CN114052155A - Formula and preparation method of morin - Google Patents
Formula and preparation method of morin Download PDFInfo
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- CN114052155A CN114052155A CN202111169165.8A CN202111169165A CN114052155A CN 114052155 A CN114052155 A CN 114052155A CN 202111169165 A CN202111169165 A CN 202111169165A CN 114052155 A CN114052155 A CN 114052155A
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- cyclocarya paliurus
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 238000009472 formulation Methods 0.000 title claims description 19
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- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 title claims description 8
- 235000007708 morin Nutrition 0.000 title claims description 8
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Polymers & Plastics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
A new formula of folium Mori and its preparation method are provided. The main components of the composition comprise: cyclocarya paliurus leaf extract, mulberry leaf extract and auxiliary materials comprise isomaltitol, soybean peptide, corn oligopeptide, collagen peptide, xylitol and resistant dextrin. The preparation method comprises extracting cyclocarya paliurus extract and folium Mori extract with the above formula, centrifuging, filtering, concentrating, adding adjuvants, removing solvent by suitable drying method, and pulverizing. The invention can effectively improve the dissolution speed of the mulberry leaf extract, solves the characteristic of strong hygroscopicity of the cyclocarya paliurus extract, and the obtained solid instant granules have good solubility, pure and sweet mouthfeel. Has good effect of reducing blood sugar. The preparation method is simple, has strong repeatability and can be applied to industrial scale-up production.
Description
Technical Field
The invention belongs to the technical field of health food processing, relates to new resource food, and particularly relates to a new mulberry leaf formula and a preparation method thereof.
Background
Mulberry (Latin name: Morus alba L.) is Moraceae, Morus deciduous tree or shrub, has about four thousand years of cultivation history in the middle of China, and has wide cultivation range, namely south of Harbin in northeast; northwest of the provinces from the southern part of inner Mongolia to Xinjiang, Qinghai, Gansu, Shaanxi; south to guangdong, guangxi, east to taiwan; west to Sichuan, Yunnan; the most cultivation is carried out in various places in the middle and lower reaches of the Yangtze river. The vertical distribution is mostly below the elevation 1200 m. The resources are extremely rich.
The compendium of materia Medica records: decoction is used as tea, and can relieve thirst, cough due to internal heat, and improve eyesight. According to the traditional Chinese medicine, the mulberry leaves are cold in nature and sweet and bitter in taste, enter lung and liver meridians, and are named as Shenxian leaves by ancient people. The mulberry leaf is particularly good at clearing lung heat and moistening lung dryness, and has better effect on treating fever cough and yellow phlegm caused by wind heat, or dry cough with little phlegm, pharynx itch and other symptoms caused by dry heat.
Cyclocarya paliurus (Latin name: Cyclocaraya palaurus.) is also called as Cyclocarya paliurus: cyclocarya paliurus, salix caprae, and ashitaba tree. The plants of the juglandaceae and cyclocarya paliurus are found in more provinces in the south of China and are distributed sporadically. Produced in Hunan, Anhui, Jiangsu, Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Sichuan, Guizhou, Guangxi, Guangdong and southeast Yunnan. Cyclocarya paliurus is a rare tree species which survives in glacier season and only exists in China. Cyclocarya paliurus leaves can regulate blood sugar and blood fat, protect and repair islet cells, and are called the third tree in the medical field.
The main active ingredients of cyclocarya paliurus comprise polysaccharide, triterpene, flavone, phenolic acid and the like. Provides a good material basis for regulating the glycolipid metabolism. Chenmandui and the research progress of looking at the senecio in the regulation of glycolipid metabolism active components and action mechanism of cyclocarya paliurus (food industry science and technology 2021, vol42 (11): 382 and 389) introduce the action mechanism of cyclocarya paliurus for reducing blood sugar, including the protection of islet cells, the regulation of insulin signal pathways, the promotion of glucose utilization, the inhibition of inflammatory response, the regulation of miRNAs expression, the immunoregulation action and the like, and the sugar metabolism disorder is improved through the action.
