CN114010535A - Degradable tooth whitening material and preparation and application thereof - Google Patents
Degradable tooth whitening material and preparation and application thereof Download PDFInfo
- Publication number
- CN114010535A CN114010535A CN202111249487.3A CN202111249487A CN114010535A CN 114010535 A CN114010535 A CN 114010535A CN 202111249487 A CN202111249487 A CN 202111249487A CN 114010535 A CN114010535 A CN 114010535A
- Authority
- CN
- China
- Prior art keywords
- tooth whitening
- polylactic acid
- whitening material
- tooth
- essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
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- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
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- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 8
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
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Images
Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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Abstract
The invention belongs to the field of tooth whitening, and particularly relates to a degradable tooth whitening material as well as preparation and application thereof. The invention provides a tooth whitening material, wherein the whitening component of the material is stereo composite polylactic acid. The invention provides a biodegradable and biocompatible tooth whitening material, which has a good whitening effect and no damage to teeth; and has a rapid tooth whitening effect under mild conditions.
Description
Technical Field
The invention belongs to the field of tooth whitening, and particularly relates to a degradable tooth whitening material as well as preparation and application thereof.
Background
Tooth whitening is a great part of modern people's concern about tooth health, and many people are not satisfied with the color of their teeth due to smoking, drinking, drug use, genetic factors, and the like.
At present, the whitening agent is mainly used for whitening teeth, the main component of the common whitening agent is peroxide, the whitening agent generally adopts an acidic reagent or a strong oxidant, heterogeneous materials adhered to the surfaces of the teeth are removed by utilizing acid etching or oxidation, and the substances can stimulate the oral cavity due to corrosion while destroying the heterogeneous materials on the surfaces of the teeth. In addition, since the dental material itself is inorganic, the dental material itself may be damaged by corrosion or oxidation. Finally, several existing whitening materials have great defects, and the whitening effect of the tooth body cannot be realized on the premise of small influence.
In view of the above-mentioned drawbacks, publication No. CN110464674A discloses a tooth whitening product containing a piezoelectric material, which indicates that the piezoelectric material containing a piezoelectric effect is used as a whitening component of the tooth whitening product, and the piezoelectric material is activated by contacting the tooth whitening product and applying pressure on the surface of the tooth, so as to generate a large amount of active groups, degrade stains on the surface of the tooth, and whiten the tooth; although this product does not harm the tooth structure, it discloses a material with piezoelectric effect selected from the group consisting of BaTiO3, GaN, ZnSnO3, (Na, K) -NbO3, ZnO, lead zirconate titanate, lead magnesium niobate, a composite or combination of one or more materials of polyvinylidene fluoride and polyvinylidene fluoride, such as lead magnesium niobate titanate; because the piezoelectric material contains lead and is not degradable, potential harm exists to human health; moreover, the piezoelectric materials need to be subjected to selective polarization treatment to achieve a good whitening effect; in addition, the selected piezoelectric material needs to be under the operating condition of high power and high frequency vibration (such as 40W and 1000Hz), the tooth color is obviously whitened; these factors all limit the scope of their use.
Disclosure of Invention
Aiming at the defects, the invention provides a biodegradable and biocompatible tooth whitening material, which has better whitening effect and no damage to teeth; and has a rapid tooth whitening effect under mild conditions.
The technical scheme of the invention is as follows:
the first technical problem to be solved by the invention is to provide a tooth whitening material, and the whitening component of the material is stereocomplex polylactic acid.
Furthermore, the stereocomplex polylactic acid is porous stereocomplex polylactic acid prepared by blending levorotatory polylactic acid and dextrorotatory polylactic acid.
The porous stereocomplex polylactic acid is prepared by adopting the method disclosed in the patent with the authorization publication number of CN 103965493B.
Further, the porosity of the stereocomplex polylactic acid is 10-70%.
