CN114010536B - Oral care composition and method of making same - Google Patents
Oral care composition and method of making same Download PDFInfo
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- CN114010536B CN114010536B CN202111309423.8A CN202111309423A CN114010536B CN 114010536 B CN114010536 B CN 114010536B CN 202111309423 A CN202111309423 A CN 202111309423A CN 114010536 B CN114010536 B CN 114010536B
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- oral care
- care composition
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- stereocomplex
- peroxide
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- 239000000203 mixture Substances 0.000 title claims abstract description 84
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 82
- 239000000701 coagulant Substances 0.000 claims abstract description 48
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 41
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 23
- 239000002904 solvent Substances 0.000 claims abstract description 21
- 239000000796 flavoring agent Substances 0.000 claims abstract description 20
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 20
- 239000002245 particle Substances 0.000 claims abstract description 20
- 239000003086 colorant Substances 0.000 claims abstract description 16
- 239000000126 substance Substances 0.000 claims abstract description 16
- 230000000694 effects Effects 0.000 claims abstract description 12
- 230000000975 bioactive effect Effects 0.000 claims abstract description 11
- 239000007800 oxidant agent Substances 0.000 claims abstract description 6
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 4
- 229920000642 polymer Polymers 0.000 claims abstract description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 57
- 239000004626 polylactic acid Substances 0.000 claims description 57
- 150000001875 compounds Chemical class 0.000 claims description 48
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 42
- 102000004190 Enzymes Human genes 0.000 claims description 27
- 108090000790 Enzymes Proteins 0.000 claims description 27
- 230000000593 degrading effect Effects 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 25
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 24
- 244000163122 Curcuma domestica Species 0.000 claims description 23
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 23
- 235000003373 curcuma longa Nutrition 0.000 claims description 23
- 235000013976 turmeric Nutrition 0.000 claims description 23
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 22
- 229940116229 borneol Drugs 0.000 claims description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 22
- 244000246386 Mentha pulegium Species 0.000 claims description 16
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 16
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 16
- 235000001050 hortel pimenta Nutrition 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
- 239000001054 red pigment Substances 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 6
- 235000019154 vitamin C Nutrition 0.000 claims description 6
- 239000011718 vitamin C Substances 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 4
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 claims description 4
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000606 toothpaste Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 3
- 150000002978 peroxides Chemical class 0.000 claims description 3
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004343 Calcium peroxide Substances 0.000 claims description 2
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 claims description 2
- 229940050390 benzoate Drugs 0.000 claims description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 2
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims description 2
- 235000019402 calcium peroxide Nutrition 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 claims description 2
- 229960004995 magnesium peroxide Drugs 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 235000010388 propyl gallate Nutrition 0.000 claims description 2
- 239000000473 propyl gallate Substances 0.000 claims description 2
- 229940075579 propyl gallate Drugs 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims 2
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 10
- 238000005516 engineering process Methods 0.000 abstract description 3
- 231100000344 non-irritating Toxicity 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 239000002105 nanoparticle Substances 0.000 abstract description 2
- 238000004043 dyeing Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 94
- 235000019441 ethanol Nutrition 0.000 description 47
- 235000010215 titanium dioxide Nutrition 0.000 description 39
- 235000003599 food sweetener Nutrition 0.000 description 24
- 239000003765 sweetening agent Substances 0.000 description 24
- 238000002156 mixing Methods 0.000 description 17
- 238000003756 stirring Methods 0.000 description 15
- 210000003298 dental enamel Anatomy 0.000 description 13
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 13
- 230000002087 whitening effect Effects 0.000 description 10
- 238000002844 melting Methods 0.000 description 8
- 230000008018 melting Effects 0.000 description 8
- 235000006679 Mentha X verticillata Nutrition 0.000 description 7
- 235000002899 Mentha suaveolens Nutrition 0.000 description 7
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 7
- 239000003999 initiator Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 6
- 238000000227 grinding Methods 0.000 description 6
- 238000010186 staining Methods 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000011165 3D composite Substances 0.000 description 3
- 238000004040 coloring Methods 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229940078916 carbamide peroxide Drugs 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 244000293323 Cosmos caudatus Species 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
- 235000012732 erythrosine Nutrition 0.000 description 1
- 239000004174 erythrosine Substances 0.000 description 1
- 229940011411 erythrosine Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- -1 herba Menthae Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 230000008566 social perception Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 230000036344 tooth staining Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Abstract
An oral care composition and method of making the same, the oral care composition comprising: a stereocomplex, a biological coagulant, a coloring agent, a solvent, and at least one of a decoloring agent, a toner, a flavoring agent, and a bioactive substance, wherein the stereocomplex has a left-right foreign polymer, the stereocomplex has a particle size of 0.01-5 μm, and has a piezoelectric effect, the coloring agent comprises nano-sized titanium dioxide, the decoloring agent is selected from the group consisting of an oxidizing agent, a reducing agent, and a combination thereof, and a method for preparing the above oral care composition is provided; the invention uses the piezoelectric technology to make the particles move in the voltage field, and the dirt is removed under the impact of the particles, so that the dyeing factors are attached to the tooth surface, and the effect of dyeing the teeth is achieved, and the invention is green, environment-friendly, nontoxic and non-irritating.
