CN114028245A - Mild cutin-removing composition and preparation method thereof - Google Patents
Mild cutin-removing composition and preparation method thereof Download PDFInfo
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- CN114028245A CN114028245A CN202111429723.XA CN202111429723A CN114028245A CN 114028245 A CN114028245 A CN 114028245A CN 202111429723 A CN202111429723 A CN 202111429723A CN 114028245 A CN114028245 A CN 114028245A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a mild exfoliating composition and a preparation method thereof, wherein the composition comprises the following components in parts by weight: inositol 3.0-8.0 weight portions; 5.0-10.0 parts of roselle flower extract; 8.0-12.0 parts of maltobionic acid; 0.05-0.3 part of polyquaternium-61; 0.5-5 parts of PEG/PPG-14/7 dimethyl ether; 64.7 to 83.45 portions of water. The preparation method comprises the following steps: mixing water and inositol uniformly, heating to 75-80 deg.C, keeping the temperature for 15min, and cooling to 50 deg.C to obtain solution A; firstly, mixing the roselle flower extract and polyquaternium-61, uniformly dispersing to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B; and uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product. The invention has the characteristics of extreme mildness, extremely high safety and capability of removing cutin from the organism.
Description
Technical Field
The invention relates to an exfoliating composition, in particular to a mild exfoliating composition and a preparation method thereof.
Background
The skin is the outermost organ of the human body, which is exposed to the air and covered with a large amount of dust, dirt and airborne contaminant particles. These pollutants include Volatile Organic Compounds (VOCs), Polycyclic Aromatic Hydrocarbons (PAHs) and heavy metals, which often slow down the metabolism of the skin, and abnormal metabolism causes keratinocytes not to be naturally exfoliated and thickly deposited on the surface. With age, the body metabolism slows down and cell viability decreases. When the skin ages, the stratum corneum turnover rate also slows, and dead cells cannot be properly removed and accumulate on the skin surface. When too much old waste cutin is accumulated on the skin, the skin loses luster, the vitality is reduced, the barrier function is invalid, the skin is dry and dehydrated, the skin color loses luster and is uniform, and then senile plaques appear. The generation of new keratinocytes is also very slow, affecting the absorption of daily skin care products.
Exfoliation is a cosmetic means that removes dead cells that accumulate on the surface of the mature epidermis and restores the vitality of the skin.
At present, two common methods for removing the stratum corneum in the field of cosmetics are available, one is physical friction, for example, mechanical friction is performed by using abrasive particles to achieve the effect of removing the stratum corneum, but the method can cause irreversible damages such as enlargement of skin pores and damage to the stratum corneum. Meanwhile, most of the ground particles are made of plastic microbeads, so that the ground particles are poor in biodegradability and do not meet the requirements of environmental friendliness at present; the other is chemical exfoliation, where the efficacy of the alpha hydroxy acid exfoliating agent diminishes with increasing pH, typically best at pH 2-3, but the lower the pH, the more irritating the skin. Beta hydroxy acids such as salicylic acid are insoluble in water, require a large amount of polyhydric alcohol for solubilization, and the skin feel of the product is poor. And the risk of teratogenesis to pregnant women exists when the addition amount is too high. Therefore, there is an urgent need to develop a mild, highly safe exfoliating composition having excellent exfoliating effects.
Disclosure of Invention
The invention aims to provide a mild exfoliating composition and a preparation method thereof. The invention has the characteristics of extreme mildness, extremely high safety and capability of removing cutin from the organism.
The technical scheme of the invention is as follows: a mild exfoliating composition and a preparation method thereof comprise the following components in parts by weight: inositol 3.0-8.0 weight portions; 5.0-10.0 parts of roselle flower extract; 8.0-12.0 parts of maltobionic acid; 0.05-0.3 part of polyquaternium-61; 0.5-5 parts of PEG/PPG-14/7 dimethyl ether; 64.7 to 83.45 portions of water.
The mild exfoliating composition comprises the following components in parts by weight: 7.5 parts of inositol; 6.0 parts of roselle flower extract; maltobionic acid, 10.0 parts; 0.1 part of polyquaternium-61; 1 part of PEG/PPG-14/7 dimethyl ether; 75.4 parts of water.
A method for preparing a mild exfoliating composition comprising the steps of:
step one, uniformly mixing water and inositol, heating to 75-80 ℃, preserving heat for 10-15min, and then starting to cool to 50-55 ℃ at a linear cooling speed of 1-2 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and polyquaternium-61 to obtain a mixture B, heating the mixture B to 50-55 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and thirdly, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40-45 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 35-38 ℃, and discharging to obtain a finished product.
