CN114010721A - Preparation method of extract for improving sleep - Google Patents
Preparation method of extract for improving sleep Download PDFInfo
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- CN114010721A CN114010721A CN202111386870.3A CN202111386870A CN114010721A CN 114010721 A CN114010721 A CN 114010721A CN 202111386870 A CN202111386870 A CN 202111386870A CN 114010721 A CN114010721 A CN 114010721A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a preparation method of an extract for improving sleep, which adopts the following technical scheme: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 5-25 meshes, then steaming for 5-30min, taking out and cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 45-60 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 30-50h, the leached materials are squeezed after leaching, then the leaching liquor is concentrated while removing ethanol, and concentrated solution is obtained after concentration; the drink is prepared by cleaning lily, Chinese date, longan and lotus seed, removing date pit and longan pit for homogenate, adding concentrated solution into fresh pulp, adding water for mixing uniformly to obtain fermented pulp, fermenting at 25-35 ℃ for 2-5 days, performing centrifugal separation on fermented liquid, adding wild jujube branch extract into the fermented clear liquid, and mixing.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a preparation method of an extract for improving sleep.
Background
Due to the accelerated pace of life, contemporary people are more and more susceptible to insomnia and anxiety. Insomnia is a disease characterized by that the normal sleep often cannot be obtained due to malnutrition or uneasiness of the heart and spirit caused by emotional or dietary internal injury, or after illness and old age, insufficient endowment, heart deficiency and timidity. The sleep time is insufficient, fatigue cannot be eliminated, physical strength and energy cannot be restored, and a light person can fall asleep difficultly, or sleep soundly, wake up when sleeping, or sleep again after waking up, and sleep all the night if the person is serious. Although insomnia is not a critical disease, it can aggravate or induce palpitation, thoracic obstruction, vertigo, headache, and apoplexy, but it can hamper normal life, work, study, and health of people. The insomnia often brings great pain and psychological burden to patients, the intractable insomnia brings long-term pain to the patients, and even the long-term administration of the hypnotic drugs can cause iatrogenic diseases because the insomnia drugs are abused to form dependence on the drugs.
At present, a plurality of medicines for treating and conditioning insomnia exist, but the medicines with the treatment effect are easy to cause dependence on people and cannot fundamentally improve the insomnia state of human bodies. Meanwhile, the health care product mainly comprising the traditional Chinese medicine components is poor in use convenience, and in most cases, only specific components in the medicinal materials are extracted, so that the problem of loss of other nutrients is caused.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides the preparation method of the drink for improving the immunity, the prepared product can be quickly taken by people, and meanwhile, the functional components in the traditional Chinese medicinal materials can be preserved to the maximum extent, so that the functional components and the nutrients of the raw materials can be simultaneously absorbed by the human body, and the effect of improving the sleep is improved.
In order to solve the technical problems, the invention adopts the technical scheme that: a preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 5-25 meshes, then steaming for 5-30min, taking out and cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 45-60 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 30-50h, the leached materials are squeezed after leaching, then the leaching liquor is concentrated while removing ethanol, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging fermented liquid, adding Zizyphi Spinosae semen extract, and mixing to obtain beverage. According to the invention, fat-soluble and water-soluble nutrients in spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thunb, keel, sandalwood and agilawood are extracted in an extraction mode, and compared with the method of simply adopting water or ethanol as an extraction liquid, the method can extract functional components to the maximum extent. Meanwhile, fresh product slurry of lily, Chinese date, longan and lotus seed is matched, functional components in the raw materials can be completely extracted, nutrient components are obtained in a fermentation mode, and macromolecular nutrients can be further metabolized into more absorbable micromolecular nutrients by microorganisms. The flavor and taste of the product prepared by fermenting the fresh lily, Chinese date, longan and lotus seed are all good, and the product is a good nutritional drink by matching with the functional components of spina date seed, polygala root, rose, tuckahoe, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood.
The weight parts of the raw materials are as follows: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
The ethanol circulating percolation leaching in the step 1 is two times of leaching, wherein the first time of leaching is carried out by adopting 50% ethanol solution, and the second time of leaching is carried out by adopting 75% ethanol solution. The ethanol solution with the concentration of 50 percent and the ethanol solution with the concentration of 75 percent are adopted for extraction, so that the nutrient components can be extracted more fully and rapidly under the condition of full infiltration. Different temperature intervals can be controlled in the two leaching processes, the temperature is increased by 50-60 ℃ for the first time, the leaching of nutrient components in cells is accelerated by increasing the temperature, and the temperature is increased by 45-50 ℃ for the second time, and the nutrient can be rapidly leached at a lower temperature under the action of a high-concentration ethanol solution.
In the leaching process of the step 1, after the first leaching, the leaching material is taken out and subjected to ultrasonic treatment for 15-20min, and then the second leaching is carried out. The ultrasonic treatment is adopted to ensure that the second leaching is more sufficient.