Description
Technical Field
The invention relates to the technical field of tooth whitening, in particular to an oral care composition and a preparation method thereof.
Background
With the development of aesthetic standards, more and more people want to improve their appearance with cosmetics, and no exception is made to teeth, more and more people want their teeth to become bright or white. People with white teeth can gain more confidence and satisfaction, and even more social perception.
The teeth include an inner dentin layer and an outer hard enamel layer as a tooth protection layer. The enamel layer of a tooth is a natural opaque or pale white ("ivory") color. The tooth enamel layer is composed of hydroxyapatite mineral crystals that create a slightly porous surface. These hydroxyapatite crystals form extremely fine hexagonal rods or prisms, constituting the enamel surface. As a result, very small voids or pores exist between the prisms in the surface of the enamel layer. It is this porous nature of the enamel layer that allows the stain and staining substance to penetrate the enamel and stain the teeth. These leave-on substances can occupy these fine voids and ultimately alter the tooth color.
Many substances that people encounter or come into contact with each day can "stain" or reduce the "whiteness" of teeth. Especially, foods, tobacco products and fluids consumed by people are easy to stain the teeth of people. These products or substances tend to accumulate on the enamel layer of the tooth and form a film on the tooth. These colouring and discolouring substances then penetrate into the enamel layer. This problem occurs gradually over many years, but can cause significant discoloration of the enamel of a person's teeth.
In order to obtain a confident smile, there are several common methods of tooth whitening, such as professional cleaning and polishing, crown coverage or veneer, abrasive toothpastes for daily brushing. Professional dental dura mater cleaning and coverings require grinding or other enamel cutting steps that can cause irreversible damage, and these techniques are expensive and time consuming. In addition, toothpastes containing water-insoluble abrasives are safe, time-saving and cost-effective, but the removal of stains is only achieved by mechanical friction between the teeth and the abrasive elements, such as aluminum hydroxide, calcium carbonate and silicon, and therefore the abrasive cleaning effect is limited and, moreover, the surface of the teeth is slightly scratched, the enamel layer on the surface of the teeth is damaged and the enamel layer after grinding is more prone to discoloration.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide an oral care composition, which uses the piezoelectric technology to enable particles to move in a voltage field and dirt to be removed under the impact of the particles, so that a staining factor is attached to the surface of teeth, and the effect of staining the teeth is achieved, and the oral care composition is green, environment-friendly, nontoxic and non-irritating.
An oral care composition comprising:
a stereocomplex, a biological coagulant, a coloring agent, a solvent, and at least one of a decoloring agent, a toner, a flavoring agent and a bioactive substance, wherein the stereocomplex has a left-right foreign polymer, the stereocomplex has a particle size of 0.01-5 μm, and has a piezoelectric effect; the coloring agent comprises nanoscale titanium dioxide; the decolorizing agent is selected from the group consisting of oxidizing agents, reducing agents, and combinations thereof.
Preferably, the method comprises the following steps:
three-dimensional complex: 35-65%
Decoloring agent: 0-35%
And (3) a coloring agent: 5-38%
Biologically active substances: 0-8%
Toner: 0-1%
Flavoring agent: 0-2%
Biological coagulant: 0.2-10%
Solvent: 1-15%.