Further, the tooth whitening material comprises the following raw materials in parts by weight: 5-50 parts of stereo composite polylactic acid, 0.1-0.2 part of sweetening agent, 0.1-0.3 part of essence, 3-5 parts of anionic surfactant, 5-10 parts of grinding material and the balance of deionized water. When the raw materials and the proportion thereof are adopted, the obtained tooth whitening material is dentifrice.
Further, the tooth whitening material comprises the following raw materials in parts by weight: 5-50 parts of stereo composite polylactic acid, 0.25-0.9 part of thickening agent, 0.1-0.2 part of sweetening agent, 20-40 parts of humectant, 0.1-0.3 part of essence, 3-5 parts of anionic surfactant and the balance of deionized water. When the raw materials and the proportion thereof are adopted, the obtained tooth whitening material is toothpaste, gel or gel.
Further, the sweetener is selected from: at least one of glucose, sucrose, maltose, dextrin, stevioside, and trichlorogalactose.
Further, the perfume is selected from: at least one of peppermint essence, methyl salicylate and spearmint essence.
Further, the anionic surfactant is selected from: at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, betaine, and PEG-40 hydrogenated castor oil.
Further, the abrasive is selected from: at least one of calcium carbonate, dicalcium phosphate, silicon dioxide, or natural microcrystalline cellulose.
Further, the thickener is selected from: carbomer, cellulose polymer and its salt, natural gum, polyethylene glycol, triethanolamine, silicon dioxide, and colloidal magnesium aluminum silicate.
Further, the humectant is selected from: at least one of glycerin, sorbitol and propylene glycol.
Further, the tooth whitening material may be prepared in the form of toothpaste, tooth powder, gel, toothbrush, dental tablet or other known forms.
The second technical problem to be solved by the present invention is to provide a method for preparing the above tooth whitening material, the method comprising: uniformly mixing various raw materials of the tooth whitening material, and sampling and detecting the pH value of a mixed system to be 5.5-10.5 to obtain the tooth whitening material.
Further, the tooth whitening material adopts the following method one: firstly, uniformly stirring and mixing a sweetening agent, an anionic surfactant and essence in a container, then putting the rest components into the container, uniformly stirring and mixing to obtain a mixture, and sieving the mixture by a 60-mesh sieve to obtain a screened substance, namely the tooth whitening material (finished dentifrice); wherein the stereocomplex polylactic acid is prepared into powder with granularity not more than 0.045mm (325 meshes), the abrasive is prepared into powder with granularity not more than 0.011mm (1300 meshes), and the anionic surfactant, the sweetener and the essence are respectively prepared into powder with granularity not more than 0.250mm (60 meshes).
Further, the tooth whitening material adopts the following method two: firstly, adding part of deionized water into a mixing pot, then adding a humectant into the mixing pot for mixing, then adding a thickener and stereocomplex polylactic acid, gradually heating to 50-75 ℃ (preferably 65 ℃) under stirring, preserving heat for 10-35 min (preferably 20min), and cooling to 15-40 ℃ (preferably 20 ℃) under continuous stirring; then adding an anionic surfactant in the stirring process; adding the sweetener, the essence and the rest deionized water into a mixing pot, and continuously stirring; and (3) sampling and detecting the pH value of the mixed system to be 5.5-10.5 to obtain the tooth whitening material.
The third technical problem to be solved by the present invention is to provide a method for using the above tooth whitening material, the method comprising: coating or spraying a tooth whitening material on the surface of teeth and applying pressure on the surface of teeth; the manner in which the tooth surface applies pressure is by vibration or friction.
The fourth technical problem to be solved by the present invention is to indicate the use of stereocomplex polylactic acid in tooth whitening materials, i.e. to indicate that stereocomplex polylactic acid can be used as a whitening component of tooth whitening materials.
The invention has the beneficial effects that:
compared with the prior art, the tooth whitening material has the advantages of reduced gum stimulation, no damage to oral soft tissues, biocompatibility and biodegradability, and can realize the effect of quickly whitening teeth (generally within 15 min) under the condition of mild pressure (realized by tooth brushing).
