reflect the treatment progress, such as electric signals of current, impedance and the like, or temperature and the like.

In order to grasp the physiological state of the patient during the treatment, the sampling device also acquires physiological signals of the patient. Such as at least one of an electrocardiographic signal, a blood signal, and the like.

As an aerosolized drug delivery system, a plurality of specific devices may be involved, and the sampling device may also collect the operating state of the relevant device, e.g. the operating state of the perfusion device and/or the sampling device, as a basis for monitoring or regulation in order to learn the state of the respective device. And in connection with a specific device, may be rotational speed, operating current, operating temperature, pressure, etc.

The fluid loaded with the therapeutic substance may be either pre-formulated or mixed in real-time with the movement of the fluid, and in one embodiment the aerosolized drug delivery system further comprises a storage device for storing at least one of the fluid and the therapeutic substance.

The storage means may be arranged in accordance with the physicochemical properties of the fluid or the therapeutic substance and the amount thereof.

Depending on the therapeutic purpose and the condition of the lesion, the therapeutic substance itself may be delivered as a single fluid within the nebulizing catheter, e.g., the therapeutic substance itself is a fluid, or the therapeutic substance is supported by a gas phase fluid, or the therapeutic substance is supported by a liquid phase fluid.

Or the atomizing conduit conveys multiphase fluid, such as fluid comprising gas phase fluid and liquid phase fluid, and the two phase fluid is mixed and atomized at the atomizing head after entering the atomizing conduit respectively.

To facilitate handling of the nebulization catheter, in one embodiment, the nebulization delivery system further comprises an auxiliary device acting on the nebulization catheter to change the relative position of the nebulization catheter to the lesion.

In one embodiment, the aerosolized drug delivery system further comprises a display device for visual and audio output of the status parameter directly or after processing.

In one embodiment, the present application provides a delivery device for treating pulmonary diseases, the delivery device being an aerosolized catheter as described in the embodiments above.

By combining the structural characteristics of the atomizing catheter, the lung diseases can be especially aimed at the lung diseases of the focus at the bronchus part.

In one embodiment, the present application provides a method of administration for treating a pulmonary disease by extending an aerosolizing catheter as described in the embodiments above into a focal site within a bronchus, aerosolizing a fluid containing a therapeutic substance via the aerosolizing catheter, and delivering the fluid to the focal site.

The lung disease is at least one of phlegm accumulation, tuberculosis, fungal infection and tumor.

The therapeutic substance is at least one of phlegm eliminating medicine, tuberculosis treating medicine, fungal infection treating medicine and tumor treating medicine.

In particular applications, for example, can be used for ICU patients to inhale aerosolized phlegm-resolving drugs, for tuberculosis patients to inhale aerosolized tuberculosis drugs, for inhalation aerosolized fungal infection-treating drugs, or for inhalation aerosolized tumor-treating drugs, etc.

Referring to fig. 19, the present application also provides a control method of an aerosolized drug delivery system for aerosolizing and delivering a fluid containing a therapeutic substance into a bronchus, the control method comprising:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

It should be understood that, although the steps in the flowchart of fig. 19 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not strictly limited to the order of execution unless explicitly recited herein, and the steps may be executed in other orders. Moreover, at least some of the steps in fig. 19 may include multiple sub-steps or stages that are not necessarily performed at the same time, but may be performed at different times, or the order in which the sub-steps or stages are performed is not necessarily sequential, but may be performed in rotation or alternatively with at least a portion of the sub-steps or stages of other steps or steps.

In one embodiment, as shown in fig. 20, there is provided a control device of an aerosolized drug delivery system for aerosolizing and delivering a fluid containing a therapeutic substance into a bronchus, the control device comprising:

a first module for acquiring a state parameter of the fluid;

The specific limitations regarding the control means of the aerosolized drug delivery system may be found in the limitations of the control method of the aerosolized drug delivery system hereinabove, and will not be described in detail herein.

In one embodiment, a computer device is provided, which may be a terminal, and an internal structure diagram thereof may be as shown in fig. 21. The computer device includes a processor, a memory, a network interface, a display screen, and an input device connected by a system bus. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage media. The network interface of the computer device is used for communicating with an external terminal through a network connection. The computer program is executed by the processor to implement a method of controlling an aerosolized drug delivery system. The display screen of the computer device may be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device may be a touch layer covered on the display screen, or may be a key, a track ball or a touch pad arranged on the casing 340 of the computer device, or may be an external keyboard, a touch pad or a mouse, etc.