The oral care composition provided by the invention has the advantages that under the combination and the proportion, all the components are synergistic, and the cleaning and whitening effects can be exerted to a greater extent.
Preferably, the composition is divided into the following components:
the first component comprises: the stereocomplex, the bioactive substance, and the solvent, and at least one of a decolorizing agent, the toner, and the flavoring agent;
the second component comprises: the stereocomplex, the coloring agent, and at least one of a biological coagulant, the toner, and the flavoring agent;
or,
the first component comprises: the stereocomplex, the bioactive substance, and the solvent, and at least one of a decolorizing agent, the toner, and the flavoring agent;
the second component comprises: the stereocomplex, the coloring agent, and at least one of the toner and the flavoring agent;
the third component comprises: the stereocomplex and the biological coagulant.
The above components exert different functions, the first component exerts a cleaning effect, the second component exerts a coloring and whitening effect, and the third component exerts a solidifying effect. Of course, the setting action of the third component can also be integrated in the second component, while the whitening and setting action is achieved, in particular by the personnel involved, according to the requirements of the concerned, and will not be described in detail here.
Preferably, the oxidizing agent is selected from the group consisting of peroxides selected from lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, hydrogen peroxide, benzoyl peroxide, urea peroxide, and mixtures thereof, and the oxidizing agent is selected from the group consisting of vitamin C, vitamin E, benzoate, butylated hydroxytoluene, butylated hydroxyanisole, propyl gallate, and combinations thereof.
Preferably, the stereocomplex is a stereocomplex, preferably biodegradable stereocomplex polylactic acid.
The polylactic acid has good thermal stability, and the product prepared from the polylactic acid has good biocompatibility and heat resistance besides biodegradation.
The toner is selected from a lake, a dye, or a combination thereof; preferably, the lake is preferably FD & C blue lake, FD & C blue lake No. 2, FD & C red lake No. 3, FD & C yellow lake No. 5, FD & C yellow lake No. 6, or a combination thereof; preferably, the dye is a natural pigment, including turmeric or purplish red pigment; the bioactive substance includes a degrading enzyme.
Preferably, the pearl powder also comprises at least one of pearl powder, borneol and mint, wherein the particle size of the pearl powder is 0.01-2 microns. The pearl powder also has the whitening effect, and can whiten teeth, and the borneol is a traditional Chinese medicine, has the effects of inducing resuscitation, refreshing, clearing heat and relieving pain, and can give cool and refreshing feel to the mint, so that the mint is liked by people.
Preferably, the 2 theta angles corresponding to the diffraction peaks of the stereocomplex are 13 degrees, 16 degrees, 20 degrees and 26 degrees, and the crystallinity is 50-60 percent. The higher crystallinity enables the three-dimensional compound to have better piezoelectric effect, thereby achieving better tooth whitening effect.
Preferably, the oral care composition is in the form of a powder, liquid, paste or gel, preferably, a toothpaste, tooth powder, chewing gum, chew, gel or tooth cleaning solution.
The preparation method of the oral care composition comprises the following steps:
vacuum drying 30-49 parts of a levorotatory compound and 51-70 parts of a dextrorotatory compound at a vacuum degree of less than 1000Pa and a temperature of 20-70 ℃ until the water content is less than 100ppm, placing the dried powder into a closed cavity for product molding, maintaining the pressure for 0.1-4.5 h under the conditions of 150-220 ℃ and 1.1-3.5 GPa by using high-pressure equipment, washing by using ethanol, heating to 250-300 ℃, stirring for 0.3-4h at a speed of 350-550r/min, grinding for 0.1-1h, and maintaining the pressure for 0.8-5.5 h under the conditions of 180-280 ℃ and 1.5-3.8 GPa by using high-pressure equipment to obtain a primary mixture of the levorotatory compound and the dextrorotatory compound;
firstly, 0.05 to 3.0 parts of initiator and 0.2 to 5.0 parts of cross-linking agent are completely dissolved in a solvent, and then the mixture is uniformly mixed with the primary mixture of the levorotatory compound and the dextrorotatory compound;
adding the mixed materials into a melting mixer, and melting and blending for 2-75min at the temperature of 110-180 ℃ and the rotating speed of 20-120rpm to obtain powdery three-dimensional compound;
mixing the part of the prepared three-dimensional compound with at least one selected from a decoloring agent, a toner and a flavoring agent, and stirring at a speed of 50-150r/min for 0.1-0.2h at normal temperature to obtain a first component;
mixing the part of the prepared three-dimensional compound, the coloring agent and at least one selected from the toner and the flavoring agent, and stirring at the speed of 250-450r/min for 0.1-1h at the temperature of 30-120 ℃ to obtain a second component;
the first component, second component together comprise the oral care composition.