The mulberry leaves and the cyclocarya paliurus leaves are new resource foods and have exact effect on reducing blood sugar. But the disadvantages of the two are also obvious: firstly, the taste is special, and the food is not suitable for direct eating: the mulberry leaf tea has beany flavor, and the cyclocarya paliurus leaves are bitter and astringent in flavor. Secondly, the mulberry leaf extract has poor water solubility; and thirdly, the cyclocarya paliurus leaf extract has good dissolvability, strong hygroscopicity and poor stability.
The application of the mulberry leaves and the cyclocarya paliurus is limited by the problems, the living standard of people is continuously improved, and in order to provide a healthy food which is good in curative effect, good in taste, rapid in dissolution, convenient to carry and good in stability, the technical process level of the food is improved, a new food manufacturing process is urgently needed to be developed to meet the application requirements.
Disclosure of Invention
The invention particularly provides a new resource food-a formula of mulberry leaf and a preparation process thereof. The preparation process is simple, good in reproducibility and easy for industrial amplification. The method comprises the following specific steps:
the formula of the morin is characterized by comprising the following main components:
the mulberry leaf extract is 0.8-4.0 weight parts of mulberry leaf
Equivalent to 0.8-2.0 parts by weight of cyclocarya paliurus leaf extract
1.6 to 12.0 parts by weight of isomalt
0-1.0 part by weight of soybean peptide
0-1.0 part by weight of corn oligopeptide
0-2.0 parts by weight of collagen peptide
0 to 1.0 part by weight of xylitol
0 to 1.0 part by weight of resistant dextrin
0 to 1.0 part by weight of maltodextrin.
The extract and auxiliary materials are prepared according to a specific preparation process to prepare the mulberry leaf granules.
Preferably, the formula of the folium mori comprises the following components:
the mulberry leaf extract is 0.8-1.0 weight part of mulberry leaf
Equivalent to 0.8-1.0 weight part of cyclocarya paliurus leaf extract
0.01-0.1 part by weight of soybean peptide
1.8 to 4.0 parts by weight of isomalt
0.01-0.1 part by weight of corn oligopeptide
0.5-1.2 parts by weight of collagen peptide
0.3 to 0.5 part by weight of xylitol
0.4 to 0.6 part by weight of resistant dextrin
0.4 to 0.6 part by weight of maltodextrin.
More preferably, the formula of the mulberry leaf comprises the following components:
folium Mori extract 1.0 weight parts of folium Mori
Equivalent to 1.0 weight part of cyclocarya paliurus leaf extract
Isomalt 2.45 parts by weight
0.05 part by weight of soybean peptide
Corn oligopeptide 0.05 weight part
Collagen peptide 0.65 weight part
0.3 part by weight of xylitol
0.5 part by weight of resistant dextrin
0.5 part by weight of maltodextrin.
Wherein the folium Mori extract is folium Mori water extract. The preparation process comprises the following steps: the preparation raw material is mulberry leaf tea, including dry mulberry leaves obtained by various processing methods. The method specifically comprises the following steps: pulverizing folium Mori, mechanically pulverizing dried folium Mori, and sieving with 40-80 mesh sieve; adding purified water with the amount of 12-20 times of the purified water, and extracting at 70-90 deg.C under the same conditions for 0.5-2 hr twice. Mixing extractive solutions, centrifuging at 3000-.
Wherein the cyclocarya paliurus leaf extract is cyclocarya paliurus leaf water extract. The preparation process comprises the following steps: the preparation raw material is cyclocarya paliurus, including cyclocarya paliurus leaves obtained by various processing methods. The method specifically comprises the following steps: pulverizing cyclocarya paliurus leaf raw material, mechanically pulverizing dried cyclocarya paliurus leaf, and sieving with 40-80 mesh sieve; adding purified water with the amount of 12-20 times of the purified water, and extracting at 70-90 deg.C under the same conditions for 0.5-2 hr twice. Mixing extractive solutions, centrifuging at 3000-.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, and mixing. And (5) packaging to obtain the product.
