CN114026427A - 诊断肾病的标志物以及诊断方法 - Google Patents
诊断肾病的标志物以及诊断方法 Download PDFInfo
- Publication number
- CN114026427A CN114026427A CN202080000764.4A CN202080000764A CN114026427A CN 114026427 A CN114026427 A CN 114026427A CN 202080000764 A CN202080000764 A CN 202080000764A CN 114026427 A CN114026427 A CN 114026427A
- Authority
- CN
- China
- Prior art keywords
- acid
- marker
- level
- carnitine
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003550 marker Substances 0.000 title claims abstract description 129
- 208000017169 kidney disease Diseases 0.000 title claims abstract description 86
- 238000002405 diagnostic procedure Methods 0.000 title abstract description 5
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 167
- 229940109239 creatinine Drugs 0.000 claims abstract description 93
- 229930185560 Pseudouridine Natural products 0.000 claims abstract description 72
- PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 claims abstract description 72
- WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 claims abstract description 72
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims abstract description 72
- VKGZCEJTCKHMRL-VWJPMABRSA-N succinyladenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(N[C@@H](CC(O)=O)C(O)=O)=C2N=C1 VKGZCEJTCKHMRL-VWJPMABRSA-N 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 44
- CIQHWLTYGMYQQR-QMMMGPOBSA-N O(4')-sulfo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(OS(O)(=O)=O)C=C1 CIQHWLTYGMYQQR-QMMMGPOBSA-N 0.000 claims abstract description 35
- MPCAJMNYNOGXPB-SLPGGIOYSA-N 1,5-anhydro-D-glucitol Chemical compound OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O MPCAJMNYNOGXPB-SLPGGIOYSA-N 0.000 claims abstract description 33
- UZTFMUBKZQVKLK-UHFFFAOYSA-N 4-acetamidobutanoic acid Chemical compound CC(=O)NCCCC(O)=O UZTFMUBKZQVKLK-UHFFFAOYSA-N 0.000 claims abstract description 33
- KXONJPJIFNGMCN-IUCAKERBSA-N (2S)-1-[(2S)-2-(trimethylazaniumyl)propanoyl]pyrrolidine-2-carboxylate Chemical compound C[C@@H](C(=O)N1CCC[C@H]1C([O-])=O)[N+](C)(C)C KXONJPJIFNGMCN-IUCAKERBSA-N 0.000 claims abstract description 29
- CPXSBHKDEPPWIX-RAYCSJGISA-N 2'-alpha-mannosyl-L-tryptophan Chemical compound N1C2=CC=CC=C2C(C[C@H](N)C(O)=O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O CPXSBHKDEPPWIX-RAYCSJGISA-N 0.000 claims abstract description 28
- 238000001514 detection method Methods 0.000 claims abstract description 27
- 230000002485 urinary effect Effects 0.000 claims abstract description 13
- 239000002207 metabolite Substances 0.000 claims description 120
- 208000020832 chronic kidney disease Diseases 0.000 claims description 99
- 239000003153 chemical reaction reagent Substances 0.000 claims description 72
- 206010012601 diabetes mellitus Diseases 0.000 claims description 51
- YGPSJZOEDVAXAB-UHFFFAOYSA-N (R)-Kynurenine Natural products OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 claims description 42
- -1 N-acetylquinolinic acid Chemical compound 0.000 claims description 40
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 36
- HCZHHEIFKROPDY-UHFFFAOYSA-N kynurenic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC(=O)C2=C1 HCZHHEIFKROPDY-UHFFFAOYSA-N 0.000 claims description 36
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 28
- WGNAKZGUSRVWRH-UHFFFAOYSA-N p-cresol sulfate Chemical compound CC1=CC=C(OS(O)(=O)=O)C=C1 WGNAKZGUSRVWRH-UHFFFAOYSA-N 0.000 claims description 26
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 24
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 24
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 claims description 24
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 22
- 229960003237 betaine Drugs 0.000 claims description 22
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 22
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 claims description 20