In the preparation of the stereocomplex, unequal amounts of the dextro compound and dextro isomer are adopted, so that the symmetry of the product is reduced. The three-dimensional compound is prepared from the heterogeneous polylactic acid, and the performances of heat resistance, hydrolysis resistance and the like of the three-dimensional compound prepared by the preparation method are obviously improved.
Preferably, the method further comprises: mixing the rest part of the prepared three-dimensional compound with biological coagulant, and stirring at the speed of 350-550r/min for 0.1-1h at the temperature of 20-100 ℃ to obtain a third component; the first component, second component, and third component together comprise the oral care composition.
Preferably, when used, the first component, the second component and the third component are used sequentially; or when in use, the first component, the second component and the third component are mixed in sequence and then used.
Preferably, the average molecular weight of the D-polylactic acid is 3×10 4 ～8×10 5 g.mol, optical purity is more than 92%; the weight average molecular weight of the L-polylactic acid is 5 multiplied by 10 4 ～9×10 5 g.mol, and the optical purity is more than 92%.
First, the present invention provides an oral care composition, which in use, employs piezoelectric technology to move particles in a voltage field, and dirt is removed under the impact of the particles, so that staining factors are attached to the tooth surface, and the effect of staining teeth is achieved, and the oral care composition is green, environment-friendly, nontoxic and non-irritating.
Secondly, the invention provides a colorant of an oral care composition, which comprises rice-grade titanium dioxide, and the rice-grade titanium dioxide is filled in pores and holes on the surface of teeth after dirt is removed, so that the colorant has good coloring effect, and can effectively reduce the probability of tooth staining and prolong the whitening aging.
Thirdly, the invention provides a preparation method of an oral care composition, and the prepared stereocomplex has high crystallinity (50-60%), a stereotactic structure and an isotactic content of more than 70%, so that the prepared oral care composition has better piezoelectricity and achieves better whitening effect.
Fourth, the process for preparing the oral care compositions of the present invention catalyzes polymerization under milder conditions and monomer conversion is greater than 80%.
Fifth, the present invention provides an oral care composition, which is simple in operation, does not require additional equipment and specialized technicians, does not harm teeth, and can obtain a long-lasting tooth whitening effect.
Detailed Description
The following describes the invention in further detail with reference to examples. The following examples are only for more clearly illustrating the technical aspects of the present invention, and are not intended to limit the scope of the present invention.
Example 1
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 30%
Hydrogen peroxide: 15%
Sweetener: 0.1%
Biological coagulant: 0.2%
Ethanol: 9.7%.
Example 2
An oral care composition comprising:
stereocomplex polylactic acid: 55% of (B)
Nanoscale titanium dioxide: 35%
Biological coagulant: 0.2%
Ethanol: 9.8%.
The oral care composition of this example is configured to form three components, respectively:
the first component comprises: 40-60% of the stereocomplex, the nano-sized titanium dioxide and the ethanol;
the second component comprises: 20-30% of the three-dimensional compound, the nano-scale titanium dioxide and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 3
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Urea peroxide: 25 percent of
Nanoscale titanium dioxide: 18%
Degrading enzyme: 5%
Turmeric: 0.2%
Sweetener: 0.1%
Biological coagulant: 3%
Ethanol: 3.7%.
The oral care composition of this example forms two components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nano titanium dioxide, carbamide peroxide and degrading enzyme;
the second component comprises: the three-dimensional compound comprises 20-30% of nano titanium dioxide, biological coagulant, turmeric and sweetener.
