CN114128808A - Fish liquid feed additive capable of promoting digestion and preparation method and application thereof - Google Patents
Fish liquid feed additive capable of promoting digestion and preparation method and application thereof Download PDFInfo
- Publication number
- CN114128808A CN114128808A CN202010914146.2A CN202010914146A CN114128808A CN 114128808 A CN114128808 A CN 114128808A CN 202010914146 A CN202010914146 A CN 202010914146A CN 114128808 A CN114128808 A CN 114128808A
- Authority
- CN
- China
- Prior art keywords
- fish
- feed additive
- parts
- digestion
- liquid feed
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 48
- 239000007788 liquid Substances 0.000 title claims abstract description 46
- 230000029087 digestion Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 230000001737 promoting effect Effects 0.000 title description 4
- 241000251468 Actinopterygii Species 0.000 claims abstract description 115
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims description 17
- -1 compound amino acid Chemical class 0.000 claims description 15
- 241000194031 Enterococcus faecium Species 0.000 claims description 14
- 229940024606 amino acid Drugs 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 241000194108 Bacillus licheniformis Species 0.000 claims description 11
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 11
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 11
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 11
- 241001134770 Bifidobacterium animalis Species 0.000 claims description 9
- 229940118852 bifidobacterium animalis Drugs 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000006041 probiotic Substances 0.000 claims description 9
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 5
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- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 5
- 210000005253 yeast cell Anatomy 0.000 claims description 5
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 3
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims description 3
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical group [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 3
- 229960003589 arginine hydrochloride Drugs 0.000 claims description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 3
- 229960005337 lysine hydrochloride Drugs 0.000 claims description 3
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 3
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims description 2
- 241000186000 Bifidobacterium Species 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 229940101006 anhydrous sodium sulfite Drugs 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 229940001607 sodium bisulfite Drugs 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 2
- 230000001502 supplementing effect Effects 0.000 claims description 2
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 4
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
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- 239000008223 sterile water Substances 0.000 description 5
- 108010084185 Cellulases Proteins 0.000 description 4
- 102000005575 Cellulases Human genes 0.000 description 4
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- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 3
- 229930003316 Vitamin D Natural products 0.000 description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000011691 vitamin B1 Substances 0.000 description 3
- 235000019166 vitamin D Nutrition 0.000 description 3
- 239000011710 vitamin D Substances 0.000 description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 229940046008 vitamin d Drugs 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229960003121 arginine Drugs 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000023852 carbohydrate metabolic process Effects 0.000 description 2
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000007413 intestinal health Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229960003646 lysine Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000033458 reproduction Effects 0.000 description 2
- 150000004666 short chain fatty acids Chemical class 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 241000287127 Passeridae Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
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- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
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- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 239000011575 calcium Substances 0.000 description 1
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- 239000005515 coenzyme Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 102000038379 digestive enzymes Human genes 0.000 description 1
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- 210000002249 digestive system Anatomy 0.000 description 1
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- 239000003797 essential amino acid Substances 0.000 description 1
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- 230000037406 food intake Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
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- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 150000003272 mannan oligosaccharides Chemical class 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
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- 150000002482 oligosaccharides Chemical class 0.000 description 1
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- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001007 puffing effect Effects 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 229960004441 tyrosine Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/10—Culture of aquatic animals of fish
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/515—Animalis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Insects & Arthropods (AREA)
- Health & Medical Sciences (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
The invention belongs to the technical field of aquaculture, and discloses a digestion-aiding fish liquid feed additive, a preparation method and an application thereof. According to the invention, four dominant bacterial strains are added to compete with harmful bacteria for oxygen attachment sites and nutrients, so that the growth of the harmful bacteria is inhibited, and the flora in intestinal tracts of fishes is regulated to be normalized; the raw materials with reasonable proportion are added to promote the proliferation of beneficial bacteria in fish intestinal tracts and improve the feed conversion rate, thereby balancing the nutritional ingredients in the fish feed, helping the fish digestion and meeting the requirements of the fish in each growth period.
Description
Technical Field
The invention belongs to the technical field of aquaculture, and relates to a feed additive and a preparation method thereof, in particular to a digestion-aiding fish liquid feed additive and a preparation method and application thereof.