Description of the drawings:
fig. 1 is a graph showing whitening effects of the tooth whitening material obtained in example 1.
Fig. 2 is a graph showing whitening effects of the tooth whitening material obtained in example 2.
Fig. 3 is a graph showing whitening effects of the tooth whitening material obtained in example 3.
Fig. 4 is a graph showing whitening effects of the tooth whitening material obtained in example 4.
Fig. 5 is a graph showing whitening effects of the tooth whitening material obtained in example 5.
Fig. 6 is a graph showing whitening effects of the tooth whitening material obtained in example 6.
Fig. 7 is a graph showing whitening effects of the tooth whitening material obtained in comparative example 1.
Fig. 8 is a graph showing whitening effects of the tooth whitening material obtained in comparative example 2.
Fig. 9 is a graph showing whitening effects of the tooth whitening material obtained in comparative example 4.
FIGS. 10a, 10b and 10c are graphs showing cytotoxicity test results of a control material (PTFE), stereocomplex polylactic acid used in the example of the present invention, and whitening gel containing 22% hydrogen peroxide (comparative example 4), respectively; as can be seen from the figure, compared with the whitening gel containing 22% of hydrogen peroxide, the cytotoxicity of the stereocomplex polylactic acid is obviously lower than that of the whitening gel containing 22% of hydrogen peroxide.
Fig. 11a, 11b, 11c and 11d are SEM images of an original tooth (tooth without whitening treatment in example 1), a tooth after whitening in comparative example 4, a tooth after whitening in comparative example 3 and a tooth after whitening treatment in example 1, respectively; as can be seen from fig. 11: the whitening gel containing 22% of hydrogen peroxide can cause irreversible damage to enamel on the surface of teeth, the barium titanate can also cause damage to the enamel after whitening the teeth, and the whitening material prepared from the stereocomplex polylactic acid can whiten the teeth, and the surface appearance of the whitening material is almost the same as that of the original teeth.
The following examples are given to further illustrate the embodiments of the present invention and are not intended to limit the scope of the present invention.
Example 1
A tooth whitening material comprising the following raw materials:
5 parts of porous stereocomplex polylactic acid, 0.25 part of thickening agent, 0.1 part of sweetening agent, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water; wherein the thickening agent is carbomer, the sweetening agent is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method of the stereocomplex polylactic acid comprises the following steps: firstly, mixing the following components in a weight ratio of 1: 1, mixing the levorotatory polylactic acid and the dextrorotatory polylactic acid, and then melting and blending the mixture and a proper amount of pore-foaming agent at 180 ℃ to obtain stereo composite polylactic acid powder; and cleaning with deionized water to obtain the porous stereocomplex polylactic acid.
The preparation method of the tooth whitening material comprises the following steps: firstly, adding part of deionized water into a mixing pot, then adding a humectant into the mixing pot for mixing, then adding a thickening agent and stereocomplex polylactic acid, stirring for 30min at 30rpm, gradually heating to 65 ℃, keeping the temperature for 20min, stirring for 5min at 2000rpm, cooling the materials in the mixing pot to 20 ℃ after stirring, keeping the speed of 15rpm for stirring, then adding an anionic surfactant and stirring for 30 min; adding sweetener, essence and the rest deionized water into a mixing pot, and stirring at 10rpm for 10 min; discharging to a storage tank to obtain the tooth whitening material after the standard is met (the pH value is 5.5-10.5 by sampling inspection).
Soaking detached bovine teeth into deionized water, cleaning, coating the obtained tooth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, then washing with clear water, drying, repeating the brushing steps for 3 times to finish brushing, observing the color change of the surface of the bovine teeth each time (the specific change result is shown in figure 1), and simultaneously observing the structural change of the surface of the bovine teeth by using a scanning electron microscope (the result is shown in figure 11).
