CN114127086A - 氘代肽酰胺类化合物及其制备方法和在医药上的用途 - Google Patents
氘代肽酰胺类化合物及其制备方法和在医药上的用途 Download PDFInfo
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- CN114127086A CN114127086A CN202080030216.6A CN202080030216A CN114127086A CN 114127086 A CN114127086 A CN 114127086A CN 202080030216 A CN202080030216 A CN 202080030216A CN 114127086 A CN114127086 A CN 114127086A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
本发明涉及一种通式(I)所示的化合物或其立体异构体、水合物、代谢产物、溶剂化物、药学上可接受的盐或共晶及其组合物、制备方法和在医药上的用途，通式(I)如下所示，各取代基的定义与说明书中一致。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN101535336A (zh) * | 2006-11-10 | 2009-09-16 | 卡拉治疗学股份有限公司 | 合成酞酰胺及其二聚体 |
| US20110212882A1 (en) * | 2006-11-10 | 2011-09-01 | Cara Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| WO2019015644A1 (zh) * | 2017-07-21 | 2019-01-24 | 四川海思科制药有限公司 | 肽酰胺类化合物及其制备方法和在医药上的用途 |
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| US5965701A (en) * | 1997-12-23 | 1999-10-12 | Ferring Bv | Kappa receptor opioid peptides |
| NZ577107A (en) * | 2006-11-10 | 2012-01-12 | Cara Therapeutics Inc | Synthetic peptide amide ligands of the kappa opiod receptor |
| US8457848B2 (en) * | 2007-10-31 | 2013-06-04 | Deere & Company | Work machine with IVT output automatically adjusted dependent upon engine load |
| WO2016181408A2 (en) * | 2015-05-11 | 2016-11-17 | Cadila Healthcare Limited | NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST |
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| CN101535336A (zh) * | 2006-11-10 | 2009-09-16 | 卡拉治疗学股份有限公司 | 合成酞酰胺及其二聚体 |
| US20110212882A1 (en) * | 2006-11-10 | 2011-09-01 | Cara Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| WO2019015644A1 (zh) * | 2017-07-21 | 2019-01-24 | 四川海思科制药有限公司 | 肽酰胺类化合物及其制备方法和在医药上的用途 |
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| TWI769493B (zh) | 2022-07-01 |
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