CN114028256A

CN114028256A - Face cream and preparation method thereof

Info

Publication number: CN114028256A
Application number: CN202111426581.1A
Authority: CN
Inventors: 张天菊
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-11-25
Filing date: 2021-11-25
Publication date: 2022-02-11

Abstract

The invention provides a face cream and a preparation method thereof, and relates to the technical field of cosmetics. The face cream mainly comprises the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water. The cream mainly contains chlorphenamine maleate and dexamethasone sodium phosphate, and has effects of promoting facial telangiectasia, improving capillary permeability, promoting facial blood microcirculation, and improving skin color and skin darkness. Meanwhile, the components also have good anti-allergy and anti-inflammatory effects, are suitable for sensitive skin, and have strong applicability. In addition, the preparation method of the face cream can ensure that the emulsification effect of the raw materials in the face cream is better, avoid the phenomenon of layering of the face cream, and has better stability and longer storage life.

Description

Face cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a face cream and a preparation method thereof.

Background

Human skin color is determined by various factors such as the activity of melanocytes that produce melanin pigment, the distribution of blood vessels, the thickness of skin, and the content of pigments such as carotenoid and bilirubin. In particular, a pigment called melanin, which is produced by melanocytes by the action of various enzymes such as tyrosinase, is the most important factor. Melanin pigmentation is affected by genetic factors, physiological factors such as hormone secretion and stress, and environmental factors such as ultraviolet irradiation. Melanin exists in the skin, and prevents ultraviolet rays, etc., thereby playing an important role in protecting the body.

However, when melanin is excessively produced, skin is dark, so that the complexion is haggard, the mental state is not good, and daily life is affected. Therefore, based on the problems, the development of the face cream capable of effectively brightening the skin color is of great significance.

Disclosure of Invention

The invention aims to provide a face cream which can effectively brighten skin color and improve skin darkness and has high use value.

The invention also aims to provide a preparation method of the face cream, which can ensure that the emulsification effect of the raw materials in the face cream is better, avoid the phenomenon of demixing of the face cream, and has better stability and longer storage life.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the invention provides a face cream which mainly comprises the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water.

On the other hand, the invention provides a preparation method of the face cream, which mainly comprises the following steps:

mixing a wetting agent and water, heating to 90-100 ℃, adding chlorphenamine maleate, maintaining for 20-30 min, cooling to 50-60 ℃, adding dexamethasone sodium phosphate, dissolving, adding an antioxidant, and mixing to obtain an emulsion; adding buffer into the emulsion, and homogenizing to obtain facial cream.

The face cream and the preparation method thereof provided by the embodiment of the invention at least have the following beneficial effects:

on one hand, the invention provides a face cream which mainly comprises the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water. The cream uses chlorphenamine maleate and dexamethasone sodium phosphate as main active ingredients, promotes the expansion of facial capillaries, improves the permeability of the capillaries, promotes the microcirculation of facial blood, and achieves the effects of improving skin color and skin darkness. Meanwhile, the components also have good anti-allergy and anti-inflammatory effects, so that the acne removing cream not only has an acne removing effect, but also is suitable for sensitive skin, and has strong applicability.

On the other hand, the invention also provides a preparation method of the face cream, and the preparation method can ensure that the emulsification effect of the raw materials in the face cream is better, avoid the phenomenon of layering of the face cream, and has better stability and longer storage life.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The invention provides a face cream which mainly comprises the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water. The specific effects of the raw materials are as follows:

chlorpheniramine maleate: chlorpheniramine maleate, also known as chlorpheniramine maleate, can achieve an anti-allergy effect through antagonism of the H1 receptor. When the chlorpheniramine maleate is externally used, the chlorpheniramine maleate can cause the facial capillaries to dilate and reduce the permeability of the capillaries, so that the cream has better anti-inflammatory and anti-allergy effects, and can also promote the facial capillaries to dilate, thereby promoting the absorption of effective components and achieving the effects of brightening the skin and whitening the skin. Because the acne-removing cream has a good anti-inflammatory effect, the acne-removing cream achieves the effect of dredging pores by inhibiting or destroying the growth of bacteria in skin pores, and further achieves the effect of removing acnes.