Example 2
A tooth whitening material comprising the following raw materials:
50 parts of porous stereocomplex polylactic acid, 0.9 part of thickening agent, 0.2 part of sweetening agent, 40 parts of humectant, 0.3 part of essence, 5 parts of anionic surfactant and the balance of deionized water; wherein the thickening agent is carbomer, the sweetening agent is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method of the tooth whitening material comprises the following steps: firstly, adding part of deionized water into a mixing pot, then adding a humectant into the mixing pot for mixing, then adding a thickening agent and stereocomplex polylactic acid, stirring for 30min at 30rpm, gradually heating to 65 ℃, keeping the temperature for 20min, stirring for 5min at 2000rpm, cooling the materials in the mixing pot to 20 ℃ after stirring, keeping the speed of 15rpm for stirring, then adding an anionic surfactant and stirring for 30 min; adding sweetener, essence and the rest deionized water into a mixing pot, and stirring at 10rpm for 10 min; discharging to a storage tank to obtain the tooth whitening material after the standard is met (the pH value is 5.5-10.5 by sampling inspection).
Soaking in-vitro bovine teeth into deionized water for cleaning, coating the teeth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, then washing with clear water, wiping to dry, repeating the brushing steps for 3 times to finish brushing, and observing the color change of the surface of the bovine teeth after 3 times of brushing.
Example 3
A tooth whitening material comprising the following raw materials:
5 parts of porous stereo composite polylactic acid, 0.25 part of sweetening agent, 90 parts of grinding material, 0.1 part of essence and 2.5 parts of anionic surfactant; wherein the sweetener is glucose, the abrasive is calcium carbonate, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method comprises the following steps: preparing stereo composite polylactic acid into powder with the granularity of not more than 0.045mm (325 meshes), preparing abrasive into powder with the granularity of not more than 0.011mm (1300 meshes), respectively preparing surfactant, sweetener and essence into powder with the granularity of not more than 0.250mm (60 meshes), uniformly stirring and mixing the sweetener, the surfactant and the essence in a container, then putting the rest components into the container, uniformly stirring and mixing to obtain a mixture, sieving the mixture by a 60-mesh sieve, and obtaining the screened substance which is finished dentifrice.
Soaking in-vitro bovine teeth into deionized water, cleaning, coating the teeth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, washing with clear water, drying, repeating the above brushing steps for 3 times, finishing brushing, and observing the color change of the surface of the bovine teeth each time.
Example 4
A tooth whitening material comprising the following raw materials:
50 parts of porous stereocomplex lactic acid, 0.25 part of sweetening agent, 40 parts of grinding material, 0.1 part of essence and 2.5 parts of anionic surfactant; wherein the sweetener is glucose, the abrasive is calcium carbonate, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method comprises the following steps: preparing porous stereocomplex polylactic acid into powder with the granularity of not more than 0.045mm (325 meshes), preparing abrasive into powder with the granularity of not more than 0.011mm (1300 meshes), respectively preparing surfactant, sweetener and essence into powder with the granularity of not more than 0.250mm (60 meshes), uniformly stirring and mixing the sweetener, the surfactant and the essence in a container, then putting the rest components into the container, uniformly stirring and mixing to obtain a mixture, sieving the mixture by a 60-mesh sieve, and obtaining the screened substance which is the finished product dentifrice.
Soaking in-vitro bovine teeth into deionized water for cleaning, coating the teeth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, then washing with clear water, wiping to dry, repeating the brushing steps for 3 times to finish brushing, and observing the color change of the surface of the bovine teeth after 3 times of brushing.
Example 5
A tooth whitening material comprising the following raw materials:
5 parts of porous stereo composite polylactic acid, 3 parts of thickening agent, 0.2 part of sweetening agent, 40 parts of humectant, 0.3 part of essence, 5 parts of anionic surfactant, 0.5 part of stabilizing agent and the balance of deionized water. Wherein the thickener is sodium carboxymethylcellulose, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, the anionic surfactant is sodium dodecyl sulfate, and the stabilizer is disodium ethylenediamine tetraacetate.