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 20
- 229960004441 tyrosine Drugs 0.000 claims description 19
- BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 claims description 18
- 108700016464 N-acetylcarnosine Proteins 0.000 claims description 18
- 229960002173 citrulline Drugs 0.000 claims description 18
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 claims description 18
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 17
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 16
- MZPWKJZDOCIALD-UHFFFAOYSA-N pyrocatechol sulfate Chemical compound OC1=CC=CC=C1OS(O)(=O)=O MZPWKJZDOCIALD-UHFFFAOYSA-N 0.000 claims description 16
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 15
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 15
- IYJILWQAFPUBHP-BQBZGAKWSA-N beta-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)C[C@H](N)C(O)=O IYJILWQAFPUBHP-BQBZGAKWSA-N 0.000 claims description 15
- 229960002743 glutamine Drugs 0.000 claims description 15
- 229960004799 tryptophan Drugs 0.000 claims description 15
- 229960002989 glutamic acid Drugs 0.000 claims description 14
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims description 14
- OLVVOVIFTBSBBH-KVTDHHQDSA-N 5-methylthioribose Chemical compound CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O OLVVOVIFTBSBBH-KVTDHHQDSA-N 0.000 claims description 13
- 230000001434 glomerular Effects 0.000 claims description 13
- CTYRPMDGLDAWRQ-UHFFFAOYSA-N phenyl hydrogen sulfate Chemical compound OS(=O)(=O)OC1=CC=CC=C1 CTYRPMDGLDAWRQ-UHFFFAOYSA-N 0.000 claims description 13
- HAEVNYBCYZZDFL-MRVPVSSYSA-N succinyl-L-carnitine Chemical compound C[N+](C)(C)C[C@@H](CC([O-])=O)OC(=O)CCC(O)=O HAEVNYBCYZZDFL-MRVPVSSYSA-N 0.000 claims description 13
- VBCLPDSIELLWDI-UHFFFAOYSA-N 2-[3-(sulfooxy)phenyl]acetic acid Chemical compound OC(=O)Cc1cccc(OS(O)(=O)=O)c1 VBCLPDSIELLWDI-UHFFFAOYSA-N 0.000 claims description 12
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 12
- IACOAKYXFIWAQN-UHFFFAOYSA-N Homovanillic acid sulfate Chemical compound COC1=CC(CC(O)=O)=CC=C1OS(O)(=O)=O IACOAKYXFIWAQN-UHFFFAOYSA-N 0.000 claims description 12
- YGPSJZOEDVAXAB-QMMMGPOBSA-N L-kynurenine Chemical compound OC(=O)[C@@H](N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-QMMMGPOBSA-N 0.000 claims description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 12
- VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims description 12
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 12
- 229960001231 choline Drugs 0.000 claims description 12
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 12
- JPAUCQAJHLSMQW-XPORZQOISA-N p-tolyl beta-D-glucuronide Chemical compound C1=CC(C)=CC=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 JPAUCQAJHLSMQW-XPORZQOISA-N 0.000 claims description 12
- XGILAAMKEQUXLS-UHFFFAOYSA-N 3-(indol-3-yl)lactic acid Chemical compound C1=CC=C2C(CC(O)C(O)=O)=CNC2=C1 XGILAAMKEQUXLS-UHFFFAOYSA-N 0.000 claims description 11
- XZARHVHXYGIXLB-UHFFFAOYSA-N 3-hydroxydecanoylcarnitine Chemical compound CCCCCCCC(O)CC(=O)OC([N+](C)(C)C)CCC([O-])=O XZARHVHXYGIXLB-UHFFFAOYSA-N 0.000 claims description 11
- BSVHAXJKBCWVDA-UHFFFAOYSA-N O-adipoylcarnitine Chemical compound C[N+](C)(C)CC(CC([O-])=O)OC(=O)CCCCC(O)=O BSVHAXJKBCWVDA-UHFFFAOYSA-N 0.000 claims description 11
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 11
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 11
- 229960000890 hydrocortisone Drugs 0.000 claims description 11
- 229940116269 uric acid Drugs 0.000 claims description 11
- UEFRDQSMQXDWTO-YGPZHTELSA-N (R)-3-hydroxybutyrylcarnitine Chemical compound CC(O)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UEFRDQSMQXDWTO-YGPZHTELSA-N 0.000 claims description 10
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims description 10
- 229930182816 L-glutamine Natural products 0.000 claims description 10