Dexamethasone sodium phosphate: dexamethasone sodium phosphate belongs to adrenocortical hormone medicine, and has effects of resisting inflammation, resisting anaphylaxis, increasing beta receptor excitability and improving capillary permeability. Moreover, it can effectively reduce the sensitivity of capillary vessels to some vasoconstrictor active substances, thereby restoring the microcirculation to normal hemodynamics. Therefore, when dexamethasone sodium phosphate is used as one of the raw materials of the face cream, the permeability and the sensitivity of capillaries can be improved, so that the microcirculation hemodynamics of facial capillaries can be recovered to be normal, the facial blood circulation can be recovered to be normal, the effects of brightening the skin color and improving the skin darkness can be achieved, and the using effect is good.

In addition, the dexamethasone sodium phosphate and the chlorphenamine maleate have good anti-inflammatory and bacteriostatic effects, so that when the dexamethasone sodium phosphate and chlorphenamine maleate are used as face cream, the facial mask can effectively prevent bacteria from breeding on the face, and the acne removing effect is achieved.

Buffering agent: in the invention, the buffering agent can effectively prevent the pH value of the cream from changing when the cream is influenced by other external factors, so that the cream has small stimulation to skin in the using process. Therefore, the buffering agent can enhance the applicability of the face cream and reduce the irritation of the face cream, and has higher use value.

In the invention, sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate are selected as buffers, so that the using effect of the cream is better. Specifically, when an acidic substance is mixed with the face cream, the acid reacts with disodium hydrogen phosphate dodecahydrate to generate sodium dihydrogen phosphate and sodium salt, namely, hydrogen phosphate ions absorb hydrogen ions ionized by external acid, so that the acidic substance has small influence on the pH value of the face cream; when the alkaline substance is mixed with the cream, the alkaline substance can react with sodium dihydrogen phosphate, and has little influence on the pH value of the cream.

In addition, the sodium dihydrogen phosphate and the disodium hydrogen phosphate dodecahydrate can also be used as pH regulators, so that the pH value of the cream is suitable for skin.

In addition, the disodium hydrogen phosphate dodecahydrate is used as one of the buffering agents, so that the quality of materials is stable, the quality of the face cream produced in each batch is uniform, the controllability of preparation can be effectively improved, and the practicability is higher. Meanwhile, the disodium hydrogen phosphate dodecahydrate can also complex metal ions in water, and reduce the hardness of the water, so that the using effect of the cream is improved.

Antioxidant: antioxidants are substances that prevent the adverse effects of oxygen, and they help to trap and neutralize free radicals, thereby achieving the effects of scavenging free radicals and resisting oxidation.

In the invention, sodium bisulfite is used as an antioxidant of the face cream, which can help to inhibit the generation of free radicals and terminate chain reaction, so as to achieve the effect of inhibiting oxidation reaction. Meanwhile, sodium sulfite can also be used as a preservative to inhibit microorganisms introduced from the outside, so that a better preservative effect is achieved, and the storage life of the cream is prolonged. Therefore, when sodium bisulfite is selected as the antioxidant, the preservative has a good preservative effect, a good antioxidant effect and a high use value.

Wetting agent: the wetting agent can reduce the surface tension or interfacial tension of the molecules of the cream, so that the affinity effect between the wetting agent and the skin is better, the cream is easy to spread on the face, and the using effect is better. Meanwhile, the wetting agent can also strengthen the combination effect between the moisture in the face cream and other raw materials, thereby achieving better moisturizing effect and better anti-freezing effect. In addition, the wetting agent can effectively reduce the loss speed of water in the face cream, can enhance the moisturizing effect on one hand, and can prevent the water in the skin or the supplemented water from transferring into the face cream on the other hand, so that a better using effect is achieved.

In the invention, the wetting agent is propylene glycol. The propylene glycol has good viscosity and hygroscopicity, so that the surface activity of the molecules of the cream can be reduced, the molecular acting force among raw materials can be enhanced, the phenomenon of layering of the cream is avoided, and the effect is better.

In addition, the propylene glycol can be used as a moisture absorbent, an antifreeze agent, a lubricant and a solvent in the face cream, has multiple effects and has higher use value.

Vaseline: vaseline is a semi-liquid mixture of alkanes or saturated hydrocarbons, also called petrolatum, and is obtained by fractionating petroleum. The vaseline is white to yellowish uniform ointment, has the characteristic of no odor or almost no odor, and has greasy feeling when contacting with skin, so that the cream has better frosting effect and better moisturizing effect.