The preparation method of the mild exfoliating composition comprises the following steps:
step one, uniformly mixing water and inositol, heating to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and step three, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
Compared with the prior art, the invention consists of inositol, the roselle flower extract, maltobionic acid, polyquaternium-61, PEG/PPG-14/7 dimethyl ether and water; the roselle flower extract contains more than 45% of alpha-hydroxy acid, can mildly and effectively remove cutin, has excellent anti-pollution capacity, can capture iron in pollutants, can be combined with ferrous ions Fe (II) with high proportion to achieve the anti-pollution effect, has a certain regulation and control effect on melanin synthesis to reduce tyrosinase activity, and has the effect of brightening skin color.
Maltobionic acid re-activates an endogenous desquamation mechanism of a body by enhancing the activity of cathepsin D and promoting the synthesis of kallikrein 5, and enhances the natural cutin removing capability of skin weakened by aging; promoting cell renewal, eliminating scales, reactivating endogenous desquamation process, realizing optimal skin barrier function, and improving skin luster and skin uniformity.
Inositol can effectively improve the generation amount of recombinant human platelet-derived growth factor (PDGF-BB) with the function of dermal stem cells, and can generate collagen, elastin, hyaluronic acid and other substances to slow down skin aging and accelerate the regeneration of skin epidermis, thereby accelerating the two substances of maltobionic acid and roselle flower extract to achieve the effect of exfoliating. Meanwhile, the roselle flower extract is anti-pollution dust from the outside of the skin, and stratum corneum accumulation outside the skin is reduced; maltobionic acid activates a desquamation mechanism from the endogenous source of the organism, has no any irritation, and has obvious effect of removing cutin of the skin from inside to outside.
The water-soluble polyquaternium-61 and PEG/PPG-14/7 dimethyl ether in the composition are PEG/PPG block copolymers, and form hydrogen bond effect with polyhydroxy in maltobionic acid to enhance the stability of the composition. Meanwhile, the polyquaternium-61 and PEG/PPG-14/7 dimethyl ether are compounded, so that the surface tension of the composition can be reduced, the composition can be spread on the skin more easily and uniformly, the penetration can be promoted effectively, the exfoliating effect of the composition is improved, and the composition promotes the keratinocyte regeneration from the inside of a living organism without any risk of damaging the skin barrier. Therefore, the components are combined together, and the proportion among the components is reasonably optimized, so that the effects of good solubility, good stability, high temperature resistance and no peculiar smell can be achieved; and exerts mild exfoliating effects under a weakly acidic pH condition.
In conclusion, the present invention has the characteristics of extreme mildness, extremely high safety and capability of removing keratin from the endogenous organism.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Example 1. A mild exfoliating composition and a preparation method thereof comprise the following components in parts by weight: inositol 3.0-8.0 weight portions; 5.0-10.0 parts of roselle flower extract; 8.0-12.0 parts of maltobionic acid; 0.05-0.3 part of polyquaternium-61; 0.5-5 parts of PEG/PPG-14/7 dimethyl ether; 64.7 to 83.45 portions of water.
Preferably: the paint comprises the following components in parts by weight: 7.5 parts of inositol; 6.0 parts of roselle flower extract; maltobionic acid, 10.0 parts; 0.1 part of polyquaternium-61; 1 part of PEG/PPG-14/7 dimethyl ether; 75.4 parts of water.
A method for preparing a mild exfoliating composition comprising the steps of:
step one, uniformly mixing water and inositol, heating to 75-80 ℃, preserving heat for 10-15min, and then starting to cool to 50-55 ℃ at a linear cooling speed of 1-2 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and polyquaternium-61 to obtain a mixture B, heating the mixture B to 50-55 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and thirdly, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40-45 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 35-38 ℃, and discharging to obtain a finished product.
Preferably:
the method comprises the following steps:
step one, uniformly mixing water and inositol, heating to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and step three, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
Example 2. A mild exfoliating composition comprises the following components in parts by weight: inositol, 7.5 g; 6.0g of roselle flower extract; maltobionic acid, 10.0 g; polyquaternium-61, 0.1 g; PEG/PPG-14/7 dimethyl ether, 1 g; water, 64.7 g.
A method for preparing a mild exfoliating composition comprising the steps of:
step one, uniformly mixing water and inositol, heating to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and step three, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
The water is deionized water.