Background
The ornamental fish is fish with ornamental value, bright color or peculiar shape, has various varieties, beautiful body, bright color and elegant swimming appearance, is deeply favored by the majority of fish enthusiasts, and more people for breeding the ornamental fish. In the process of feeding ornamental fishes, requirements on fish feed are strict in addition to requirements on external factors such as water quality, fish tanks, oxygen and the like. In the current market, the ornamental fish feed has a plurality of defects, the feed has single components, incomplete nutritional ingredients and poor palatability, and dyspepsia of the ornamental fish is easily caused, even the ornamental fish is eaten by overeating and dies; if the fed fish feed is not eaten in time, the fish feed floats on the water surface to pollute the water quality, so that the aquarium fish is diseased and died. In order to solve the problem of insufficient nutritional ingredients of the aquarium fish feed, most of the aquarium fish feed sold in the market is prepared by mixing raw materials, puffing, granulating, drying and forming and other processes, and high-temperature drying inevitably loses part of nutritional ingredients such as vitamins and proteins, so that comprehensive nutritional ingredients cannot be provided for the aquarium fish.
Disclosure of Invention
The invention aims to provide a digestion-aiding fish liquid feed additive to balance nutrient components in fish feed, help fish digestion and meet the requirements of fish in each growth period;
the invention also aims to provide a preparation method of the digestion-aiding fish liquid feed additive;
still another object of the present invention is to provide an application of the liquid feed additive for fish for aiding digestion.
In order to achieve the purpose, the invention adopts the technical scheme that:
a digestion-aiding fish liquid feed additive contains four probiotics, namely bacillus licheniformis, enterococcus faecium, lactobacillus acidophilus and bifidobacterium animalis;
the raw materials for preparing the effective components of the digestion-aiding fish liquid feed additive in every 1000 volume parts comprise:
main materials: 3-15 parts of compound amino acid, 0.2-0.6 part of saccharicterpenin, 0.3-0.8 part of galactooligosaccharide, 0.2-0.9 part of mannooligosaccharide, 0.3-1.5 parts of cellulase, 0.3-1.6 parts of yeast cell wall powder and 2-8 parts of compound vitamin;
auxiliary materials: 0.2-0.6 part of antioxidant and 0.1-0.3 part of complexing agent;
supplementing to 1000 parts by volume with sterile water;
wherein, the proportion relation of the parts by weight to the parts by volume is 1 kg: 1L;
bacillus licheniformis and enterococcus faecium were purchased from Oucaceae Behcer Biotech Ltd;
lactobacillus acidophilus and Bifidobacterium animalis were purchased from Jiayi bioengineering, Inc., of middle-school of Shandong;
the cellulase (with enzyme activity of 10000U/g) is purchased from Shandong Su Koehan bioengineering GmbH;
in the present invention, these probiotics and cellulases are used, but not limited to the probiotics and cellulases of the above companies, and it is to be understood that the probiotics to be referred to in the technical solution claimed in the present invention are all probiotics of the same genus and the cellulases to be referred to are all cellulases having the same performance.
As a limitation, the raw materials for preparing the effective components of the digestion-aiding fish liquid feed additive per 1000 parts by volume further comprise: 3-10 parts of bacillus licheniformis powder, 2-8 parts of enterococcus faecium powder, 1-6 parts of lactobacillus acidophilus powder and 1-5 parts of bifidobacterium animalis powder.
As another limitation, in the digestion-aiding fish liquid feed additive, the content of the bacillus licheniformis in the digestion-aiding fish liquid feed additive is more than or equal to 3.0 multiplied by 105CFU/mL, enterococcus faecium content greater than or equal to 2.0 × 105CFU/mL, Lactobacillus acidophilus content not less than 1.0 × 105CFU/mL and the content of animal bifidobacterium is more than or equal to 1.0 multiplied by 104CFU/mL。
As a third limitation, the raw materials for preparing the effective components of the compound amino acid comprise, by weight: 2.5-4.5 parts of lysine hydrochloride, 2-4 parts of arginine hydrochloride and 0.1-0.7 part of tyrosine.
As a fourth definition, the antioxidant is sodium bisulfite, anhydrous sodium sulfite, sodium metabisulfite, thiourea, or dibutylhydroxytoluene;
the complexing agent is disodium ethylene diamine tetraacetate or citric acid.
The invention also provides a preparation method of the digestion-aiding fish liquid feed additive, which comprises the steps of adding the main material and the auxiliary material into sterile water, dissolving, filtering and sterilizing, then adding the four probiotics, uniformly mixing and fixing the volume to obtain the digestion-aiding fish liquid feed additive.
As a limitation, both the dissolving and the blending are performed at room temperature.
As another limitation, the filter sterilization is performed using a microporous filter membrane.
As a third limitation, the temperature for filtration sterilization is 4-8 ℃;
the digestion-aiding fish liquid feed additive also needs to be filled at room temperature.
