CN1141161A

CN1141161A - Mouthwash for cleaning mouth and health-care

Info

Publication number: CN1141161A
Application number: CN 95108486
Authority: CN
Inventors: 李雄伟; 郭维薇
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-07-27
Filing date: 1995-07-27
Publication date: 1997-01-29

Abstract

Said health-care gargle contains no special-purpose steirlizing agent, and contains a certain quantity of polyphenol type edible plant extract and 2-6% of polyether high-molecular material whose heavy average molecular weight is 1.5-2.5 X 10000 as its active components. Said gargle is safe, non-toxic, free from irritation, and can kill several pathogens in mouth cavity, can improve the tension of tooth surface and inhibit the formation of dental plaque and dental calculus, remove ozostomia, and has the good effects for preventing and curing odontopathies, dental caries, peridentitis, and ulcer of mouth cavity.

Description

Mouthwash for cleaning mouth and health-care

The present invention relates to oral cavity cleaning gargarism for health care and active component thereof, belong to health care commodity field.

China is a populous nation, has 80% above population to suffer from oral diseases such as dental caries, gingivitis, halitosis.Existing oral cavity cleaning health-care method is to use toothpaste toothbrush.Yet toothpaste has certain limitation to the control of oral disease, and many oral pathology patients also are the user of toothpaste.Simultaneously, the improper use of toothbrush often causes the mechanical damage of tooth, even causes other oral diseases.Therefore, new and effective oral cavity cleaning health product is demanded exploitation urgently.In recent years, be that a class biocide of representative is widely used in oral bacteriostasis with the hibitane, external recent development quaternary ammonium compounds such as Triclonsun be used for oral bacteriostasis.Though above active matter all has fungistatic effect preferably, antihalitosis DeGrain, and mouthfeel bitterness have certain zest and certain toxicity to mucosa.

Gargarism is easy to use, and the position that the teeth space toothbrush can't touch is goed deep in energy comprehensive engagement oral cavity, and practice shows, uses gargarism can obtain effective oral cavity cleaning health-care effect, abroad it is extensive use of as the oral cavity cleaning health product.Domestic also have a spot of gargarism product, but all be limited to clinical treatment usefulness, can be that number is few as the oral cavity health gargarism for most of people, and its reason is that most of gargarism all contain the antipathogenic composition of hibitane class.Can be almost blank as oral cavity cleaning safe, nontoxic, nonirritant for health care, efficient gargarism for most of people.

Natural polyphenol class plant extract is a kind of mixture that contains the fragrant phenol of kind more than 30.It is extracted and is got by natural edible-plant, and long edible history is arranged in the human lives, is to guarantee safety to health.Through safety evaluation, anxious toxicity test rat LD50, female Mus 12.6g/kg, male Mus 10.8g/kg, its coefficient k of accumulation test＞5.3, the property accumulated a little less than the genus; Micronucleus test dosage reaches 0.73g/kg, and to the effect of mouse bone marrow cells not damaged, ball sexual cell primary spermatocyte does not produce the distortion effect; Salmonella reversion test according to " food safety toxicity study assessment process " regulation, is determined to belong to safe to bacterial strain TA98, TA100, TA97, TA102, no mutagenicity.Show through biocidal property test and applied research, natural polyphenol class plant extract has good sterilization, antiinflammatory, convergence, complexation function, and multiple pathogen such as staphylococcus aureus, streptococcus, dysentery bacterium, Bacillus typhi are had the obvious suppression effect; Simultaneously can also alleviate the murder by poisoning of heavy metal, absorb and eliminate abnormal flavour human body.At present with this Application and Development in the natural food antisepsis antistaling agent.Because the natural polyphenol class is planted and is got the above-mentioned characteristic that thing has, so can be used as the effective ingredient of oral cavity cleaning health product.Its sterilization, antiinflammatory, astriction can suppress pathogen in intraoral growth, control periodontitis, gingivitis, oral ulcer and dental caries; Its convergence, complexing energy cracking halitosis composition absorb counteract oral malodour; It is safe, nontoxic, nonirritant, good mouthfeel, easily is that people accept, can long-term regular use.With existing with the hibitane be main component the oral cavity cleaning health product relatively, with natural polyphenol class plant extract is nontoxic, the nonirritant of oral cavity cleaning health product of active component, safety, comfortable taste improve greatly, the bactericidal antiphlogistic effect is obvious, it is exclusive to eliminate the halitosis effect, a kind of good oral cavity cleaning health product of can yet be regarded as.