The preparation method comprises the following steps: adding the thickening agent into the humectant to form a colloid under the stirring state; dissolving the stereo composite polylactic acid and the stabilizer in deionized water in a small pot, stirring uniformly, sucking into a vacuum paste making machine in a vacuum state, and stirring uniformly with the glue; and finally stirring and degassing for 10min under a vacuum state to obtain the tooth whitening material.
Taking a separated bovine tooth, soaking the separated bovine tooth into deionized water, cleaning, coating the tooth whitening material on the bovine tooth, performing ultrasonic vibration for 1 hour at 40W and 0.6-0.8 kHz, and observing the color change of the surface of the bovine tooth.
Example 6
A tooth whitening material comprising the following raw materials:
50 parts of porous stereocomplex polylactic acid, 0.35 part of thickening agent, 0.1 part of sweetening agent, 20 parts of humectant, 0.1 part of essence, 2 parts of anionic surfactant, 0.3 part of stabilizer and the balance of deionized water; wherein the thickener is sodium carboxymethylcellulose, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, the anionic surfactant is sodium dodecyl sulfate, and the stabilizer is disodium ethylenediamine tetraacetate.
The preparation method comprises the following steps: adding the thickening agent into the humectant to form a colloid under the stirring state; dissolving the stereo composite polylactic acid and the stabilizer in deionized water in a small pot, stirring uniformly, sucking into a vacuum paste making machine in a vacuum state, and stirring uniformly with the glue; and finally stirring and degassing for 10min under a vacuum state to obtain the tooth whitening material.
Taking in-vitro bovine teeth, immersing the in-vitro bovine teeth into deionized water, cleaning, coating the teeth whitening material on the bovine teeth, performing ultrasonic vibration for 1 hour at 40W and 0.6-0.8 kHz to complete brushing, and observing the color change of the surfaces of the bovine teeth.
Comparative example 1
5 parts of levorotatory polylactic acid, 0.25 part of thickening agent, 0.1 part of sweetening agent, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water; wherein the thickening agent is carbomer, the sweetening agent is glucose, the humectant is triethanolamine, the essence is mint essence, and the anionic surfactant is sodium dodecyl sulfate; the tooth whitening material was prepared in the same manner as in example 1 using the above raw materials.
Soaking in-vitro bovine teeth into deionized water for cleaning, coating the teeth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, then washing with clear water, wiping to dry, repeating the brushing steps for 3 times to finish brushing, and observing the color change of the surface of the bovine teeth after 3 times of brushing.
Comparative example 2
5 parts of solid spherical stereo composite polylactic acid, 0.25 part of thickening agent, 0.1 part of sweetening agent, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water. Wherein the thickening agent is carbomer, the sweetening agent is glucose, the humectant is triethanolamine, the essence is mint essence, and the anionic surfactant is sodium dodecyl sulfate; the tooth whitening material was prepared in the same manner as in example 1 using the above raw materials.
The preparation method of the solid-sphere stereo-structure composite polylactic acid comprises the following steps: firstly, mixing the following components in a weight ratio of 1: 1, melting and blending the levorotatory polylactic acid and the dextrorotatory polylactic acid at 180 ℃ to obtain the stereocomplex polylactic acid powder.
Soaking in-vitro bovine teeth into deionized water for cleaning, coating the teeth whitening material on the bovine teeth, brushing the bovine teeth in a conventional tooth brushing manner for 5min each time, then washing with clear water, wiping to dry, repeating the brushing steps for 3 times to finish brushing, and observing the color change of the surface of the bovine teeth after 3 times of brushing.
Comparative example 3
Placing the detached bovine tooth in a suspension containing barium titanate powder at a concentration of 1mg/ml, ultrasonically vibrating at 0.6kHz and 40W for 1 hour for 100nm to observe the color change of the surface of the bovine tooth after ultrasonically vibrating for 1 hour, and observing the structural change of the surface of the bovine tooth by using a scanning electron microscope.