The invention also provides an application of the digestion-aiding fish liquid feed additive, and the digestion-aiding fish liquid feed additive is added into fish feed for feeding fish so as to promote the digestion of the fish.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
according to the invention, beneficial bacteria such as lactobacillus and bacillus can be used as members of inherent flora in fish bodies, and can be planted in fish digestive tracts, antagonize potential pathogenic bacteria, maintain intestinal microecological balance, compete for oxygen attachment sites and nutrients with harmful bacteria, competitively inhibit the growth of the harmful bacteria, regulate the intestinal flora of fish to be normalized and enhance the disease resistance; the four probiotics are metabolized to generate organic acid, so that the pH value in the intestinal tract can be reduced, and harmful bacteria which are not acid-resistant can be killed;
the bacillus licheniformis can generate various digestive enzymes, is beneficial to decomposing feed nutrients, synthesizing nutrient substances such as growth promoting factors and the like, and stimulating intestinal immune cells, so that local immune antibodies are increased, and the disease resistance of an organism is enhanced;
enterococcus faecium can be quickly adhered to the intestinal mucosa, and pathogenic bacteria are inhibited from adhering to the intestinal mucosa through exclusion effect, so that an intestinal barrier is formed, the intestinal health is protected, and the micro-ecological balance is maintained. Enterococcus faecium can also produce substances such as lactic acid, bacteriocin, hydrogen peroxide and the like in the metabolic process, so that the pH value of the intestinal tract is reduced, the reproduction of pathogenic bacteria in the intestinal tract is inhibited, the microecological balance of the intestinal tract is maintained and adjusted, the contents of endotoxin and urease in the intestinal tract are reduced, the contents of toxin and ammonia in blood are reduced, the organ maturation of fishes is promoted, and the physiological state of the fishes is improved. Enterococcus faecium can also produce various nutrient substances (such as vitamins, amino acids, growth promotion factors and the like), and the nutrient substances can participate in fish metabolism and promote fish growth. The enterococcus faecium can also induce organisms to generate cytokines, interferon, interleukin and the like, enhance the nonspecific immunity of the organisms, improve the disease resistance, reduce the inflammatory reaction and promote the intestinal health;
the lactobacillus acidophilus can secrete antibiotic substances, such as acidophilic lactobacillus (acidophilolin), acidophilic lactobacillus (acidophilophilin), lactobacillin (1 aerocidon) and the like, and has antagonistic action on intestinal pathogenic bacteria, so that the effects of regulating the balance of intestinal flora and inhibiting the proliferation of harmful bacteria in the intestinal tract are achieved;
the bifidobacterium animalis can secrete a large amount of short-chain fatty acids to acidify the intestinal tract, control abnormal fermentation of harmful bacteria, increase the osmotic pressure in the intestinal tract, stimulate gastrointestinal peristalsis and promote defecation;
according to the invention, by adding the compound amino acid, saccharicterpenin, galactooligosaccharide, mannooligosaccharide, cellulase, yeast cell wall powder and compound vitamin in a reasonable ratio, the multiplication of beneficial bacteria in fish intestinal tracts can be promoted, the feed conversion rate is improved, the fish organism immunity is enhanced, the disease resistance of fish is stimulated, especially the immunity and the disease resistance of ornamental fish are enhanced, the healthy growth of the ornamental fish is promoted, and the beautiful body color is formed, wherein the survival rate of the ornamental fish is more than 95%;
the compound amino acid contains lysine, arginine and tyrosine;
lysine is a limiting amino acid, the balance degree of the amino acid can be improved, the amino acid and the protein in the feed have the highest nutritional value, and the digestion utilization rate of the protein in the feed is improved;
the addition of a proper amount of arginine can promote the growth of the fish and also can improve the intestinal tract morphological structure of the fish;
tyrosine is an important nutritional essential amino acid and plays an important role in the metabolism, growth and development of fishes;
after the saccharicterpenin is fed, the immunity and disease resistance of fish organisms can be obviously enhanced, the growth is promoted, the daily gain and the feed conversion rate are improved, the anti-stress and anti-oxidation effects are achieved, and meanwhile, the saccharicterpenin has a strong prevention effect on intestinal bacterial diseases;
the galacto-oligosaccharide can selectively promote the proliferation of beneficial bacteria in the intestinal tracts of the aquatic animals, and the beneficial bacteria utilize oligosaccharide fermentation to generate short-chain fatty acid, reduce the pH value of the intestinal tracts, inhibit pathogenic bacteria from consuming nutrients in vivo and reduce the generation of toxic and pathogenic metabolites, thereby maintaining and improving the health of the aquatic animals; the mannan oligosaccharide can improve the immune response capability of organisms to drugs and antigens and enhance the immune capability of aquatic animals;
the cellulase can promote the digestion and absorption of feed and promote the ingestion and growth of aquatic animals; the cellulase has effects of improving digestive system function, increasing feed effect, and reducing content of nutrients in excrement.