Water: water in the face cream can be used as a solvent and can be used as a solvent, and the entropy value of a system is increased, namely the fluidity, so that the molecular acting force among raw materials is increased, and a better effect is achieved. Meanwhile, water can also supplement moisture to skin, and the moisturizing effect is better.

In conclusion, the cream takes chlorpheniramine maleate and dexamethasone sodium phosphate as main active ingredients, promotes the expansion of facial capillaries, improves the permeability of the capillaries, promotes the microcirculation of facial blood, and achieves the effects of improving skin color and skin darkness. Meanwhile, the components also have good anti-allergy and anti-inflammatory effects, so that the acne removing cream not only has an acne removing effect, but also is suitable for sensitive skin, and has strong applicability.

In the invention, the face cream also comprises 0.45-0.55 weight part of sodium edetate. Sodium edetate can be combined with various metals and metal ions to form a stable and soluble complex, so that the metal ions are prevented from entering blood circulation through absorption, permeation and the like, and the use safety of the cream is enhanced. In view of the fact that the equipment is mostly made of metal products in the manufacturing process, the problem can be solved by adding sodium edetate.

In addition, sodium edetate can also be used as a softener. Specifically, the water softening agent can be combined with calcium and magnesium ions in water to reduce the hardness of the water and achieve the softening effect, so that the wetting efficiency of the wetting agent is enhanced, and the moisturizing effect of the cream is better.

In the invention, the face cream also comprises the following raw materials in parts by weight: 23-27 parts of miconazole nitrate and 9-11 parts of clobetasol propionate.

Miconazole nitrate: miconazole nitrate belongs to antifungal drugs, can influence the metabolic process of bacteria by inhibiting the synthesis of fungal cell membranes, has good effects on dermatophytes, candida and the like on skin, and has good effects on skin infection diseases. Therefore, when the acne cream is used as a face cream, the acne cream can effectively inhibit fungi and bacteria from inducing the growth of acnes, thereby achieving a better acne removing effect.

Clobetasol propionate: the clobetasol propionate is an anti-inflammatory corticosteroid, and is suitable for pruritic and noninfectious inflammatory skin diseases such as chronic eczema, neurodermatitis, psoriasis, lichen planus, discoid lupus erythematosus and the like.

In conclusion, when the miconazole nitrate and the clobetasol propionate are added into the face cream, the acne removing effect of the face cream can be enhanced, so that the face cream is more suitable for people with acne.

The invention also provides a preparation method of the face cream, which mainly comprises the following steps:

mixing wetting agent, vaseline and water, heating to 90-100 deg.C, adding chlorphenamine maleate, maintaining for 20-30 min, cooling to 50-60 deg.C, adding dexamethasone sodium phosphate, dissolving, adding antioxidant, and mixing to obtain emulsion; adding buffer into the emulsion, and homogenizing to obtain facial cream.

Specifically, the wetting agent, vaseline and water are mixed according to a certain proportion, and after the wetting agent, the vaseline and the water are uniformly mixed, the mixture is heated to 90-100 ℃, and at the moment, chlorphenamine maleate is added. So that the chlorpheniramine maleate can be fully dissolved in a system containing a wetting agent and vaseline, and the wetting agent can effectively reduce the surface activity of the chlorpheniramine maleate. At lower temperatures, the entropy value in the system is lower and the activity of the wetting agent does not reach the expected penetration and adhesion effect. At higher temperatures, the uncontrollable nature of the reaction increases, which is not conducive to the preparation of a cream.

When the chlorpheniramine maleate is added, the temperature is kept for 20min to 30min, so that the mixing degree of the chlorpheniramine maleate and the wetting agent is better. When the heat preservation time is too long, the moisture evaporation condition is serious, and after a large amount of moisture is replenished again, the layering phenomenon of the face cream is easy to occur, and the preservation effect is poor. When the heat preservation time is too short, the fusion state cannot achieve the expected effect, and the produced face cream has poor using effect.

Then, after cooling to the condition of 50-60 ℃, dexamethasone sodium phosphate is added to dissolve. According to the invention, the energy use cost in the preparation process can be effectively reduced by reducing the temperature, so that the cost performance of the face cream is improved, and the market demand is met. In addition, at the temperature, dexamethasone sodium phosphate can be fully dissolved and uniformly mixed with chlorphenamine maleate and a wetting agent in the system, so that the preparation effect is achieved.