- QWYFHHGCZUCMBN-SECBINFHSA-N O-butanoyl-L-carnitine Chemical compound CCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C QWYFHHGCZUCMBN-SECBINFHSA-N 0.000 claims description 10
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims description 10
- 229960004106 citric acid Drugs 0.000 claims description 10
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims description 10
- 229940045145 uridine Drugs 0.000 claims description 10
- GOOOCIIXFLVRAG-UHFFFAOYSA-N 9-Decenoylcarnitine Chemical compound C[N+](C)(C)CC(CC([O-])=O)OC(=O)CCCCCCCC=C GOOOCIIXFLVRAG-UHFFFAOYSA-N 0.000 claims description 9
- LOSHAHDSFZXVCT-LXKVQUBZSA-N 2-octenoyl-L-carnitine Chemical compound CCCCC\C=C\C(=O)O[C@@H](CC([O-])=O)C[N+](C)(C)C LOSHAHDSFZXVCT-LXKVQUBZSA-N 0.000 claims description 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 8
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 239000004202 carbamide Substances 0.000 claims description 8
- 229960004203 carnitine Drugs 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 7
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- 229940039227 diagnostic agent Drugs 0.000 claims description 7
- 239000000032 diagnostic agent Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 229960005190 phenylalanine Drugs 0.000 claims description 7
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 7
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 7
- 206010020772 Hypertension Diseases 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 5
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- LBAYFEDWGHXMSM-UHFFFAOYSA-N butaneperoxoic acid Chemical compound CCCC(=O)OO LBAYFEDWGHXMSM-UHFFFAOYSA-N 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 201000008265 mesangial proliferative glomerulonephritis Diseases 0.000 claims description 4
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 3
- 208000033626 Renal failure acute Diseases 0.000 claims description 3
- 201000011040 acute kidney failure Diseases 0.000 claims description 3
- 208000012998 acute renal failure Diseases 0.000 claims description 3
- 230000003902 lesion Effects 0.000 claims description 3
- 208000010444 Acidosis Diseases 0.000 claims description 2
- 206010018366 Glomerulonephritis acute Diseases 0.000 claims description 2
- 206010018367 Glomerulonephritis chronic Diseases 0.000 claims description 2
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims description 2
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 claims description 2
- 206010069384 Ischaemic nephropathy Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010037601 Pyelonephritis chronic Diseases 0.000 claims description 2
- 206010048302 Tubulointerstitial nephritis Diseases 0.000 claims description 2
- 206010046337 Urate nephropathy Diseases 0.000 claims description 2
- 230000007950 acidosis Effects 0.000 claims description 2
- 208000026545 acidosis disease Diseases 0.000 claims description 2
- 231100000851 acute glomerulonephritis Toxicity 0.000 claims description 2
- 206010002022 amyloidosis Diseases 0.000 claims description 2
- 201000006368 chronic pyelonephritis Diseases 0.000 claims description 2
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 2
- 201000005637 crescentic glomerulonephritis Diseases 0.000 claims description 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 230000001631 hypertensive effect Effects 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 238000013178 mathematical model Methods 0.000 claims description 2
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims description 2
- 231100000855 membranous nephropathy Toxicity 0.000 claims description 2
- 201000008383 nephritis Diseases 0.000 claims description 2
- CYGSXDXRHXMAOV-UHFFFAOYSA-M o-cresol sulfate Chemical compound CC1=CC=CC=C1OS([O-])(=O)=O CYGSXDXRHXMAOV-UHFFFAOYSA-M 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 201000002674 obstructive nephropathy Diseases 0.000 claims description 2