The yeast cell wall powder has the functions of stimulating and enhancing immunity, and can enhance the resistance to diseases and environmental changes and improve the survival rate in the face of the stress of water environment changes;
the compound vitamin comprises vitamin D, vitamin E, and vitamin B1. Vitamin D is an essential substance for keeping calcium and phosphorus in fish body balance; the vitamin E plays a role in resisting oxidation; vitamin B1Is a coenzyme of a plurality of enzymes catalyzing carbohydrate metabolism, and is essential for carbohydrate metabolism, appetite promotion, normal digestion, growth and reproduction; when vitamin B is present1In case of deficiency, the fishes show abnormal conditions of easy fright, anorexia and swimming;
the feed additive is dissolved and mixed at room temperature, and is filtered and sterilized at low temperature, so that the loss of nutrient components caused by the conventional feed preparation process can be effectively avoided;
the invention has wide raw material source and low cost, and can bring good economic benefit for breeding enterprises.
The digestion-aiding fish liquid feed additive is used for being added into fish feed to feed fishes, and is particularly suitable for feeding ornamental fishes.
Detailed Description
The present invention is further illustrated by the following specific examples, which are to be construed as merely illustrative, and not limitative of the remainder of the disclosure.
Example 1 preparation of a digestive liquid feed additive for fish
The preparation method of the 1000L digestion-aiding fish liquid feed additive comprises the following steps in sequence:
1) 2.8kg of lysine hydrochloride, 2.5kg of arginine hydrochloride and 0.4kg of tyrosine are taken and mixed evenly to obtain the compound amino acid (marked as FA 1).
2) Collecting 1.5kg vitamin D, 1kg vitamin E and 0.8kg vitamin B1And mixing uniformly to obtain the compound vitamin (marked as W1).
3) Adding 5.7kg of compound amino acid A1, 0.2kg of saccharicterpenin, 0.4kg of galacto-oligosaccharide, 0.3kg of mannooligosaccharide, 0.8kg of cellulase (enzyme activity is 10000U/g), 0.6kg of yeast cell wall powder, 4kg of compound vitamin W1, 0.35kg of sodium bisulfite and 0.15kg of disodium ethylene diamine tetraacetate into 700L of sterile water (recorded as sterile water for dissolution), stirring and dissolving at room temperature, cooling to 5 ℃, filtering and sterilizing by a microporous filter membrane sterilizing filter with the diameter of 0.22 mu m, and then adding 4kg of bacillus licheniformis powder (the content of bacillus licheniformis is 1.03 multiplied by 10)8CFU/g), 3kg enterococcus faecium powder (enterococcus faecium content is 1.02 × 10)8CFU/g), 2kg Lactobacillus acidophilus powder (Lactobacillus acidophilus content is 1.01 × 10)8CFU/g) and 2kg Bifidobacterium animalis powder (Bifidobacterium animalis content of 1.05 × 10)7And (3) stirring and mixing the CFU/g uniformly at room temperature, and then adding sterile water to a constant volume of 1000L to obtain the digestion-aiding fish liquid feed additive.
Aseptically packaging the digestion-promoting fish liquid feed additive at room temperature to obtain commercially available digestion-promoting fish liquid feed additive (labeled as N1) containing 4.12 × 105CFU/mL Bacillus licheniformis, 3.06X 105CFU/mL enterococcus faecium, 2.02X 105CFU/mL Lactobacillus acidophilus and 2.1X 104CFU/mL Bifidobacterium animalis.
The digestion-aiding fish liquid feed additive prepared in the embodiment is used for being added into fish feed to feed fishes, and is particularly suitable for feeding ornamental fishes.
Example 2-6 preparation method of digestion-promoting fish liquid feed additive
Examples 2 to 6 are methods for preparing a digestion-aiding liquid fish feed additive, which have substantially the same steps as in example 1, but differ only in the amount of raw materials and process parameters, as detailed in table 1:
table 1 summary of the process parameters
The contents of the other portions of examples 2 to 6 are the same as those of example 1.
