CN114107220B - 噬菌体疗法 - Google Patents

噬菌体疗法 Download PDF

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Publication number
CN114107220B
CN114107220B CN202111287234.5A CN202111287234A CN114107220B CN 114107220 B CN114107220 B CN 114107220B CN 202111287234 A CN202111287234 A CN 202111287234A CN 114107220 B CN114107220 B CN 114107220B
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phage
staphylococcus aureus
phages
aureus
strain
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Chinese (zh)
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CN114107220A (zh
Inventor
辛迪·费弗
海伦妮·布洛伊斯
马修·梅迪纳
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Airuitai Pharmaceutical Co
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Airuitai Pharmaceutical Co
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40Viruses, e.g. bacteriophages
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50Isolated enzymes; Isolated proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10111Myoviridae
    • C12N2795/10121Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10111Myoviridae
    • C12N2795/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10111Myoviridae
    • C12N2795/10131Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10111Myoviridae
    • C12N2795/10132Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10111Myoviridae
    • C12N2795/10171Demonstrated in vivo effect
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10211Podoviridae
    • C12N2795/10221Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10211Podoviridae
    • C12N2795/10222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10211Podoviridae
    • C12N2795/10231Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10211Podoviridae
    • C12N2795/10232Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10211Podoviridae
    • C12N2795/10271Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Agronomy & Crop Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
CN202111287234.5A 2017-03-08 2018-03-07 噬菌体疗法 Active CN114107220B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17305245.7A EP3372085A1 (en) 2017-03-08 2017-03-08 Phage therapy
EP17305245.7 2017-03-08
CN201880016793.2A CN110545670B (zh) 2017-03-08 2018-03-07 噬菌体疗法
PCT/EP2018/055629 WO2018162566A1 (en) 2017-03-08 2018-03-07 Phage therapy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880016793.2A Division CN110545670B (zh) 2017-03-08 2018-03-07 噬菌体疗法

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CN114107220A CN114107220A (zh) 2022-03-01
CN114107220B true CN114107220B (zh) 2025-01-10

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CN202111287234.5A Active CN114107220B (zh) 2017-03-08 2018-03-07 噬菌体疗法
CN201880016793.2A Active CN110545670B (zh) 2017-03-08 2018-03-07 噬菌体疗法

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US (2) US11690885B2 (enExample)
EP (2) EP3372085A1 (enExample)
JP (2) JP7492337B2 (enExample)
CN (2) CN114107220B (enExample)
AU (2) AU2018231408B2 (enExample)
BR (1) BR112019018593A2 (enExample)
CA (1) CA3054874A1 (enExample)
IL (2) IL288099B (enExample)
WO (1) WO2018162566A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3372085A1 (en) 2017-03-08 2018-09-12 Pherecydes Pharma Phage therapy
WO2021146598A1 (en) * 2020-01-17 2021-07-22 Second Genome, Inc. Methods and compositions for treating atopic dermatitis
US20210252083A1 (en) * 2020-02-18 2021-08-19 Armata Pharmaceuticals, Inc. Bacteriophage compositions for treating staphylococcus infection
CZ309429B6 (cs) * 2020-03-31 2023-01-04 MB PHARMA s.r.o Lyofilizovaná testovací sada ke stanovení antimikrobiální biologické účinnosti fágových přípravků na bakterii Staphylococcus aureus
EP4132552A2 (en) * 2020-04-06 2023-02-15 Adaptive Phage Therapeutics, Inc. Method for treating implantable device infections
CA3218291A1 (en) * 2021-05-12 2022-11-17 Lior Moshe ZELCBUCH Staphylococcus bacteriophage and uses thereof
FR3161553A1 (fr) 2024-04-30 2025-10-31 Hospices Civils De Lyon Compositions, en particulier, pharmaceutiques de bactériophages de la classe des Caudoviricetes , procédé et utilisations associés

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1690194A (zh) * 2004-04-26 2005-11-02 何俭 一株治疗金黄色葡萄球菌感染的噬菌体
CN101977616A (zh) * 2008-03-20 2011-02-16 菲托莱恩有限责任公司 制备噬菌体混合物的方法以及该噬菌体混合物在抗生素抗性葡萄球菌治疗中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0800149D0 (en) * 2008-01-04 2008-02-13 Novolytics Ltd Improved host range phage
US7745194B2 (en) * 2008-09-16 2010-06-29 Intralytix, Inc. Staphylococcus aureus: bacteriophage and uses thereof
US8043613B2 (en) * 2009-02-12 2011-10-25 Intron Biotechnology, Inc. Podoviriedae bacteriophage having killing activity specific to Staphylococcus aureus
KR20130142820A (ko) * 2012-06-20 2013-12-30 한국외국어대학교 연구산학협력단 스태필로코커스 아우레우스의 박테리오파아지 및 그 용도
EP2865383A1 (en) 2013-10-25 2015-04-29 Pherecydes Pharma Phage therapy of pseudomonas infections
EP2893933A1 (en) 2014-01-10 2015-07-15 Pherecydes Pharma Phage Therapy of E coli infections
EP3018201A1 (en) 2014-11-07 2016-05-11 Pherecydes Pharma Phage therapy
CN104845942A (zh) * 2015-04-22 2015-08-19 上海交通大学 可裂解多种耐药性金黄色葡萄球菌的噬菌体及其分离方法和用途
US20190167736A1 (en) 2015-07-23 2019-06-06 Enbiotix, Inc. Bacteriophage for treating staphylococcus infections
CN105567647B (zh) * 2015-11-06 2019-06-11 中国海洋大学 一株耐甲氧西林金黄色葡萄球菌噬菌体及其抑菌应用
EP3372085A1 (en) 2017-03-08 2018-09-12 Pherecydes Pharma Phage therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1690194A (zh) * 2004-04-26 2005-11-02 何俭 一株治疗金黄色葡萄球菌感染的噬菌体
CN101977616A (zh) * 2008-03-20 2011-02-16 菲托莱恩有限责任公司 制备噬菌体混合物的方法以及该噬菌体混合物在抗生素抗性葡萄球菌治疗中的用途

Also Published As

Publication number Publication date
JP7492337B2 (ja) 2024-05-29
US12280080B2 (en) 2025-04-22
US20240024391A1 (en) 2024-01-25
US20200030392A1 (en) 2020-01-30
JP2024105630A (ja) 2024-08-06
WO2018162566A1 (en) 2018-09-13
BR112019018593A2 (pt) 2020-04-28
IL288099B (en) 2022-07-01
AU2018231408B2 (en) 2023-07-27
CN110545670B (zh) 2021-11-23
IL288099A (en) 2022-01-01
AU2023251526A1 (en) 2023-11-16
AU2018231408A1 (en) 2019-09-12
IL268905B (en) 2021-12-01
CN114107220A (zh) 2022-03-01
EP3592150A1 (en) 2020-01-15
EP3372085A1 (en) 2018-09-12
US11690885B2 (en) 2023-07-04
CN110545670A (zh) 2019-12-06
JP2020510024A (ja) 2020-04-02
CA3054874A1 (en) 2018-09-13
IL268905A (en) 2019-10-31

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