Comparative example 1: a composition containing 7.5g of inositol (not containing roselle flower extract and maltobionic acid) and the balance of the components in the same proportion as in example 2;
the preparation method comprises the following steps: uniformly mixing water and 7.5g of inositol, heating to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
and secondly, uniformly mixing the PEG/PPG-14/7 and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 40 ℃, adding the mixture B into the solution A, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
Comparative example 2: composition containing 6.0g of Hibiscus sabdariffa flower extract (without inositol and maltobionic acid), and the rest components are the same as in example 2;
the preparation method comprises the following steps: step one, heating water to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and step three, uniformly mixing the PEG/PPG-14/7 to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
Comparative example 3: composition containing maltobionate 10.0g (not containing inositol and roselle flower extract), and the rest components in the same ratio as in example 2;
the preparation method comprises the following steps:
step one, heating water to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
and secondly, mixing and uniformly dispersing the roselle flower extract and polyquaternium-61 to obtain a mixture B, uniformly mixing PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
The composition of example 2 provides various improvements in exfoliating and lightening. The data are as follows:
experimental protocol
50 healthy female volunteers were recruited, with an average age of 40 ± 2 years, skin characteristics that were consistent with a scale stage of ≥ 2, dark skin color, wrinkling (crow's feet) and senile plaques. The volunteers were divided into 5 groups of 10 each. All volunteers were used half-face, with no serum on the left face and serum on the right face, twice daily.
TABLE 1 essence formula table
The preparation process comprises the following steps:
dispersing the raw materials 2 and 3 uniformly at room temperature, adding deionized water, stirring at 300rpm/min for 30min, stirring to dissolve completely to obtain a uniform liquid, adding the raw material 4, heating to 70 ℃ at 1 min/DEG C, adding the raw materials 5 and 6, and keeping the temperature for 15min to obtain a phase A;
cooling to 60 deg.C at 0.5 min/deg.C, stirring to obtain liquid gel, and collecting phase B.
Cooling to 40 deg.C at 0.5 min/deg.C, adding raw materials 8 and 9, stirring, adding raw material 10, adjusting pH to 5.5-6.5, stirring, cooling to 38 deg.C, stopping stirring, and discharging to obtain sample.
The essence 1-5 is prepared by the method, wherein the essence 5 is a positive control group.
The following tests were performed.
Exfoliating power
Use of D-
Tape analysis (
Systematic) scale variation.
Preparing a test part: the cheek area is 3cm multiplied by 2 cm;
② under a certain pressure (10-25 kPa or 100-250 g/cm)2) Then, adhering the D-Squame disc to the skin test part for 30 s;
removing the D-Squame disc, and adhering scales on the D-Squame disc;
and measuring the exfoliating capacity by using a D-Squame Scan 850A instrument, wherein the higher the protein content of the stratum corneum stuck on the D-Squame disc is, the stronger the exfoliating capacity is, and the weaker the exfoliating capacity is in turn.
Compared with the left untreated face group, the right face of the essence 1 has the most obvious exfoliating effect which is nearly twice of the exfoliating capacity of the control group and is better than that of the positive control group (p is less than 0.05).
Skin shining
Skin gloss was measured on a half-face using a German cK Probe instrument Skin-Glossimer;
after 5 days, there was essentially no significant change in the gloss of the untreated left face skin compared to the day 0 untreated group; the glossiness of the essence 1, the glossiness of the essence 2, the glossiness of the essence 3, the glossiness of the essence 4 and the glossiness of the essence 5 are respectively improved to 14.2%, 3.0%, 5.2%, 9.4% and 13.5%. It can be seen that serum 1 has an excellent ability to improve skin gloss.
Irritation to human skin
The method for evaluating the safety of the cosmetic product by adopting the human body repeatability open type smearing test is simple and easy to implement. Referring to the operation in technical Specification for safety of cosmetics (2015 edition), 30 qualified volunteers were selected, and the appropriate area of the forearm curve of the subject was selected and smeared in examples 3, 4 and 5, and a positive control group; the skin reactions were observed 2 times daily for 7 consecutive days with saline as a blank control. The judgment standard is 0 min-negative reaction; 1 point-faint erythema, dry skin, wrinkles; 2 points-erythema, edema, papules, wheal, desquamation, fissures; 3 points-marked erythema, edema, blisters; 4 points-severe erythema, edema, bullae, erosion, pigmentation or hypopigmentation, acne-like changes.
The test sites of the forearms of 30 subjects were observed for 7 days, and the results are shown in a human body repeated open type smearing test result table.
As can be seen from Table 1, the exfoliating composition has a skin irritation score of 0 and less irritation than glycolic acid in a repeated open application test on human skin, and is non-irritating to human skin. Therefore, the exfoliating composition can be applied to mild exfoliating cosmetics and has great advantages.
Based on the preparation process and composition of example 2, with the only difference being shown in the following table (different contents of inositol, roselle flower extract and maltobionic acid), examples 3, 4 were obtained.