- 201000008158 rapidly progressive glomerulonephritis Diseases 0.000 claims description 2
- 230000003156 vasculitic effect Effects 0.000 claims description 2
- 125000000089 arabinosyl group Chemical class C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 claims 4
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 abstract description 8
- 102000009027 Albumins Human genes 0.000 abstract description 8
- 230000001419 dependent effect Effects 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 40
- 210000002966 serum Anatomy 0.000 description 39
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 34
- 239000000523 sample Substances 0.000 description 34
- 201000010099 disease Diseases 0.000 description 28
- 230000003907 kidney function Effects 0.000 description 27
- 238000004949 mass spectrometry Methods 0.000 description 26
- 238000010200 validation analysis Methods 0.000 description 24
- 210000003734 kidney Anatomy 0.000 description 23
- 102000012192 Cystatin C Human genes 0.000 description 21
- 108010061642 Cystatin C Proteins 0.000 description 21
- 239000012071 phase Substances 0.000 description 19
- 210000004369 blood Anatomy 0.000 description 18
- 239000008280 blood Substances 0.000 description 18
- 238000012216 screening Methods 0.000 description 17
- 206010001580 Albuminuria Diseases 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000003745 diagnosis Methods 0.000 description 15
- 210000002700 urine Anatomy 0.000 description 15
- 206010061481 Renal injury Diseases 0.000 description 14
- 238000012417 linear regression Methods 0.000 description 14
- 230000002829 reductive effect Effects 0.000 description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 13
- 230000008859 change Effects 0.000 description 13
- 229960001031 glucose Drugs 0.000 description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 11
- 239000008103 glucose Substances 0.000 description 11
- 210000002254 renal artery Anatomy 0.000 description 11
- 230000035945 sensitivity Effects 0.000 description 11
- 230000005856 abnormality Effects 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 238000004364 calculation method Methods 0.000 description 10
- BXFFHSIDQOFMLE-UHFFFAOYSA-M indoxyl sulfate(1-) Chemical compound C1=CC=C2C(OS(=O)(=O)[O-])=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-M 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 230000002503 metabolic effect Effects 0.000 description 10
- 239000002904 solvent Substances 0.000 description 9
- 230000002159 abnormal effect Effects 0.000 description 8
- 150000001479 arabinose derivatives Chemical class 0.000 description 8
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 8
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 230000024924 glomerular filtration Effects 0.000 description 8
- 108091005995 glycated hemoglobin Proteins 0.000 description 8
- 230000010412 perfusion Effects 0.000 description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 8
- 230000002596 correlated effect Effects 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 150000002500 ions Chemical class 0.000 description 7
- 238000002705 metabolomic analysis Methods 0.000 description 7
- 230000001431 metabolomic effect Effects 0.000 description 7
- 238000007637 random forest analysis Methods 0.000 description 7
- 238000001195 ultra high performance liquid chromatography Methods 0.000 description 7
- 238000012795 verification Methods 0.000 description 7
- 206010061818 Disease progression Diseases 0.000 description 6
- 238000010219 correlation analysis Methods 0.000 description 6
- 230000005750 disease progression Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 206010027525 Microalbuminuria Diseases 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000013211 curve analysis Methods 0.000 description 5