The isomaltitol serving as the auxiliary material selected in the invention has the effects of controlling blood sugar and reducing fat, and the soybean peptide has various physiological activities including oxidation resistance, blood pressure reduction, cholesterol reduction, blood fat reduction, fatigue resistance, immunity enhancement and the like. The corn oligopeptide has the functions of resisting oxidation, resisting hypertension, enhancing strength, resisting fatigue, protecting liver and the like. The collagen peptide has the effects of resisting oxidation, whitening skin and protecting liver and stomach, and the xylitol and the resistant dextrin are acceptable additive food for diabetics. The composition of the raw and auxiliary materials gives attention to the nutrition supplement and the body immunity regulation on the basis of reducing blood sugar. All selected components are food, so the beverage can be drunk by ordinary people and is particularly suitable for people with blood sugar control requirements.
The formula of the invention can be prepared into dosage forms such as the mulberry leaf granules and the like which are convenient to eat.
The formula of the invention comprises: (1) the beany flavor of the mulberry leaves is eliminated, the bitter taste of the cyclocarya paliurus leaves is overcome, and the problem of compliance is solved; (2) the invention solves the problem of poor water solubility of the mulberry leaf extract, and provides a new formula and a new resource food which are quick to dissolve and convenient to use; (3) the problems of strong hygroscopicity and poor stability of the cyclocarya paliurus leaf extract are solved; (4) the sugar dosage is reduced, the design of complete sugar-free is realized, the favor of people on low-calorie and sugar-free food is met, the special requirements of people with sensitive blood sugar are met, and the national health is promoted.
Drawings
FIG. 1 is a graph comparing the moisture absorption curves of example 2 and example 3;
FIG. 2 is a graph showing a comparison of moisture absorption curves of examples 1 and 2, and 1+ 2, 3, and 4.
Detailed Description
Example 1 preparation of mulberry leaf extract
Taking medicinal and edible mulberry leaves (including mulberry leaves obtained by various processing methods) as raw materials, and comprising the following steps:
1. the mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate is filtered by a ceramic membrane until the solution is clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, concentrating the medicinal liquid, drying the concentrated extract in a 60 deg.C oven, and pulverizing.
Example 2 preparation of cyclocarya paliurus extract
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate is filtered by a ceramic membrane until the solution is clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, concentrating the medicinal liquid, drying the concentrated extract in a 60 deg.C oven, and pulverizing.
Example 3 preparation of Isomaltol granules from folium Mori and cyclocarya paliurus
Table 1 example 3 formulation
| |
|
| Mulberry Leaves | 1.0g |
| Cyclocarya paliurus leaf | 1.0g |
| Isomalt | 2.45g |
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Example 4 preparation of Isomaltulitol particles from folium Mori and cyclocarya paliurus
Table 2 example 4 formulation
| |
|
| Mulberry Leaves | 1.0g |
| Cyclocarya paliurus leaf | 1.0g |
| Isomalt | 1.2g |
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes.
Example 5 preparation of a granule formulation of Phellinus Linteus
Table 3 example 5 formulation
| |
|
| Mulberry Leaves | 1.0g |
| Cyclocarya paliurus leaf | 1.0g |
| Isomalt | 1.2g |
| Soybean peptide | 0.05g |
| Corn oligopeptide | 0.05g |
| Collagen peptide | 0.65g |
| Xylitol, its preparation method and use | 0.3g |
| Resistant dextrins | 0.5g |
| Maltodextrin | 0.5g |
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, and mixing. And (5) packaging to obtain the product.
The granules in the formula 3 prepared by the process are dissolved quickly, and have mellow and sweet mouthfeel.