The weight ratio of water to the concentrated solution in the step 2 is 5-10: 1.
in the step 2, saccharomycetes and bacillus are used as fermentation inoculants, the fermentation inoculants and cane sugar are added during fermentation, and the weight ratio of the fermentation inoculants to the fermentation slurry to the cane sugar is (5-10): 100: 3-5.
The concentration of the yeast is 1 × 107CFU/mL, Bacillus concentration 1.5X 108CFU/mL。
The wild jujube branch extract is a dry product, and the weight part ratio of the wild jujube branch extract to the fermentation liquor is 1-5: 50. the wild jujube branch extract used in the invention is a dry product obtained by performing cyclic reflux extraction by adopting ethanol and then performing reduced pressure concentration.
Compared with the prior art, the invention has the beneficial effects that: the potion prepared by the invention has the effects of calming nerves, relieving depression, inducing resuscitation, regulating qi and blood, balancing yin and yang, improving brain nerve cell tissues, promoting collateral circulation, improving the recovery rate of damaged brain cells, improving an excitant of cerebral cortex, improving blood circulation, nourishing, repairing cranial nerves and improving an immune system, thereby effectively improving insomnia.
Detailed Description
The invention is further illustrated by reference to the following examples.
Example 1
A preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 5 meshes, then steaming for 30min, taking out, cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 60 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 50 hours, the leached materials are squeezed after leaching, then the leaching liquor is concentrated, ethanol is removed at the same time, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging fermented liquid, adding Zizyphi Spinosae semen extract, and mixing to obtain beverage.
The weight parts of the raw materials are as follows: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
The ethanol circulating percolation leaching in the step 1 is two times of leaching, wherein the first time of leaching is carried out by adopting 50% ethanol solution, and the second time of leaching is carried out by adopting 75% ethanol solution. In the leaching process of the step 1, after the first leaching, the leaching material is taken out and subjected to ultrasonic treatment for 20min, and then the second leaching is carried out.
The weight ratio of water to the concentrated solution in the step 2 is 10: 1.
in the step 2, saccharomycetes and bacillus are used as fermentation inoculants, the fermentation inoculants and cane sugar are added during fermentation, and the weight ratio of the fermentation inoculants to the fermentation slurry to the cane sugar is 2: 50: 1.
the concentration of the yeast is 1 × 107CFU/mL, Bacillus concentration 1.5X 108CFU/mL。
The wild jujube branch extract is a dry product, and the weight part ratio of the wild jujube branch extract to the fermentation liquor is 1: 50.
example 2
A preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 25 meshes, then steaming for 5min, taking out, cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 45 ℃, and preparing a feed liquid with the weight part ratio of 1: 20, the time is 30 hours, the leached materials are squeezed after leaching, then the leaching liquor is concentrated, ethanol is removed at the same time, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging fermented liquid, adding Zizyphi Spinosae semen extract, and mixing to obtain beverage.
The weight parts of the raw materials are as follows: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
The ethanol circulating percolation leaching in the step 1 is two times of leaching, wherein the first time of leaching is carried out by adopting 50% ethanol solution, and the second time of leaching is carried out by adopting 75% ethanol solution. In the leaching process of the step 1, after the first leaching, the leaching material is taken out and subjected to ultrasonic treatment for 15min, and then the second leaching is carried out.
The weight ratio of water to the concentrated solution in the step 2 is 5: 1.
in the step 2, saccharomycetes and bacillus are used as fermentation inoculants, the fermentation inoculants and cane sugar are added during fermentation, and the weight ratio of the fermentation inoculants to the fermentation slurry to the cane sugar is 5: 100: 3.
the concentration of the yeast is 1 × 107CFU/mL, Bacillus concentration 1.5X 108CFU/mL。
The wild jujube branch extract is a dry product, and the weight part ratio of the wild jujube branch extract to the fermentation liquor is 1: 10.
example 3
A preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 15 meshes, then steaming for 10min, taking out, cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 50 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 40 hours, the leached materials are squeezed after leaching, then the leaching liquor is concentrated, ethanol is removed at the same time, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging fermented liquid, adding Zizyphi Spinosae semen extract, and mixing to obtain beverage. The weight parts of the raw materials are as follows: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
The ethanol circulating percolation leaching in the step 1 is two times of leaching, wherein the first time of leaching is carried out by adopting 50% ethanol solution, and the second time of leaching is carried out by adopting 75% ethanol solution.
In the leaching process of the step 1, after the first leaching, the leaching material is taken out and subjected to ultrasonic treatment for 18min, and then the second leaching is carried out.
The weight ratio of water to the concentrated solution in the step 2 is 7: 1.
in the step 2, saccharomycetes and bacillus are used as fermentation inoculants, the fermentation inoculants and cane sugar are added during fermentation, and the weight ratio of the fermentation inoculants to the fermentation slurry to the cane sugar is 6: 100: 4.
the concentration of the yeast is 1 × 107CFU/mL, Bacillus concentration 1.5X 108CFU/mL。
The wild jujube branch extract is a dry product, and the weight part ratio of the wild jujube branch extract to the fermentation liquor is 3: 50.
example 4
A preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 20 meshes, then steaming for 10min, taking out, cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 55 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 30-50h, the leached materials are squeezed after leaching, then the leaching liquor is concentrated while removing ethanol, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging fermented liquid, adding Zizyphi Spinosae semen extract, and mixing to obtain beverage. The weight parts of the raw materials are as follows: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
The ethanol circulating percolation leaching in the step 1 is two times of leaching, wherein the first time of leaching is carried out by adopting 50% ethanol solution, and the second time of leaching is carried out by adopting 75% ethanol solution.