Example 4
An oral care composition comprising:
stereocomplex polylactic acid: 65 % of (B)
Nanoscale titanium dioxide: 10 percent of
Degrading enzyme: 3%
Vitamin C:15%
FD & C red No. 3 lake: 1%
Sour agent: 1.2%
Biological coagulant: 0.2%
Ethanol: 4.6%.
Example 5
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 28%
Degrading enzyme: 2%
Benzoate: 15%
FD & C blue lake: 0.1%
Sweetener: 2%
Biological coagulant: 2.9%
Ethanol: 5%.
Example 6
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 18%
Degrading enzyme: 2%
Borneol: 0.2%
Peppermint: 0.5%
Benzoate: 15%
FD & C blue lake: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the stereocomplex, benzoate, FD & C blue lake, nanoscale titanium dioxide, and the solvent;
the second component comprises: 20-30% of the three-dimensional compound, nanoscale titanium dioxide, FD & C blue lake, peppermint, borneol, sweetener and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 7
An oral care composition comprising:
stereocomplex polylactic acid: 55% of (B)
Nanoscale titanium dioxide: 19%
Hydrogen peroxide, sodium peroxide: 15%
Purplish red pigment: 1%
Biological coagulant: 0.2%
Ethanol: 9.8%.
The oral care composition of this example is configured to form three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, purplish red pigment, the nanoscale titanium dioxide, hydrogen peroxide, sodium peroxide and the ethanol;
the second component comprises: 20-30% of the three-dimensional compound, purplish red pigment, the nanoscale titanium dioxide and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 8
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Urea peroxide: 28%
Nanoscale titanium dioxide: 15%
Degrading enzyme: 3%
Turmeric: 0.1%
Sweetener: 0.2%
Biological coagulant: 5%
Ethanol: 3.7%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, carbamide peroxide, degrading enzyme, nano-scale titanium dioxide and the ethanol;
the second component comprises: 20-30% of the three-dimensional compound, nano-scale titanium dioxide, turmeric and sweetener and the ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and the ethanol.
Example 9
An oral care composition comprising:
stereocomplex polylactic acid: 65 % of (B)
Nanoscale titanium dioxide: 10 percent of
Degrading enzyme: 3%
Vitamin C:15%
Turmeric: 1%
Sour agent: 1.2%
Biological coagulant: 0.2%
Ethanol: 4.6%.
Example 10
An oral care composition comprising:
stereocomplex polylactic acid: 48 % of (B)
Nanoscale titanium dioxide: 25 percent of
Degrading enzyme: 5%
Benzoate: 12%
FD & C blue lake: 0.1%
Sour agent: 2%
Biological coagulant: 2.9%
Ethanol: 5%.
Example 11
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 18%
Degrading enzyme: 2%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nanoscale titanium dioxide, degrading enzyme, hydrogen peroxide and the solvent;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, peppermint, borneol, sweetener, turmeric and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 12
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 15%
Degrading enzyme: 2%
Pearl powder: 3%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the stereocomplex, nanoscale titanium dioxide, hydrogen peroxide and the solvent;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, pearl powder, mint, borneol, sweetener, turmeric and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 13
An oral care composition comprising:
stereocomplex polylactic acid: 65 % of (B)
Nanoscale titanium dioxide: 10 percent of
Degrading enzyme: 3%
Vitamin C:15%
Turmeric: 1%
Spicy agent: 1.2%
Biological coagulant: 0.2%
Polyethylene glycol: 4.6%.
Example 14
An oral care composition comprising:
stereocomplex polylactic acid: 48 % of (B)
Nanoscale titanium dioxide: 25 percent of
Degrading enzyme: 5%
Benzoate: 12%
Turmeric: 0.1%
Sour agent: 2%
Biological coagulant: 2.9%
Ethylene oxide: 5%.
Example 15
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 18%
Degrading enzyme: 2%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Propylene oxide: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nano titanium dioxide, degrading enzyme, hydrogen peroxide and propylene oxide;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, peppermint, borneol, sweetener, turmeric and propylene oxide;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 16
An oral care composition comprising:
stereocomplex polylactic acid: 45 % of (B)
Nanoscale titanium dioxide: 15%
Degrading enzyme: 2%
Pearl powder: 3%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Purplish red pigment: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nanoscale titanium dioxide, degrading enzyme, hydrogen peroxide and the solvent;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, pearl powder, mint, borneol, sweetener, purplish red pigment and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 17
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 0.05 micron: 48 % of (B)
Nanoscale titanium dioxide: 25 percent of
Degrading enzyme: 5%
Benzoate: 12%
FD & C blue lake: 0.1%
Sour agent: 2%
Biological coagulant: 2.9%
Ethanol: 5%.