Comparative example 4
Using a whitening agent containing 22% hydrogen peroxide, the structural change of the bovine tooth surface was observed by a scanning electron microscope for the same time as in whitening in example 1.
In addition, the cytotoxicity test was performed on the stereocomplex polylactic acid, the control material, and the whitening agent containing 22% hydrogen peroxide, which were used in the examples of the present invention; the detailed process is as follows: leaching medium: 89% MEM medium + 10% fetal bovine serum + 1% penicillin-streptomycin solution; cell preparation: mouse fibroblast (L-929) cells at 37 ℃ with 5% CO2Culturing under saturated humidity condition; sample preparation: preparing a storage solution with the concentration of 0.2g/ml by using an extraction medium for the stereocomplex polylactic acid; respectively taking stored liquid (four concentration groups of 100%, 50%, 25% and 12.5%); the whitening gel containing 22% of hydrogen peroxide is treated by the same method as the stereocomplex polylactic acid; the polytetrafluoroethylene is leached with leaching mediumExtracting, namely extracting a leaching solution; grouping experiments: l-929 cells were seeded at a density of 1.5X 104 cells/well in 96-well plates and cultured for 24 hours. Discarding the supernatant, adding 150 μ L of extract culture medium, culturing for 24h, gently washing with PBS for 2 times, adding 10% CCK-8DMEM culture medium 110 μ L, incubating in the incubator for 2h, and measuring absorbance density (OD) at 450nm wavelength with enzyme-labeling instrument; after the detection, the sample was washed 2 times with PBS and photographed under the mirror, and the result is shown in FIG. 10.
Claims (10)
1. A tooth whitening material is characterized in that the whitening component of the material is stereocomplex polylactic acid.
2. The tooth whitening material according to claim 1, wherein the stereocomplex polylactic acid is a porous stereocomplex polylactic acid prepared by blending L-polylactic acid and D-polylactic acid.
3. The tooth whitening material according to claim 2, wherein the porosity of the stereocomplex polylactic acid is 10 to 70%.
4. The tooth whitening material according to any one of claims 1 to 3, wherein the raw materials and the proportions thereof comprise: 5-50 parts of stereo composite polylactic acid, 0.1-0.2 part of sweetening agent, 0.1-0.3 part of essence, 3-5 parts of anionic surfactant, 5-10 parts of grinding material and the balance of deionized water.
5. The tooth whitening material according to any one of claims 1 to 3, wherein the raw materials and the proportions thereof comprise: 5-50 parts of stereo composite polylactic acid, 0.25-0.9 part of thickening agent, 0.1-0.2 part of sweetening agent, 20-40 parts of humectant, 0.1-0.3 part of essence, 3-5 parts of anionic surfactant and the balance of deionized water.
6. Tooth whitening material according to claim 4 or 5,
the sweetener is selected from: at least one of glucose, sucrose, maltose, dextrin, stevioside, or trichlorogalactose;
the essence is selected from: at least one of peppermint flavor, methyl salicylate, or spearmint flavor;
the anionic surfactant is selected from: at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, betaine, and PEG-40 hydrogenated castor oil;
further, the abrasive is selected from: at least one of calcium carbonate, dicalcium phosphate, silicon dioxide, or natural microcrystalline cellulose;
further, the thickener is selected from: at least one of carbomers, cellulosic polymers and salts thereof, natural gums, polyethylene glycols, triethanolamine, silica or colloidal magnesium aluminum silicate;
further, the humectant is selected from: at least one of glycerin, sorbitol and propylene glycol.
7. The tooth whitening material according to any one of claims 1 to 6, wherein the tooth whitening material is prepared in the form of toothpaste, tooth powder, gel, toothbrush, dental tablet or other known forms.
