CN114011479B - 跨界面磁性分离 - Google Patents

跨界面磁性分离 Download PDF

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Publication number
CN114011479B
CN114011479B CN202111135982.1A CN202111135982A CN114011479B CN 114011479 B CN114011479 B CN 114011479B CN 202111135982 A CN202111135982 A CN 202111135982A CN 114011479 B CN114011479 B CN 114011479B
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chamber
liquid
pmp
transfer
analyte
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Chinese (zh)
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CN114011479A (zh
Inventor
D·M·凯尔索
A·K·阿加瓦尔
S·M·麦克法尔
T·韦斯特伯格
M·A·布泽尔
J·L·里德
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Northwestern University
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Northwestern University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B01L2300/166—Suprahydrophobic; Ultraphobic; Lotus-effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Compounds Of Iron (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
CN202111135982.1A 2017-06-06 2018-06-06 跨界面磁性分离 Active CN114011479B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111135982.1A CN114011479B (zh) 2017-06-06 2018-06-06 跨界面磁性分离

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762515876P 2017-06-06 2017-06-06
US62/515,876 2017-06-06
PCT/US2018/036348 WO2018226891A1 (en) 2017-06-06 2018-06-06 Trans-interfacial magnetic separation
CN201880048221.2A CN111148572B (zh) 2017-06-06 2018-06-06 跨界面磁性分离
CN202111135982.1A CN114011479B (zh) 2017-06-06 2018-06-06 跨界面磁性分离

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CN201880048221.2A Division CN111148572B (zh) 2017-06-06 2018-06-06 跨界面磁性分离

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CN114011479A CN114011479A (zh) 2022-02-08
CN114011479B true CN114011479B (zh) 2023-05-02

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US (2) US11673134B2 (https=)
EP (1) EP3634634A4 (https=)
JP (1) JP7168230B2 (https=)
CN (2) CN114011479B (https=)
AU (2) AU2018281310B2 (https=)
CA (1) CA3065928C (https=)
WO (1) WO2018226891A1 (https=)

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WO2021002937A1 (en) 2019-07-03 2021-01-07 Siemens Healthcare Diagnostics Inc. Rotary platform for cell lysing and purification and method of use
US12601542B2 (en) 2019-12-16 2026-04-14 Northwestern University Lyophilized reagents
CN117716239A (zh) 2021-01-29 2024-03-15 雅培诊断产品士嘉堡公司 磁性粒子空气转移
CN114107035B (zh) * 2021-11-30 2022-06-03 珠海黑马生物科技有限公司 一种封闭式全自动核酸提取试剂盒
WO2023097922A1 (zh) * 2021-11-30 2023-06-08 珠海黑马生物科技有限公司 一种全封闭全自动核酸提取试剂盒
WO2023192350A1 (en) * 2022-03-29 2023-10-05 Salus Discovery, LLC Systems and methods for isolating a target from a fluid sample
CN114657049B (zh) * 2022-05-12 2023-06-13 广州国家实验室 一种核酸扩增用卡盒

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Also Published As

Publication number Publication date
US20210146351A1 (en) 2021-05-20
AU2023237099A1 (en) 2023-10-12
JP7168230B2 (ja) 2022-11-09
US11673134B2 (en) 2023-06-13
US20240024865A1 (en) 2024-01-25
AU2018281310A1 (en) 2020-01-02
WO2018226891A1 (en) 2018-12-13
CN114011479A (zh) 2022-02-08
EP3634634A4 (en) 2021-03-10
CA3065928C (en) 2025-05-20
CN111148572A (zh) 2020-05-12
CN111148572B (zh) 2022-05-06
AU2018281310B2 (en) 2023-06-29
JP2020523570A (ja) 2020-08-06
CA3065928A1 (en) 2018-12-13
AU2023237099B2 (en) 2025-10-02
EP3634634A1 (en) 2020-04-15

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