And after the dexamethasone sodium phosphate is fully dissolved, adding an antioxidant into the dexamethasone sodium phosphate, and mixing to obtain the emulsion. At this time, the texture of the lotion was better, resulting in better quality of the cream.

In the invention, stirring is carried out in the mixing process after the antioxidant is added, the stirring speed is 800rpm-1000rpm, and the stirring time is 10min-30 min. Stirring under the condition of above-mentioned stirring speed can make the emulsification effect of emulsion better for the molecular size of water drum oil in the emulsion is comparatively homogeneous, avoids the emulsion to appear that partial emulsification effect is better, the not good condition of partial emulsification effect, thereby makes the quality of face cream better.

When the stirring speed is lower, the emulsification effect of the emulsion cannot reach the expected effect, and when the stirring speed is higher, the promotion range of the emulsification effect is smaller, but the equipment running cost is higher and the cost performance is lower.

When mixing with stirring is complete, a buffer may be added to the emulsion. In the process, the buffering agent can achieve a good adjusting effect on the pH value of the emulsion, so that the pH value of the cream is adaptive to the skin, and the use value is high.

After the addition of the buffer, homogenization is carried out. The homogenization can further ensure that the emulsion has better emulsifying effect, so that the bonding effect between the molecules of the raw materials of the face cream is stronger, the layering phenomenon of the face cream is avoided, and the cold resistance and the heat resistance are stronger. In the invention, the homogenizing pressure is 0.3MPa-0.4MPa, and the homogenizing time is 15min-25 min. Under the homogenization condition, on one hand, the antioxidant can be uniformly dispersed in the emulsion, and on the other hand, the dispersion uniformity of other raw materials in the cream can be further improved.

When the homogenizing pressure is higher, the particle structure of successful emulsification is easy to break, so that the raw materials are separated, and the layering phenomenon is caused. When the homogenizing pressure is lower, the homogenizing effect is not obvious, and the cost is increased, so that the performance-to-price ratio of the face cream is higher.

According to the invention, after the cream is prepared, the pH value of the cream is 6.5-7.0, the cream has small stimulation effect on skin, including sensitive skin, dry skin, oily skin and mixed skin, and the applicability is strong. And due to the buffer, when the pH value of the cream is influenced by external factors to a certain degree, the pH value is basically unchanged, so that the cream has good stability and high use value.

In the present invention, since the moisture is vaporized in the process of heating and dissolving, the moisture has a certain loss amount. In order to make the cream have proper viscosity and easy to push away from the face, 3% -5% of water can be added before the buffer is added into the emulsion to supplement the moisture content in the cream and avoid the excessive viscosity of the cream.

When the supplemented moisture content is high, the combination effect between the moisture and other emulsifying ions in the emulsion is not strong, and the layering phenomenon is obvious.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment aims to provide a face cream, which comprises the following raw materials:

0.5g of chlorpheniramine maleate, 2.5g of dexamethasone sodium phosphate, 8.5g of a buffering agent, 5.5g of an antioxidant, 0.5g of a wetting agent, 30g of vaseline and 28g of water, wherein the buffering agent is citric acid and sodium citrate, the antioxidant is benzyl alcohol, and the wetting agent is sorbitol laurate.

The preparation method of the face cream comprises the following steps:

mixing wetting agent, vaseline and water, heating to 95-96 deg.C, adding chlorphenamine maleate, maintaining for 25min, cooling to 55-56 deg.C, adding dexamethasone sodium phosphate, dissolving, adding antioxidant, and mixing to obtain emulsion; adding buffer into the emulsion, and homogenizing to obtain facial cream.

Example 2

0.5g of chlorpheniramine maleate, 2g of dexamethasone sodium phosphate, 8.5g of a buffering agent, 5g of an antioxidant, 0.5g of a wetting agent, 25g of vaseline and 25g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

Example 3

0.45g of chlorpheniramine maleate, 3g of dexamethasone sodium phosphate, 7.45g of a buffering agent, 6g of an antioxidant, 0.45g of a wetting agent, 0.45g of sodium edetate, 35g of vaseline and 30g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

mixing a wetting agent, vaseline and water, heating to 90-92 ℃, adding chlorphenamine maleate, maintaining for 20min, cooling to 50-52 ℃, adding dexamethasone sodium phosphate, dissolving, adding an antioxidant and sodium edetate, and stirring in the mixing process at the stirring speed of 800rpm for 15min to obtain an emulsion; adding buffer into the emulsion, and homogenizing under 0.3MPa for 15min to obtain facial cream.