Example 18
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 5 microns: 45 % of (B)
Nanoscale titanium dioxide: 18%
Degrading enzyme: 2%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nano titanium dioxide, degrading enzyme, hydrogen peroxide and ethanol;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, peppermint, borneol, sweetener, turmeric and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Example 19
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 2 microns: 45 % of (B)
Nanoscale titanium dioxide: 17%
Pearl powder with a particle size of 0.01 micron: 3%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the stereocomplex, nanoscale titanium dioxide, hydrogen peroxide and the solvent;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, pearl powder, mint, borneol, sweetener, turmeric and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
Embodiment example 20
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 0,3 microns: 65 % of (B)
Nanoscale titanium dioxide: 10 percent of
Degrading enzyme: 3%
Vitamin C:15%
Turmeric: 1%
Spicy agent: 1.2%
Biological coagulant: 0.2%
Polyethylene glycol: 4.6%.
Example 21
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 0.1 micrometer: 48 % of (B)
Nanoscale titanium dioxide: 25 percent of
Degrading enzyme: 5%
Benzoate: 12%
Turmeric: 0.1%
Sour agent: 2%
Biological coagulant: 2.9%
Ethylene oxide: 5%.
The degrees of 2 theta corresponding to the diffraction peaks of the three-dimensional composite polylactic acid are 13 degrees, 16 degrees, 20 degrees and 26 degrees, and the crystallinity is 60 percent.
Example 22
An oral care composition comprising:
the particle diameter of the stereocomplex polylactic acid is 1 micrometer: 45 % of (B)
Nanoscale titanium dioxide: 18%
Degrading enzyme: 2%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Turmeric: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Propylene oxide: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the three-dimensional compound, nano titanium dioxide, degrading enzyme, hydrogen peroxide and propylene oxide;
the second component comprises: 20-30% of the three-dimensional compound, nano titanium dioxide, peppermint, borneol, sweetener, turmeric and propylene oxide;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
The degrees of 2 theta corresponding to the diffraction peaks of the three-dimensional composite polylactic acid are 13 degrees, 16 degrees, 20 degrees and 26 degrees, and the crystallinity is 55 percent.
Example 23
An oral care composition comprising:
the particle size of the stereocomplex polylactic acid is 0.5 micrometer: 47 % of (B)
Nanoscale titanium dioxide: 15%
Pearl powder with a particle size of 1 micron: 3%
Borneol: 0.2%
Peppermint: 0.5%
Hydrogen peroxide: 15%
Purplish red pigment: 0.1%
Sweetener: 2%
Biological coagulant: 10 percent of
Ethanol: 7.2%.
The oral care composition of this example forms three components, respectively:
the first component comprises: 40-60% of the stereocomplex, nanoscale titanium dioxide, hydrogen peroxide and the solvent;
the second component comprises: 20-30% of the stereocomplex polylactic acid, nano titanium dioxide, pearl powder, peppermint, borneol, sweetener, purplish red pigment and ethanol;
the third component comprises: the remainder of the stereocomplex, a biological coagulant, and ethanol.
The degrees of 2 theta corresponding to the diffraction peaks of the three-dimensional composite polylactic acid are 13 degrees, 16 degrees, 20 degrees and 26 degrees, and the crystallinity is 50 percent.