In one embodiment, there is also provided a computer device configured for use in a aerosolized drug delivery system for aerosolizing and outputting a fluid containing a therapeutic substance into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor implementing the following steps when executing the computer program:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

The specific definition of the implementation steps when the computer program is executed may be found in the definition of the control method of the nebulized drug delivery system hereinabove, and will not be described in detail here.

It will be appreciated by persons skilled in the art that the architecture shown in fig. 21 is merely a block diagram of some of the architecture relevant to the present inventive arrangements and is not limiting as to the computer device to which the present inventive arrangements are applicable, and that a particular computer device may include more or fewer components than shown, or may combine some of the components, or have a different arrangement of components.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description. When technical features of different embodiments are embodied in the same drawing, the drawing can be regarded as a combination of the embodiments concerned also being disclosed at the same time.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application.

Claims

1. An atomization catheter suitable for multiphase fluid comprises a tube body, and is characterized in that one end of the tube body is a proximal end, the other end of the tube body is a distal end which can extend into a bronchus, a channel capable of conveying the fluid from the proximal end to the distal end is arranged in the tube body, an atomization head is arranged at the distal end of the tube body, and the fluid in the channel is atomized by the atomization head and then output;

the atomization head is internally provided with an atomization chamber for mixing multiphase fluid, and the fluid is atomized through the atomization chamber; the atomizing chamber is provided with at least a first fluid inlet, a second fluid inlet and a nozzle for atomized fluid;

the body proximal end is fixed with the coupling, the coupling includes:

and each joint is communicated with one input end of the confluence piece.

2. An atomising catheter for multiphase fluids according to claim 1 wherein the tube is in the form of a multi-tube, at least two tubes being arranged side by side or nested inside and outside, each tube being independently configurable or being a single multi-lumen tube.

3. The atomizing conduit for multiphase fluids according to claim 2, wherein said manifold has two inputs, one of which is connected to a first connector for accessing a gas or liquid phase and the other of which is connected to a second connector for accessing a liquid or gas phase; inside the confluence part, a first branch and a second branch extend from each input end respectively, and the two branches gather together and keep isolated from each other when adjacent to the output end.

4. An atomising tube according to claim 3 wherein the first and second legs are adjacent the output end of the junction, one of the legs being distributed around the periphery of the other leg.

5. An atomizing conduit for a multiphase fluid according to claim 3, wherein,

At the output of converging piece, be provided with:

The first branch pipe is communicated with the first branch pipe;

The second branch pipes are communicated with all the second branch pipes, and rings spaced by the second branch pipes are distributed on the periphery of the first branch pipes;

The first branch pipe and the second branch pipes integrally form a plug structure, and corresponding channels inserted into the multi-cavity pipe are communicated.

6. An atomizing conduit for a multiphase fluid according to claim 3, wherein the atomizing head comprises:

A plurality of said atomising chambers, each said atomising chamber having said first fluid inlet, said second fluid inlet, and said orifice for the atomised fluid;

the plurality of cannulas are in plug-in connection with corresponding fluid channels in the tube body;

and each cannula is connected into a corresponding fluid inlet in the atomization chamber through the corresponding communicating pipe.

7. An aerosolized drug delivery system, comprising:

A perfusion device for supplying a fluid containing a therapeutic substance;

An atomising catheter as claimed in any one of claims 1 to 6, in communication with the perfusion device, for receiving fluid and outputting it into the bronchus after atomisation;

the sampling device is used for collecting the state parameters of the fluid;

8. A method of controlling an aerosolized drug delivery system of claim 7, wherein the aerosolized drug delivery system is configured to aerosolize and deliver a fluid comprising a therapeutic substance, the method comprising:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

9. A computer device configured in the aerosolized delivery system of claim 7 for aerosolizing and outputting a fluid containing a therapeutic substance into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor implementing the following steps when executing the computer program:

Acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

10. A drug delivery device for the treatment of pulmonary diseases, characterized in that the drug delivery device is an nebulizing catheter according to any one of claims 1 to 6.