Example 4

0.55g of chlorpheniramine maleate, 2.2g of dexamethasone sodium phosphate, 9.55g of a buffering agent, 5.2g of an antioxidant, 0.55g of a wetting agent, 0.55g of sodium edetate, 27g of miconazole nitrate, 11g of clobetasol propionate, 28g of vaseline and 26g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

mixing a wetting agent, vaseline and water, heating to 99-100 ℃, adding chlorphenamine maleate, maintaining for 30min, cooling to 58-60 ℃, adding dexamethasone sodium phosphate, dissolving, adding an antioxidant and sodium edetate, stirring in the mixing process, wherein the stirring speed is 1000rpm, and the stirring time is 25min, so as to prepare an emulsion; and adding a buffering agent, miconazole nitrate and clobetasol propionate into the emulsion, and homogenizing (the homogenizing pressure is 0.4MPa, and the homogenizing time is 25min) to obtain the face cream.

Example 5

0.48g of chlorpheniramine maleate, 2.8g of dexamethasone sodium phosphate, 7.85g of a buffering agent, 5.8g of an antioxidant, 0.48g of a wetting agent, 0.48g of sodium edetate, 23g of miconazole nitrate, 9g of clobetasol propionate, 33g of vaseline and 29g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

mixing a wetting agent, vaseline and water, heating to 93-94 ℃, adding chlorphenamine maleate, maintaining for 23min, cooling to 53-54 ℃, adding dexamethasone sodium phosphate, dissolving, adding an antioxidant and sodium edetate, and stirring in the mixing process at the stirring speed of 850rpm for 18min to obtain an emulsion; then, after 4 wt% of water is supplemented in the emulsion, a buffering agent, miconazole nitrate and clobetasol propionate are added in the emulsion, and after homogenization (the homogenization pressure is 0.33MPa, and the homogenization time is 18min), the face cream is prepared.

Example 6

0.53g of chlorpheniramine maleate, 2.1g of dexamethasone sodium phosphate, 9.05g of a buffering agent, 5.5g of an antioxidant, 0.53g of a wetting agent, 0.53g of sodium edetate, 25g of miconazole nitrate, 10g of clobetasol propionate, 30g of vaseline and 28g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

mixing a wetting agent, vaseline and water, heating to 95-96 ℃, adding chlorphenamine maleate, maintaining for 25min, cooling to 55-56 ℃, adding dexamethasone sodium phosphate, dissolving, adding an antioxidant and sodium edetate, and stirring in the mixing process at the stirring speed of 900rpm for 20min to obtain an emulsion; and then supplementing 4 wt% of water into the emulsion, adding a buffering agent, miconazole nitrate and clobetasol propionate, and homogenizing (the homogenizing pressure is 0.35MPa, and the homogenizing time is 20min) to obtain the face cream.

Example 7

0.5g of chlorpheniramine maleate, 2.9g of dexamethasone sodium phosphate, 8.5g of a buffering agent, 5.5g of an antioxidant, 0.5g of a wetting agent, 0.5g of sodium edetate, 24g of miconazole nitrate, 9.5g of clobetasol propionate, 30g of vaseline and 28g of water, wherein the buffering agent is sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate, the antioxidant is sodium bisulfite, and the wetting agent is propylene glycol.

The preparation method of the face cream comprises the following steps:

Effect example 1

The creams prepared in examples 1 to 7 were subjected to quality evaluation, the evaluation results are shown in Table 1, and the evaluation criteria are referred to QB/T1857-93 criteria.

The heat resistance test method comprises the following steps: the creams prepared in examples 1 to 7 were left at 40 ℃ for 24 hours to observe whether the cream bodies had separation phenomenon;

the cold resistance test method comprises the following steps: the creams prepared in examples 1 to 7 were placed at-15 deg.C, -10 deg.C and-5 deg.C for 24 hours, and after they returned to room temperature, whether the cream body had separation or not was observed.