Example 6 preparation of a granule formulation of Phellinus Linteus
Table 4 example 6 formulation
| |
|
| Mulberry Leaves | 1.0g |
| Cyclocarya paliurus leaf | 0.8g |
| Isomalt | 2.2g |
| Soybean peptide | 0.05g |
| Corn oligopeptide | 0.05g |
| Collagen peptide | 0.65g |
| Xylitol, its preparation method and use | 0.3g |
| Resistant dextrins | 0.5g |
| Maltodextrin | 0.5g |
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 80 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 80 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol according to formula proportion, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, mixing, and packaging.
The prescription 4 prepared by the process is quickly dissolved, and tastes mellow and sweet.
Example 7 preparation of a granule formulation of Phellinus Linteus
Table 5 example 7 formulation
| |
|
| Mulberry Leaves | 0.8g |
| Cyclocarya paliurus leaf | 1.0g |
| Isomalt | 2.20g |
| Soybean peptide | 0.05g |
| Corn oligopeptide | 0.05g |
| Collagen peptide | 0.65g |
| Xylitol, its preparation method and use | 0.3g |
| Resistant dextrins | 0.5g |
| Maltodextrin | 0.5g |
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 90 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 90 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol according to formula proportion, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, mixing, and packaging.
The prescription 5 prepared by the process is quickly dissolved, and tastes mellow and sweet.
Example 8 preparation of a granule formulation of Phellinus Linteus
Table 6 example 8 formulation
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol according to formula proportion, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, and mixing. And (5) packaging to obtain the product.
The prescription 4 prepared by the process is quickly dissolved, and tastes mellow and sweet.
Example 9 preparation of a granule formulation of Phellinus Linteus
Table 7 example 9 formulation
Taking medicinal and edible mulberry leaves (including dried mulberry leaves and mulberry leaf tea obtained by various processing methods) as raw materials, and comprising the following steps:
1. the dried mulberry leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. The filtered solution is concentrated under reduced pressure at 60 ℃, and the liquid medicine is concentrated to 1.4g which is equivalent to 1.0g of mulberry leaves.
The method takes cyclocarya paliurus leaves (including cyclocarya paliurus leaves obtained by various processing methods) with homology of medicine and food as raw materials, and comprises the following steps:
1. the cyclocarya paliurus leaves are mechanically crushed and sieved by a 60-mesh sieve.
2. Adding 12 times of purified water, extracting at 70 deg.C for 2 times (each time for 0.5 hr).
3. Mixing extractive solutions, and centrifuging at 5000r/min for 20 min to remove coarse residue.
4. The crude filtrate was filtered through a ceramic membrane (pore size: 50nm) until the solution was clear.
5. Concentrating the filtered solution at 60 deg.C under reduced pressure, and concentrating the medicinal liquid to 0.64g equivalent to 1.0g of cyclocarya paliurus leaf.
Mixing folium Mori extract and cyclocarya paliurus extract, adding isomaltitol, mixing, spreading in stainless steel plate, and drying under reduced pressure at 60 deg.C. The dried material is crushed, and the granularity is controlled to be 60-80 meshes. Adding soybean peptide, corn oligopeptide, collagen peptide, xylitol, resistant dextrin and maltodextrin, mixing, and packaging.
The formula 7 granules prepared by the process are quickly dissolved, and have mellow and sweet mouthfeel.
Example 10 moisture absorption Curve comparison
Taking 0.5g of the samples of example 2 and example 3 respectively, placing the samples in weighing bottles, and placing the samples under the RH 75% condition for comparison of moisture absorption rate, from the data in figure 1, it is obvious that the moisture absorption rate of the cyclocarya paliurus extract is significantly higher than that of the folium mori cyclocarya paliurus isomaltitol particles under the 75% humidity condition. The preparation process of the mulberry leaf and green tea granules can improve the moisture absorption problem of cyclocarya paliurus.