8. The method of preparing a tooth whitening material according to any one of claims 4 to 7, characterized in that the method comprises: uniformly mixing various raw materials of the tooth whitening material, sampling and detecting the pH value of a mixed system to be 5.5-10.5 to obtain the tooth whitening material;
further, the tooth whitening material adopts the following method one: firstly, uniformly stirring and mixing the sweetening agent, the anionic surfactant and the essence in a container, then putting the rest components into the container, uniformly stirring and mixing to obtain a mixture, and sieving the mixture by a 60-mesh sieve to obtain a sieved substance, namely the tooth whitening material; wherein the stereocomplex polylactic acid is prepared into powder with the granularity of not more than 0.045mm, the grinding material is prepared into powder with the granularity of not more than 0.011mm, and the anionic surfactant, the sweetener and the essence are respectively prepared into powder with the granularity of not more than 0.250 mm;
further, the tooth whitening material adopts the following method two: firstly, adding part of deionized water into a mixing pot, then adding a humectant into the mixing pot for mixing, then adding a thickening agent and stereocomplex polylactic acid, gradually heating to 50-75 ℃ under stirring, preserving heat for 10-35 min, and continuously cooling to 15-40 ℃ during stirring; then adding an anionic surfactant in the stirring process; adding the sweetener, the essence and the rest deionized water into a mixing pot, and continuously stirring; and (3) sampling and detecting the pH value of the mixed system to be 5.5-10.5 to obtain the tooth whitening material.
9. The method of using the tooth whitening material according to any one of claims 4 to 7, characterized in that the method comprises: coating or spraying a tooth whitening material on the surface of teeth and applying pressure on the surface of teeth; the manner in which the tooth surface applies pressure is by vibration or friction.
10. Use of stereocomplex polylactic acid in a tooth whitening material, the stereocomplex polylactic acid being a whitening component of the tooth whitening material.
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| CN202111249487.3A CN114010535B (en) | 2021-10-26 | 2021-10-26 | Degradable tooth whitening material and preparation and application thereof |
| PCT/CN2022/124219 WO2023071750A1 (en) | 2021-10-26 | 2022-10-09 | Degradable tooth whitening material, preparation thereof and application thereof |
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| WO2023071750A1 (en) * | 2021-10-26 | 2023-05-04 | 泰世德(北京)医药科技有限公司 | Degradable tooth whitening material, preparation thereof and application thereof |
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| CN103608445A (en) * | 2011-06-20 | 2014-02-26 | 宝洁公司 | Liquid cleaning and/or cleansing composition |
| CN106947228A (en) * | 2017-05-05 | 2017-07-14 | 四川大学 | Multistage porous poly-lactic acid material and preparation method thereof |
| CN107670108A (en) * | 2017-09-27 | 2018-02-09 | 四川大学 | A kind of tissue engineering bracket polylactic acid porous material and preparation method thereof |
| CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
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| CN114010535B (en) * | 2021-10-26 | 2023-11-28 | 泰世德(北京)医药科技有限公司 | Degradable tooth whitening material and preparation and application thereof |
| CN114058165B (en) * | 2021-11-04 | 2022-10-28 | 泰世德(北京)医药科技有限公司 | Piezoelectric polylactic acid material and preparation method and application thereof |
| CN113975196B (en) * | 2021-11-06 | 2024-03-15 | 周敏 | Oral cavity health care compound and preparation method thereof |
| CN114010536B (en) * | 2021-11-06 | 2024-03-15 | 周敏 | Oral care composition and method of making same |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103608445A (en) * | 2011-06-20 | 2014-02-26 | 宝洁公司 | Liquid cleaning and/or cleansing composition |
| CN106947228A (en) * | 2017-05-05 | 2017-07-14 | 四川大学 | Multistage porous poly-lactic acid material and preparation method thereof |
| CN107670108A (en) * | 2017-09-27 | 2018-02-09 | 四川大学 | A kind of tissue engineering bracket polylactic acid porous material and preparation method thereof |
| CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023071750A1 (en) * | 2021-10-26 | 2023-05-04 | 泰世德(北京)医药科技有限公司 | Degradable tooth whitening material, preparation thereof and application thereof |
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