TABLE 1 evaluation results of sensory and physicochemical indices

As can be seen from the above table, the sensory index and the physicochemical index of the creams prepared in the examples 2 to 7 both meet the index requirements and reach the use standard. Moreover, the creams prepared in examples 1-7 were milky white, without fragrance, and fine in texture and good in feeling of use. However, further comparison shows that the viscosity of the liquid is higher in examples 1 to 4, while the push-open property is stronger and the light and thin feeling is stronger in use in examples 5 to 7 due to the effect of water replenishing. In addition, the two acne removing components are added in the embodiment 4, so the viscosity is more viscous than that of the embodiments 1 to 3.

In example 1, due to different choices of a buffering agent, an antioxidant and a wetting agent, the coordination effect of the compound with chlorpheniramine maleate and dexamethasone sodium phosphate is poor, and therefore, the heat resistance and the cold resistance of the compound are poor.

Effect example 2

The creams prepared in examples 1 to 5 were used as a sample, and 50 female volunteers with dark skin were collected, randomly divided into 5 groups, example 1 to example 5, and used in the creams prepared in examples 1 to 5, respectively, with volunteers aged 23 to 50 years and the mean age (34.29 ± 6.31) years.

Volunteers selected criteria: 1) dark pigment on the face; 2) other trials were not engaged within 1 month prior to the start of the trial;

the using method comprises the following steps: after cleaning the face, the volunteer uses the face cream once in the morning and at night every day, and observes the use condition of the skin after continuously using for 3 months;

the test method comprises the following steps: the test was carried out with a multifunctional skin tester, model CK-MPA 10.

TABLE 2 melanin values before and after volunteer testing

As can be seen from Table 2, the facial creams prepared in examples 1-5 can reduce the melanin value of the face of a volunteer, and thus the facial cream provided by the invention can effectively brighten the skin color, improve the dark skin condition and simultaneously have a good whitening effect. In examples 2 to 5, the selection of the buffer and the wetting agent is a preferable raw material in the present invention, and therefore, the brightening effect is more excellent.

To sum up, the invention provides a face cream which mainly comprises the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water. The cream uses chlorphenamine maleate and dexamethasone sodium phosphate as main active ingredients, promotes the expansion of facial capillaries, improves the permeability of the capillaries, promotes the microcirculation of facial blood, and achieves the effects of improving skin color and skin darkness. Meanwhile, the components also have good anti-allergy and anti-inflammatory effects, so that the acne removing cream not only has an acne removing effect, but also is suitable for sensitive skin, and has strong applicability.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The face cream is characterized by comprising the following raw materials in parts by weight: 0.45-0.55 part of chlorpheniramine maleate, 2-3 parts of dexamethasone sodium phosphate, 7.45-9.55 parts of buffering agent, 5-6 parts of antioxidant, 0.45-0.55 part of wetting agent, 25-35 parts of vaseline and 25-30 parts of water.

2. The cream of claim 1, wherein the buffering agent comprises sodium phosphate monobasic and sodium phosphate dibasic dodecahydrate.

3. The cream of claim 1, wherein the antioxidant is sodium bisulfite.

4. The cream of claim 1, wherein said humectant is propylene glycol.

5. The cream of claim 1, comprising 0.45-0.55 parts by weight sodium edetate.

6. The cream according to any one of claims 1-5, further comprising the following raw materials in parts by weight: 23-27 parts of miconazole nitrate and 9-11 parts of clobetasol propionate.

7. A method of preparing a cream as claimed in any one of claims 1 to 6, comprising the steps of:

mixing the wetting agent, vaseline and water, heating to 90-100 ℃, adding chlorphenamine maleate, maintaining for 20-30 min, cooling to 50-60 ℃, adding the dexamethasone sodium phosphate, dissolving, adding the antioxidant, and mixing to obtain emulsion; and adding a buffering agent into the emulsion, and homogenizing to obtain the cream.

8. The method according to claim 7, wherein stirring is performed during mixing after the antioxidant is added, and the stirring speed is 800rpm to 1000rpm, and the stirring time is 10min to 30 min.

9. The method of claim 7 or 8, wherein the cream has a pH of 6.5 to 7.0.

10. The method of claim 9, wherein 3 wt% to 5 wt% water is added before the buffer is added to the emulsion.