- 238000004811 liquid chromatography Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 208000037978 tubular injury Diseases 0.000 description 5
- 230000010024 tubular injury Effects 0.000 description 5
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 201000000523 end stage renal failure Diseases 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 208000037806 kidney injury Diseases 0.000 description 4
- 238000001819 mass spectrum Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000000750 progressive effect Effects 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000009103 reabsorption Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- BBOWBNGUEWHNQZ-KTKRTIGZSA-N (10Z)-nonadec-10-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCC(O)=O BBOWBNGUEWHNQZ-KTKRTIGZSA-N 0.000 description 3
- QIVBCDIJIAJPQS-HLTLGYGQSA-N (2s)-2-amino-3-(2,4,5,6,7-pentadeuterio-1h-indol-3-yl)propanoic acid Chemical compound [2H]C1=C([2H])C([2H])=C2C(C[C@H](N)C(O)=O)=C([2H])NC2=C1[2H] QIVBCDIJIAJPQS-HLTLGYGQSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- BHQCQFFYRZLCQQ-YFEOEUIKSA-N Cholic acid-2,2,4,4-d4 Chemical compound C([C@@H]12)[C@H](O)[C@]3(C)[C@@H]([C@H](C)CCC(O)=O)CC[C@H]3[C@@H]1[C@H](O)C[C@H]1[C@]2(C)CC([2H])([2H])[C@@H](O)C1([2H])[2H] BHQCQFFYRZLCQQ-YFEOEUIKSA-N 0.000 description 3
- 102000015833 Cystatin Human genes 0.000 description 3
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 3
- 206010029164 Nephrotic syndrome Diseases 0.000 description 3
- FUJLYHJROOYKRA-QGZVFWFLSA-N O-lauroyl-L-carnitine Chemical compound CCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C FUJLYHJROOYKRA-QGZVFWFLSA-N 0.000 description 3
- FNPHNLNTJNMAEE-HSZRJFAPSA-N O-octadecanoyl-L-carnitine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C FNPHNLNTJNMAEE-HSZRJFAPSA-N 0.000 description 3
- CXTATJFJDMJMIY-CYBMUJFWSA-N O-octanoyl-L-carnitine Chemical compound CCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C CXTATJFJDMJMIY-CYBMUJFWSA-N 0.000 description 3
- 235000009697 arginine Nutrition 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000004422 calculation algorithm Methods 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 108050004038 cystatin Proteins 0.000 description 3
- 208000028208 end stage renal disease Diseases 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- AFENDNXGAFYKQO-VKHMYHEASA-N (S)-2-hydroxybutyric acid Chemical compound CC[C@H](O)C(O)=O AFENDNXGAFYKQO-VKHMYHEASA-N 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 229930010555 Inosine Natural products 0.000 description 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
- 229930064664 L-arginine Natural products 0.000 description 2
- 235000014852 L-arginine Nutrition 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 2
- 235000019454 L-leucine Nutrition 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 229930195722 L-methionine Natural products 0.000 description 2
- 229930182821 L-proline Natural products 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000012901 Milli-Q water Substances 0.000 description 2
- LZOSYCMHQXPBFU-UHFFFAOYSA-N O-decanoylcarnitine Chemical compound CCCCCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)C LZOSYCMHQXPBFU-UHFFFAOYSA-N 0.000 description 2
- VVPRQWTYSNDTEA-LLVKDONJSA-N O-hexanoyl-L-carnitine Chemical compound CCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VVPRQWTYSNDTEA-LLVKDONJSA-N 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- CZWCKYRVOZZJNM-UHFFFAOYSA-N Prasterone sodium sulfate Natural products C1C(OS(O)(=O)=O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 CZWCKYRVOZZJNM-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010062237 Renal impairment Diseases 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- XBJFCYDKBDVADW-UHFFFAOYSA-N acetonitrile;formic acid Chemical compound CC#N.OC=O XBJFCYDKBDVADW-UHFFFAOYSA-N 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- HQVFCQRVQFYGRJ-UHFFFAOYSA-N formic acid;hydrate Chemical compound O.OC=O HQVFCQRVQFYGRJ-UHFFFAOYSA-N 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 235000008085 high protein diet Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229960003786 inosine Drugs 0.000 description 2