EXAMPLE 7 use of a liquid Fish feed additive to aid digestion
700 peacock fishes (half of male and half of female) with 7 days old and good health condition are selected and randomly divided into 7 groups, each group comprises 100 peacock (half of male and half of female), a control group and A1-A6 groups, wherein the control group is fed with common commercial fish feed (Italian small fish feed), the A1-A6 group is also fed with common commercial fish feed (Italian small fish feed), meanwhile, the A1-A6 group is also fed with liquid feed additives N1-N6 respectively, the addition amount is 0.5 percent of the fish feed amount, the feeding is carried out for 1 time every day, and the test period is 90 days according to the standard feeding method of the peacock fishes under other conditions of illumination, oxygen, water changing and the like. The health condition, fish body performance, and the like of the sparrow fish are observed every day during the test period, statistics is carried out, and the specific results are shown in the following table:
TABLE 2 summary of the effects of the use of the liquid fish feed additive for aiding digestion
As can be seen from table 2, the average body weight of peacock fish increases with the day-old peacock fish, but the average body weight of peacock fish after 90 days in the a1-a6 groups was 1.9g or more higher than that of the control group, the survival rate of the a1-a6 groups was 13% higher than that of the control group, and the fish body appearance with bright color and uniform body color was exhibited after 90 days in the a1-a6 groups, while the fish body appearance with dark color was exhibited in the control group. The experimental results prove that the digestion-aiding fish liquid feed additive prepared by the invention is beneficial to balancing the nutrient components in fish feed, improving the feed conversion rate, accelerating the growth and development of fish, enhancing the immunity and disease resistance of fish, improving the survival rate, promoting the healthy growth of ornamental fish and forming bright body color.
Claims (10)
1. A fish liquid feed additive for aiding digestion is characterized in that,
the digestion-aiding fish liquid feed additive contains four probiotics, namely bacillus licheniformis, enterococcus faecium, lactobacillus acidophilus and bifidobacterium animalis;
the raw materials for preparing the effective components of the digestion-aiding fish liquid feed additive in every 1000 volume parts comprise:
main materials: 3-15 parts of compound amino acid, 0.2-0.6 part of saccharicterpenin, 0.3-0.8 part of galactooligosaccharide, 0.2-0.9 part of mannooligosaccharide, 0.3-1.5 parts of cellulase, 0.3-1.6 parts of yeast cell wall powder and 2-8 parts of compound vitamin;
auxiliary materials: 0.2-0.6 part of antioxidant and 0.1-0.3 part of complexing agent;
supplementing 1000 parts by volume of water;
wherein, the proportion relation of the parts by weight to the parts by volume is 1 kg: 1L of the compound.
2. The liquid fish feed additive according to claim 1, wherein the raw materials for preparing the effective components of the liquid fish feed additive according to 1000 parts by volume further comprise: 3-10 parts of bacillus licheniformis powder, 2-8 parts of enterococcus faecium powder, 1-6 parts of lactobacillus acidophilus powder and 1-5 parts of bifidobacterium animalis powder.
3. The liquid fish feed additive as claimed in claim 1, wherein the content of Bacillus licheniformis in the liquid fish feed additive is not less than 3.0X 105CFU/mL, enterococcus faecium content greater than or equal to 2.0 × 105CFU/mL, Lactobacillus acidophilus content not less than 1.0 × 105CFU/mL and the content of animal bifidobacterium is more than or equal to 1.0 multiplied by 104CFU/mL。
4. The digestion-aiding fish liquid feed additive according to any one of claims 1 to 3, wherein the raw materials for preparing the effective components of the compound amino acid comprise, by weight: 2.5-4.5 parts of lysine hydrochloride, 2-4 parts of arginine hydrochloride and 0.1-0.7 part of tyrosine.
5. The liquid digestive fish feed additive according to any one of claims 1 to 3,
the antioxidant is sodium bisulfite, anhydrous sodium sulfite, sodium metabisulfite, thiourea or dibutyl hydroxy toluene;
the complexing agent is disodium ethylene diamine tetraacetate or citric acid.
6. A preparation method of the digestion-aiding fish liquid feed additive as claimed in any one of claims 1 to 5, characterized in that the digestion-aiding fish liquid feed additive is obtained by adding the main material and the auxiliary material into water, dissolving, filtering and sterilizing, then adding the four probiotics, mixing uniformly and fixing the volume.
7. The method for preparing a liquid feed additive for fish according to claim 6, wherein the dissolving and the mixing are performed at room temperature.
8. The method for preparing a liquid feed additive for digestive fishes according to claim 6 or 7, wherein the filtration sterilization is performed by using a microporous membrane.
9. The method for preparing the digestion-aiding fish liquid feed additive according to claim 6 or 7, wherein the temperature for filtration sterilization is 4-8 ℃.
10. Use of the digestive fish liquid feed additive according to any one of claims 1 to 5, wherein the digestive fish liquid feed additive is added to fish feed for feeding fish to promote fish digestion.
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