Human body repeatability open type smearing test result table
Claims (4)
1. The mild exfoliating composition is characterized by comprising the following components in parts by weight: inositol 3.0-8.0 weight portions; 5.0-10.0 parts of roselle flower extract; 8.0-12.0 parts of maltobionic acid; 0.05-0.3 part of polyquaternium-61; 0.5-5 parts of PEG/PPG-14/7 dimethyl ether; 64.7 to 83.45 portions of water.
2. The mild exfoliating composition of claim 1, comprising the following components in parts by weight: 7.5 parts of inositol; 6.0 parts of roselle flower extract; maltobionic acid, 10.0 parts; 0.1 part of polyquaternium-61; 1 part of PEG/PPG-14/7 dimethyl ether; 75.4 parts of water.
3. A process for preparing a mild exfoliating composition as in any of claims 1-2, comprising the steps of:
step one, uniformly mixing water and inositol, heating to 75-80 ℃, preserving heat for 10-15min, and then starting to cool to 50-55 ℃ at a linear cooling speed of 1-2 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and polyquaternium-61 to obtain a mixture B, heating the mixture B to 50-55 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and thirdly, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40-45 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 35-38 ℃, and discharging to obtain a finished product.
4. A process for the preparation of a mild exfoliating composition as in claim 3, comprising the steps of:
step one, uniformly mixing water and inositol, heating to 75 ℃, keeping the temperature for 15min, and then starting to cool to 50 ℃ at a linear cooling speed of 1.5 ℃/min to obtain a solution A;
secondly, mixing and uniformly dispersing the roselle flower extract and the polyquaternium-61 to obtain a mixture B, heating the mixture B to 50 ℃, adding the mixture B into the solution A, and uniformly mixing to obtain a solution B;
and step three, uniformly mixing the PEG/PPG-14/7 and maltobionic acid to obtain a mixture C, heating the mixture C to 40 ℃, adding the mixture C into the solution B, stirring, defoaming, cooling to 38 ℃, and discharging to obtain a finished product.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1612723A (en) * | 2001-11-13 | 2005-05-04 | 宝洁公司 | Local compositions containing enzymes stabilized with inhibitors |
| CN107049880A (en) * | 2017-06-16 | 2017-08-18 | 湖南御家化妆品制造有限公司 | Lightening compositions and its application |
| CN109453089A (en) * | 2018-12-29 | 2019-03-12 | 吕飞 | Exquisite anti-age corrective eye treatment cream and preparation method thereof |
| CN110882194A (en) * | 2019-12-20 | 2020-03-17 | 广州无添加主义化妆品有限公司 | Additive-free pink skin-beautifying facial mask liquid and preparation method thereof |
| CN112370415A (en) * | 2020-11-24 | 2021-02-19 | 杭州百芮生物科技有限公司 | Quick-acting pore-shrinking composition and preparation method thereof |
| CN112641694A (en) * | 2020-12-31 | 2021-04-13 | 广州美璟生物科技有限公司 | Whitening essence milk and preparation method thereof |
| CN113662982A (en) * | 2021-09-24 | 2021-11-19 | 杭州配方师科技有限公司 | Extract of grifola frondosa seeds and roselle flowers, extraction method and application |
-
2021
- 2021-11-29 CN CN202111429723.XA patent/CN114028245B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1612723A (en) * | 2001-11-13 | 2005-05-04 | 宝洁公司 | Local compositions containing enzymes stabilized with inhibitors |
| CN107049880A (en) * | 2017-06-16 | 2017-08-18 | 湖南御家化妆品制造有限公司 | Lightening compositions and its application |
| CN109453089A (en) * | 2018-12-29 | 2019-03-12 | 吕飞 | Exquisite anti-age corrective eye treatment cream and preparation method thereof |
| CN110882194A (en) * | 2019-12-20 | 2020-03-17 | 广州无添加主义化妆品有限公司 | Additive-free pink skin-beautifying facial mask liquid and preparation method thereof |
| CN112370415A (en) * | 2020-11-24 | 2021-02-19 | 杭州百芮生物科技有限公司 | Quick-acting pore-shrinking composition and preparation method thereof |
| CN112641694A (en) * | 2020-12-31 | 2021-04-13 | 广州美璟生物科技有限公司 | Whitening essence milk and preparation method thereof |
| CN113662982A (en) * | 2021-09-24 | 2021-11-19 | 杭州配方师科技有限公司 | Extract of grifola frondosa seeds and roselle flowers, extraction method and application |
Non-Patent Citations (1)
| Title |
|---|
| 匹夫测评: "不止是水乳！拯救黑头闭口的【宅家刷酸】指南-花皙蔻洛神花精华套装测评", Retrieved from the Internet <URL:https://zhuanlan.zhihu.com/p/404181534?utm_id=0> * |
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