In the leaching process of the step 1, after the first leaching, the leaching material is taken out and subjected to ultrasonic treatment for 16min, and then the second leaching is carried out.
The weight ratio of water to the concentrated solution in the step 2 is 9: 1.
in the step 2, saccharomycetes and bacillus are used as fermentation inoculants, the fermentation inoculants and cane sugar are added during fermentation, and the weight ratio of the fermentation inoculants to the fermentation slurry to the cane sugar is 7: 100: 4.
the concentration of the yeast is 1 × 107CFU/mL, bacillus concentration 1.5 extract108CFU/mL。
The wild jujube branch extract is a dry product, and the weight part ratio of the wild jujube branch extract to the fermentation liquor is 3: 50.
the above embodiments are merely illustrative of the principles of the present invention and its effects, and do not limit the present invention. It will be apparent to those skilled in the art that modifications and improvements can be made to the above-described embodiments without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications or changes be made by those skilled in the art without departing from the spirit and technical spirit of the present invention, and be covered by the claims of the present invention.
Claims (8)
1. A preparation method of an extract for improving sleep comprises the following steps:
1) preparing a mixed concentrated solution: weighing spina date seed, polygala tenuifolia, rose, poria cocos, pepper, hovenia dulcis thumb, keel, sandalwood and agilawood, cleaning, airing and crushing, wherein the crushing granularity is 5-25 meshes, then steaming for 5-30min, taking out and cooling, performing circulating percolation extraction by using an ethanol solution, controlling the temperature to be 45-60 ℃, and controlling the weight ratio of feed liquid to be 1: 20, the time is 30-50h, the leached materials are squeezed after leaching, then the leaching liquor is concentrated while removing ethanol, and concentrated solution is obtained after concentration;
2) cleaning Bulbus Lilii, fructus Jujubae, arillus longan and semen Nelumbinis, removing semen Ziziphi Spinosae and arillus longan, homogenizing, adding the concentrated solution into fresh pulp, adding water, mixing to obtain fermented pulp, fermenting at 25-35 deg.C for 2-5 days, centrifuging the fermented liquid, adding the extract of ramulus Ziziphi Spinosae, and mixing to obtain beverage.
2. The preparation method of the extract for improving sleep as claimed in claim 1, wherein the raw materials comprise the following components in parts by weight: 4 parts of spina date seed, 5 parts of lily, 4 parts of polygala tenuifolia, 2 parts of rose, 10 parts of Chinese date, 2 parts of poria cocos, 1 part of pepper, 2 parts of hovenia dulcis thunb, 15 parts of longan, 5 parts of lotus seed, 2 parts of keel, 1 part of sandalwood and 1 part of agilawood.
3. The method for preparing an extract for improving sleep as claimed in claim 1, wherein the ethanol circulation percolation leaching in step 1 is two leaching, the first leaching is performed by using 50% ethanol solution, and the second leaching is performed by using 75% ethanol solution.
4. The method as claimed in claim 3, wherein the leaching process of step 1 is carried out by taking out the extract after the first leaching and performing ultrasonic treatment for 15-20min before performing the second leaching.
5. The method for preparing an extract for improving sleep as claimed in claim 1, wherein the ratio of the water to the concentrated solution in the step 2 is 5-10 parts by weight: 1.
6. the method for preparing the extract for improving sleep as claimed in claim 1, wherein yeast and bacillus are used as fermentation agents in the step 2, the fermentation agents and sucrose are added during fermentation, and the weight ratio of the fermentation agents to the fermentation slurry and the sucrose is 5-10: 100: 3-5.
7. The method for preparing an extract for improving sleep as claimed in claim 1, wherein the concentration of yeast is 1 x 107CFU/mL, Bacillus concentration 1.5X 108CFU/mL。
8. The preparation method of the extract for improving sleep as claimed in claim 1, wherein the extract of the branch of wild jujube is a dry product, and the weight ratio of the dry product to the fermentation liquid is 1-5: 50.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528919A (en) * | 2019-01-14 | 2019-03-29 | 王斌 | A kind of Insomnic plaster and preparation method thereof for treating insomnia |
| CN111772066A (en) * | 2020-07-20 | 2020-10-16 | 洛阳北苑生物科技有限公司 | Preparation method of health beverage helpful for sleep |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528919A (en) * | 2019-01-14 | 2019-03-29 | 王斌 | A kind of Insomnic plaster and preparation method thereof for treating insomnia |
| CN111772066A (en) * | 2020-07-20 | 2020-10-16 | 洛阳北苑生物科技有限公司 | Preparation method of health beverage helpful for sleep |
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