Example 11 moisture absorption Curve comparison
Taking 0.5g of samples of example 1, example 2, example 1+ example 2 (1: 1), example 3, example 4 and example 5 respectively, placing the samples in a weighing bottle, and carrying out comparison of moisture absorption rates under the conditions of 25 ℃ and 60% RH, it is obvious from the data in figure 2 that under the condition of 60% humidity, the moisture absorption rate of example 1 (mulberry leaf extract) and the moisture absorption rate of example 2 (cyclocarya paliurus extract) are significantly higher than those of examples 3 and 4 (mulberry leaf cyclocarya paliurus isomaltitol particles). The preparation process of the mulberry leaf granules can improve the moisture absorption problem of extracts of cyclocarya paliurus and mulberry leaves. When the amount of isomalt added was small (example 4), the anti-hygroscopic effect was weaker than that of example 3.
Example 5 has better stability than example 4.
Example 12 appearance stability test.
Table 8 summary of appearance changes of samples packed in sealed bags at room temperature
The data in table 8 show that no or little isomalt addition affects the stability of the samples and shows hygroscopic properties with standing. In example 5, substances such as polypeptide, xylitol and dextrin are added, and the substances are functionally synergistic with the mulberry leaves and the cyclocarya paliurus, so that the stability is improved.
Claims (6)
1. The formula of the morin is characterized by comprising the following main components:
the mulberry leaf extract is 0.8-4.0 weight parts of mulberry leaf
Equivalent to 0.8-2.0 parts by weight of cyclocarya paliurus leaf extract
1.6 to 12.0 parts by weight of isomalt
0-1.0 part by weight of soybean peptide
0-1.0 part by weight of corn oligopeptide
0-2.0 parts by weight of collagen peptide
0 to 1.0 part by weight of xylitol
0 to 1.0 part by weight of resistant dextrin
0 to 1.0 part by weight of maltodextrin.
2. The morin formulation of claim 1, including:
the mulberry leaf extract is 0.8-1.0 weight part of mulberry leaf
Equivalent to 0.8-1.0 weight part of cyclocarya paliurus leaf extract
0.01-0.1 part by weight of soybean peptide
1.8 to 4.0 parts by weight of isomalt
0.01-0.1 part by weight of corn oligopeptide
0.5-1.2 parts by weight of collagen peptide
0.3 to 0.5 part by weight of xylitol
0.4 to 0.6 part by weight of resistant dextrin
0.4 to 0.6 part by weight of maltodextrin.
3. The morin formulation of claim 2, including:
folium Mori extract 1.0 weight parts of folium Mori
Equivalent to 1.0 weight part of cyclocarya paliurus leaf extract
Isomalt 2.45 parts by weight
0.05 part by weight of soybean peptide
Corn oligopeptide 0.05 weight part
Collagen peptide 0.65 weight part
0.3 part by weight of xylitol
0.5 part by weight of resistant dextrin
0.5 part by weight of maltodextrin.
4. The morin formulation of claims 1-3, wherein the mulberry leaf extract is prepared by a process comprising: taking 1 weight part of dry mulberry leaves, crushing, and sieving by a 40-80 mesh sieve; adding 12-20 times of water, and extracting at 70-90 deg.C for 0.5-2 hr; extracting twice; mixing extractive solutions, centrifuging to remove residue, filtering to obtain solution, and concentrating under reduced pressure to 1-1.4 weight parts to obtain folium Mori extract.
5. The sang Qing formulation of claims 1-3, wherein the preparation method of cyclocarya paliurus leaf extract: taking 1 weight part of cyclocarya paliurus leaves, crushing, and sieving by a 40-80-mesh sieve; adding 12-20 times of water, and extracting at 70-90 deg.C for 0.5-2 hr; extracting; the extraction was performed twice. Mixing extractive solutions, centrifuging to remove residue, filtering to obtain solution, concentrating under reduced pressure, and concentrating under reduced pressure to 0.5-0.7 weight parts to obtain cyclocarya paliurus leaf extract.
6. A process for granulating a morin formulation according to claims 1-3, wherein: mixing folium Mori and cyclocarya paliurus extract, adding isomalt, mixing, and drying at 60 deg.C under reduced pressure; crushing the dried material, and controlling the granularity to be 60-80 meshes; adding soybean peptide, corn oligopeptide, collagen peptide, xylitol and resistant dextrin, and mixing.
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