Example 24
The method of preparing the oral care composition of any of the above examples 1-2, 4-23 is as follows:
vacuum drying 30 parts of L-polylactic acid and 70 parts of D-polylactic acid at a vacuum degree of less than 1000Pa at a temperature of 70 ℃ until the water content is lower than 100ppm, placing the dried powder into a closed cavity for product molding, maintaining the pressure for 4.5 hours at a temperature of 150 ℃ and a pressure of 3.5GPa by using high-pressure equipment, washing by using ethanol, heating to 250 ℃, stirring for 4 hours at a speed of 550r/min, grinding for 0.1 hour, and maintaining the pressure for 5.5 hours at a temperature of 180 ℃ and a pressure of 3.8GPa by using high-pressure equipment to obtain an initial mixture of the L-polylactic acid and the D-polylactic acid;
firstly, completely dissolving 3.0 parts of an initiator and 5.0 parts of a cross-linking agent in a solvent, and then uniformly mixing the initiator with the primary mixture of the levorotatory polylactic acid and the dextrorotatory polylactic acid;
adding the mixed materials into a melting mixer, and melting and blending for 75min at the temperature of 110 ℃ and the rotating speed of 120rpm to obtain powdery three-dimensional compound polylactic acid;
mixing 40-60% of the three-dimensional compound prepared by the method, decolorizing agent, bioactive substances, toner, flavoring agent and solvent, and stirring at 150r/min for 0.1h at normal temperature to obtain a first component;
mixing 20-30% of the above three-dimensional compound, toner, flavoring agent, pearl powder, borneolum Syntheticum and herba Menthae, and stirring at 120deg.C and 250r/min for 1 hr to obtain a second component;
mixing the rest part of the prepared stereocomplex polylactic acid with biological coagulant, and stirring at the speed of 550r/min for 0.1h at the temperature of 100 ℃ to obtain a third component.
It should be noted that, if no component is present in the corresponding examples, the preparation method is carried out without adding the component.
Example 25
The preparation method of the oral care composition of any of the above examples 1, 3-5, 9-10, 13-14, 17, 20-21 is as follows:
drying 49 parts of L-polylactic acid and 51 parts of D-polylactic acid in vacuum at a vacuum degree of less than 1000Pa at 50 ℃ until the water content is lower than 100ppm, placing the dried powder into a closed cavity for product molding, maintaining the pressure for 2.5 hours at 180 ℃ and 2.5GPa by using high-pressure equipment, washing by using ethanol, heating to 280 ℃, stirring for 2 hours at a speed of 450r/min, grinding for 0.5 hour, and maintaining the pressure for 3.5 hours at 220 ℃ and 2.8GPa by using high-pressure equipment to obtain an initial mixture of the L-polylactic acid and the D-polylactic acid;
01.0 parts of initiator and 2.0 parts of cross-linking agent are completely dissolved in a solvent, and then the initiator and the primary mixture of the L-polylactic acid and the D-polylactic acid are uniformly mixed;
adding the mixed materials into a melting mixer, and melting and blending for 35min at the temperature of 150 ℃ and the rotating speed of 80rpm to obtain powdery three-dimensional compound polylactic acid;
mixing 50% of the three-dimensional compound prepared by the method, decolorizing agent, bioactive substances, toner, flavoring agent and solvent, and stirring at a speed of 100r/min for 0.15h at normal temperature to obtain a first component;
mixing 50% of the above three-dimensional compound, margarita powder, herba Menthae, colorant, borneolum Syntheticum, biological coagulant, toner and flavoring agent, and stirring at 75deg.C and 350r/min for 0.6 hr to obtain second component.
Example 26
The method of preparing the oral care composition of any of the above examples 1-2, 4-23 is as follows:
vacuum drying 40 parts of L-polylactic acid and 60 parts of D-polylactic acid at a vacuum degree of less than 1000Pa at a temperature of 70 ℃ until the water content is lower than 100ppm, placing the dried powder into a closed cavity for product molding, maintaining the pressure for 4.5 hours at a temperature of 150 ℃ and a pressure of 1.1GPa by using high-pressure equipment, washing by using ethanol, heating to 300 ℃, stirring for 4 hours at a speed of 350r/min, grinding for 1 hour, and maintaining the pressure for 0.8 hour at a temperature of 280 ℃ and a pressure of 3.8GPa by using high-pressure equipment to obtain an initial mixture of the L-polylactic acid and the D-polylactic acid;
firstly, completely dissolving 3.0 parts of an initiator and 5.0 parts of a cross-linking agent in a solvent, and then uniformly mixing the initiator with the primary mixture of the levorotatory polylactic acid and the dextrorotatory polylactic acid;
adding the mixed materials into a melting mixer, and melting and blending for 75min at the temperature of 180 ℃ and the rotating speed of 20rpm to obtain powdery three-dimensional compound polylactic acid;
mixing 60% of the three-dimensional compound prepared by the method, decolorizing agent, bioactive substances, toner, flavoring agent and solvent, and stirring at a speed of 150r/min for 0.2h at normal temperature to obtain a first component;
mixing 20% of the prepared three-dimensional compound, coloring agent, toner, borneol, mint, pearl powder and flavoring agent, and stirring at the speed of 450r/min for 0.1h at 120 ℃ to obtain a second component;
mixing the rest part of the prepared stereocomplex polylactic acid with biological coagulant, and stirring at the speed of 350r/min for 1h at the temperature of 100 ℃ to obtain a third component.