- 230000000155 isotopic effect Effects 0.000 description 2
- 229960003136 leucine Drugs 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229960004452 methionine Drugs 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 description 2
- 229950009829 prasterone sulfate Drugs 0.000 description 2
- 238000007781 pre-processing Methods 0.000 description 2
- 229960002429 proline Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 150000003212 purines Chemical class 0.000 description 2
- 238000000611 regression analysis Methods 0.000 description 2
- 230000008085 renal dysfunction Effects 0.000 description 2
- 201000010384 renal tubular acidosis Diseases 0.000 description 2
- 229960002920 sorbitol Drugs 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229960002898 threonine Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 229940035893 uracil Drugs 0.000 description 2
- 229960004295 valine Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NWNOWCGAHDFNFJ-RUCXOUQFSA-N (2s)-2,5-bis(azanyl)-5-oxidanylidene-pentanoic acid Chemical compound OC(=O)[C@@H](N)CCC(N)=O.OC(=O)[C@@H](N)CCC(N)=O NWNOWCGAHDFNFJ-RUCXOUQFSA-N 0.000 description 1
- QDJIJLMECSQFMG-VWURTLBMSA-N (2s)-2-amino-3-phenylpropanoic acid;(2r)-2-amino-3-sulfanylpropanoic acid Chemical compound SC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 QDJIJLMECSQFMG-VWURTLBMSA-N 0.000 description 1
- PYXDZWUIPFCTJP-XFNAGHOKSA-N (2s)-2-azanyl-3-(1h-indol-3-yl)propanoic acid Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1.C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 PYXDZWUIPFCTJP-XFNAGHOKSA-N 0.000 description 1
- HQBKFSFXKKNIDP-GRHHLOCNSA-N (2s)-2-azanyl-3-(4-hydroxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 HQBKFSFXKKNIDP-GRHHLOCNSA-N 0.000 description 1
- KUNFMZSTKSLIEY-GRHHLOCNSA-N (2s)-2-azanyl-3-phenyl-propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1.OC(=O)[C@@H](N)CC1=CC=CC=C1 KUNFMZSTKSLIEY-GRHHLOCNSA-N 0.000 description 1
- BQMPVGMHZKZPBH-BYZBDTJCSA-N (3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O.C[N+](C)(C)C[C@H](O)CC([O-])=O BQMPVGMHZKZPBH-BYZBDTJCSA-N 0.000 description 1
- JYGXADMDTFJGBT-MKIDGPAKSA-N 11alpha-Hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-MKIDGPAKSA-N 0.000 description 1
- AHEUFXCMFDEOOW-UHFFFAOYSA-N 2-(1h-indol-3-yl)acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1.C1=CC=C2C(CC(=O)O)=CNC2=C1 AHEUFXCMFDEOOW-UHFFFAOYSA-N 0.000 description 1
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 description 1
- LHZHXEJKKMIKME-UHFFFAOYSA-N 2-hydroxy-3-(1H-indol-3-yl)propanoic acid Chemical compound N1C=C(C2=CC=CC=C12)CC(C(=O)O)O.N1C=C(C2=CC=CC=C12)CC(C(=O)O)O LHZHXEJKKMIKME-UHFFFAOYSA-N 0.000 description 1
- FZIPCQLKPTZZIM-UHFFFAOYSA-N 2-oxidanylpropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FZIPCQLKPTZZIM-UHFFFAOYSA-N 0.000 description 1
- HWRXDTFKKWFXQB-UHFFFAOYSA-N 3,3-dihydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(O)(C[N+](C)(C)C)CC([O-])=O HWRXDTFKKWFXQB-UHFFFAOYSA-N 0.000 description 1
- HNPVERUJGFNNRV-UHFFFAOYSA-N 3-iodophthalic acid Chemical compound OC(=O)C1=CC=CC(I)=C1C(O)=O HNPVERUJGFNNRV-UHFFFAOYSA-N 0.000 description 1
- JHPNVNIEXXLNTR-UHFFFAOYSA-O 4-(trimethylammonio)butanoic acid Chemical compound C[N+](C)(C)CCCC(O)=O JHPNVNIEXXLNTR-UHFFFAOYSA-O 0.000 description 1
- NTDFJPCHHGBHCO-UHFFFAOYSA-N 7,9-dihydro-3H-purine-2,6,8-trione Chemical compound OC1=NC(O)=C2NC(O)=NC2=N1.N1C(=O)NC(=O)C2=C1NC(=O)N2 NTDFJPCHHGBHCO-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- RHXPAKJZPMGZQK-UHFFFAOYSA-N C(C=C/C(=O)O)(=O)O.C1(CCC(=O)O1)=O Chemical compound C(C=C/C(=O)O)(=O)O.C1(CCC(=O)O1)=O RHXPAKJZPMGZQK-UHFFFAOYSA-N 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010054044 Diabetic microangiopathy Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010052098 Iodine allergy Diseases 0.000 description 1