Polyether type high polymer (Polyether.PE) is widely used as food and drug additive at present, has the clarification peptizaiton.Since low toxicity, the low irritant of PE, the food additive that FAO of the World Food Programme and the WHO of World Health Organization (WHO) (FAO/WHO, 1985) approval is used for human body.Nearest studies show that PE has good antibiotic, bacteriostasis.Mori.Y studies show that (Trans.Am.Soc.Artif.Drgans, 1982.28.459) handle a kind of alkyd resins with PE, can greatly improve the anti-adhesion ability of this material, the inhibition effect of staphylococcus aureus, table Portugal coccus and bacillus pyocyaneus is reached 70%-90% antibacterial.The research of Bridett etc. shows that also the water-soluble polymer that has the PE side chain has good bacteriostasis antibiosis effect.In view of PE is used in the record of food additive to organism hypotoxicity, low irritant and long-term safety, in the recent period about the research report of fungistatic effect, so PE can be as a kind of effective active composition that keeps healthy as oral cavity cleaning.The water solublity of PE and dispersion effect, can with other components compatibilities, obtain a kind of good oral cavity cleaning health product, such as gargarism, toothpaste etc., these articles for use are to low, the no bitter taste of oral mucosa zest, can overcome existing is the drawback of the oral cavity cleaning health product of main component with the hibitane, is a kind of good oral cavity cleaning health product.

The object of the present invention is to provide a kind of safe, nontoxic, nonirritant, efficient, novel kill the oral cavity pathogen, suppress bacterial plaque adhering on facing, cracking halitosis composition, control periodontitis, gingivitis, oral ulcer and dental caries, eliminate halitosis, suppress the oral cavity cleaning health product that dental calculus forms.

Technology contents of the present invention: with natural polyphenol class plant extract and polyethers form height molecule PE is main raw material(s), assistant is with water-soluble fluorine of available quantity (as the complex of sodium fluoride, potassium fluoride and fluorine sodium monofluorophosphate salt particularly) and mint type essence, essence can be selected in Folium Menthae extracts such as Mentholum, Oleum menthae, L-menthone, menthyl acetate, is mixed with the oral cavity cleaning health product of various dosage forms (as gargarism, spray, toothpaste etc.).

PE weight average molecular weight of the present invention should be in 1.5-2.5 * 10 ⁴Between, the content in gargarism should be 2-6%.

Adopt the present invention to make to have and kill the oral cavity pathogen, improve facing tension force, prevent antibacterial and the albumen formation of adhering to, suppress dental plaque and dental calculus, the cracking halitosis one-tenth on facing grade multifunctional efficient, nontoxic, nonirritant gargarism and other oral cavity cleaning health products.This gargarism can produce good preventive and therapeutic effect to multiple oral disease such as dental caries, periodontitis, gingivitis, dental calculus, oral ulcer, halitosis.

Good effect of the present invention is: owing to adopted natural polyphenol class plant extract and PE among the present invention is main active, do not add hibitane or any other chemical antibacterial, make oral cavity cleaning health products such as gargarism not only have bacteriostatic activity preferably, and with other like products relatively, its toxicity reduces widely, safety improves, to the oral mucosa nonirritant, it is remarkable to eliminate the halitosis effect, the scope of application enlarges, and can obtain one novel, efficient, multiple-effect gargarism and other oral cavity cleaning health products.This gargarism is easy to use, comfortable taste, protect tooth, clean mouthful effective, filled up can for the regular use of most of people, safety non-toxic, nonirritant, the blank of oral cavity cleaning gargarism for health care efficiently.

Be embodiments of the invention below:

Weighing PE20g is with being transferred to behind the dissolved in distilled water in the 1000ml volumetric flask.Weighing natural polyphenol class plant extract 5g is with moving in the volumetric flask behind the 100ml dissolved in distilled water.Weighing sodium fluoride 0.5g is with moving in the volumetric flask behind the dissolved in distilled water.Weighing Mentholum 0.25g adds in the volumetric flask, the vibration mixing, and adding distil water shakes up and makes its dissolving to scale, gets a shallow sepia clear solution.

Claims

Safe, nontoxic a, nonirritant, be used for the gargarism of oral cavity cleaning health care, its active component comprises that the natural polyphenol class plant extract of effective dose and weight percentage are that 2-6%, weight average molecular weight are 1.5-2.5 * 10 ⁴Polyether type high polymer.Gargarism can be killed the oral cavity pathogen, suppresses the formation of dental calculus, and cracking halitosis composition can be prevented and treated multiple oral diseases such as dental caries, periodontitis, gingivitis, oral ulcer, halitosis.
2. natural polyphenol class plant extract and the polyether type high polymer in the claim 1 is used for the purposes of oral cavity cleaning health care, as the prescription of gargarism, toothpaste and other oral cavity cleaning health products containings.