Claims (10)
1. An oral care composition comprising:
three-dimensional complex: 35-65%
Decoloring agent: 0-35%
And (3) a coloring agent: 5-38%
Biologically active substances: 0-8%
Toner: 0-1%
Flavoring agent: 0-2%
Biological coagulant: 0.2-10%
Solvent: 1-15%;
the three-dimensional compound is provided with left and right foreign polymer, the particle size of the three-dimensional compound is 0.01-5 microns, the three-dimensional compound has a piezoelectric effect, and the three-dimensional compound is biodegradable three-dimensional compound polylactic acid; the coloring agent comprises nanoscale titanium dioxide; the decolorizing agent is selected from the group consisting of an oxidizing agent, a reducing agent, and combinations thereof;
is divided into the following components:
the first component comprises: the stereocomplex and the solvent, and at least one selected from the group consisting of the bioactive substance, the decolorizing agent, the toner, and the flavoring agent;
the second component comprises: the stereocomplex, the coloring agent, and the biological coagulant, and at least one selected from the group consisting of the toner and the flavoring agent;
or,
the first component comprises: the stereocomplex and the solvent, and at least one selected from the group consisting of the bioactive substance, the decolorizing agent, the toner, and the flavoring agent;
the second component comprises: the stereocomplex and the coloring agent, and at least one selected from the group consisting of the toner and the flavoring agent;
the third component comprises: the stereocomplex and the biological coagulant.
2. The oral care composition of claim 1, wherein the oxidizing agent is selected from the group consisting of peroxides, metal chlorites, persulfates, and combinations thereof.
3. The oral care composition according to claim 2, wherein the peroxide is selected from the group consisting of lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, hydrogen peroxide, benzoyl peroxide, urea peroxide, and mixtures thereof; the reducing agent is selected from the group consisting of vitamin C, vitamin E, benzoate, butylated hydroxytoluene, butylated hydroxyanisole, propyl gallate, and combinations thereof.
4. The oral care composition of claim 1, wherein the toner is selected from lakes, dyes, or combinations thereof.
5. The oral care composition of claim 4, wherein the lake is FD & C blue lake, FD & C blue lake No. 2, FD & C red lake No. 3, FD & C yellow lake No. 5, FD & C yellow lake No. 6, or a combination thereof.
6. The oral care composition of claim 4, wherein the dye is a natural pigment comprising turmeric or purplish red pigment; the bioactive substance includes a degrading enzyme.
7. The oral care composition of any one of claims 1-6, further comprising at least one of pearl powder, borneol and peppermint, wherein the pearl powder has a particle size of 0.01-2 microns.
8. The oral care composition of any one of claims 1-6 wherein the stereocomplex diffraction peaks correspond to 2Θ angles of 13 °, 16 °, 20 °, 26 °, and a crystallinity of 50-60%.
9. The oral care composition according to any one of claims 1 to 6 wherein the oral care composition is in the form of a powder, liquid, paste or gel.
10. The oral care composition according to any one of claims 1 to 6 wherein the oral care composition is in the form of a toothpaste, a tooth powder, a chewing gum, a bite-size or a tooth cleaning solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111309423.8A CN114010536B (en) | 2021-11-06 | 2021-11-06 | Oral care composition and method of making same |
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| CN115737458A (en) * | 2022-10-18 | 2023-03-07 | 北京化工大学 | Oral antibacterial material capable of being used with electric toothbrush and preparation method thereof |
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