- 241000483399 Ipimorpha retusa Species 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 125000000174 L-prolyl group Chemical class [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 description 1
- UFAHZIUFPNSHSL-UHFFFAOYSA-N O-propanoylcarnitine Chemical compound CCC(=O)OC(CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-UHFFFAOYSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- HTLKVLPYYQCQCA-ZCFIWIBFSA-N S(=O)(=O)(O)O[C@@H](C[N+](C)(C)C)CC([O-])=O Chemical compound S(=O)(=O)(O)O[C@@H](C[N+](C)(C)C)CC([O-])=O HTLKVLPYYQCQCA-ZCFIWIBFSA-N 0.000 description 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 239000006035 Tryptophane Substances 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 238000011497 Univariate linear regression Methods 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 1
- 229960001009 acetylcarnitine Drugs 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 206010001584 alcohol abuse Diseases 0.000 description 1
- 208000025746 alcohol use disease Diseases 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000002665 bowman capsule Anatomy 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000001736 capillary Anatomy 0.000 description 1
- 208000015669 capillary disease Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000009535 clinical urine test Methods 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000003544 deproteinization Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000009101 diabetic angiopathy Diseases 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000005086 glomerual capillary Anatomy 0.000 description 1
- 206010061989 glomerulosclerosis Diseases 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003617 indole-3-acetic acid Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- UJKDYMOBUGTJLZ-RUCXOUQFSA-N ksc605q1h Chemical compound OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CCC(O)=O UJKDYMOBUGTJLZ-RUCXOUQFSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000005955 light diet Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000010245 tubular reabsorption Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000007473 univariate analysis Methods 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Abstract
本公开涉及诊断肾病的标志物以及诊断方法。该方法包括以下步骤：测定及分析来自所述受试者的样品中的标志物的水平，以诊断所述受试者的肾病发展分期。其中，所述标志物包括选自琥珀酰腺苷、假尿苷、N,N,N‑三甲基‑L‑丙氨酰‑L‑脯氨酸甜菜碱、2‑(α‑D‑吡喃甘露糖基)‑L‑色氨酸、4‑乙酰氨基丁酸、磺基酪氨酸和1,5‑脱水‑D‑山梨糖醇组成的组中的至少一种，并配合肌酐成联合标志物，组成至少两个标志物的组合，以改善现时临床依赖肌酐估算GFR造成的误差以及尿白蛋白定量检测难测准的情况。
Description
PCT国内申请，说明书已公开。
Claims (26)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/090927 WO2021232211A1 (zh) | 2020-05-19 | 2020-05-19 | 诊断肾病的标志物以及诊断方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114026427A true CN114026427A (zh) | 2022-02-08 |
| CN114026427B CN114026427B (zh) | 2023-11-17 |
Family
ID=78708940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080000764.4A Active CN114026427B (zh) | 2020-05-19 | 2020-05-19 | 诊断肾病的标志物以及诊断方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114026427B (zh) |
| WO (1) | WO2021232211A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115491415A (zh) * | 2022-09-26 | 2022-12-20 | 天津医科大学总医院 | 一种与hua合并慢性肾病相关的生物标志物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019067699A1 (en) * | 2017-09-28 | 2019-04-04 | Metabolon, Inc. | COMPOUNDS, REAGENTS AND USES THEREOF |
| CN110088615A (zh) * | 2016-12-19 | 2019-08-02 | 梅塔博隆股份有限公司 | 用于肾功能代谢物的检测和定量的质谱法测定方法 |
| CN110196335A (zh) * | 2013-05-14 | 2019-09-03 | 梅塔博隆股份有限公司 | 与肾功能相关的生物标记及其使用方法 |
| CN110286189A (zh) * | 2019-06-13 | 2019-09-27 | 山西大学 | 肾病综合征病变进程相关代谢标志物及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018022866A1 (en) * | 2016-07-28 | 2018-02-01 | Metabolon, Inc. | Diagnostic methods, therapeutic agents and uses thereof |
-
2020
- 2020-05-19 CN CN202080000764.4A patent/CN114026427B/zh active Active
- 2020-05-19 WO PCT/CN2020/090927 patent/WO2021232211A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110196335A (zh) * | 2013-05-14 | 2019-09-03 | 梅塔博隆股份有限公司 | 与肾功能相关的生物标记及其使用方法 |
| CN110088615A (zh) * | 2016-12-19 | 2019-08-02 | 梅塔博隆股份有限公司 | 用于肾功能代谢物的检测和定量的质谱法测定方法 |
| WO2019067699A1 (en) * | 2017-09-28 | 2019-04-04 | Metabolon, Inc. | COMPOUNDS, REAGENTS AND USES THEREOF |
| CN110286189A (zh) * | 2019-06-13 | 2019-09-27 | 山西大学 | 肾病综合征病变进程相关代谢标志物及其应用 |
Non-Patent Citations (4)
| Title |
|---|
| MARTA KORDALEWSKA等: "Multiplatform metabolomics provides insight intothe molecular basis of chronic kidney disease", 《J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI.》 * |
| R TAKAHIRA等: "Tryptophan glycoconjugate as a novel marker ofrenal function", 《THE AMERICAN JOURNAL OF MEDICINE》 * |
| TOSHIHIRO KOBAYASHI等: "Exploration of novel predictive markers in rat plasma of the early stages of chronic renal failure", 《ANALYTICAL AND BIOANALYTICAL CHEMISTRY》 * |
| YAN-NI WANG等: "Chronic kidney disease: Biomarker diagnosis to therapeutic targets", 《CLIN CHIM ACTA.》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115491415A (zh) * | 2022-09-26 | 2022-12-20 | 天津医科大学总医院 | 一种与hua合并慢性肾病相关的生物标志物及其应用 |
| CN115491415B (zh) * | 2022-09-26 | 2023-08-18 | 天津医科大学总医院 | 一种与hua合并慢性肾病相关的生物标志物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021232211A1 (zh) | 2021-11-25 |
| CN114026427B (zh) | 2023-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wolak-Dinsmore et al. | A novel NMR-based assay to measure circulating concentrations of branched-chain amino acids: Elevation in subjects with type 2 diabetes mellitus and association with carotid intima media thickness | |
| Iida et al. | Application of metabolomics to epidemiological studies of atherosclerosis and cardiovascular disease | |
| CN106979982B (zh) | 一种用于糖尿病风险预测、治疗评价的方法及试剂盒 | |
| EP2005189B1 (en) | MEANS AND METHOD FOR DIAGNOSING DIABETES type II | |
| CN102119330B (zh) | 诊断胃改道手术及其相关状况的工具和方法 | |
| JP6021187B2 (ja) | 自閉症の代謝バイオマーカー | |
| Forni et al. | Rapid determination of C4-acylcarnitine and C5-acylcarnitine isomers in plasma and dried blood spots by UPLC–MS/MS as a second tier test following flow-injection MS/MS acylcarnitine profile analysis | |
| WO2017070114A2 (en) | Diabetes-related biomarkers and treatment of diabetes-related conditions | |
| EP1837657A1 (en) | Means and method for predicting or diagnosing diabetes | |
| CN103403548A (zh) | 用于预测糖尿病的工具和方法 | |
| JP5876826B2 (ja) | 糖尿病前症及び２型糖尿病におけるアポリポタンパク質ｃｉｉｉ | |
| CN114026427A (zh) | 诊断肾病的标志物以及诊断方法 | |
| WO2024007778A1 (zh) | 一种血浆分子标志物犬尿氨酸在早期心力衰竭检测中的应用 | |
| TWI822802B (zh) | 腎病變蛋白生物標記及其應用 | |
| KR102377089B1 (ko) | 전당뇨 진단 키트 및 진단 방법 | |
| WO2023035045A1 (en) | Biological markers of liver fat | |
| TWI721462B (zh) | 非酒精性脂肪肝疾病的檢測方法、非酒精性脂肪肝疾病檢測用試劑盒和非酒精性脂肪肝疾病檢測用生物標記 | |
| JP5748751B2 (ja) | 糖尿病前症及び２型糖尿病における血清アミロイドの表現型比率 | |
| CN113552228A (zh) | 一组用于诊断儿童毛细支气管炎的联合标志物及其应用和检测试剂盒 | |
| CN112763570B (zh) | 一种多囊卵巢综合征并发代谢综合征预测标记物及其应用 | |
| Li et al. | Changes in urinary exosomal protein CALM1 may serve as an early noninvasive biomarker for diagnosing diabetic kidney disease | |
| CN114137192B (zh) | 7-甲基黄嘌呤作为检测靶点在制备2型糖尿病高危个体筛查试剂盒中的应用 | |
| Delrue | The use of proteomics in diabetic nephropathy | |
| Mbhele et al. | The determination of early potential biomarkers for Diabetic Nephropathy in human urine samples using ultra high-performance liquid chromatography coupled to quadrupole time of flight high-resolution mass spectrometer (UHPLC–QTOF HRMS) | |
| WO2023104788A1 (en) | Reactive aldehyde biomarkers of type 2 diabetes and diabetic nephropathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |